Indications

Herein, we summarize information about the clinical applications for all experimental and FDA-approved medicines. For these analyses, we adopt the Medical Subject Headings (MeSH) hierarchy as covered by the National Library of Medicine of the NIH. MeSH provides an accepted, albeit imperfect, way to convey ambiguities surrounding the many types of interventions included in CDEK, which include treatment, prevention and diagnosis of health and disease. Please note that the summaries below generally reflect the highest level of the MeSH hierarchies for Diseases (Group C), Psychiatry and Psychology (Group F) and Phenomena and Processes (Group G). For interventions that reflect multiple MeSH headings, we prioritize Groups C, F and G and in that order.

Top indications in clinical trials

1.Neoplasms64,908
2.Pathological Conditions, Signs and Symptoms36,232
3.Immune System Diseases26,848
4.Urogenital Diseases23,194
5.Digestive System Diseases22,942
6.Infections22,209
7.Respiratory Tract Diseases22,138
8.Skin and Connective Tissue Diseases19,862
9.Hemic and Lymphatic Diseases19,468
10.Nervous System Diseases19,144
11.Nutritional and Metabolic Diseases18,642
12.Cardiovascular Diseases18,211
13.Endocrine System Diseases16,319
14.Mental Disorders12,889
15.Persons12,803
16.Congenital, Hereditary, and Neonatal Diseases and Abnormalities8,759
17.Musculoskeletal Diseases8,390
18.Psychological Phenomena7,191
19.Musculoskeletal and Neural Physiological Phenomena7,142
20.Eye Diseases5,742

Indication mix by drug type

Small molecule 164,883

Neoplasms49,383
Pathological Conditions, Signs and Symptoms28,516
Urogenital Diseases17,818
Immune System Diseases17,632
Digestive System Diseases17,027

mAb 29,596

Neoplasms19,612
Immune System Diseases7,028
Skin and Connective Tissue Diseases5,484
Hemic and Lymphatic Diseases5,140
Digestive System Diseases5,117

Recombinant protein 13,022

Cell therapy 10,757

Neoplasms4,851
Hemic and Lymphatic Diseases3,064
Immune System Diseases2,984
Pathological Conditions, Signs and Symptoms1,639
Digestive System Diseases1,331

Vaccine 9,235

Botanical 8,228

Biological 6,078

Neoplasms1,284
Pathological Conditions, Signs and Symptoms1,179
Urogenital Diseases762
Immune System Diseases702
Nervous System Diseases687

Peptide 5,552

Nutritional and Metabolic Diseases1,951
Endocrine System Diseases1,510
Pathological Conditions, Signs and Symptoms1,299
Urogenital Diseases878
Neoplasms871

Animal product 3,088

Nucleic acid 1,268

Gene therapy 913

Allergen 553

Biologics 13

Browse all indications

31,135 MeSH conditions, ranked by number of drugs studied.

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