zavegepant
Trade name: zavzpret
Small moleculeapproved
Approved
Mar 9, 2023
Clinical trial activity
12 trials · 4 clinical orgs · 1 marketing orgs
Phase 1
6
Phase 2
3
Phase 3
4
Phase 4
2
Earliest trial started Oct 27, 2020 (NCT04571060)
Timeline
Indications
Approved for
Mechanism of action
- Calcitonin gene-related peptide 1ANTAGONIST
CALCA antagonist
Calcitonin-gene-related peptide receptor, CALCRL/RAMP1 antagonist
Calcitonin gene-related peptide type 1 receptor antagonist
Approval history
- approvedMar 9, 2023
Chemistry & pharmacology
Loading structure…
SMILES
Cc1cc(C[C@@H](NC(=O)N2CCC(c3cc4ccccc4[nH]c3=O)CC2)C(=O)N2CCN(C3CCN(C)CC3)CC2)cc2cn[nH]c12- Mol. weight
- 638.82 g/mol
- Lipinski Ro5
- 1 violation(s)
- Rule of 3
- No
- Chirality
- Single Stereoisomer
- Inorganic
- No
- Polymer
- No
- Delivery
- Topical
- Availability
- Prescription Only
Oral
No
Parenteral
No
Topical
Yes
Sources
- ChEMBLCHEMBL4650220 ↗
- ChEMBLCHEMBL2397415 ↗
Clinical trials
| NCT ID | Phase | Start date | Sponsor(s) |
|---|---|---|---|
| NCT06985342 | Phase 4 | Jun 5, 2025 | Icahn School of Medicine at Mount Sinai, Pfizer |
| NCT06995729 | Phase 1 | May 16, 2025 | Pfizer |
| NCT06453356 | Phase 1 | Jun 10, 2024 | Pfizer |
| NCT06401642 | Phase 4 | Mar 22, 2024 | Mayo Clinic |
| NCT05989048 | Phase 3 | Nov 29, 2023 | Pfizer |
| NCT06103734 | Phase 3 | Nov 17, 2023 | Pfizer |
| NCT05960032 | Phase 1 | Oct 23, 2023 | Pfizer |
| NCT05948085 | Phase 1 | Jul 10, 2023 | Pfizer |
| NCT06137703 | Phase 1 | Aug 24, 2022 | Pfizer |
| NCT04987944 | Phase 1 | Oct 18, 2021 | Biohaven Pharmaceuticals Inc. |
| NCT04804033 | Phase 2/Phase 3 (Phase 3) | Mar 26, 2021 | Biohaven Pharmaceuticals Inc. |
| NCT04571060 | Phase 3 | Oct 27, 2020 | Biohaven Pharmaceuticals Inc. |
Showing 12 of 12 trials
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Organizations
Research & Development (4)
| Organization | Org type | Trials | As lead sponsor | Phases | Earliest year |
|---|---|---|---|---|---|
| Pfizer | For profit | 8 | 7 | 3 | 2022 |
| Biohaven Pharmaceuticals Inc. | For profit | 3 | 3 | 2 | 2020 |
| Icahn School of Medicine at Mount Sinai | Academic/Hospital | 1 | 1 | 1 | 2025 |
| Mayo Clinic | Academic/Hospital | 1 | 1 | 1 | 2024 |
4 organizations
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