substance p
Small moleculeexperimental
Substance P (SP) is an undecapeptide and a type of neuropeptide, belonging to the tachykinin family of neuropeptides. It acts as a neurotransmitter and a neuromodulator. Substance P and the closely related neurokinin A (NKA) are produced from a polyprotein precursor after alternative splicing of the preprotachykinin A gene. The deduced amino acid sequence of substance P is as follows:Arg Pro Lys Pro Gln Gln Phe Phe Gly Leu Met (RPKPQQFFGLM) — Wikipedia
Clinical trial activity
8 trials · 8 clinical orgs · 0 marketing orgs
Phase 1
2
Phase 2
0
Phase 3
0
Phase 4
1
Earliest trial started Jan 1, 2011 (NCT01280149)
Timeline
2010s
- Jan 1, 2011
Earliest Phase 1 Sponsor(trial)
Indications
Approved for
Mechanism of action
- Neurokinin 1 receptorINHIBITOR
TACR1 inhibitor
Chemistry & pharmacology
Loading structure…
SMILES
CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CCCN=C(N)N)C(N)=O- Mol. weight
- 1347.66 g/mol
- Chirality
- Single Stereoisomer
- Inorganic
- No
- Polymer
- No
Oral
No
Parenteral
No
Topical
No
Sources
- WikipediaSubstance P ↗
- ChEMBLCHEMBL235363 ↗
Also known as
- substance p
- substance p
- substance p
Clinical trials
| NCT ID | Phase | Start date | Sponsor(s) |
|---|---|---|---|
| NCT06959004 | N/A | May 13, 2025 | University of Copenhagen |
| NCT06632080 | N/A | Oct 14, 2024 | University of Copenhagen |
| NCT04676763 | N/A | Feb 4, 2021 | GlaxoSmithKline |
| NCT03738878 | Phase 4 | Nov 15, 2018 | Vanderbilt University |
| NCT02820558 | Phase 1 | May 1, 2016 | University of Toronto, Vanilloid Genetics Inc. |
| NCT01599728 | N/A | May 1, 2012 | NHS Lothian, University of Edinburgh |
| NCT01413542 | N/A | Nov 1, 2011 | Vanderbilt University |
| NCT01280149 | Phase 1 | Jan 1, 2011 | Northwestern University |
Showing 8 of 8 trials
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Organizations
Research & Development (8)
| Organization | Org type | Trials | As lead sponsor | Phases | Earliest year |
|---|---|---|---|---|---|
| University of Copenhagen | Academic/Hospital | 2 | 2 | 1 | 2024 |
| Vanderbilt University | Academic/Hospital | 2 | 2 | 2 | 2011 |
| GlaxoSmithKline | For profit | 1 | 1 | 1 | 2021 |
| NHS Lothian | Academic/Hospital | 1 | 0 | 1 | 2012 |
| Northwestern University | Academic/Hospital | 1 | 1 | 1 | 2011 |
| University of Edinburgh | Academic/Hospital | 1 | 1 | 1 | 2012 |
| University of Toronto | Academic/Hospital | 1 | 0 | 1 | 2016 |
| Vanilloid Genetics Inc. | For profit | 1 | 1 | 1 | 2016 |
8 organizations
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