triamcinolone

Trade name: kenalog

Small moleculeapproved

Approved

Dec 3, 1957

Triamcinolone acetonide, sold under the brand name Kenalog among others, is a synthetic corticosteroid medication used topically to treat various skin conditions, to relieve the discomfort of mouth sores, and by injection into joints to treat various joint conditions. It is also injected into lesions to treat inflammation in some parts of the body, particularly the skin. In nasal spray form, it is used to treat allergic rhinitis. It is used for the treatment of macular edema associated with uveitis. It is a more potent derivative of triamcinolone, and is about eight times as potent as prednisone. — Wikipedia

Clinical trial activity

575 trials · 423 clinical orgs · 81 marketing orgs

Phase 1

Phase 2

191

Phase 3

119

Phase 4

149

Earliest trial started Sep 1, 1993 (NCT00000569)

Timeline

1950s

Dec 3, 1957
Earliest FDA Approval
Dec 3, 1957
Astellas — NDA Secondary Org
Jan 14, 1958
delcor — NDA Secondary Org
Oct 23, 1958
Mylan — NDA Secondary Org
Mar 12, 1959
Fosun — NDA Secondary Org

1960s

Jan 4, 1960
Apothecon — NDA Secondary Org
Jul 30, 1963
American Cyanamid — First NDA Organization
Jul 30, 1963
American Cyanamid — NDA Organization
Jul 29, 1969
Sandoz — NDA Secondary Org

1970s

Apr 26, 1972
Astellas — Marketing Organization
Jan 29, 1974
delcor — Marketing Organization
Oct 11, 1974
Sun Pharmaceuticals — NDA Secondary Org
Apr 22, 1975
Impax Laboratories — Marketing Organization
Oct 16, 1975
Barr Laboratories — Marketing Organization
May 24, 1976
Teva — Marketing Organization
Jan 24, 1977
Watson Pharmaceuticals — Marketing Organization
Mar 9, 1978
Fougera — Marketing Organization
Jun 23, 1978
Ivax — Marketing Organization
Apr 10, 1979
Taro Pharmaceuticals — Marketing Organization

1980s

Apr 9, 1981
Padagis Us — Marketing Organization
Apr 23, 1982
AbbVie — NDA Secondary Org
Jun 4, 1982
Actavis — Marketing Organization
Jul 30, 1982
Sandoz — Marketing Organization
Sep 8, 1982
Alpharma — Marketing Organization
Mar 25, 1983
Savage Labs — Marketing Organization
May 9, 1983
Ambix — Marketing Organization
Mar 19, 1984
Crown Laboratories, Inc. — Marketing Organization
Apr 1, 1985
Wockhardt — Marketing Organization
May 28, 1985
ACP Nimble — Marketing Organization
May 28, 1985
Cosette — Marketing Organization
Oct 16, 1987
Parnell Pharmaceuticals — NDA Secondary Org
Dec 23, 1988
G & W Laboratories Inc. — Marketing Organization
Feb 21, 1989
Topiderm — Marketing Organization

1990s

Jul 11, 1991
Sanofi-Aventis — NDA Secondary Org
Jul 11, 1991
Sanofi — Marketing Organization
Jul 11, 1991
Sanofi — NDA Secondary Org
Jan 1, 1993
Earliest Phase 3 Sponsor(trial)
Mar 23, 1995
CMP Therapeutics Ltd — Marketing Organization

2000s

Feb 4, 2000
Lupin — NDA Secondary Org
Jan 1, 2001
Earliest Phase 2 Sponsor(trial)
Jan 1, 2002
Earliest Phase 1 Sponsor(trial)
Jun 9, 2006
Lannett Company, Inc. — Marketing Organization
Jun 9, 2006
Mylan — Marketing Organization
Jun 9, 2006
Micro Labs Ltd India — Marketing Organization
Dec 13, 2006
Allied Pharmaceutical Services — Marketing Organization
Dec 13, 2006
Saptalis Pharmaceuticals — Marketing Organization
Nov 29, 2007
Alcon — NDA Secondary Org
Nov 29, 2007
Novartis — NDA Secondary Org
Nov 29, 2007
Novartis — Marketing Organization
Nov 29, 2007
Nestle — NDA Secondary Org
Nov 29, 2007
Harrow Health — Marketing Organization
Jun 16, 2008
Allergan — NDA Secondary Org
Jun 16, 2008
GlaxoSmithKline — NDA Secondary Org
Jul 30, 2009
Perrigo — Marketing Organization

2010s

Jul 1, 2010
Lyne Laboratories — Marketing Organization
May 8, 2013
Akorn, Inc. — Marketing Organization
May 8, 2013
Epic Pharma Llc — Marketing Organization
May 13, 2016
Teligent Pharmaceuticals — Marketing Organization
Jul 7, 2016
Pharmaceutical Associates — Marketing Organization
Oct 26, 2016
Dr. Reddy's Laboratories — Marketing Organization
Dec 29, 2016
ANDA Repository — Marketing Organization
Feb 1, 2017
Chartwell Pharmaceuticals — Marketing Organization
Aug 22, 2017
Glenmark Pharmaceuticals — Marketing Organization
Sep 8, 2017
Rising Pharmaceuticals — Marketing Organization
Oct 6, 2017
Flexion Therapeutics — NDA Secondary Org
Oct 6, 2017
Pacira Pharmaceuticals — Marketing Organization
Oct 6, 2017
Pacira Pharmaceuticals — NDA Secondary Org
Dec 11, 2017
Amneal Pharmaceuticals — Marketing Organization
Dec 26, 2017
Alkem Labs Ltd — Marketing Organization
Jan 29, 2018
Strides Pharma Science — Marketing Organization
May 18, 2018
Macleods Pharmaceuticals, Ltd — Marketing Organization
May 18, 2018
Neogen — Marketing Organization
May 31, 2018
Lupin — Marketing Organization
Oct 12, 2018
Novel Anti-Infective Technologies, LLC — Marketing Organization
Nov 8, 2018
Zydus Discovery DMCC — Marketing Organization
Nov 8, 2018
Cadila Healthcare — Marketing Organization
Nov 18, 2019
Vitruvias Therapeutics — Marketing Organization
Nov 29, 2019
Encube Ethicals Pvt. Ltd. — Marketing Organization

2020s

Jul 1, 2020
Quagen Pharma — Marketing Organization
Jul 14, 2020
Torrent Pharmaceuticals Limited — Marketing Organization
Nov 11, 2020
Cintex Services — Marketing Organization
Mar 31, 2021
Alembic — Marketing Organization
Oct 22, 2021
Clearside Biomedical, Inc. — Marketing Organization
Oct 22, 2021
Bausch & Lomb — Marketing Organization
Oct 22, 2021
Bausch Health Companies — NDA Secondary Org
Jan 19, 2022
LONG GROVE PHARMS — Marketing Organization
Jul 5, 2022
Eugia Pharma — Marketing Organization
Jan 19, 2023
Apotex — Marketing Organization

Indications

Studied for

Mechanism of action

Glucocorticoid receptorAGONIST
NR3C1 agonist
- Glucocorticoid receptor (NR3C1) ↗

Combination products

mycolog-ii
with nystatin
Also known as myco-triacet ii, mykacet, mytrex f
neomycin sulfate-triamcinolone acetonide
with neomycin
Also known as mytrex a

Approval history

approvedPriority reviewDec 3, 1957

Chemistry & pharmacology

Loading structure…

SMILES

CC(=O)OCC(=O)[C@@]1(O)[C@H](OC(C)=O)C[C@H]2[C@@H]3CCC4=CC(=O)C=C[C@]4(C)[C@@]3(F)[C@@H](O)C[C@@]21C

Mol. weight: 478.51 g/mol
Lipinski Ro5: Pass
Rule of 3: No
Chirality: Single Stereoisomer
Inorganic: No
Polymer: No
Delivery: Oral, Parenteral
Availability: Discontinued

Oral

Yes

Parenteral

Yes

Topical

Prodrug

Sources

Also known as

(11 beta, 16 alpha)-21-(3,3-dimethyl-1-oxobutoxy)-9-fluoro-11-hydroxy-16,17-((1-methylethylidene)bis(oxy)) pregna-1,4-diene-3,20-dione
11β,16α,17α,21-tetrahydroxy-9α-fluoro-1,4-pregnadiene-3,20-dione
11β,16α,17α,21-tetrahydroxy-9α-fluoro-1,4-pregnadiene-3,20-dione
9-fluoro-11 beta,16 alpha,17,21-tetrahydroxypregna-1,4-diene-3,20-dione cyclic 16,17-acetal with acetone, 21-(3,3-dimethylbutyrate)
9-fluoro-11β,16α,17,21-tetrahydroxypregna-1,4-diene-3,20-dione
9-fluoro-11β,16α,17,21-tetrahydroxypregna-1,4-diene-3,20-dione
9α-fluoro-11β,16α,17,21-tetrahydroxypregna-1,4-diene-3,20-dione
9α-fluoro-11β,16α,17,21-tetrahydroxypregna-1,4-diene-3,20-dione
9α-fluoro-11β,16α,17α,21-tetrahydroxypregna-1,4-diene-3,20-dione
9α-fluoro-11β,16α,17α,21-tetrahydroxypregna-1,4-diene-3,20-dione
9α-fluoro-16α-hydroxyprednisolone
9α-fluoro-16α-hydroxyprednisolone
adcortyl
adcortyl
adcortyl
adcortyl in orabase
allernaze
allernaze
allernaze
aristicort
aristocort
aristocort
aristocort
aristocort
aristocort a
aristocort a
aristocort diacetate
aristogel
aristogel
aristospan
aristospan
aristospan
aristospan
aristospan
audicort
aureocort
azmacort
azmacort
cl 34433
cl-34433
cl-34433
cl-34433
cls-ta
delphicort
delphicort
fluoxiprednisolone
fluoxiprednisolone
fluoxyprednisolone
fluoxyprednisolone
flutex
fx006
fx006
gppe ear dps cap
gppe ear oint
gramicidin, neomycin sulfate, nystatin, triamcinolone acetonide drug combination
hexatrione
kenacomb
kenacort
kenacort
kenacourt
kenacourt
kenalog
kenalog
kenalog
kenalog-10
kenalog-40
kenalog-40
kenalog-h
kenalog-h
kenalog in orabase
kenalog in orabase
lederspan
lederspan
mycolog
nasacort
nasacort
nasacort
nasacort
nasacort
nasacort
nasacort aq
nasacort aq
nasacort hfa
nasacort hfa
nystadermal
oracort
oralone
orion
orion
pevaryl t.c.
polcartolone
polcortolon
polcortolon
polcortolon
polcortolon
remiderm
remotic
rodinolone
shincort
silderm
tac ointment
tatba
tatba
tedarol
tedarol
tiamcinolonum
tiamcinolonum
tibicorten
tramcinolone
triacet
triacet
triacort
triadcortyl
tri-adcortyl
tri-adcortyl
triadcortyl otic
triamcenolone
triamcinalone
triamcinalone
triamcinlon
triamcinolon
triamcinolona
triamcinolona
triamcinolone
triamcinolone
triamcinolone
triamcinolone
triamcinolone
triamcinolone
triamcinolone
triamcinolone
triamcinolone
triamcinolone
triamcinolone
triamcinolone
triamcinolone acetonide
triamcinolone acetonide
triamcinolone acetonide
triamcinolone acetonide
triamcinolone acetonide
triamcinolone acetonide
triamcinolone acetonide in absorbase
triamcinolone acetonide in absorbase
triamcinolone benetonide
triamcinolone benetonide
triamcinolone benetonide
triamcinolone benetonide
triamcinolone diacetate
triamcinolone diacetate
triamcinolone diacetate
triamcinolone diacetate
triamcinolone diacetate
triamcinolone diacetate
triamcinolone diacetate
triamcinolone diacetate
triamcinolone hexacetonide
triamcinolone hexacetonide
triamcinolone hexacetonide
triamcinolone hexacetonide
triamcinolone hexacetonide
triamcinolone hexacetonide
triamcinolone hexacetonide
triamcinolone hexacetonide
triamcinolonum
triamcinolonum
triatex
triatex
triderm
triderm
triesence
triesence
tri-nasal
tri-nasal
trivaris
trivaris
trymex
trymex
vetalog
vetalog
volon
volon

Clinical trials

NCT ID	Phase	Start date	Sponsor(s)
NCT07277998	N/A	Mar 31, 2026	Karachi Medical and Dental College
NCT07100145	Phase 4	Jan 1, 2026	Ain Shams University
NCT07228104	Phase 3	Jan 1, 2026	Johns Hopkins University, National Heart, Lung, and Blood Institute (NHLBI)
NCT07283874	Phase 4	Dec 31, 2025	Assiut University
NCT07201766	N/A	Dec 2, 2025	King Edward Medical University
NCT07168148	Phase 2	Nov 10, 2025	Washington University in St. Louis
NCT07189572	Phase 3	Oct 31, 2025	Chinese Academy of Medical Sciences, Huazhong University of Science and Technology, Sun Yat-Sen University
NCT07131813	Phase 4	Oct 10, 2025	All India Institute of Medical Sciences
NCT07242846	Phase 4	Oct 2, 2025	Nigde Omer Halisdemir University
NCT07151417	Phase 2/Phase 3 (Phase 3)	Sep 1, 2025	United States Army
NCT07134075	Phase 2	Aug 25, 2025	Fudan University, Jiao Tong University
NCT06761768	N/A	Aug 1, 2025	Government of Taiwan, Tri-Service General Hospital
NCT06977568	Phase 2	Jul 25, 2025	Pacira Pharmaceuticals
NCT06985537	Phase 1	Jun 30, 2025	Assiut University
NCT06981767	Phase 2	Jun 15, 2025	Cairo University
NCT06993337	Phase 2	Jun 15, 2025	Cairo University
NCT06994520	Phase 2	May 1, 2025	KhonKaen University
NCT06758739	Phase 3	Apr 30, 2025	Services Institute of Medical Sciences, Pakistan
NCT06935877	Phase 4	Apr 25, 2025	Shin Kong Wu Ho-Su Memorial Hospital
NCT06897969	Phase 4	Apr 1, 2025	Nishtar Medical University

Showing 20 of 575 trials

Page 1 / 29

Organizations

Research & Development (423)

Organization	Org type	Trials	As lead sponsor	Phases	Earliest year
Cairo University	Academic/Hospital	18	18	5	2007
Flexion Therapeutics	For profit	17	15	3	2012
Shahid Beheshti University of Medical Sciences	Academic/Hospital	16	15	4	2001
University of Sao Paulo	Academic/Hospital	15	14	4	2004
Assiut University	Academic/Hospital	14	13	5	2016
National Eye Institute (NEI)	Government	14	8	4	2003
Novartis	For profit	9	7	2	2003
United States Army	Government	9	9	5	2000
Al Azhar University	Academic/Hospital	8	8	4	2020
Alexandria University	Academic/Hospital	8	8	3	2018
Mayo Clinic	Academic/Hospital	8	7	5	2005
Taipei Veteran General hospital	Government	8	8	1	2012
Allergan	For profit	7	0	3	2004
Clearside Biomedical, Inc.	For profit	7	7	2	2013
Mahidol University	Academic/Hospital	7	6	3	2009
Northwestern University	Academic/Hospital	6	6	3	2013
Sanofi	For profit	6	6	3	2003
Tanta University	Academic/Hospital	6	6	3	2020
Benha University	Academic/Hospital	5	5	2	2020
Genentech	For profit	5	0	4	2007

423 organizations

Page 1 / 22

Marketing (116)

Organization	Org type	Relationship	Date
ACP Nimble	For profit	MKTG	May 28, 1985
ANDA Repository	For profit	MKTG	Dec 29, 2016
AbbVie	For profit	NDA2	Apr 23, 1982
Actavis	For profit	MKTG	Jun 4, 1982
Akorn, Inc.	For profit	MKTG	May 8, 2013
Alcon	For profit	NDA2	Nov 29, 2007
Alembic	For profit	MKTG	Mar 31, 2021
Alembic	For profit	SYN	Mar 31, 2021
Alkem Labs Ltd	For profit	MKTG	Dec 26, 2017
Allergan	For profit	NDA2	Jun 16, 2008
Allied Pharmaceutical Services	For profit	MKTG	Dec 13, 2006
Alpharma	For profit	MKTG	Sep 8, 1982
Ambix	For profit	MKTG	May 9, 1983
American Cyanamid	For profit	NDA	Jul 30, 1963
Amneal Pharmaceuticals	For profit	MKTG	Dec 11, 2017
Amneal Pharmaceuticals	For profit	SYN	Feb 15, 2018
Amneal Pharmaceuticals	For profit	SYN	Dec 11, 2017
Apotex	For profit	MKTG	Jan 19, 2023
Apothecon	For profit	NDA2	Jan 4, 1960
Astellas	For profit	NDA2	Dec 3, 1957
Astellas	For profit	MKTG	Apr 26, 1972
Barr Laboratories	For profit	MKTG	Oct 16, 1975
Bausch & Lomb	For profit	MKTG	Oct 22, 2021
Bausch Health Companies	For profit	NDA2	Oct 22, 2021
CMP Therapeutics Ltd	For profit	MKTG	Mar 23, 1995
Cadila Healthcare	For profit	MKTG	Nov 8, 2018
Chartwell Pharmaceuticals	For profit	MKTG	Feb 1, 2017
Cintex Services	For profit	MKTG	Nov 11, 2020
Clearside Biomedical, Inc.	For profit	MKTG	Oct 22, 2021
Cosette	For profit	MKTG	May 28, 1985
Crown Laboratories, Inc.	For profit	MKTG	Mar 19, 1984
Crown Laboratories, Inc.	For profit	SYN	Dec 26, 2017
Dr. Reddy's Laboratories	For profit	SYN	Oct 26, 2016
Dr. Reddy's Laboratories	For profit	MKTG	Oct 26, 2016
Encube Ethicals Pvt. Ltd.	For profit	MKTG	Nov 29, 2019
Epic Pharma Llc	For profit	MKTG	May 8, 2013
Eugia Pharma	For profit	MKTG	Jul 5, 2022
Flexion Therapeutics	For profit	NDA2	Oct 6, 2017
Fosun	For profit	NDA2	Mar 12, 1959
Fougera	For profit	MKTG	Mar 9, 1978
Fougera	For profit	SYN	Oct 8, 1985
G & W Laboratories Inc.	For profit	MKTG	Dec 23, 1988
G & W Laboratories Inc.	For profit	SYN	May 28, 1985
GlaxoSmithKline	For profit	NDA2	Jun 16, 2008
Glenmark Pharmaceuticals	For profit	MKTG	Aug 22, 2017
Glenmark Pharmaceuticals	For profit	SYN	Jun 23, 2016
Harrow Health	For profit	MKTG	Nov 29, 2007
Impax Laboratories	For profit	MKTG	Apr 22, 1975
Ivax	For profit	MKTG	Jun 23, 1978
LONG GROVE PHARMS	For profit	MKTG	Jan 19, 2022
Lannett Company, Inc.	For profit	MKTG	Jun 9, 2006
Lupin	For profit	NDA2	Feb 4, 2000
Lupin	For profit	MKTG	May 31, 2018
Lupin	For profit	SYN	Feb 1, 2017
Lyne Laboratories	For profit	MKTG	Jul 1, 2010
Macleods Pharmaceuticals, Ltd	For profit	MKTG	May 18, 2018
Micro Labs Ltd India	For profit	SYN	Jun 9, 2006
Micro Labs Ltd India	For profit	MKTG	Jun 9, 2006
Morton Grove Pharmaceuticals	For profit	MKTG	—
Mylan	For profit	SYN	Oct 23, 1958
Mylan	For profit	MKTG	Jun 9, 2006
Mylan	For profit	SYN	Oct 23, 1958
Mylan	For profit	SYN	Nov 2, 2022
Mylan	For profit	NDA2	Oct 23, 1958
Neogen	For profit	MKTG	May 18, 2018
Nestle	For profit	NDA2	Nov 29, 2007
Novartis	For profit	NDA2	Nov 29, 2007
Novartis	For profit	MKTG	Nov 29, 2007
Novel Anti-Infective Technologies, LLC	For profit	MKTG	Oct 12, 2018
Pacira Pharmaceuticals	For profit	MKTG	Oct 6, 2017
Pacira Pharmaceuticals	For profit	NDA2	Oct 6, 2017
Padagis Us	For profit	SYN	Apr 13, 2015
Padagis Us	For profit	SYN	Apr 9, 1981
Padagis Us	For profit	MKTG	Apr 9, 1981
Parnell Pharmaceuticals	For profit	NDA2	Oct 16, 1987
Perrigo	For profit	SYN	Jul 30, 2009
Perrigo	For profit	MKTG	Jul 30, 2009
Perrigo	For profit	SYN	Apr 9, 1981
Perrigo	For profit	SYN	Apr 13, 2015
Perrigo	For profit	SYN	Jul 30, 2009
Pharmaceutical Associates	For profit	MKTG	Jul 7, 2016
Pharmaderm	For profit	MKTG	—
Pharmafair	For profit	MKTG	—
Puracap Pharmaceutical	For profit	MKTG	—
Quagen Pharma	For profit	MKTG	Jul 1, 2020
Rising Pharmaceuticals	For profit	SYN	Dec 29, 2016
Rising Pharmaceuticals	For profit	MKTG	Sep 8, 2017
Roxane Laboratories	For profit	MKTG	—
Sandoz	For profit	MKTG	Jul 30, 1982
Sandoz	For profit	SYN	May 27, 2009
Sandoz	For profit	NDA2	Jul 29, 1969
Sandoz	For profit	SYN	Jul 29, 1969
Sanofi	For profit	MKTG	Jul 11, 1991
Sanofi	For profit	NDA2	Jul 11, 1991
Sanofi-Aventis	For profit	NDA2	Jul 11, 1991
Saptalis Pharmaceuticals	For profit	MKTG	Dec 13, 2006
Savage Labs	For profit	MKTG	Mar 25, 1983
Solvay	For profit	MKTG	—
Strides Pharma Science	For profit	MKTG	Jan 29, 2018
Sun Pharmaceuticals	For profit	NDA2	Oct 11, 1974
Taro Pharmaceuticals	For profit	MKTG	Apr 10, 1979
Taro Pharmaceuticals	For profit	SYN	Sep 30, 1994
Teligent Pharmaceuticals	For profit	MKTG	May 13, 2016
Teligent Pharmaceuticals	For profit	SYN	May 13, 2016
Teva	For profit	MKTG	May 24, 1976
Teva	For profit	SYN	Oct 5, 2018
Teva	For profit	SYN	Mar 11, 1974
Topiderm	For profit	MKTG	Feb 21, 1989
Torrent Pharmaceuticals Limited	For profit	MKTG	Jul 14, 2020
Vitruvias Therapeutics	For profit	MKTG	Nov 18, 2019
Watson Pharmaceuticals	For profit	MKTG	Jan 24, 1977
Wockhardt	For profit	MKTG	Apr 1, 1985
Zydus Discovery DMCC	For profit	MKTG	Nov 8, 2018
Zydus Discovery DMCC	For profit	SYN	Nov 8, 2018
delcor	For profit	NDA2	Jan 14, 1958
delcor	For profit	MKTG	Jan 29, 1974