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riboflavin

Small moleculeapproved

Approved

Jul 28, 1947

Mirasol may refer to: — Wikipedia

Clinical trial activity

111 trials · 121 clinical orgs · 10 marketing orgs

Phase 1
20
Phase 2
52
Phase 3
38
Phase 4
8

Earliest trial started Jun 1, 2000 (NCT00170404)

Timeline

1940s

  1. Jul 28, 1947

    Roche — Earliest FDA Approval

  2. Jul 28, 1947

    Roche — Marketing Organization

  3. Jul 28, 1947

    Roche — NDA Secondary Org

  4. Jul 28, 1947

    Roche — NDA Organization

1950s

  1. Feb 20, 1953

    Hospira — Marketing Organization

  2. Feb 20, 1953

    Hospira — NDA Secondary Org

1980s

  1. Nov 6, 1981

    Abraxis — Marketing Organization

  2. Nov 6, 1981

    Abraxis — NDA Secondary Org

  3. Jul 13, 1982

    Watson Pharmaceuticals — Marketing Organization

  4. Jul 13, 1982

    Watson Pharmaceuticals — NDA Secondary Org

2000s

  1. Jan 1, 2000

    Earliest Phase 3 Sponsor(trial)

  2. May 18, 2000

    Sandoz — Marketing Organization

  3. May 18, 2000

    Sandoz — NDA Secondary Org

  4. May 18, 2000

    Novartis — NDA Secondary Org

  5. Jan 1, 2001

    Earliest Phase 2 Sponsor(trial)

  6. Jan 1, 2005

    Earliest Phase 1 Sponsor(trial)

2010s

  1. Apr 15, 2016

    Avedro, Inc. — NDA Secondary Org

  2. Apr 15, 2016

    Glaukos Corporation — Marketing Organization

  3. Apr 15, 2016

    Glaukos Corporation — NDA Secondary Org

2020s

  1. Apr 9, 2026

    Apotex — Marketing Organization

Indications

Approved for

Studied for

Mechanism of action

  • Unspecified targetOTHER

    Unknown

Combination products

Approval history

  • approvedJul 28, 1947

Chemistry & pharmacology

Loading structure…

SMILES

Cc1cc2nc3c(=O)[nH]c(=O)nc-3n(C[C@H](O)[C@H](O)[C@H](O)COP(=O)([O-])O)c2cc1C.O.O.[Na+]
Mol. weight
514.36 g/mol
Lipinski Ro5
1 violation(s)
Rule of 3
No
Chirality
Single Stereoisomer
Inorganic
No
Polymer
No
Delivery
Parenteral
Availability
Prescription Only

Oral

No

Parenteral

Yes

Topical

No

Sources

Also known as

  • 1-deoxy-1-(7,8-dimethyl-2,4-dioxo-3,4-dihydrobenzo[g]pteridin-10(2h)-yl)pentitol
  • 1-deoxy-1-(7,8-dimethyl-2,4-dioxo-3,4-dihydrobenzo[g]pteridin-10(2h)-yl)pentitol
  • 6,7-dimethyl-9-d-ribitylisoalloxazine
  • 6,7-dimethyl-9-d-ribitylisoalloxazine
  • 7,8-dimethyl-10-(d-ribo-2,3,4,5-tetrahydroxypentyl)isoalloxazine
  • 7,8-dimethyl-10-(d-ribo-2,3,4,5-tetrahydroxypentyl)isoalloxazine
  • 7,8-dimethyl-10-ribitylisoalloxazine
  • 7,8-dimethyl-10-ribitylisoalloxazine
  • beflavine
  • e101
  • e101
  • e101
  • e-101
  • e-101
  • e101a
  • e101a
  • e106
  • e106
  • e-b2
  • flavaxin
  • flavaxin
  • flavin mononucleotide
  • freeda
  • lactoflavin
  • lactoflavin
  • lactoflavin
  • lactoflavin
  • lactoflavine
  • lactoflavine
  • lactoflavine
  • mirasol
  • riboflavin
  • riboflavin
  • riboflavin
  • riboflavin
  • riboflavin
  • riboflavin
  • riboflavin
  • riboflavin
  • riboflavin 5'-(dihydrogen phosphate)
  • riboflavin 5'-phosphate
  • riboflavin 5'-phosphate
  • riboflavin 5'-phosphate sodium
  • riboflavin 5'-phosphate sodium
  • riboflavin 5'-phosphate sodium
  • riboflavin 5'-phosphate sodium
  • riboflavina
  • riboflavina
  • riboflavine
  • riboflavine
  • riboflavine
  • riboflavine
  • riboflavine
  • riboflavine
  • riboflavin phosphate
  • riboflavin phosphate
  • riboflavin sodium phosphate
  • riboflavin sodium phosphate
  • riboflavin sodium phosphate
  • riboflavin sodium phosphate
  • riboflavin sodium phosphate
  • riboflavin tetrabutyrate
  • riboflavin tetrabutyrate
  • riboflavin tetrabutyrate
  • riboflavin tetrabutyrate, riboflavin-2-14c-labeled
  • riboflavinum
  • riboflavinum
  • riboflavin (vit b2)
  • riboflavin (vit b2)
  • riboflavin (vit b2)
  • vitamin b2
  • vitamin b2
  • vitamin b2
  • vitamin b2
  • vitamin b2
  • vitamin b2
  • vitamin b 2
  • vitamin b 2
  • vitamin b2 phosphate
  • vitamin b2 tetrabutyrate
  • vitamin g
  • vitamin g
  • vitamin g

Clinical trials

NCT IDPhaseStart dateSponsor(s)
NCT07093463N/AJul 18, 2025analyze & realize GmbH, DSM
NCT06100952Phase 3Nov 1, 2023Epion Therapeutics
NCT06100939Phase 3Oct 30, 2023Epion Therapeutics
NCT05907850Early Phase 1 (Phase 1)Jun 23, 2023University of Texas, San Antonio
NCT05881187N/AJun 15, 2023Sohag University
NCT05935787Phase 3Mar 23, 2023Polysan, Ltd.
NCT05803811N/ADec 12, 2022Atlantia Food Clinical Trials, DSM, National University of Ireland
NCT05488106N/ASep 1, 2022DSM, Ulster University
NCT05321043N/AJul 31, 2022Chinese Academy of Medical Sciences, Tsinghua University
NCT05255016Phase 2/Phase 3 (Phase 3)Mar 14, 2022Pacific Clear Vision Institute, Peschke GmbH
NCT04584125Early Phase 1 (Phase 1)Jan 31, 2022Harvard University, Massachusetts Eye and Ear Infirmary
NCT05027295Phase 3Jul 30, 2021Cornea and Laser Eye Institute, Hersh Vision Group
NCT04731727Early Phase 1 (Phase 1)Jun 30, 2021Wellish Vision Institute
NCT04905108Phase 3Jun 2, 2021Cornea and Laser Eye Institute, Hersh Vision Group
NCT04787471Phase 2/Phase 3 (Phase 3)May 3, 2021Cornea Research Foundation of America, Price Vision Group
NCT04897503Phase 3Apr 16, 2021Cornea and Laser Eye Institute, Hersh Vision Group
NCT04667572Phase 1Feb 1, 2021Cornea Associates of Texas
NCT05056025N/ADec 2, 2020Igen BioLab, Institut de la Macula y la Retina
NCT04481841Early Phase 1 (Phase 1)Nov 20, 2020Guiyang Hospital of Stomatology, Stomatological Hospital of Guiyang, Zhejiang Chinese Medical University, Zhejiang University
NCT04631484Phase 3Oct 8, 2020Polysan, Ltd.
Showing 20 of 111 trials
Page 1 / 6

Organizations

Research & Development (121)

OrganizationOrg typeTrialsAs lead sponsorPhasesEarliest year
DSMFor profit7422013
Avedro, Inc.For profit6522012
Cornea and Laser Eye InstituteAcademic/Hospital6612010
Ulster UniversityAcademic/Hospital5412011
Polysan, Ltd.For profit4412017
Price Vision GroupAcademic/Hospital4432009
Columbia UniversityAcademic/Hospital3322008
Harvard UniversityAcademic/Hospital3222012
Hersh Vision GroupAcademic/Hospital3012021
National Institute of Allergy and Infectious Diseases (NIAID)Government3322000
Topcon Medical Systems, Inc.For profit3312010
University of VirginiaAcademic/Hospital3322014
Atlantia Food Clinical TrialsFor profit2012018
Cornea Associates of TexasAcademic/Hospital2212019
Cornea Research Foundation of AmericaAcademic/Hospital2022009
Department of DefenseGovernment2022008
Epion TherapeuticsFor profit2212023
James Madison UniversityAcademic/Hospital2022014
National University of IrelandAcademic/Hospital2012018
Oregon Health and Science UniversityAcademic/Hospital2122012
121 organizations
Page 1 / 7

Marketing (17)

OrganizationOrg typeRelationshipDate
AbraxisFor profitMKTGNov 6, 1981
AbraxisFor profitNDA2Nov 6, 1981
ApotexFor profitMKTGApr 9, 2026
Avedro, Inc.For profitNDA2Apr 15, 2016
Glaukos CorporationFor profitMKTGApr 15, 2016
Glaukos CorporationFor profitNDA2Apr 15, 2016
HospiraFor profitMKTGFeb 20, 1953
HospiraFor profitNDA2Feb 20, 1953
NovartisFor profitNDA2May 18, 2000
RocheFor profitMKTGJul 28, 1947
RocheFor profitNDA2Jul 28, 1947
RocheFor profitNDAJul 28, 1947
SandozFor profitMKTGMay 18, 2000
SandozFor profitNDA2May 18, 2000
Teligent PharmaceuticalsFor profitNDA2—
Watson PharmaceuticalsFor profitMKTGJul 13, 1982
Watson PharmaceuticalsFor profitNDA2Jul 13, 1982