magnesium sulfate
Trade name: Tis-U-Sol
Small moleculeapproved
Approved
Oct 6, 1981
Magnesium sulfate or magnesium sulphate is a chemical compound, a salt with the formula MgSO4, consisting of magnesium cations Mg2+ (20.19% by mass) and sulfate anions SO2−4. It is a white crystalline solid, soluble in water. — Wikipedia
Clinical trial activity
435 trials · 296 clinical orgs · 29 marketing orgs
Phase 1
46
Phase 2
125
Phase 3
104
Phase 4
106
Earliest trial started Aug 1, 1987 (NCT00065949)
Timeline
1980s
1990s
- Jun 24, 1994
Hospira — NDA Secondary Org
- Sep 27, 1996
Lukare Medical — Marketing Organization
- Sep 27, 1996
Lukare Medical — NDA Secondary Org
2010s
- Aug 5, 2010
Braintree Laboratories — Marketing Organization
- Aug 5, 2010
Braintree Laboratories — NDA Secondary Org
- Dec 18, 2014
Exela Pharma Sciences, LLC. — Marketing Organization
- May 14, 2015
Hospira — Marketing Organization
- May 14, 2015
Pfizer — Marketing Organization
- Mar 2, 2016
Hq Speciality Pharma — Marketing Organization
- Mar 7, 2016
Fresenius — Marketing Organization
- Aug 18, 2016
Paddock Laboratories — Marketing Organization
- Aug 18, 2016
Perrigo — Marketing Organization
- Nov 14, 2016
Esteve Labs — Marketing Organization
- Dec 27, 2016
Gator Pharmaceuticals — Marketing Organization
- Dec 27, 2016
Gator Pharmaceuticals — NDA Secondary Org
- Feb 23, 2017
Novel Anti-Infective Technologies, LLC — Marketing Organization
- Sep 10, 2018
Mylan — Marketing Organization
- Oct 26, 2018
Taro Pharmaceuticals — Marketing Organization
- Oct 26, 2018
Sun Pharmaceuticals — Marketing Organization
2020s
- Jun 1, 2020
Takeda — Marketing Organization
- Jul 10, 2020
Gland Pharma Ltd — Marketing Organization
- Jul 10, 2020
Fosun — Marketing Organization
- Oct 27, 2020
B. Braun — Marketing Organization
- Jun 15, 2021
Annora Pharma — Marketing Organization
- Nov 8, 2021
Milla Pharms — Marketing Organization
- Nov 8, 2021
Pts Consulting — Marketing Organization
- Feb 15, 2023
Amneal Pharmaceuticals — Marketing Organization
- Nov 22, 2023
Strides Pharma Science — Marketing Organization
- Dec 29, 2023
Alkem Labs Ltd — Marketing Organization
- Jun 24, 2024
Bionpharma Inc — Marketing Organization
- Jul 15, 2024
Lannett Company, Inc. — Marketing Organization
Indications
Approved for
Studied for
- Abruptio Placentae · Phase 3
- Acidosis, Lactic · Phase 2/Phase 3
- Acute Febrile Encephalopathy · Phase 3
- Acute Pain · Phase 4
- Airway Extubation · Phase 4
- Alcohol Withdrawal Delirium · Phase 2/Phase 3
- Analgesia · Phase 4
- Analgesics, Opioid · Phase 4
- Anemia, Sickle Cell · Phase 3
- Anesthesia · Phase 4
- Anesthesia and Analgesia · Phase 4
- Anesthesia, General · Phase 4
- Anesthesia, Intravenous · Phase 4
- Anesthesia, Local · Phase 4
- Anterior Cruciate Ligament Injuries · Phase 1
- Anxiety · Phase 4
- Aortic Coarctation · Phase 4
- Appendicitis · Phase 4
- Arrhythmias, Cardiac · Phase 4
- Arterial Pressure · Early Phase 1
- Arthritis · Phase 3
- Arthropathy, Neurogenic · Phase 4
- Arthroplasty, Replacement, Hip · Phase 3
- Arthroplasty, Replacement, Knee · Phase 4
- Asphyxia · Phase 3
- Asthma · Phase 4
- Atrial Fibrillation · Phase 4
- Atrial Flutter · Phase 3
- Blood Pressure · Phase 3
- Bone Diseases · Phase 2/Phase 3
- Brain · Phase 3
- Brain Concussion · Phase 3
- Brain Diseases · Phase 2
- Brain Injuries · Phase 3
- Brain Injuries, Traumatic · Phase 3
- Brain Neoplasms · Phase 4
- Breast · Phase 2
- Breast Neoplasms · Phase 3
- Bronchiolitis · Phase 2
- Burns · Phase 1
- Cardiovascular Diseases · Phase 4
- Cerebral Intraventricular Hemorrhage · Phase 3
- Cerebral Palsy · Phase 3
- Cerebrum · Phase 3
- Cesarean Section · Phase 3
- Cholecystectomy · Phase 3
- Cholecystectomy, Laparoscopic · Phase 4
- Chronic Pain · Phase 2/Phase 3
- Colonic Diseases · Phase 4
- Colonic Neoplasms · Phase 3
- Colonic Polyps · Phase 4
- Colonoscopy · Phase 4
- Colorectal Neoplasms · Phase 3
- Colorectal Surgery · Phase 3
- Coronary Artery Disease · Phase 4
- Cough · Phase 4
- Craniocerebral Trauma · Phase 3
- Craniotomy · Phase 1
- Critical Illness · Phase 4
- Cytomegalovirus Infections · Phase 4
- Deficiency Diseases · Phase 2/Phase 3
- Dehydroepiandrosterone · Phase 4
- Delirium · Phase 4
- Dexmedetomidine · Phase 4
- Drug-Related Side Effects and Adverse Reactions · Phase 4
- Drugs, Investigational · Phase 3
- Duloxetine Hydrochloride · Phase 4
- Eclampsia · Phase 4
- Emergence Delirium · Phase 4
- Endoscopy · Early Phase 1
- Enhanced Recovery After Surgery · Phase 4
- Esophageal Spasm, Diffuse · Phase 2
- Facial Pain · Phase 2/Phase 3
- Fasting · Phase 4
- Fentanyl · Phase 4
- General Surgery · Phase 4
- Hamartoma · Phase 4
- Hand, Foot and Mouth Disease · Phase 2
- Headache · Phase 4
- Head and Neck Neoplasms · Phase 1
- Heart Arrest · Phase 1
- Heart Valve Diseases · Phase 4
- Hemodynamics · Phase 4
- Hemorrhage · Phase 4
- Hernia · Phase 4
- Hip Fractures · Phase 2/Phase 3
- HIV Infections · Phase 4
- Hydrocortisone · Phase 4
- Hypertension · Phase 2/Phase 3
- Hypertension, Pregnancy-Induced · Phase 2/Phase 3
- Hypertension, Pulmonary · Phase 1/Phase 2
- Hypocalcemia · Phase 4
- Hypospadias · Phase 4
- Hypotension · Phase 1
- Hypoxia-Ischemia, Brain · Phase 4
- Hysterectomy · Phase 4
- Hysteroscopy · Phase 4
- Infant, Premature · Early Phase 1
- Infertility, Male · Early Phase 1
- Injections, Intra-Articular · Phase 4
- Intestinal Diseases · Phase 3
- Intraoperative Neurophysiological Monitoring · Phase 4
- Intubation · Phase 4
- Ischemic Stroke · Phase 1
- Ketamine · Phase 4
- Kidney Transplantation · Phase 1/Phase 2
- Knee Injuries · Phase 3
- Labor, Obstetric · Phase 4
- Laparoscopy · Phase 3
- Leukemia, Myeloid, Acute · Phase 2
- Leukomalacia, Periventricular · Phase 3
- Lidocaine · Phase 4
- Lumbar Vertebrae · Phase 4
- Lung Diseases · Phase 4
- Lung Neoplasms · Phase 2/Phase 3
- Magnesium · Phase 2/Phase 3
- Magnesium Deficiency · Phase 4
- Magnesium Sulfate · Phase 4
- Mastectomy · Early Phase 1
- Meningioma · Phase 3
- Mesothelioma · Phase 2
- Migraine Disorders · Phase 3
- Muscle Cramp · Phase 4
- Muscle Relaxation · Phase 2/Phase 3
- Muscle, Skeletal · Phase 2/Phase 3
- Myofascial Pain Syndromes · Phase 4
- Nasal Surgical Procedures · Phase 4
- Nasopharynx · Phase 4
- Neoplasms · Phase 4
- Neostigmine · Phase 4
- Neuralgia · Phase 4
- Neuralgia, Postherpetic · Phase 1/Phase 2
- Neuromuscular Blockade · Phase 4
- Neuroprotection · Phase 2/Phase 3
- Obesity · Phase 4
- Obstetric Labor, Premature · Phase 4
- Only Child · Phase 3
- Osteoarthritis, Knee · Phase 4
- Pain · Phase 4
- Pancreatitis · Phase 3
- Parathyroid Diseases · Phase 4
- Pediatrics · Phase 4
- Pelvic Pain · Phase 3
- Perfusion · Phase 1/Phase 2
- Perinatal Death · Phase 2/Phase 3
- Perineum · Phase 2
- Peripheral Nerve Injuries · Phase 3
- Persistent Fetal Circulation Syndrome · Phase 1/Phase 2
- Pharmacology · Phase 1/Phase 2
- Pharyngitis · Phase 4
- Placenta Previa · Phase 3
- Poisoning · Phase 3
- Postoperative Complications · Phase 4
- Postoperative Nausea and Vomiting · Phase 4
- Postoperative Pain · Phase 4
- Pre-Eclampsia · Phase 4
- Pregnancy · Phase 4
- Pregnancy Complications · Phase 4
- Premature Birth · Phase 2/Phase 3
- Procedural Pain · Phase 4
- Procedural Sedation · Phase 2
- Prostatectomy · Phase 4
- Psychomotor Agitation · Phase 4
- Pulmonary Disease, Chronic Obstructive · Phase 4
- Pulmonary Edema · Phase 3
- Purpura, Thrombotic Thrombocytopenic · Phase 3
- Renal Colic · Phase 2
- Renal Insufficiency, Chronic · Phase 2/Phase 3
- Return of Spontaneous Circulation · Phase 1
- Rocuronium · Phase 4
- Scoliosis · Phase 2
- Seizures · Phase 4
- Shivering · Phase 4
- Shoulder Pain · Phase 4
- Sinusitis · Phase 1/Phase 2
- Spinal Injuries · Phase 4
- Spine · Phase 4
- Sprains and Strains · Phase 2
- Status Asthmaticus · Phase 1
- Stomach Neoplasms · Phase 4
- Stress Disorders, Post-Traumatic · Phase 4
- Stroke · Phase 3
- Subarachnoid Hemorrhage · Phase 3
- Tachycardia · Phase 3
- Temporomandibular Joint Disorders · Early Phase 1
- Tennis Elbow · Phase 1
- Thoracic Surgery · Phase 3
- Thyroid Diseases · Phase 4
- Tonsillectomy · Phase 3
- Urinary Bladder Diseases · Phase 2
- Urinary Retention · Phase 4
- Urological Manifestations · Phase 3
- Varicose Ulcer · Phase 4
- Varicose Veins · Phase 4
- Vascular Calcification · Phase 2/Phase 3
- Vasospasm, Intracranial · Phase 2/Phase 3
- Wernicke Encephalopathy · Phase 2/Phase 3
- Wounds and Injuries · Phase 4
- X-Linked Combined Immunodeficiency Diseases · Phase 1/Phase 2
Mechanism of action
- Unspecified targetOTHER
Unknown
Combination products
elliotts b solution
with potassium chloride, sodium bicarbonate, sodium phosphate, sodium chloride, calcium chloride, glucose monohydrate
kabiven
with soybean oil, potassium chloride, sodium acetate, amino acids, sodium glycerophosphate pentahydrate, calcium chloride, glucose monohydrate
Also known as perikabiven
suclear
with potassium chloride, potassium sulfate, sodium sulfate, sodium bicarbonate, sodium chloride, polyethylene glycol
suflave
with potassium chloride, sodium sulfate, sodium chloride, polyethylene glycol
suprep bowel prep
with potassium sulfate, sodium sulfate
Also known as colprep
sutab
tis-u-sol
with potassium chloride, sodium phosphate, sodium chloride, potassium phosphate
Approval history
- approvedOct 6, 1981
Chemistry & pharmacology
Loading structure…
SMILES
O.O.O.O.O.O.O.O=S(=O)([O-])[O-].[Mg+2]- Mol. weight
- 246.47 g/mol
- Chirality
- Achiral Molecule
- Inorganic
- Yes
- Polymer
- No
- Delivery
- Oral, Parenteral
- Availability
- Prescription Only
Oral
Yes
Parenteral
Yes
Topical
No
Sources
- ChEMBLCHEMBL3989857 ↗
- WikipediaMagnesium sulfate ↗
- ChEMBLCHEMBL2021423 ↗
- ChEMBLCHEMBL1200456 ↗
Also known as
- epsom salt
- epsom salt
- magesium sulphate
- magnesium(ii) sulfate
- magnesium(ii) sulfate
- magnesiumsulfat
- magnesiumsulfat
- magnesium sulfate
- magnesium sulfate
- magnesium sulfate
- magnesium sulfate
- magnesium sulfate
- magnesium sulfate
- magnesium sulfate
- magnesium sulfate
- magnesium sulfate
- magnesium sulfate
- magnesium sulfate (1:1)
- magnesium sulfate (1:1)
- magnesium sulfate anhydrous
- magnesium sulfate anhydrous
- magnesium sulfate anhydrous
- magnesium sulfate anhydrous
- magnesium sulfate heptahydrate
- magnesium sulfate mixture with potassium sulfate and sodium sulfate
- magnesium sulfate, unspecified
- magnesium sulphate
- magnesium sulphate
- magnesium sulphate
- magnesium sulphate
- magnesium sulphate
- mag sulf
- mgso4
- mgso4
- original andrews salts
- sulfuric acid magnesium salt
Clinical trials
| NCT ID | Phase | Start date | Sponsor(s) |
|---|---|---|---|
| NCT07298564 | N/A | Jan 30, 2026 | Azad University |
| NCT07220902 | Phase 3 | Jan 1, 2026 | Nebraska Methodist Health System |
| NCT07309640 | N/A | Jan 1, 2026 | Univerisiti Sains Malaysia |
| NCT07126795 | Phase 1 | Jan 1, 2026 | Hennepin Healthcare |
| NCT06904287 | Phase 3 | Dec 31, 2025 | Wake Forest University |
| NCT07149649 | Phase 2/Phase 3 (Phase 3) | Dec 31, 2025 | Swiss Cancer Institute |
| NCT07252505 | Early Phase 1 (Phase 1) | Nov 30, 2025 | Assiut University |
| NCT07173855 | Phase 4 | Nov 25, 2025 | Scarborough General Hospital |
| NCT07213037 | Phase 3 | Nov 1, 2025 | Assiut University |
| NCT07139847 | N/A | Oct 30, 2025 | Ondokuz Mayıs University |
| NCT07199595 | N/A | Oct 20, 2025 | Assiut University |
| NCT07258628 | N/A | Oct 10, 2025 | Ankara Yildirim Beyazıt University |
| NCT06959251 | N/A | Oct 2, 2025 | Instituto Nacional de Enfermedades Respiratorias |
| NCT06785272 | Phase 3 | Sep 30, 2025 | McMaster University, St. Justine's Hospital, University of Alberta, University of Calgary, University of Toronto |
| NCT07181564 | N/A | Sep 11, 2025 | University of Patras |
| NCT07105618 | N/A | Aug 10, 2025 | Zagazig University |
| NCT07082894 | N/A | Jul 25, 2025 | Tanta University |
| NCT06975072 | Phase 4 | Jul 1, 2025 | University of California, San Francisco |
| NCT07248540 | N/A | Jul 1, 2025 | Gaziosmanpasa University |
| NCT06956521 | Phase 1 | Jun 30, 2025 | Baylor University |
Showing 20 of 435 trials
Page 1 / 22
Organizations
Research & Development (296)
| Organization | Org type | Trials | As lead sponsor | Phases | Earliest year |
|---|---|---|---|---|---|
| Assiut University | Academic/Hospital | 52 | 52 | 5 | 2015 |
| Cairo University | Academic/Hospital | 37 | 36 | 5 | 2012 |
| Seoul National University | Academic/Hospital | 19 | 18 | 2 | 2010 |
| Ain Shams University | Academic/Hospital | 17 | 16 | 5 | 2013 |
| Mansoura University | Academic/Hospital | 8 | 7 | 3 | 2016 |
| University of Sao Paulo | Academic/Hospital | 8 | 8 | 4 | 2004 |
| Queen's University, Belfast | Academic/Hospital | 6 | 6 | 2 | 2006 |
| University of Monastir | Academic/Hospital | 6 | 6 | 2 | 2005 |
| Zagazig University | Academic/Hospital | 6 | 6 | 3 | 2018 |
| Beni Suef University | Academic/Hospital | 5 | 5 | 4 | 2019 |
| Braintree Laboratories | For profit | 5 | 5 | 2 | 2007 |
| National Cancer Institute, Egypt | Government | 5 | 5 | 3 | 2015 |
| National Cancer Institute (NCI) | Government | 5 | 2 | 2 | 2006 |
| Hamad Medical Corporation | For profit | 4 | 4 | 3 | 2012 |
| Mayo Clinic | Academic/Hospital | 4 | 2 | 2 | 2006 |
| Tanta University | Academic/Hospital | 4 | 4 | 2 | 2023 |
| University Clermont Auvergne | Academic/Hospital | 4 | 4 | 4 | 2004 |
| University of British Columbia | Academic/Hospital | 4 | 4 | 1 | 2007 |
| University of Geneva | Academic/Hospital | 4 | 4 | 2 | 2006 |
| University of Toronto | Academic/Hospital | 4 | 4 | 2 | 2006 |
296 organizations
Page 1 / 15
Marketing (38)
| Organization | Org type | Relationship | Date |
|---|---|---|---|
| Alkem Labs Ltd | For profit | MKTG | Dec 29, 2023 |
| Amneal Pharmaceuticals | For profit | MKTG | Feb 15, 2023 |
| Annora Pharma | For profit | MKTG | Jun 15, 2021 |
| B. Braun | For profit | MKTG | Oct 27, 2020 |
| Baxalta | For profit | SYN | Jun 1, 2020 |
| Baxalta | For profit | NDA | — |
| Baxalta | For profit | MKTG | Oct 6, 1981 |
| Baxter | For profit | NDA2 | Oct 6, 1981 |
| Bionpharma Inc | For profit | MKTG | Jun 24, 2024 |
| Braintree Laboratories | For profit | MKTG | Aug 5, 2010 |
| Braintree Laboratories | For profit | NDA2 | Aug 5, 2010 |
| Esteve Labs | For profit | MKTG | Nov 14, 2016 |
| Exela Pharma Sciences, LLC. | For profit | MKTG | Dec 18, 2014 |
| Exela Pharma Sciences, LLC. | For profit | SYN | Dec 18, 2014 |
| Fosun | For profit | MKTG | Jul 10, 2020 |
| Fresenius | For profit | NDA2 | Sep 8, 1986 |
| Fresenius | For profit | MKTG | Mar 7, 2016 |
| Gator Pharmaceuticals | For profit | MKTG | Dec 27, 2016 |
| Gator Pharmaceuticals | For profit | NDA2 | Dec 27, 2016 |
| Gland Pharma Ltd | For profit | MKTG | Jul 10, 2020 |
| Hospira | For profit | NDA2 | Jun 24, 1994 |
| Hospira | For profit | MKTG | May 14, 2015 |
| Hq Speciality Pharma | For profit | MKTG | Mar 2, 2016 |
| Lannett Company, Inc. | For profit | MKTG | Jul 15, 2024 |
| Lukare Medical | For profit | MKTG | Sep 27, 1996 |
| Lukare Medical | For profit | NDA2 | Sep 27, 1996 |
| Milla Pharms | For profit | MKTG | Nov 8, 2021 |
| Mylan | For profit | MKTG | Sep 10, 2018 |
| Novel Anti-Infective Technologies, LLC | For profit | MKTG | Feb 23, 2017 |
| Paddock Laboratories | For profit | MKTG | Aug 18, 2016 |
| Perrigo | For profit | MKTG | Aug 18, 2016 |
| Pfizer | For profit | MKTG | May 14, 2015 |
| Pts Consulting | For profit | MKTG | Nov 8, 2021 |
| Strides Pharma Science | For profit | MKTG | Nov 22, 2023 |
| Sun Pharmaceuticals | For profit | MKTG | Oct 26, 2018 |
| Takeda | For profit | MKTG | Jun 1, 2020 |
| Taro Pharmaceuticals | For profit | MKTG | Oct 26, 2018 |
| Taro Pharmaceuticals | For profit | SYN | Mar 19, 2024 |