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carbon monoxide

Small moleculeexperimental

Carbon monoxide is a poisonous, flammable gas that is colorless, odorless, tasteless, and slightly less dense than air. Carbon monoxide consists of one carbon atom and one oxygen atom connected by a triple bond. It is the simplest carbon oxide. In coordination complexes, the carbon monoxide ligand is called carbonyl. It is a key ingredient in many processes in industrial chemistry. — Wikipedia

Clinical trial activity

26 trials · 32 clinical orgs · 0 marketing orgs

Phase 1
12
Phase 2
10
Phase 3
0
Phase 4
0

Earliest trial started Oct 13, 2004 (NCT00094406)

Timeline

2000s

  1. Jan 1, 2004

    Earliest Phase 1 Sponsor(trial)

  2. Jan 1, 2005

    Earliest Phase 2 Sponsor(trial)

Indications

Studied for

Mechanism of action

Chemistry & pharmacology

Loading structure…

SMILES

[C-]#[O+]
Mol. weight
28.01 g/mol
Lipinski Ro5
Pass
Rule of 3
Yes
Chirality
Achiral Molecule
Inorganic
No
Polymer
No

Oral

No

Parenteral

No

Topical

No

Sources

Also known as

  • carboneum oxygenisatum
  • carboneum oxygenisatum
  • carbon(ii) oxide
  • carbon(ii) oxide
  • carbon monoxide
  • carbon monoxide
  • carbon monoxide
  • carbon monoxide
  • co
  • co

Clinical trials

NCT IDPhaseStart dateSponsor(s)
NCT07005180Phase 2Aug 31, 2025Hillhurst Biopharmaceuticals, Inc.
NCT06763536N/AJun 13, 2025National Cancer Institute (NCI), Ohio State University
NCT06144749Phase 1/Phase 2 (Phase 2)Jan 8, 2024Hillhurst Biopharmaceuticals, Inc., National Heart, Lung, and Blood Institute (NHLBI)
NCT04870125Phase 1Sep 30, 2022Cornell University, Duke University, Harvard University, National Heart, Lung, and Blood Institute (NHLBI), Washington University in St. Louis
NCT04679402N/ANov 1, 2021Case Western Reserve University, Duke University
NCT04928183N/AJun 10, 2021University of Alberta
NCT03926819Phase 1Dec 31, 2019Hillhurst Biopharmaceuticals, Inc., National Heart, Lung, and Blood Institute (NHLBI)
NCT03799874Phase 2Jan 31, 2019Cornell University, Department of Veteran Affairs, Duke University, Harvard University, United States Army, Washington University in St. Louis
NCT03385174N/AOct 1, 2017University of Copenhagen
NCT03166787Phase 1Jul 15, 2017Cedars-Sinai Medical Center, National Institute on Drug Abuse (NIDA), National Institutes of Health (NIH)
NCT03067701Phase 1Mar 13, 2017Cedars-Sinai Medical Center
NCT03075020N/AOct 31, 2016University of Copenhagen
NCT02425579Phase 1Apr 1, 2015Cornell University, Duke University, Harvard University
NCT02567240Phase 1/Phase 2 (Phase 2)Jan 31, 2015Medical University of South Carolina
NCT02066558N/AFeb 28, 2014University of Copenhagen
NCT01727167Phase 1/Phase 2 (Phase 2)Feb 1, 2014Duke University
NCT02032082N/AJan 31, 2014CHU Mont-Godinne
NCT01523548Phase 1/Phase 2 (Phase 2)Jul 1, 2012National Heart, Lung, and Blood Institute (NHLBI), National Institutes of Health (NIH), University of Illinois at Chicago
NCT01818843N/AApr 30, 2012People's Liberation Army of China
NCT01214187Phase 2Jul 1, 2011Columbia University, Harvard University, National Heart, Lung, and Blood Institute (NHLBI), Tulane University, University of California, San Francisco, University of Chicago, University of Illinois at Chicago, University of Michigan, University of Washington
Showing 20 of 26 trials
Page 1 / 2

Organizations

Research & Development (32)

OrganizationOrg typeTrialsAs lead sponsorPhasesEarliest year
Duke UniversityAcademic/Hospital5232014
National Heart, Lung, and Blood Institute (NHLBI)Government5022011
Harvard UniversityAcademic/Hospital4322011
Cornell UniversityAcademic/Hospital3122015
Hillhurst Biopharmaceuticals, Inc.For profit3322019
National Institutes of Health (NIH)Government3122004
University of CopenhagenAcademic/Hospital3312014
Cedars-Sinai Medical CenterAcademic/Hospital2212017
Queen's University, BelfastAcademic/Hospital2222010
The Physicians' Services Incorporated FoundationAcademic/Hospital2022010
University of Illinois at ChicagoAcademic/Hospital2112011
Washington University in St. LouisAcademic/Hospital2022019
Case Western Reserve UniversityAcademic/Hospital1012021
CHU Mont-GodinneAcademic/Hospital1112014
Columbia UniversityAcademic/Hospital1012011
Department of Veteran AffairsGovernment1012019
MallinckrodtFor profit1112007
Medical University of South CarolinaAcademic/Hospital1112015
National Cancer Institute (NCI)Government1012025
National Institute on Drug Abuse (NIDA)Government1012017
32 organizations
Page 1 / 2