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verapamil

Trade name: calan

Small moleculeapproved

Approved

Aug 12, 1981

Verapamil is a FDA approved drug used to treat high blood pressure and to control chest pain. Verapamil is an L-type calcium channel blocker that also has antiarrythmic activity. The R-enantiomer is more effective at reducing blood pressure compared to the S-enantiomer. However, the S-enantiomer is 20 times more potent than the R-enantiomer at prolonging the PR interval in treating arrhythmias. Verapamil inhibits voltage-dependent calcium channels. Specifically, its effect on L-type calcium channels in the heart causes a reduction in ionotropy and chronotropy, thuis reducing heart rate and blood pressure. Verapamil's mechanism of effect in cluster headache is thought to be linked to its calcium-channel blocker effect, but which channel subtypes are involved is presently not known. — NCATS

Clinical trial activity

101 trials · 118 clinical orgs · 48 marketing orgs

Phase 1
45
Phase 2
22
Phase 3
11
Phase 4
24

Earliest trial started Nov 1, 1994 (NCT00518947)

Timeline

1980s

  1. Aug 12, 1981

    Earliest FDA Approval

  2. Aug 12, 1981

    Mt Adams Technologies — NDA Secondary Org

  3. Mar 30, 1984

    Exela Pharma Sciences, LLC. — NDA Secondary Org

  4. Mar 30, 1984

    G D Searle — NDA Secondary Org

  5. Mar 30, 1984

    Exela Pharma Sciences, LLC. — Marketing Organization

  6. Nov 12, 1985

    Lutipold — Marketing Organization

  7. Dec 16, 1985

    International Medication — Marketing Organization

  8. Aug 20, 1986

    Warner Chilcott — Marketing Organization

  9. Sep 23, 1986

    Actavis — Marketing Organization

  10. Sep 23, 1986

    Mutual Pharmaceutical — Marketing Organization

  11. Sep 23, 1986

    Watson Pharmaceuticals — Marketing Organization

  12. Dec 16, 1986

    Pfizer — First NDA Organization

  13. Dec 16, 1986

    Pfizer — NDA Organization

  14. Feb 2, 1987

    Hospira — Marketing Organization

  15. Jan 13, 1988

    Sun Pharmaceuticals — Marketing Organization

  16. Apr 5, 1988

    Heritage Pharma — Marketing Organization

  17. May 25, 1988

    Fosun — Marketing Organization

  18. May 25, 1988

    Chartwell Pharmaceuticals — Marketing Organization

  19. Jan 26, 1989

    Pliva — Marketing Organization

  20. Feb 15, 1989

    Rising Pharmaceuticals — Marketing Organization

  21. Feb 15, 1989

    Mylan — Marketing Organization

1990s

  1. May 29, 1990

    Recro Pharma, Inc. — NDA Secondary Org

  2. May 29, 1990

    Azurity — Marketing Organization

  3. May 29, 1990

    SOCIETAL CDMO — Marketing Organization

  4. May 29, 1990

    SOCIETAL CDMO — NDA Secondary Org

  5. Jul 31, 1992

    Teva — Marketing Organization

  6. Feb 26, 1993

    Marsam Pharmaceuticals — Marketing Organization

  7. Jan 1, 1994

    Earliest Phase 3 Sponsor(trial)

  8. Jul 28, 1995

    Bedford Pharmaceuticals — Marketing Organization

  9. Oct 22, 1996

    AbbVie — Marketing Organization

  10. Oct 22, 1996

    AbbVie — NDA Secondary Org

  11. May 25, 1999

    Strides Pharma Science — Marketing Organization

  12. May 25, 1999

    Par Pharmaceuticals — Marketing Organization

2000s

  1. Jan 1, 2006

    Mylan — Earliest Phase 1 Sponsor(trial)

  2. Jan 1, 2007

    Earliest Phase 2 Sponsor(trial)

  3. Sep 17, 2009

    Glenmark Pharmaceuticals — Marketing Organization

2010s

  1. Apr 20, 2012

    Apotex — Marketing Organization

  2. May 5, 2017

    Cadila Healthcare — Marketing Organization

  3. Jun 18, 2018

    ANDA Repository — Marketing Organization

  4. Jun 18, 2018

    Somerset Pharmaceuticals — Marketing Organization

  5. Jul 13, 2018

    Amneal Pharmaceuticals — Marketing Organization

  6. Dec 28, 2018

    Micro Labs Ltd India — Marketing Organization

2020s

  1. Mar 17, 2020

    Areva Med LLC — Marketing Organization

  2. Mar 17, 2020

    Nephron Pharmaceuticals Corporation — Marketing Organization

  3. Mar 25, 2020

    Caplin Point Laboratories — Marketing Organization

  4. Jul 6, 2020

    Aurobindo Pharma — Marketing Organization

  5. Jul 6, 2020

    Eugia Pharma — Marketing Organization

  6. Oct 15, 2020

    Gland Pharma Ltd — Marketing Organization

  7. Oct 15, 2020

    Zydus Discovery DMCC — Marketing Organization

  8. Mar 17, 2022

    Acic Pharmaceuticals — Marketing Organization

  9. Jun 15, 2022

    Mankind Pharma — Marketing Organization

  10. Apr 23, 2024

    Fresenius — Marketing Organization

Indications

Approved for

Studied for

Mechanism of action

Combination products

Approval history

  • approvedPriority reviewAug 12, 1981

Chemistry & pharmacology

Loading structure…

SMILES

COc1ccc(CCN(C)CCCC(C#N)(c2ccc(OC)c(OC)c2)C(C)C)cc1OC
Mol. weight
454.61 g/mol
Lipinski Ro5
1 violation(s)
Rule of 3
No
Chirality
Racemic Mixture
Inorganic
No
Polymer
No
Delivery
Oral, Parenteral
Availability
Prescription Only

Oral

Yes

Parenteral

Yes

Topical

No

Sources

Also known as

  • arverapamil
  • arverapamil
  • berkatens
  • berkatens
  • calan
  • calan
  • calan sr
  • calan sr
  • cordilox
  • cordilox
  • cordilox i.v.
  • cordilox mr 240
  • covera
  • covera
  • covera-hs
  • covera-hs
  • cp-165331
  • cp-165331
  • cp-16533-1
  • cp-16533-1
  • d-365
  • d-365
  • ethimil mr 240
  • geangin
  • geangin
  • half securon sr
  • iproveratril
  • iproveratril
  • iproveratril
  • isoptin
  • isoptin
  • isoptin
  • isoptin
  • isoptin sr
  • isoptin sr
  • manidon sr
  • ranvera mr
  • rs-verapamil
  • securon
  • securon
  • securon iv
  • securon mid
  • securon sr
  • tarka
  • tarka
  • univer
  • univer
  • verapamil
  • verapamil
  • verapamil
  • verapamil
  • verapamil
  • verapamil
  • verapamil
  • verapamil
  • verapamil
  • verapamil
  • (+/-)-verapamil
  • vérapamil
  • vérapamil
  • verapamil hcl
  • verapamil hcl
  • verapamil hcl
  • verapamil hydrochloride
  • verapamil hydrochloride
  • verapamil hydrochloride
  • verapamil hydrochloride
  • verapamil hydrochloride
  • verapamilo
  • verapamilo
  • verapamilum
  • verapamilum
  • verapress mr 240
  • vera-til sr
  • verelan
  • verelan
  • verelan
  • verelan pm
  • verelan pm
  • vertab sr 240
  • zolvera
  • zolvera

Clinical trials

NCT IDPhaseStart dateSponsor(s)
NCT07061574Phase 1/Phase 2 (Phase 2)Dec 15, 2026City of Hope National Medical Center, Jaeb Center for Health Research
NCT07199946Phase 1/Phase 2 (Phase 2)Aug 6, 2025Government of Sweden, Linkoping University, Region Östergötland
NCT06455319Phase 2Apr 30, 2025University of Colorado, Denver, University of Florida, University of Miami
NCT06897969Phase 4Apr 1, 2025Nishtar Medical University
NCT06799169Phase 4Mar 31, 2025University of California, Irvine
NCT06916897Phase 1Jan 8, 2025Edgewise Therapeutics, Inc.
NCT06717685Phase 3Oct 28, 2024Rashid Latif Medical College, University of the Punjab
NCT06483789Phase 2Aug 31, 2024Honeybrains Biotech LLC, Ramsay General Health
NCT06447688Phase 4Jun 5, 2024Mersin Medicalpark Hastanesi
NCT06354556Phase 1Apr 26, 2024Suzhou Suncadia Biopharmaceuticals Co., Ltd.
NCT06847620Phase 4Mar 1, 2024Ain Shams University
NCT06118684Phase 1Oct 23, 2023Clinical Trial Consultants AB, EpiEndo Pharmaceuticals
NCT06031454Phase 1Sep 1, 2023Guangdong Raynovent Biotech Co., Ltd
NCT05855070N/AMay 20, 2023Benha University
NCT05625503Early Phase 1 (Phase 1)Nov 14, 2022University of Illinois at Chicago
NCT05593757Phase 2Oct 31, 2022University of Amsterdam
NCT05569382Phase 4Aug 10, 2022Aarhus University, University of Copenhagen, University of Southern Denmark, Viborg Regional Hospital
NCT05304533Phase 1Apr 21, 2022Bristol-Myers Squibb
NCT05183997N/AJan 31, 2022Assiut University
NCT04790331Early Phase 1 (Phase 1)Mar 1, 2021Assiut University
Showing 20 of 101 trials
Page 1 / 6

Organizations

Research & Development (118)

OrganizationOrg typeTrialsAs lead sponsorPhasesEarliest year
AbbottFor profit6521997
MylanFor profit5512006
PRACSFor profit5012006
AstraZenecaFor profit4312008
Harvard UniversityAcademic/Hospital4242015
Assiut UniversityAcademic/Hospital3322020
Boehringer IngelheimFor profit3312008
Hoosier Cancer Research NetworkAcademic/Hospital3312006
Mayo ClinicAcademic/Hospital3132012
University of KentuckyAcademic/Hospital3312013
Ain Shams UniversityAcademic/Hospital2222020
AstellasFor profit2212009
Bristol-Myers SquibbFor profit2222011
Cardiff UniversityAcademic/Hospital2122006
City of Hope National Medical CenterAcademic/Hospital2222017
Isfahan UniversityAcademic/Hospital2212010
Jaeb Center for Health ResearchAcademic/Hospital2122020
Juvenile Diabetes Research FoundationAcademic/Hospital2012015
National Institute on Drug Abuse (NIDA)Government2012008
ParexelFor profit2012008
118 organizations
Page 1 / 6

Marketing (59)

OrganizationOrg typeRelationshipDate
ANDA RepositoryFor profitMKTGJun 18, 2018
AbbVieFor profitMKTGOct 22, 1996
AbbVieFor profitNDA2Oct 22, 1996
AbraxisFor profitMKTG—
Acic PharmaceuticalsFor profitMKTGMar 17, 2022
ActavisFor profitMKTGSep 23, 1986
Amneal PharmaceuticalsFor profitMKTGJul 13, 2018
Amneal PharmaceuticalsFor profitSYNJul 13, 2018
ApotexFor profitMKTGApr 20, 2012
Areva Med LLCFor profitMKTGMar 17, 2020
Athenex, Inc.For profitMKTG—
Aurobindo PharmaFor profitMKTGJul 6, 2020
AzurityFor profitMKTGMay 29, 1990
Bedford PharmaceuticalsFor profitMKTGJul 28, 1995
Cadila HealthcareFor profitMKTGMay 5, 2017
Caplin Point LaboratoriesFor profitMKTGMar 25, 2020
Chartwell PharmaceuticalsFor profitMKTGMay 25, 1988
Eugia PharmaFor profitMKTGJul 6, 2020
Exela Pharma Sciences, LLC.For profitNDA2Mar 30, 1984
Exela Pharma Sciences, LLC.For profitMKTGMar 30, 1984
FosunFor profitMKTGMay 25, 1988
FreseniusFor profitMKTGApr 23, 2024
G D SearleFor profitNDA2Mar 30, 1984
Gland Pharma LtdFor profitMKTGOct 15, 2020
Gland Pharma LtdFor profitSYNOct 15, 2020
Glenmark PharmaceuticalsFor profitMKTGSep 17, 2009
Glenmark PharmaceuticalsFor profitSYNSep 17, 2009
Heritage PharmaFor profitMKTGApr 5, 1988
Heritage PharmaFor profitSYNApr 5, 1988
Heritage PharmaFor profitSYNApr 5, 1988
HospiraFor profitMKTGFeb 2, 1987
International MedicationFor profitMKTGDec 16, 1985
LutipoldFor profitMKTGNov 12, 1985
Mankind PharmaFor profitMKTGJun 15, 2022
Marsam PharmaceuticalsFor profitMKTGFeb 26, 1993
Micro Labs Ltd IndiaFor profitMKTGDec 28, 2018
Mt Adams TechnologiesFor profitNDA2Aug 12, 1981
Mutual PharmaceuticalFor profitMKTGSep 23, 1986
MylanFor profitMKTGFeb 15, 1989
Nephron Pharmaceuticals CorporationFor profitMKTGMar 17, 2020
Par PharmaceuticalsFor profitMKTGMay 25, 1999
PfizerFor profitNDADec 16, 1986
PlivaFor profitMKTGJan 26, 1989
Recro Pharma, Inc.For profitNDA2May 29, 1990
Rising PharmaceuticalsFor profitMKTGFeb 15, 1989
Rising PharmaceuticalsFor profitSYNFeb 15, 1989
SOCIETAL CDMOFor profitMKTGMay 29, 1990
SOCIETAL CDMOFor profitNDA2May 29, 1990
SOLOPAKFor profitMKTG—
Smith & NephewFor profitMKTG—
Somerset PharmaceuticalsFor profitMKTGJun 18, 2018
Somerset PharmaceuticalsFor profitSYNJun 18, 2018
Strides Pharma ScienceFor profitMKTGMay 25, 1999
Sun PharmaceuticalsFor profitSYNDec 30, 2011
Sun PharmaceuticalsFor profitMKTGJan 13, 1988
TevaFor profitMKTGJul 31, 1992
Warner ChilcottFor profitMKTGAug 20, 1986
Watson PharmaceuticalsFor profitMKTGSep 23, 1986
Zydus Discovery DMCCFor profitMKTGOct 15, 2020