oxygen
Small moleculeapproved
Approved
Jun 16, 2013
Carbogen, also called Meduna's Mixture after its inventor Ladislas Meduna, is a mixture of carbon dioxide and oxygen gas. Meduna's original formula was 30% CO2 and 70% oxygen, but the term carbogen can refer to any mixture of these two gases, from 1.5% to 50% CO2. It is a hallucinogen. — Wikipedia
Clinical trial activity
656 trials · 532 clinical orgs · 26 marketing orgs
Phase 1
67
Phase 2
161
Phase 3
84
Phase 4
85
Earliest trial started Oct 31, 1989 (NCT01099995)
Timeline
1810s
- Jun 1, 1810
Evidence of US Marketing
1980s
- Jan 1, 1989
Earliest Phase 3 Sponsor(trial)
1990s
- Jan 1, 1994
Earliest Phase 2 Sponsor(trial)
2000s
- Jan 1, 2000
Earliest Phase 1 Sponsor(trial)
2010s
- Jun 16, 2013
Air Liquide — Earliest FDA Approval
- Jun 16, 2013
Air Liquide — NDA Organization
- Jul 5, 2013
Linde AG — NDA Secondary Org
- Jul 5, 2013
BOC International — NDA Secondary Org
- Jul 13, 2013
Air Liquide — NDA Secondary Org
- Jul 13, 2013
Machine & Welding Supply Co — NDA Secondary Org
- Jul 14, 2013
Norco — NDA Secondary Org
- Jul 14, 2013
Purity Cylinder Gases, Inc — NDA Secondary Org
- Jul 14, 2013
Scott-Gross Company — NDA Secondary Org
- Jul 14, 2013
Westair Gases & Equipment Inc — NDA Secondary Org
- Jul 15, 2013
Dupuy Oxygen — NDA Secondary Org
- Jul 16, 2013
Airgas Usa Llc — NDA Secondary Org
- Jul 20, 2013
Oxarc Inc — NDA Secondary Org
- Jul 21, 2013
Praxair — NDA Secondary Org
- Jul 23, 2013
Air Products And Chemicals Inc — NDA Secondary Org
- Jul 23, 2013
Aspen Air — NDA Secondary Org
- Jul 23, 2013
Nexair — NDA Secondary Org
- Aug 2, 2013
Matheson Tri-Gas Inc — NDA Secondary Org
- Aug 31, 2013
United States Welding Inc — NDA Secondary Org
- Sep 1, 2013
Acetylene Oxygene Co — NDA Secondary Org
- Apr 22, 2014
Cee Kay Supply — NDA Secondary Org
- May 12, 2014
American Welding And Gas Inc — NDA Secondary Org
- Dec 25, 2015
Central Welding Supply — Marketing Organization
- Dec 25, 2015
Central Welding Supply — NDA Secondary Org
- Dec 25, 2016
General Services & Supply Co — NDA Secondary Org
- Aug 24, 2018
Universal Industrial Gases, Inc — NDA Secondary Org
- Sep 10, 2018
Cristal Therapeutics — NDA Secondary Org
2020s
- Jun 10, 2022
ABSOLUTE AIR, LLC — Marketing Organization
- Jun 10, 2022
ABSOLUTE AIR, LLC — NDA Secondary Org
- Jul 13, 2024
WSM SUPPLIER LLC — Marketing Organization
Indications
Studied for
- Abdominoplasty · Phase 4
- Abortion, Induced · Phase 3
- Abscess · Phase 4
- Acidosis, Respiratory · Phase 1/Phase 2
- Acne Vulgaris · Phase 2
- Acute Coronary Syndrome · Phase 3
- Acute Kidney Injury · Phase 3
- Acute Lung Injury · Phase 4
- Acute Pain · Phase 4
- Adolescent Health · Phase 2/Phase 3
- Airway Extubation · Phase 3
- Airway Management · Phase 2
- Airway Obstruction · Phase 1/Phase 2
- Allergy and Immunology · Phase 1
- Amputation, Surgical · Phase 4
- Amyotrophic Lateral Sclerosis · Phase 1/Phase 2
- Analgesia · Phase 2/Phase 3
- Analgesics, Opioid · Phase 1/Phase 2
- Anemia · Phase 2
- Anemia, Sickle Cell · Phase 2
- Anesthesia · Phase 4
- Anesthesia, Inhalation · Phase 4
- Angina Pectoris · Phase 2
- Angina, Unstable · Phase 3
- Ankle Fractures · Phase 3
- Anxiety · Phase 4
- Anxiety Disorders · Phase 4
- Arterial Occlusive Diseases · Phase 2
- Asthma · Phase 2
- Autistic Disorder · Phase 3
- Autonomic Nervous System Diseases · Phase 1
- Bariatric Surgery · Phase 4
- Biomarkers · Phase 2
- Bone Marrow Transplantation · Phase 2
- Brachytherapy · Phase 2
- Brain Concussion · Phase 1
- Brain Injuries, Traumatic · Phase 3
- Brain Injury, Chronic · Phase 2
- Brain Ischemia · Phase 2
- Brain Neoplasms · Phase 1/Phase 2
- Breast Neoplasms · Phase 3
- Bronchiolitis · Phase 4
- Bronchitis, Chronic · Phase 2/Phase 3
- Bronchopulmonary Dysplasia · Phase 3
- Bronchoscopy · Phase 3
- Burns · Phase 3
- Bursitis · Phase 4
- Calciphylaxis · Phase 4
- Carbon Monoxide Poisoning · Phase 4
- Carcinoma, Hepatocellular · Phase 1
- Carcinoma, Non-Small-Cell Lung · Phase 1
- Carcinoma, Squamous Cell · Phase 1
- Cardiomyopathies · Phase 3
- Cardiopulmonary Bypass · Phase 4
- Cardiovascular Diseases · Phase 4
- Carotid Artery Diseases · Phase 3
- Carotid Stenosis · Phase 3
- Cartilage Diseases · Phase 4
- Central Nervous System Diseases · Phase 2/Phase 3
- Cerebral Arteries · Phase 2
- Cerebral Infarction · Phase 2
- Cerebral Intraventricular Hemorrhage · Phase 2/Phase 3
- Child · Phase 3
- Child Behavior · Phase 3
- Chlorhexidine · Phase 3
- Cleft Lip · Phase 1
- Cluster Headache · Phase 1
- Cognition Disorders · Phase 1
- Colitis, Ulcerative · Phase 4
- Colonic Pseudo-Obstruction · Phase 1
- Communicable Diseases · Phase 3
- Contraceptive Devices · Phase 2/Phase 3
- Coronary Artery Disease · Phase 3
- Coronavirus Infections · Phase 2
- COVID-19 · Phase 4
- Craniocerebral Trauma · Phase 4
- Critical Care · Phase 3
- Critical Illness · Phase 4
- Crohn Disease · Phase 4
- Cystic Fibrosis · Phase 1
- Cystitis · Phase 4
- Cystitis, Interstitial · Early Phase 1
- Cytokine Release Syndrome · Phase 2/Phase 3
- Cytoprotection · Phase 1/Phase 2
- Decompression · Phase 1
- Decompression Sickness · Phase 2/Phase 3
- Delayed Graft Function · Phase 3
- Dental Caries · Phase 3
- Depression · Phase 2
- Depressive Disorder, Treatment-Resistant · Phase 4
- Dermal Fillers · Phase 4
- Dermatitis, Atopic · Phase 2
- Dermatitis, Seborrheic · Phase 2
- Diabetes Mellitus · Phase 3
- Diabetes Mellitus, Type 2 · Phase 1/Phase 2
- Diabetic Foot · Phase 4
- Dilatation · Early Phase 1
- Diving · Phase 2/Phase 3
- Down Syndrome · Phase 2
- Drug-Related Side Effects and Adverse Reactions · Phase 4
- Dyspnea · Phase 2
- Ehlers-Danlos Syndrome · Phase 4
- Electroencephalography · Phase 2
- Emphysema · Phase 1
- Endothelial Cells · Phase 2/Phase 3
- Enterocolitis, Pseudomembranous · Phase 4
- Epidermolysis Bullosa · Phase 4
- Erectile Dysfunction · Phase 4
- Escherichia coli Infections · Phase 4
- Exercise · Phase 2
- Extracorporeal Membrane Oxygenation · Phase 4
- Familial Primary Pulmonary Hypertension · Phase 3
- Femur · Phase 4
- Fetal Distress · Phase 3
- Fibrosis · Phase 2
- Fissure in Ano · Phase 4
- Frostbite · Phase 4
- General Surgery · Phase 4
- Geriatrics · Phase 4
- Gingival Diseases · Phase 4
- Glaucoma · Phase 4
- Glioblastoma · Phase 2
- Glioma · Phase 1
- Gliosarcoma · Phase 2
- Graft vs Host Disease · Phase 4
- Gynecology · Phase 2/Phase 3
- Hamstring Tendons · Phase 3
- Headache · Phase 1
- Head and Neck Neoplasms · Phase 1
- Healthy Volunteers · Phase 4
- Heart Arrest · Phase 2
- Heart Diseases · Phase 4
- Heart Failure · Phase 4
- Hematologic Neoplasms · Phase 2/Phase 3
- Hematopoietic Stem Cells · Phase 2
- Hemoglobins · Phase 2
- Hodgkin Disease · Phase 2
- Hyperalgesia · Phase 2
- Hyperbaric Oxygenation · Phase 4
- Hypercapnia · Phase 1
- Hyperoxia · Phase 4
- Hypertension, Pulmonary · Phase 4
- Hypoplastic Left Heart Syndrome · Phase 1/Phase 2
- Hypospadias · Phase 4
- Hypovolemia · Phase 1
- Hypoxia · Phase 4
- Hypoxia, Brain · Phase 4
- Idiopathic Pulmonary Fibrosis · Phase 2
- Ileus · Phase 1
- Immune System Diseases · Phase 4
- Immunocompromised Host · Phase 3
- Infant · Phase 4
- Infant, Newborn, Diseases · Phase 3
- Infant, Premature · Phase 3
- Infant, Premature, Diseases · Phase 2/Phase 3
- Infant, Small for Gestational Age · Phase 3
- Infections · Phase 3
- Inflammation · Phase 2/Phase 3
- Inflammatory Bowel Diseases · Phase 1/Phase 2
- Injection Site Reaction · Phase 3
- Intestinal Diseases · Phase 4
- Invasive Fungal Infections · Phase 4
- Ischemic Stroke · Phase 3
- Kidney Failure, Chronic · Phase 2
- Kidney Transplantation · Phase 3
- Labor Pain · Phase 3
- Lacerations · Phase 4
- Laminaria · Early Phase 1
- Laparotomy · Phase 4
- Leukemia, Lymphoid · Phase 2
- Leukemia, Myeloid · Early Phase 1
- Leukemia, Myeloid, Acute · Phase 2
- Leukemia, Myeloid, Chronic, Atypical, BCR-ABL Negative · Early Phase 1
- Leukemia, Myelomonocytic, Chronic · Early Phase 1
- Leukomalacia, Periventricular · Phase 2/Phase 3
- Ligaments · Phase 4
- Live Birth · Phase 3
- Liver Diseases · Phase 4
- Long-Acting Reversible Contraception · Phase 2/Phase 3
- Lower Urinary Tract Symptoms · Phase 4
- Lumbar Vertebrae · Phase 2
- Lung Diseases · Phase 4
- Lung Diseases, Interstitial · Phase 4
- Lung Diseases, Obstructive · Phase 4
- Lung Neoplasms · Phase 1
- Lung Transplantation · Phase 2
- Lymphedema · Phase 2
- Lymphoma · Phase 2
- Lymphoma, Non-Hodgkin · Phase 2
- Major Depressive Disorder · Phase 4
- Mastectomy, Radical · Phase 1/Phase 2
- Meningioma · Phase 1
- Mental Disorders · Phase 4
- Metabolomics · Early Phase 1
- Middle East Respiratory Syndrome Coronavirus · Phase 1
- Migraine Disorders · Phase 2
- Mitochondria · Phase 3
- Motor Activity · Early Phase 1
- Multiple Myeloma · Phase 2
- Multiple Sclerosis · Phase 4
- Myelodysplastic Syndromes · Phase 2
- Myeloproliferative Disorders · Early Phase 1
- Myocardial Infarction · Phase 3
- Myocardial Ischemia · Phase 2/Phase 3
- Myocardial Reperfusion Injury · Phase 1/Phase 2
- Myositis, Inclusion Body · Phase 4
- Natriuretic Peptide, Brain · Phase 4
- Neoplasm Metastasis · Phase 3
- Neoplasms · Phase 4
- Nervous System Diseases · Phase 4
- Neuralgia · Phase 2/Phase 3
- Neurobehavioral Manifestations · Phase 4
- Neurocognitive Disorders · Phase 2
- Neurologic Manifestations · Phase 1
- Nitrous Oxide · Phase 2
- Obesity · Phase 2
- Obesity, Morbid · Phase 4
- Opioid-Related Disorders · Phase 2
- Optic Neuropathy, Ischemic · Phase 4
- Oral Surgical Procedures · Early Phase 1
- Osteoarthritis · Phase 3
- Osteoarthritis, Knee · Phase 2
- Osteonecrosis · Phase 4
- Osteoradionecrosis · Phase 2/Phase 3
- Oxidative Stress · Phase 4
- Oxygen · Phase 4
- Oxygen Inhalation Therapy · Early Phase 1
- Oxygen Saturation · Phase 4
- Pain · Phase 4
- Paroxysmal Hemicrania · Phase 1
- Pathologic Processes · Phase 3
- Pediatrics · Phase 2
- Peer Review, Research · Phase 3
- Peripheral Vascular Diseases · Phase 4
- Persistent Fetal Circulation Syndrome · Phase 4
- Pneumonia · Phase 3
- Pneumonia, Viral · Phase 2
- Polycythemia · Phase 2
- Post-Acute COVID-19 Syndrome · Phase 3
- Post-Concussion Syndrome · Phase 3
- Postoperative Complications · Phase 4
- Postoperative Nausea and Vomiting · Phase 3
- Postpartum Hemorrhage · Phase 4
- Pouchitis · Phase 4
- Prader-Willi Syndrome · Phase 4
- Pregnancy Complications · Phase 3
- Premature Birth · Phase 3
- Pressure Ulcer · Phase 4
- Primary Myelofibrosis · Early Phase 1
- Prostatic Hyperplasia · Phase 4
- Prostatic Neoplasms · Phase 4
- Prosthesis-Related Infections · Phase 4
- Psychiatry · Phase 2
- Pterygium · Phase 4
- Pulmonary Arterial Hypertension · Phase 2
- Pulmonary Atelectasis · Phase 4
- Pulmonary Disease, Chronic Obstructive · Phase 4
- Pulmonary Embolism · Phase 3
- Pulmonary Fibrosis · Phase 2
- Pyoderma Gangrenosum · Phase 4
- Quality of Life · Phase 4
- Radiation Fibrosis Syndrome · Phase 2
- Radiation Pneumonitis · Phase 2
- Rapid Sequence Induction and Intubation · Phase 4
- Raynaud Disease · Phase 4
- Rectovaginal Fistula · Phase 4
- Regional Blood Flow · Phase 4
- Renal Colic · Phase 2
- Reperfusion Injury · Phase 3
- Respiration · Phase 2/Phase 3
- Respiration, Artificial · Phase 4
- Respiratory Distress Syndrome · Phase 3
- Respiratory Insufficiency · Phase 4
- Respiratory Syncytial Virus Infections · Phase 3
- Respiratory Tract Diseases · Phase 4
- Respiratory Tract Infections · Phase 1/Phase 2
- Retina · Phase 4
- Retinal Artery Occlusion · Phase 4
- Retinal Diseases · Phase 4
- Retinal Vein Occlusion · Phase 4
- Retinitis Pigmentosa · Early Phase 1
- Retinopathy of Prematurity · Phase 3
- Rosacea · Phase 2
- Sarcoma · Phase 4
- Schizophrenia · Phase 3
- Sclerosis · Phase 3
- Seizures, Febrile · Phase 2/Phase 3
- Sepsis · Phase 4
- Severe Acute Respiratory Syndrome · Phase 2/Phase 3
- Shock, Cardiogenic · Phase 3
- Sleep · Phase 2
- Sleep Apnea, Central · Phase 4
- Sleep Apnea, Obstructive · Phase 2
- Sleep Apnea Syndromes · Phase 4
- Sleep Disorders, Intrinsic · Phase 2
- Sleep Wake Disorders · Phase 2
- Soft Tissue Injuries · Phase 2/Phase 3
- Spinal Cord Injuries · Phase 4
- Spinal Puncture · Phase 4
- Squamous Cell Carcinoma of Head and Neck · Phase 2
- Status Asthmaticus · Phase 2
- ST Elevation Myocardial Infarction · Phase 4
- Stem Cell Research · Phase 2
- Stomach Neoplasms · Phase 1/Phase 2
- Stress Disorders, Post-Traumatic · Phase 2
- Stroke · Phase 4
- Subarachnoid Hemorrhage · Phase 2
- Substance-Related Disorders · Phase 2
- Suicidal Ideation · Phase 2
- Suicide · Phase 2
- Surgical Wound Infection · Phase 4
- Systemic Inflammatory Response Syndrome · Phase 4
- Thoracic Surgery · Phase 4
- Tibial Fractures · Phase 2/Phase 3
- Tinea Pedis · Phase 2
- Tinnitus · Phase 4
- Tonsillitis · Phase 2
- Trauma, Nervous System · Phase 4
- Urinary Bladder Neoplasms · Phase 3
- Urinary Incontinence, Stress · Phase 4
- Urinary Tract Infections · Early Phase 1
- Vascular Diseases · Phase 3
- Vasectomy · Early Phase 1
- Venous Thromboembolism · Early Phase 1
- Wound Infection · Phase 3
- Wounds and Injuries · Phase 4
- Xerostomia · Phase 2
Mechanism of action
- Unspecified targetOTHER
Essential for cellular homeostasis
- oxygenSupplementation
oxygen supplementation
Approval history
- approvedJun 16, 2013
- approvedJun 1, 1810
Chemistry & pharmacology
Loading structure…
SMILES
O=O- Mol. weight
- 32 g/mol
- Lipinski Ro5
- Pass
- Rule of 3
- Yes
- Chirality
- Achiral Molecule
- Inorganic
- No
- Polymer
- No
- Delivery
- Topical
- Availability
- Prescription Only
Oral
No
Parenteral
No
Topical
Yes
Sources
- WikipediaCarbogen ↗
- NCATSK21NZZ5Y0B ↗
- ChEMBLCHEMBL4297716 ↗
- ChEMBLCHEMBL1234886 ↗
- WikipediaOxygen ↗
- NCATSS88TT14065 ↗
Also known as
- carbogen
- carbogen
- dioxygen
- dioxygen
- e948
- e948
- helium; molecular oxygen
- hyperbaric oxygen
- medical air
- molecular oxygen
- molecular oxygen
- molecular oxygen
- oxygen
- oxygen
- oxygen
- oxygen
- oxygen
- oxygen
- oxygen
- oxygen
- oxygen
- oxygen
- oxygen (93%)
- oxygen (93%)
- oxygen molecule
- oxygen molecule
- oxygen usp
- oxygen usp
- oxygen, usp
- oxygne
- pure oxygen
- pure oxygen
Clinical trials
| NCT ID | Phase | Start date | Sponsor(s) |
|---|---|---|---|
| NCT07280468 | Phase 4 | Feb 1, 2026 | Patient-Centered Outcomes Research Institute, University of Arizona |
| NCT07263399 | N/A | Jan 31, 2026 | Blekinge Institute of Technology, Karolinska Institute, Lund University, University of Gothenburg |
| NCT07210606 | Phase 4 | Jan 1, 2026 | Department of Veteran Affairs |
| NCT07307716 | N/A | Dec 31, 2025 | Riyadh Elm University |
| NCT07240649 | Phase 4 | Dec 31, 2025 | Dartmouth University |
| NCT07293286 | N/A | Dec 30, 2025 | Sun Yat-Sen University |
| NCT07311109 | N/A | Dec 15, 2025 | Fujian Medical University |
| NCT07186634 | Phase 4 | Dec 1, 2025 | Monash University |
| NCT07245628 | Early Phase 1 (Phase 1) | Oct 20, 2025 | Harvard University |
| NCT07200180 | Phase 3 | Oct 1, 2025 | Negovsky Reanimatology Research Institute |
| NCT07049692 | N/A | Oct 1, 2025 | Capital Medical University |
| NCT07214415 | Phase 2 | Oct 1, 2025 | Summit Hyperbarics and Wellness |
| NCT07118644 | Phase 3 | Sep 1, 2025 | University of Western Brittany |
| NCT06959485 | N/A | Aug 1, 2025 | Assiut University |
| NCT07123870 | Phase 4 | Jul 23, 2025 | Kocaeli City Hospital |
| NCT07063563 | N/A | Jul 23, 2025 | Eastern Switzerland University of Applied Sciences, Government of Russia, University of Zurich |
| NCT07044843 | N/A | Jul 23, 2025 | Eastern Switzerland University of Applied Sciences, Government of Russia, University of Zurich |
| NCT07107828 | N/A | Jul 23, 2025 | Eastern Switzerland University of Applied Sciences, Government of Russia, University of Edinburgh |
| NCT06749093 | N/A | Jul 1, 2025 | University of British Columbia |
| NCT06327373 | Phase 1/Phase 2 (Phase 2) | Jul 1, 2025 | Duke University |
Showing 20 of 656 trials
Page 1 / 33
Organizations
Research & Development (532)
| Organization | Org type | Trials | As lead sponsor | Phases | Earliest year |
|---|---|---|---|---|---|
| University of Copenhagen | Academic/Hospital | 22 | 18 | 4 | 2006 |
| Harvard University | Academic/Hospital | 21 | 21 | 5 | 2005 |
| Duke University | Academic/Hospital | 16 | 14 | 5 | 2005 |
| University of Toronto | Academic/Hospital | 16 | 13 | 4 | 2003 |
| Capital Medical University | Academic/Hospital | 14 | 14 | 3 | 2015 |
| University of Zurich | Academic/Hospital | 14 | 10 | 3 | 2009 |
| University of British Columbia | Academic/Hospital | 11 | 10 | 3 | 2006 |
| University of Rochester | Academic/Hospital | 11 | 9 | 4 | 2002 |
| Air Liquide | For profit | 10 | 9 | 3 | 2000 |
| National Heart, Lung, and Blood Institute (NHLBI) | Government | 10 | 1 | 4 | 2005 |
| University of California, San Diego | Academic/Hospital | 10 | 7 | 5 | 2005 |
| Federal University of Pernambuco | Academic/Hospital | 9 | 9 | 2 | 2008 |
| Department of Veteran Affairs | Government | 8 | 6 | 2 | 2010 |
| Hebrew University | Academic/Hospital | 8 | 6 | 2 | 2009 |
| Karolinska Institute | Academic/Hospital | 8 | 6 | 4 | 2012 |
| University of Cincinnati | Academic/Hospital | 8 | 6 | 3 | 2000 |
| University of Vienna | Academic/Hospital | 8 | 8 | 2 | 2002 |
| National Institutes of Health (NIH) | Government | 7 | 0 | 3 | 2005 |
| Tel Aviv University | Academic/Hospital | 7 | 7 | 2 | 2009 |
| Washington University in St. Louis | Academic/Hospital | 7 | 4 | 1 | 2008 |
532 organizations
Page 1 / 27
Marketing (40)
| Organization | Org type | Relationship | Date |
|---|---|---|---|
| ABSOLUTE AIR, LLC | For profit | MKTG | Jun 10, 2022 |
| ABSOLUTE AIR, LLC | For profit | NDA2 | Jun 10, 2022 |
| Acetylene Oxygene Co | For profit | NDA2 | Sep 1, 2013 |
| Air Liquide | For profit | NDA2 | Jul 13, 2013 |
| Air Liquide | For profit | SYN | Jun 23, 2013 |
| Air Liquide | For profit | SYN | Jun 16, 2013 |
| Air Liquide | For profit | SYN | Jun 16, 2013 |
| Air Liquide | For profit | SYN | Jun 2, 2020 |
| Air Liquide | For profit | NDA | Jun 16, 2013 |
| Air Products And Chemicals Inc | For profit | NDA2 | Jul 23, 2013 |
| Airgas Usa Llc | For profit | NDA2 | Jul 16, 2013 |
| Airgas Usa Llc | For profit | SYN | Sep 7, 2013 |
| American Welding And Gas Inc | For profit | NDA2 | May 12, 2014 |
| Aspen Air | For profit | NDA2 | Jul 23, 2013 |
| BOC International | For profit | NDA2 | Jul 5, 2013 |
| Cee Kay Supply | For profit | NDA2 | Apr 22, 2014 |
| Central Welding Supply | For profit | MKTG | Dec 25, 2015 |
| Central Welding Supply | For profit | NDA2 | Dec 25, 2015 |
| Cristal Therapeutics | For profit | NDA2 | Sep 10, 2018 |
| Dupuy Oxygen | For profit | NDA2 | Jul 15, 2013 |
| General Services & Supply Co | For profit | NDA2 | Dec 25, 2016 |
| Linde AG | For profit | NDA2 | Jul 5, 2013 |
| Linde AG | For profit | SYN | Jul 5, 2013 |
| Machine & Welding Supply Co | For profit | NDA2 | Jul 13, 2013 |
| Matheson Tri-Gas Inc | For profit | NDA2 | Aug 2, 2013 |
| Nexair | For profit | NDA2 | Jul 23, 2013 |
| Norco | For profit | NDA2 | Jul 14, 2013 |
| Oxarc Inc | For profit | NDA2 | Jul 20, 2013 |
| Praxair | For profit | SYN | Aug 27, 2013 |
| Praxair | For profit | NDA2 | Jul 21, 2013 |
| Praxair | For profit | SYN | Sep 3, 2017 |
| Praxair | For profit | SYN | Aug 5, 2013 |
| Praxair | For profit | SYN | Aug 5, 2013 |
| Praxair | For profit | SYN | Jul 14, 2013 |
| Purity Cylinder Gases, Inc | For profit | NDA2 | Jul 14, 2013 |
| Scott-Gross Company | For profit | NDA2 | Jul 14, 2013 |
| United States Welding Inc | For profit | NDA2 | Aug 31, 2013 |
| Universal Industrial Gases, Inc | For profit | NDA2 | Aug 24, 2018 |
| WSM SUPPLIER LLC | For profit | MKTG | Jul 13, 2024 |
| Westair Gases & Equipment Inc | For profit | NDA2 | Jul 14, 2013 |