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memantine

Trade name: namenda

Small moleculeapproved

Approved

Oct 16, 2003

NAMENDA (marketed under the brands Namenda among others) is an N-methyl-D-aspartate (NMDA) receptor antagonist indicated for the treatment of moderate to severe dementia of the Alzheimer’s type. Persistent activation of central nervous system N-methyl-D-aspartate (NMDA) receptors by the excitatory amino acid glutamate has been hypothesized to contribute to the symptomatology of Alzheimer’s disease. Memantine is postulated to exert its therapeutic effect through its action as a low to moderate affinity uncompetitive (open-channel) NMDA receptor antagonist which binds preferentially to the NMDA receptor-operated cation channels. There is no evidence that memantine prevents or slows neurodegeneration in patients with Alzheimer’s disease. Memantine showed low to negligible affinity for GABA, benzodiazepine, dopamine, adrenergic, histamine and glycine receptors and for voltage-dependent Ca2+, Na+ or K+ channels. Memantine also showed antagonistic effects at the 5HT3 receptor with a potency similar to that for the NMDA receptor and blocked nicotinic acetylcholine receptors with one-sixth to one-tenth the potency. In vitro studies have shown that memantine does not affect the reversible inhibition of acetylcholinesterase by donepezil, galantamine, or tacrine. — NCATS

Clinical trial activity

229 trials · 212 clinical orgs · 50 marketing orgs

Phase 1
34
Phase 2
103
Phase 3
60
Phase 4
56

Earliest trial started Dec 1, 1996 (NCT00000867)

Timeline

1990s

  1. Jan 1, 1996

    Earliest Phase 2 Sponsor(trial)

  2. Jan 1, 1997

    Earliest Phase 1 Sponsor(trial)

  3. Jan 1, 1999

    Allergan — Earliest Phase 3 Sponsor(trial)

2000s

  1. Oct 16, 2003

    Forest Laboratories — Earliest FDA Approval

  2. Oct 16, 2003

    Allergan — NDA Secondary Org

  3. Oct 16, 2003

    AbbVie — NDA Secondary Org

  4. Oct 16, 2003

    Forest Laboratories — NDA Organization

  5. Apr 18, 2005

    GlaxoSmithKline — NDA Secondary Org

2010s

  1. Apr 14, 2010

    Dr. Reddy's Laboratories — Marketing Organization

  2. May 5, 2010

    Sun Pharmaceuticals — Marketing Organization

  3. Oct 25, 2011

    Teva — Marketing Organization

  4. Mar 12, 2012

    Orbion Pharms — Marketing Organization

  5. Mar 12, 2012

    Orchid Pharma — Marketing Organization

  6. Jan 30, 2015

    Mylan — Marketing Organization

  7. Apr 10, 2015

    Amneal Pharmaceuticals — Marketing Organization

  8. Apr 10, 2015

    Lupin — Marketing Organization

  9. Jul 31, 2015

    Upsher-Smith Laboratories — Marketing Organization

  10. Sep 4, 2015

    Wockhardt — Marketing Organization

  11. Sep 4, 2015

    Celltrion — Marketing Organization

  12. Oct 13, 2015

    Alembic — Marketing Organization

  13. Oct 13, 2015

    Aurobindo Pharma — Marketing Organization

  14. Oct 13, 2015

    Jubilant Innovation Ltd. — Marketing Organization

  15. Oct 13, 2015

    Lannett Company, Inc. — Marketing Organization

  16. Oct 13, 2015

    Macleods Pharmaceuticals, Ltd — Marketing Organization

  17. Oct 13, 2015

    Torrent Pharmaceuticals Limited — Marketing Organization

  18. Oct 13, 2015

    Unichem — Marketing Organization

  19. Oct 13, 2015

    Neogen — Marketing Organization

  20. Nov 17, 2015

    Puracap Pharmaceutical — Marketing Organization

  21. Nov 30, 2015

    Ajanta Pharma Ltd — Marketing Organization

  22. Dec 7, 2015

    Sciegen Pharmaceticals — Marketing Organization

  23. Sep 28, 2016

    Rising Pharmaceuticals — Marketing Organization

  24. Nov 22, 2016

    Apotex — Marketing Organization

  25. May 23, 2017

    Strides Pharma Science — Marketing Organization

  26. Jun 9, 2017

    Anchen Pharmaceuticals, Inc — Marketing Organization

  27. Jun 9, 2017

    Endo Pharmaceuticals — Marketing Organization

  28. Jun 9, 2017

    Bristol-Myers Squibb — Marketing Organization

  29. Jul 10, 2017

    Cadila Healthcare — Marketing Organization

  30. Aug 3, 2017

    Zydus Discovery DMCC — Marketing Organization

  31. May 7, 2018

    Allied Pharmaceutical Services — Marketing Organization

  32. May 7, 2018

    Shijiazhuang Pharma Group (CSPC) — Marketing Organization

  33. May 7, 2018

    Renata — Marketing Organization

  34. May 7, 2018

    ACME Laboratories — Marketing Organization

  35. Jul 11, 2018

    Chartwell Pharmaceuticals — Marketing Organization

2020s

  1. Feb 28, 2020

    Ani Pharmaceuticals — Marketing Organization

  2. Feb 28, 2020

    Hikma — Marketing Organization

  3. Apr 3, 2020

    Yiling Pharmaceutical Inc. — Marketing Organization

  4. Apr 3, 2020

    Menovo — Marketing Organization

  5. Aug 31, 2020

    Seton Pharm — Marketing Organization

  6. Aug 31, 2020

    Saptalis Pharmaceuticals — Marketing Organization

  7. Dec 11, 2020

    Polygen Pharmaceuticals — Marketing Organization

  8. Apr 2, 2021

    Yichang Humanwell Pharmaceutical Co.,Ltd — Marketing Organization

  9. Aug 11, 2022

    Novast Labs — Marketing Organization

  10. Sep 26, 2022

    Hetero Labs Ltd — Marketing Organization

  11. Oct 11, 2022

    LP Pharmaceuticals — Marketing Organization

Indications

Approved for

Studied for

Mechanism of action

Combination products

Approval history

  • approvedOct 16, 2003

Chemistry & pharmacology

Loading structure…

SMILES

CC12CC3CC(C)(C1)CC(N)(C3)C2
Mol. weight
179.31 g/mol
Lipinski Ro5
Pass
Rule of 3
Yes
Chirality
Racemic Mixture
Inorganic
No
Polymer
No
Delivery
Oral
Availability
Prescription Only

Oral

Yes

Parenteral

No

Topical

No

Sources

Also known as

  • 1,3-dimethyl-5-adamantanamine
  • 1,3-dimethyl-5-adamantanamine
  • 1-amino-3,5-dimethyladamantane
  • 1-amino-3,5-dimethyladamantane
  • 3,5-dimethyl-1-adamantanamine
  • 3,5-dimethyl-1-adamantanamine
  • 3,5-dimethyl-1-aminoadamantane
  • 3,5-dimethyl-1-aminoadamantane
  • 3,5-dimethyltricyclo(3.3.1.1(3,7))decan-1-amine
  • 3,5-dimethyltricyclo(3.3.1.1(3,7))decan-1-amine
  • akatinol
  • akatinol
  • alzantin
  • ebixa
  • ebixa
  • ebixa
  • marixino
  • maruxa
  • memantina
  • memantina
  • memantina
  • memantine
  • memantine
  • memantine
  • memantine
  • memantine
  • memantine
  • memantine
  • memantine
  • memantine
  • memantine
  • memantine
  • memantine hcl
  • memantine hcl
  • memantine hcl
  • memantine hydrochloride
  • memantine hydrochloride
  • memantine hydrochloride
  • memantine hydrochloride
  • memantine hydrochloride
  • memantine hydrochloride
  • memantine hydrochloride / donepezil hydrochloride
  • memantinol
  • memantinum
  • memantinum
  • memnatine
  • namenda
  • namenda
  • namenda
  • namenda
  • namenda xr
  • namenda xr
  • nemdatine
  • nemdatine
  • nemdatine
  • valios

Clinical trials

NCT IDPhaseStart dateSponsor(s)
NCT07139834Phase 1Jan 31, 2026Columbia University
NCT07248228Phase 2Dec 31, 2025Case Western Reserve University
NCT07164794Phase 2Nov 30, 2025Southeast University, The First People's Hospital of Lianyungang
NCT06914310Phase 2/Phase 3 (Phase 3)Mar 25, 2025Mansoura University
NCT06789757Phase 2Feb 25, 2025Inova Health System
NCT06727773Phase 2Dec 31, 2024National Institute on Aging (NIA), University of North Carolina at Chapel Hill
NCT06679387Phase 2Oct 30, 2024Ain Shams University
NCT06594172Phase 2Sep 10, 2024Fujian Medical University, Guangzhou Medical University, Shantou University, Southern Medical University
NCT06501638N/AJul 7, 2024Huazhong University of Science and Technology
NCT06153238Phase 1Feb 28, 2024Sandoz
NCT06159790Phase 3Feb 28, 2024Sandoz
NCT06275035Phase 3Feb 22, 2024Tata Memorial Hospital
NCT06337994Phase 3Jan 1, 2024Assiut University
NCT05834231Phase 1/Phase 2 (Phase 2)Aug 31, 2023Mansoura University
NCT06007846Phase 2/Phase 3 (Phase 3)Jul 31, 2023Inova Health System
NCT05796752Phase 2/Phase 3 (Phase 3)Jun 1, 2023University of Chicago
NCT05660863Phase 1Jun 1, 2023Guangzhou Magpie Pharmaceuticals Co., Ltd.
NCT05664464Phase 1/Phase 2 (Phase 2)Jan 31, 2023Swiss National Science Foundation, University of Zurich
NCT05418049Early Phase 1 (Phase 1)Sep 1, 2022National Institutes of Health (NIH), University of Cincinnati
NCT05430867Phase 4Jul 1, 2022Jiao Tong University
Showing 20 of 229 trials
Page 1 / 12

Organizations

Research & Development (212)

OrganizationOrg typeTrialsAs lead sponsorPhasesEarliest year
Forest LaboratoriesFor profit431142004
LundbeckFor profit18752003
Harvard UniversityAcademic/Hospital11842005
Columbia UniversityAcademic/Hospital9832002
National Cancer Institute (NCI)Government8132008
MerzFor profit7532007
National Cheng Kung UniversityAcademic/Hospital7722009
National Institute on Drug Abuse (NIDA)Government7042003
Stanford UniversityAcademic/Hospital5432004
University of California, San DiegoAcademic/Hospital5532008
University of LondonAcademic/Hospital5242005
AllerganFor profit4321999
Government of TaiwanGovernment4022009
Mclean HospitalAcademic/Hospital4342006
National Institutes of Health (NIH)Government4031997
NRG OncologyAcademic/Hospital4312008
The University of Texas, DallasAcademic/Hospital4322004
Yale UniversityAcademic/Hospital4422006
Case Western Reserve UniversityAcademic/Hospital3322005
Department of Veteran AffairsGovernment3322005
212 organizations
Page 1 / 11

Marketing (61)

OrganizationOrg typeRelationshipDate
ACME LaboratoriesFor profitMKTGMay 7, 2018
AbbVieFor profitNDA2Oct 16, 2003
Ajanta Pharma LtdFor profitMKTGNov 30, 2015
AlembicFor profitMKTGOct 13, 2015
AlembicFor profitSYNOct 13, 2015
AllerganFor profitNDA2Oct 16, 2003
AllerganFor profitSYNOct 16, 2003
Allied Pharmaceutical ServicesFor profitMKTGMay 7, 2018
Amneal PharmaceuticalsFor profitMKTGApr 10, 2015
Anchen Pharmaceuticals, IncFor profitMKTGJun 9, 2017
Ani PharmaceuticalsFor profitMKTGFeb 28, 2020
Ani PharmaceuticalsFor profitSYNFeb 28, 2020
ApotexFor profitMKTGNov 22, 2016
ApotexFor profitSYNNov 22, 2016
Aurobindo PharmaFor profitMKTGOct 13, 2015
Bristol-Myers SquibbFor profitMKTGJun 9, 2017
Cadila HealthcareFor profitMKTGJul 10, 2017
CelltrionFor profitMKTGSep 4, 2015
Chartwell PharmaceuticalsFor profitMKTGJul 11, 2018
Chartwell PharmaceuticalsFor profitSYNOct 13, 2015
Dr. Reddy's LaboratoriesFor profitMKTGApr 14, 2010
Endo PharmaceuticalsFor profitMKTGJun 9, 2017
Forest LaboratoriesFor profitNDAOct 16, 2003
GlaxoSmithKlineFor profitNDA2Apr 18, 2005
Hetero Labs LtdFor profitMKTGSep 26, 2022
HikmaFor profitMKTGFeb 28, 2020
HikmaFor profitSYNFeb 28, 2020
Jubilant Innovation Ltd.For profitMKTGOct 13, 2015
LP PharmaceuticalsFor profitMKTGOct 11, 2022
Lannett Company, Inc.For profitMKTGOct 13, 2015
LupinFor profitMKTGApr 10, 2015
Macleods Pharmaceuticals, LtdFor profitMKTGOct 13, 2015
MenovoFor profitMKTGApr 3, 2020
MylanFor profitMKTGJan 30, 2015
MylanFor profitSYNJan 30, 2015
NeogenFor profitMKTGOct 13, 2015
Novast LabsFor profitMKTGAug 11, 2022
Orbion PharmsFor profitMKTGMar 12, 2012
Orchid PharmaFor profitMKTGMar 12, 2012
Polygen PharmaceuticalsFor profitMKTGDec 11, 2020
Puracap PharmaceuticalFor profitMKTGNov 17, 2015
RenataFor profitMKTGMay 7, 2018
Rising PharmaceuticalsFor profitSYNJan 30, 2015
Rising PharmaceuticalsFor profitMKTGSep 28, 2016
Saptalis PharmaceuticalsFor profitMKTGAug 31, 2020
Sciegen PharmaceticalsFor profitMKTGDec 7, 2015
Seton PharmFor profitMKTGAug 31, 2020
Shijiazhuang Pharma Group (CSPC)For profitMKTGMay 7, 2018
Strides Pharma ScienceFor profitMKTGMay 23, 2017
Sun PharmaceuticalsFor profitMKTGMay 5, 2010
Sun PharmaceuticalsFor profitSYNMay 5, 2010
TevaFor profitMKTGOct 25, 2011
Torrent Pharmaceuticals LimitedFor profitMKTGOct 13, 2015
UnichemFor profitMKTGOct 13, 2015
UnichemFor profitSYNOct 13, 2015
Upsher-Smith LaboratoriesFor profitMKTGJul 31, 2015
WockhardtFor profitMKTGSep 4, 2015
Yichang Humanwell Pharmaceutical Co.,LtdFor profitMKTGApr 2, 2021
Yiling Pharmaceutical Inc.For profitMKTGApr 3, 2020
Zydus Discovery DMCCFor profitMKTGAug 3, 2017
Zydus Discovery DMCCFor profitSYNJul 10, 2017