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cellulose

Botanicalapproved

Approved

Dec 28, 1982

Microbicides for sexually transmitted infections are pharmacologic agents and chemical substances that are capable of killing or destroying certain microorganisms that commonly cause sexually transmitted infection. — Wikipedia

Clinical trial activity

181 trials · 202 clinical orgs · 2 marketing orgs

Phase 1
21
Phase 2
57
Phase 3
29
Phase 4
30

Earliest trial started Feb 1, 2004 (NCT00386646)

Timeline

1980s

  1. Dec 28, 1982

    Earliest FDA Approval

  2. Dec 28, 1982

    Mission Pharmacal — NDA Secondary Org

1990s

  1. Oct 29, 1998

    Bracco — First NDA Organization

  2. Oct 29, 1998

    Bracco — NDA Organization

2000s

  1. Jan 1, 2004

    Earliest Phase 3 Sponsor(trial)

  2. Jan 1, 2005

    Earliest Phase 2 Sponsor(trial)

  3. Jan 1, 2009

    Earliest Phase 1 Sponsor(trial)

Indications

Approved for

Studied for

Mechanism of action

  • Unspecified targetOTHER

    Unknown

    Oxidised cellulose dressings work to stop bleeding by accelerating blood platelet aggregation and helping the blood clotting process to start. The fibres are able to absorb up to seven times their own volume in blood. When saturated the oxidised cellulose swells into a gelatinous mass. Oxidised cellulose is naturally acidic and it is this acid that starts to break down the blood cells triggering the clotting process in the body. The oxidised cellulose also lowers the pH within the wound due to its acidity. This creates a hostile environment for most bacteria and also gives it antimicrobial benefit.

  • CalciumSEQUESTERING AGENT

    Calcium sequestering agent

Approval history

  • approvedPriority reviewDec 28, 1982

Chemistry & pharmacology

Chirality
Single Stereoisomer
Inorganic
No
Polymer
No
Delivery
Oral
Availability
Discontinued

Oral

Yes

Parenteral

No

Topical

No

Sources

Also known as

  • anacalcit
  • avicel ph
  • avicel ph-101
  • blandlax
  • calcibind
  • calcibind
  • calcibind
  • calcisorb
  • calcisorb
  • capcell
  • carboxymethylcellulose
  • carboxymethylcellulose
  • carboxymethylcellulose
  • carboxy-methylcellulose
  • carboxymethyl cellulose
  • carboxymethyl cellulose
  • carboxymethylcellulose sodium
  • carboxymethylcellulose sodium
  • carboxymethylcellulose sodium
  • carmellose
  • carmellose
  • carmellose
  • carmellose sodium
  • carmellose sodium
  • cellufresh
  • cellufresh
  • cellulose
  • cellulose
  • cellulose, absorbable
  • cellulose, crystalline
  • cellulose, dispersible
  • cellulose gum
  • cellulose gum
  • cellulose, hydrogen sulfate
  • cellulose, microcrystalline
  • cellulose, microcrystalline
  • cellulose, microcrystalline
  • cellulose, oxidized
  • cellulose phosphate
  • cellulose polyphosphate
  • cellulose sodium phosphate
  • cellulose sodium phosphate
  • cellulose sodium phosphate
  • cellulose sulfate
  • cellulose sulfate
  • cellulose sulfate, potassium salt
  • cellulose sulfate, sodium salt
  • cellulosum mycrocryst
  • celluvisc
  • celluvisc
  • cephere
  • croscarmellose sodium
  • croscarmellose sodium
  • crystalline cellulose
  • crystalline cellulose powder
  • dispersible cellulose
  • e460
  • ethispheres250
  • gppe paste
  • microcrystalline cellulose
  • microcrystalline cellulose
  • microcrystalline cellulose
  • nanocellulose
  • nutriose
  • nutriose
  • orabase
  • orabase
  • oxidised cellulose
  • oxidized cellulose
  • oxidized cellulose
  • oxycel
  • pharmacel 101
  • phosphocellulose
  • potassium cellulose phosphate
  • refresh plus, cellufresh formula
  • refresh plus, cellufresh formula
  • rengalin
  • silicified microcrystalline cellulose
  • simethicone-cellulose
  • simethicone-cellulose
  • simethicone-cellulose
  • sodium carboximethycellulose
  • sodium carboxymethylcellulose
  • sodium carboxymethylcellulose
  • sodium carboxymethylcellulose
  • sodium cellulose phosphate
  • sodium cellulose phosphate
  • sonorx
  • sonorx
  • surgicel
  • ushercell

Clinical trials

NCT IDPhaseStart dateSponsor(s)
NCT07149649Phase 2/Phase 3 (Phase 3)Dec 31, 2025Swiss Cancer Institute
NCT07284381Phase 3Dec 15, 2025AbbVie
NCT07258433N/ANov 26, 2025Nuritas Ltd
NCT07149506Phase 3Sep 1, 2025Hospital Regional Alta Especialidad Bajio, Universidad de Guanajuato
NCT07093463N/AJul 18, 2025analyze & realize GmbH, DSM
NCT07033754N/AJun 25, 2025Vedic Lifesciences Pvt. Ltd.
NCT06859346N/AApr 1, 2025Vedic Lifesciences Pvt. Ltd.
NCT06758856N/AJan 31, 2025University of Guelph
NCT06790290Phase 2Jan 27, 2025Inventprise Inc.
NCT06730594N/ADec 20, 2024Vedic Lifesciences Pvt. Ltd.
NCT06515210N/ANov 30, 2024University of Alberta, Weston Foundation
NCT06686888N/ASep 25, 2024Katholieke Universiteit Leuven
NCT06440213N/AMay 20, 2024Nuritas Ltd
NCT06412926Phase 1May 7, 2024Bayer
NCT06348212N/AApr 30, 2024Taipei Veteran General hospital
NCT05894109N/AJan 31, 2024AbbVie, University of New Mexico
NCT06068543Phase 2Jan 1, 2024University of Rochester
NCT06153758Phase 1Nov 27, 2023Pfizer
NCT05795816Phase 3Oct 25, 2023RDC Clinical Pty Ltd
NCT06039358N/AOct 6, 2023Central University of Catalonia, European Union
Showing 20 of 181 trials
Page 1 / 10

Organizations

Research & Development (202)

OrganizationOrg typeTrialsAs lead sponsorPhasesEarliest year
AllerganFor profit211942005
Vedic Lifesciences Pvt. Ltd.For profit141422018
University of FloridaAcademic/Hospital5532011
Department of Veteran AffairsGovernment4222007
PfizerFor profit4322009
Roquette FreresFor profit4132006
University of AlbertaAcademic/Hospital4332009
Columbia UniversityAcademic/Hospital3122009
Johns Hopkins UniversityAcademic/Hospital3212008
Maastricht UniversityAcademic/Hospital3222010
NestleFor profit3212022
RDC Clinical Pty LtdFor profit3322023
University of British ColumbiaAcademic/Hospital3232008
University of UtahAcademic/Hospital3222012
AbbVieFor profit2122024
Akorn, Inc.For profit2012013
Boston UniversityAcademic/Hospital2122009
CONRADFor profit2222005
Federal University of Minas GeraisAcademic/Hospital2212014
Heart and Stroke Foundation of CanadaAcademic/Hospital2022015
202 organizations
Page 1 / 11

Marketing (2)

OrganizationOrg typeRelationshipDate
BraccoFor profitNDAOct 29, 1998
Mission PharmacalFor profitNDA2Dec 28, 1982