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Migraine Disorders
A class of disabling primary headache disorders, characterized by recurrent unilateral pulsatile headaches. The two major subtypes are common migraine (without aura) and classic migraine (with aura or neurological symptoms). (International Classification of Headache Disorders, 2nd ed. Cephalalgia 2004: suppl 1)
Subtype terms (5)
More specific conditions that are subtypes of Migraine Disorders in the MeSH hierarchy.
- Alice in Wonderland Syndrome
- Migraine with Aura
48 drugs (42 approved, 6 experimental)
- Migraine without Aura
53 drugs (43 approved, 10 experimental)
- Ophthalmoplegic Migraine
- Vestibular Migraine
Drugs by status
Approved for this indication (48)
- celecoxib
- acetaminophen
- codeine
- diclofenac
- calcitonin gene related peptide
- caffeine
- petasites hybridus leaf extract
- secobarbital
- naproxen
- topiramate
- ubrogepant
- propranolol
- ergotamine
- prochlorperazine
- pseudoephedrine
- diltiazem
- almotriptan
- zolmitriptan
- atogepant
- chlorpromazine
- fentanyl
- galcanezumab-gnlm
- rimegepant
- dihydroergotamine
- butalbital
- sibelium
- diethylpropion hydrochloride
- zavegepant
- danzhen
- ergoloid mesylate
- +18 more
Phase 4 trials (50)
- metoclopramide
- ibuprofen
- histamine
- bupivacaine
- sodium chloride
- tetrahydrocannabinol
- diphenhydramine
- urea
- acetylcarnitine
- Dexketoprofen
- ramelteon
- naoandiwan
- venlafaxine
- ethinyl estradiol
- tromethamine
- duloxetine
- methylprednisolone
- rivaroxaban
- magnesium
- haloperidol
- cannabidiol
- zonisamide
- estradiol
- clopidogrel
- ketorolac
- nortriptyline
- milnacipran
- eszopiclone
- betamethasone
- dexibuprofen
- +20 more
Phase 3 trials (28)
- vancomycin
- magnesium lactate
- candesartan
- memantine
- metamizole
- cyclobenzaprine
- acetylcysteine
- clorazepate
- telcagepant potassium
- magnesium sulfate
- telcagepant
- levonorgestrel
- vitamin d3
- propofol
- sitagliptin
- melatonin
- ketoprofen
- prasugrel
- meloxicam
- incobotulinumtoxinA
- albuterol
- dabigatran
- lacosamide
- vitamin e
- vitamin c
- Vazegepant
- palmitoylethanolamide
- apixaban
Phase 2 trials (68)
- ipn10200
- tricaprylyl glycerol
- atenolol
- lactose
- loxapine
- bi 44370
- simvastatin
- Zelminemab
- bhv-2100
- donepezil
- lornoxicam
- ionis-pkkrx
- carisbamate
- ly2590443
- carbon dioxide
- sb-705498
- norgestrel
- motexafin gadolinium
- sepranolone
- filorexant
- medi0618
- gw 274150
- ly3451838
- mtx-101
- niacin
- ly2300559
- perampanel
- corticotropin
- oxygen
- gabapentin
- +38 more
Phase 1 trials (21)
Other trials (73)
- carbon monoxide
- prednisone
- tanacetum parthenium
- doxycycline
- eucalyptus oil
- Andrographis paniculata
- riboflavin
- isopropyl alcohol
- dinoprostone
- nesiritide
- ropivacaine
- baclofen
- cellulose
- dermofungin
- lactulose
- substance p
- maxipost
- menthol
- pacap27
- prilocaine
- omega-3 fatty acids
- ergot
- triamcinolone
- adrenomedullin (22-52)
- cocoa extract
- adenosine
- ginger
- autologous microbiome
- coffee
- tifenazoxide
- +43 more
Organizations
Organization Involved with Phase 4 Indications (89)
- Daiichi Sankyo
- Eisai
- Takeda
- Bristol-Myers Squibb
- Pernix
- Amgen
- Sanofi
- Novartis
- Allergan
- Clinvest
- Endo Pharmaceuticals
- Jiangsu Kanion Pharmaceutical Co., Ltd
- MedVadis Research Corporation
- Targeted Medical Pharma
- Sunovion
- Tian Medical Inc.
- Zogenix, Inc.
- National Institutes of Health (NIH)
- National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
- National Institute of Neurological Disorders and Stroke (NINDS)
- United States Navy
- Danish Headache Center
- University of Manitoba
- University of Pittsburgh
- Akdeniz University
- Birjand University of Medical Sciences
- Bozok University
- California Medical Clinic for Headache
- Charlottesville Neuroscience
- University of London
- +59 more
Organization Involved with Phase 3 Indications (75)
- Abbott
- Ache Laboratorios Farmaceuticos S.A.
- Cephalon
- Vernalis
- Impax Laboratories
- Avanir
- Ipsen
- Allodynic Therapeutics, LLC
- Axsome Therapeutics, Inc.
- CoLucid Pharmaceuticals
- Eurofarma Laboratorios S.A.
- Lotus Pharmaceutical
- OptiNose AS
- POZEN
- ProEthic Pharmaceuticals
- Sponsor GmbH
- Boehringer Ingelheim
- IlDong Pharmaceutical Co Ltd
- Otsuka
- Pharmalyte Solutions LLC
- The EMMES Corporation
- Zosano Pharma Inc.
- Fundação de Amparo à Pesquisa do Estado de São Paulo
- ZonMw: The Netherlands Organisation for Health Research and Development
- Behar, Caren, M.D.
- Shahid Beheshti University of Medical Sciences
- University of Pennsylvania
- Hospital Militar del General Luis Felipe Brieba Aran
- Indiana University
- Kennedy Medical Group
- +45 more
Organization Involved with Phase 2 Indications (85)
- Achelios Therapeutics
- XenoPort, Inc.
- Shire
- Elan Pharmaceuticals
- BTG
- AOBiome LLC
- ASIS Corporation
- Alexza Pharmaceuticals, Inc.
- Ariston Pharmaceuticals, Inc.
- BioHealthonomics Inc.
- Charleston Laboratories, Inc
- FGK Clinical Research GmbH
- Ionis Pharmaceuticals, Inc.
- Minster Research Ltd
- NeurAxon Inc.
- Nektar Therapeutics
- RZN Nutraceuticals, Inc.
- Arvelle
- Solvay
- TorreyPines Therapeutics
- Trigemina, Inc
- D-Pharm Ltd.
- Duramed Research
- Asarina Pharma
- Casa Espirita Terra de Ismael
- IRCCS National Neurological Institute C. Mondino Foundation
- United States Army
- Baylor University
- Canisius-Wilhelmina Hospital
- Dent Neurologic Institute
- +55 more
Organization Involved with Phase 1 Indications (17)
- PPD
- Acorda Therapeutics
- Kimberly Clark
- University of Tehran
- University of Adelaide
- University of Colorado, Denver
- Nucleus Network Ltd
- Quotient
- Wake Research Associates
- Prism Research
- MeritCare Broadway Health Center
- University of Liege
- University of Colorado
- Ecion Pharmaceutical Co
- Government of Denmark
- IQVIA
- Wallace Research Foundation
Organization Involved with Other Experimental Indications (47)
- Fresenius
- Neurological Research Center
- Verifomics LLC
- Accumetrics, Inc.
- American Academy of Otolaryngology-Head and Neck Surgery Foundation
- Fondazione I.R.C.C.S. Istituto Neurologico Carlo Besta
- University of Roma La Sapienza
- Biohit Oyj
- Rambam Health Care Campus
- Ataturk University
- Case Western Reserve University
- European Institute for Evidence Based Osteopathic Medicine
- Federal University of Minas Gerais
- HealthPartners Institute
- Kuang Tien General Hospital
- Neurological Associates of West Los Angeles
- New York University
- Ohio State University
- Shanghai University of Traditional Chinese Medicine
- Texas A&M University
- University of Louisville
- University of Missouri, Kansas City
- University of Toronto
- University of Bern
- Wageningen University
- Netherlands Organisation for Scientific Research
- St. Louis University
- Virginia Polytechnic Institute and State University
- Mercy Health Research
- University of Haifa
- +17 more