secobarbital
Trade name: seconal
Approved
Jul 19, 1950
Secobarbital sodium, a barbiturate, is FDA approved for the treatment of insomnia and for pre-anesthetic use. This drug binds at a distinct site associated with a Cl- ionopore at the GABAA receptor, increasing the duration of time for which the Cl- ionopore is open. The post-synaptic inhibitory effect of GABA in the thalamus is, therefore, prolonged. Adverse reactions are drowsiness, lethargy, hangover, paradoxical excitement in elderly patients, somnolence. Rifampin may decrease secobarbital levels by increasing metabolism. — NCATS
Clinical trial activity
0 trials · 0 clinical orgs · 18 marketing orgs
Timeline
1950s
- Jul 19, 1950
Earliest FDA Approval
- Jul 19, 1950
Eli Lilly — NDA Secondary Org
1970s
- Dec 3, 1973
American Home Products — Marketing Organization
- Apr 7, 1975
Barr Laboratories — Marketing Organization
- Dec 2, 1976
Lumara Health — Marketing Organization
- Oct 25, 1977
Ivax — Marketing Organization
- Apr 24, 1978
Lannett Company, Inc. — Marketing Organization
- Apr 24, 1978
Whiteworth Towne Paulsen — Marketing Organization
- Oct 30, 1978
Everylife Foundation for Rare Diseases — Marketing Organization
1980s
- Dec 10, 1981
Bausch Health Companies — Marketing Organization
Indications
Mechanism of action
Approval history
- approvedJul 19, 1950
Chemistry & pharmacology
SMILES
C=CCC1(C(C)CCC)C(=O)NC(=O)NC1=O- Mol. weight
- 238.29 g/mol
- Lipinski Ro5
- Pass
- Rule of 3
- No
- Chirality
- Racemic Mixture
- Inorganic
- No
- Polymer
- No
- Delivery
- Oral, Parenteral, Topical
- Availability
- Prescription Only
Oral
Yes
Parenteral
Yes
Topical
Yes
Sources
- ChEMBLCHEMBL447 ↗
- WikipediaSecobarbital ↗
- NCATSXBP604F6UM ↗
- ChEMBLCHEMBL1200903 ↗
Also known as
- 5-(1-methylbutyl)-5-(2-propenyl)-2,4,6(1h,3h,5h)-pyrimidinetrione
- 5-(1-methylbutyl)-5-(2-propenyl)-2,4,6(1h,3h,5h)-pyrimidinetrione
- 5-allyl-5-(1-methylbutyl)-2,4,6(1h,3h,5h)-pyrimidinetrione
- 5-allyl-5-(1-methylbutyl)-2,4,6(1h,3h,5h)-pyrimidinetrione
- 5-allyl-5-(1-methylbutyl)barbituric acid
- 5-allyl-5-(1-methylbutyl)barbituric acid
- 5-allyl-5-(1-methylbutyl)pyrimidine-2,4,6(1h,3h,5h)-trione
- 5-allyl-5-(1-methylbutyl)pyrimidine-2,4,6(1h,3h,5h)-trione
- evronal
- hypotrol
- immenox
- meballymal
- meballymal
- meballymal
- quinalbarbital
- quinalbarbitone
- quinalbarbitone
- quinalbarbitone
- quinalbarbitone sodium
- quinalbarbitone sodium
- quinobarbitone
- secobarbital
- secobarbital
- secobarbital
- secobarbital
- secobarbital
- secobarbital
- secobarbital
- secobarbital
- secobarbital
- secobarbital
- (+-)-secobarbital
- (+-)-secobarbital
- (±)-secobarbital
- (±)-secobarbital
- secobarbital sodium
- secobarbital sodium
- secobarbital sodium
- secobarbital sodium
- secobarbitalum
- secobarbitalum
- secobarbitone
- secobarbitone
- secobarbitone
- seconal
- seconal
- seconal
- seconal
- seconal sodium
- seconal sodium
- seconesin
Organizations
Marketing (21)
| Organization | Org type | Relationship | Date |
|---|---|---|---|
| American Home Products | For profit | MKTG | Dec 3, 1973 |
| Anabolic Pharma | Academic/Hospital | MKTG | — |
| Barr Laboratories | For profit | MKTG | Apr 7, 1975 |
| Bausch Health Companies | For profit | MKTG | Dec 10, 1981 |
| Bausch Health Companies | For profit | SYN | Oct 3, 1983 |
| Eli Lilly | For profit | NDA2 | Jul 19, 1950 |
| Eli Lilly | For profit | NDA | — |
| Eli Lilly | For profit | MKTG | — |
| Elkins Sinn | For profit | MKTG | — |
| Everylife Foundation for Rare Diseases | Academic/Hospital | MKTG | Oct 30, 1978 |
| Halsey | For profit | MKTG | — |
| Ivax | For profit | MKTG | Oct 25, 1977 |
| Lannett Company, Inc. | For profit | MKTG | Apr 24, 1978 |
| Lumara Health | For profit | MKTG | Dec 2, 1976 |
| Parke-Davis | For profit | MKTG | — |
| Perrigo | For profit | MKTG | — |
| Puracap Pharmaceutical | For profit | MKTG | — |
| Vitarine | For profit | MKTG | — |
| Watson Pharmaceuticals | For profit | MKTG | — |
| West-Ward Pharmaceutical | For profit | MKTG | — |
| Whiteworth Towne Paulsen | For profit | MKTG | Apr 24, 1978 |