CDEK by Data4ThePeople
Sign in Sign up
← All drugs Report issue

propofol

Trade name: diprivan

Small moleculeapproved

Approved

Oct 2, 1989

Propofol is the active component of an intravenous anesthetic formulation used for induction and maintenance of general anesthesia. It is chemically termed 2,6-diisopropylphenol. The formulation was approved under the brand name Diprivan. Numerous generic versions have since been released. Intravenous administration is used to induce unconsciousness, after which anesthesia may be maintained using a combination of medications. It is manufactured as part of a sterile injectable emulsion formulation using soybean oil and lecithin, giving it a white milky coloration. — Wikipedia

Clinical trial activity

1,293 trials · 675 clinical orgs · 21 marketing orgs

Phase 1
94
Phase 2
178
Phase 3
128
Phase 4
446

Earliest trial started Jul 1, 1996 (NCT00004424)

Timeline

1980s

  1. Oct 2, 1989

    Fresenius — Earliest FDA Approval

  2. Oct 2, 1989

    Fresenius — NDA Organization

  3. Oct 2, 1989

    Fresenius — NDA Secondary Org

1990s

  1. Jun 8, 1998

    Gensia Sicor — Marketing Organization

  2. Dec 23, 1998

    Baxalta — Marketing Organization

  3. Dec 23, 1998

    Baxter — Marketing Organization

  4. Jan 4, 1999

    Sagent Pharmaceuticals, Inc. — Marketing Organization

  5. Nov 24, 1999

    Lederle — Marketing Organization

  6. Nov 24, 1999

    American Home Products — Marketing Organization

2000s

  1. Sep 19, 2000

    Teva — Marketing Organization

  2. Jan 1, 2002

    Earliest Phase 2 Sponsor(trial)

  3. Jan 1, 2002

    Earliest Phase 3 Sponsor(trial)

  4. Jan 1, 2004

    Earliest Phase 1 Sponsor(trial)

  5. Apr 19, 2005

    West-Ward Pharmaceutical — Marketing Organization

  6. Apr 19, 2005

    Hikma — Marketing Organization

  7. Mar 17, 2006

    Hospira — Marketing Organization

2010s

  1. Dec 22, 2015

    Watson Pharmaceuticals — Marketing Organization

  2. Dec 22, 2015

    Allergan PLC (2015) — Marketing Organization

  3. Nov 15, 2018

    Dr. Reddy's Laboratories — Marketing Organization

2020s

  1. Sep 16, 2020

    InnoPharma — Marketing Organization

  2. Sep 16, 2020

    Pfizer — Marketing Organization

  3. Oct 12, 2021

    Emcure — Marketing Organization

  4. Oct 12, 2021

    Avet Lifesciences — Marketing Organization

  5. Jun 20, 2024

    Aspiro — Marketing Organization

  6. Aug 15, 2024

    Amneal Pharmaceuticals — Marketing Organization

  7. Dec 2, 2025

    Nanjing King-Friend — Marketing Organization

Indications

Approved for

Studied for

Mechanism of action

Approval history

  • approvedOct 2, 1989

Chemistry & pharmacology

Loading structure…

SMILES

CC(C)C1=CC=CC(C(C)C)=C1OC(=O)CCC(O)=O
Mol. weight
278.3435 g/mol
Lipinski Ro5
Pass
Rule of 3
No
Chirality
Single Stereoisomer
Inorganic
No
Polymer
No
Availability
Prescription Only

Oral

No

Parenteral

No

Topical

No

Sources

Also known as

  • 2,6-bis(1-methylethyl)phenol
  • 2,6-bis(1-methylethyl)phenol
  • 2,6-diisopropylphenol
  • 2,6-diisopropylphenol
  • 2,6-diisopropylphenol
  • ampofol
  • diprivan
  • diprivan
  • diprivan
  • diprivan
  • diprivan
  • disoprivan
  • disoprivan
  • disoprivan
  • disoprofol
  • disoprofol
  • disoprofol
  • disoprofol
  • fresofol
  • fresofol
  • ici-35868
  • ici-35868
  • pofol
  • propofol
  • propofol
  • propofol
  • propofol
  • propofol
  • propofol
  • propofol
  • propofol
  • propofol
  • propofol
  • propofol
  • propofolum
  • propofolum
  • rapinovet
  • rapinovet

Clinical trials

NCT IDPhaseStart dateSponsor(s)
NCT07294092Early Phase 1 (Phase 1)Mar 1, 2026National Institute of General Medical Sciences (NIGMS), University of Pittsburgh
NCT07268924Phase 4Jan 31, 2026Assiut University
NCT07251101N/AJan 2, 2026Ilsan Hospital
NCT07211399Early Phase 1 (Phase 1)Jan 1, 2026University of Pittsburgh
NCT07265050N/AJan 1, 2026Seoul National University
NCT07303985Phase 4Dec 31, 2025Fudan University
NCT07271459N/ADec 31, 2025Ain Shams University
NCT07190612Phase 4Dec 31, 2025Ain Shams University
NCT06810843N/ADec 31, 2025Shandong first medical University, Shandong Province Qianfoshan Hospital
NCT07299630Phase 3Dec 20, 2025Ain Shams University
NCT07304206N/ADec 8, 2025Inonu University
NCT07271472N/ADec 1, 2025Ataturk University
NCT07269808Phase 3Dec 1, 2025Harvard University
NCT07268872N/ANov 21, 2025Henan Provincal People's Hospital
NCT07213544Phase 4Nov 12, 2025Medical University of South Carolina
NCT07116733Phase 3Oct 20, 2025Xijing Hospital
NCT07204106N/AOct 2, 2025Huazhong University of Science and Technology, Tongji University
NCT07161518Phase 4Sep 30, 2025Stanford University
NCT07118579Phase 4Sep 23, 2025Huazhong University of Science and Technology
NCT07099014Phase 3Sep 15, 2025Assistance Publique - Hôpitaux de Paris
Showing 20 of 1,293 trials
Page 1 / 65

Organizations

Research & Development (675)

OrganizationOrg typeTrialsAs lead sponsorPhasesEarliest year
Yonsei UniversityAcademic/Hospital504922009
Haisco PharmaceuticalFor profit373642014
Jiao Tong UniversityAcademic/Hospital262232011
Seoul National UniversityAcademic/Hospital262522009
Huazhong University of Science and TechnologyAcademic/Hospital252042009
Ain Shams UniversityAcademic/Hospital222252014
Capital Medical UniversityAcademic/Hospital221632013
Cairo UniversityAcademic/Hospital202052014
Assiut UniversityAcademic/Hospital171752015
Mansoura UniversityAcademic/Hospital171632015
Peking UniversityAcademic/Hospital171332013
Harvard UniversityAcademic/Hospital161552005
People's Liberation Army of ChinaGovernment161122013
Fudan UniversityAcademic/Hospital141042007
Tanta UniversityAcademic/Hospital121232016
Nanjing Medical UniversityAcademic/Hospital111122008
Sun Yat-Sen UniversityAcademic/Hospital11932013
University of ParisAcademic/Hospital11642006
Hengrui Therapeutics, Inc.For profit101032014
Konkuk UniversityAcademic/Hospital10922007
675 organizations
Page 1 / 34

Marketing (24)

OrganizationOrg typeRelationshipDate
Allergan PLC (2015)For profitMKTGDec 22, 2015
American Home ProductsFor profitMKTGNov 24, 1999
Amneal PharmaceuticalsFor profitMKTGAug 15, 2024
AspiroFor profitMKTGJun 20, 2024
Avet LifesciencesFor profitMKTGOct 12, 2021
BaxaltaFor profitMKTGDec 23, 1998
BaxterFor profitMKTGDec 23, 1998
Dr. Reddy's LaboratoriesFor profitMKTGNov 15, 2018
Dr. Reddy's LaboratoriesFor profitSYNNov 15, 2018
EmcureFor profitMKTGOct 12, 2021
FreseniusFor profitNDAOct 2, 1989
FreseniusFor profitNDA2Oct 2, 1989
Gensia SicorFor profitMKTGJun 8, 1998
HikmaFor profitMKTGApr 19, 2005
HospiraFor profitMKTGMar 17, 2006
InnoPharmaFor profitMKTGSep 16, 2020
LederleFor profitMKTGNov 24, 1999
Nanjing King-FriendFor profitMKTGDec 2, 2025
PfizerFor profitMKTGSep 16, 2020
Sagent Pharmaceuticals, Inc.For profitMKTGJan 4, 1999
Sagent Pharmaceuticals, Inc.For profitSYNJan 4, 1999
TevaFor profitMKTGSep 19, 2000
Watson PharmaceuticalsFor profitMKTGDec 22, 2015
West-Ward PharmaceuticalFor profitMKTGApr 19, 2005