autologous microbiome
Cell therapyexperimental
Probiotics are live microorganisms in foods intended to improve or restore microbiota in the gut. Probiotic products include yogurt, cheese, some fermented foods, such as sourdough bread and nattō, dietary supplements, and clinical capsules containing a specific probiotic strain. — Wikipedia
Clinical trial activity
151 trials · 204 clinical orgs · 0 marketing orgs
Phase 1
16
Phase 2
40
Phase 3
17
Phase 4
17
Earliest trial started Feb 1, 1997 (NCT00167700)
Timeline
Indications
Approved for
Studied for
- Abdominal Injuries · Phase 2
- Adiposity · Phase 2
- Aged · Early Phase 1
- Anxiety · Phase 2
- Asthma · Phase 2/Phase 3
- Asthma, Occupational · Phase 4
- Autism Spectrum Disorder · Phase 4
- Bone Diseases, Metabolic · Phase 1/Phase 2
- Breast Neoplasms · Phase 4
- Candidiasis · Phase 4
- Carcinoma · Phase 3
- Cholangitis, Sclerosing · Phase 3
- Clostridioides difficile · Phase 1
- Clostridium Infections · Phase 4
- Cognition Disorders · Phase 3
- Colitis, Ulcerative · Phase 4
- Colorectal Neoplasms · Phase 3
- Communicable Diseases · Phase 2
- Conjunctivitis, Allergic · Phase 2/Phase 3
- Constipation · Phase 4
- Critical Illness · Phase 2
- Crohn Disease · Phase 4
- Cross Infection · Phase 3
- Dental Caries · Phase 4
- Dental Plaque · Phase 4
- Depression · Phase 2
- Dermatitis, Atopic · Phase 3
- Diabetes, Gestational · Phase 4
- Diabetes Mellitus · Phase 1/Phase 2
- Diabetes Mellitus, Type 2 · Phase 3
- Diarrhea · Phase 4
- Diet Therapy · Phase 2
- Drug-Related Side Effects and Adverse Reactions · Phase 1
- Eczema · Phase 2
- Enteritis · Phase 4
- Enterocolitis · Phase 4
- Enterocolitis, Necrotizing · Phase 3
- Fatigue · Phase 3
- Fatty Liver · Phase 1/Phase 2
- Feeding and Eating Disorders of Childhood · Phase 4
- Feeding Behavior · Phase 2
- Food Hypersensitivity · Phase 2/Phase 3
- Gastroenteritis · Phase 4
- Gingivitis · Phase 4
- Healthy Volunteers · Early Phase 1
- Heart Disease Risk Factors · Phase 2
- Hemolysis · Phase 1
- Hirschsprung Disease · Phase 4
- HIV Infections · Phase 2
- Inflammation · Phase 2
- Intestinal Diseases · Phase 2
- Intestinal Neoplasms · Phase 3
- Iron Deficiencies · Phase 2
- Irritable Bowel Syndrome · Phase 3
- Liver Diseases · Phase 2
- Lung Diseases · Phase 3
- Lung Neoplasms · Phase 1
- Malnutrition · Phase 4
- Methicillin-Resistant Staphylococcus aureus · Phase 2
- Neoplasms · Phase 3
- Neurodevelopmental Disorders · Phase 2
- Obesity · Phase 4
- Pain · Phase 3
- Periodontal Diseases · Phase 1/Phase 2
- Peritonitis · Phase 4
- Pneumonia · Phase 1
- Postoperative Complications · Phase 4
- Pregnancy · Phase 4
- Probiotics · Phase 2
- Renal Insufficiency, Chronic · Phase 4
- Respiratory Sounds · Phase 3
- Respiratory Tract Diseases · Phase 3
- Restless Legs Syndrome · Phase 2
- Rhinitis, Allergic · Phase 2
- Rhinitis, Allergic, Seasonal · Phase 2/Phase 3
- Schizophrenia · Phase 3
- Signs and Symptoms, Digestive · Phase 2
- Smoking Cessation · Phase 2
- Steatitis · Phase 1/Phase 2
- Stomach Diseases · Phase 4
- Vaginal Diseases · Phase 4
- Vaginosis, Bacterial · Phase 4
- Xerostomia · Phase 1
Mechanism of action
- microbiotaTissue restoration
microbiota tissue restoration
Chemistry & pharmacology
Oral
No
Parenteral
No
Topical
No
Sources
- WikipediaProbiotic ↗
Also known as
- autologous microbiome
- probiotic
- probiotic
- probiotics
- probitiocs
Clinical trials
| NCT ID | Phase | Start date | Sponsor(s) |
|---|---|---|---|
| NCT05554185 | N/A | Sep 21, 2022 | Southern Medical University |
| NCT05523024 | N/A | Aug 2, 2022 | Poznan University |
| NCT05566171 | N/A | Aug 1, 2022 | Eastern Mediterranean University |
| NCT05562518 | Phase 4 | Mar 21, 2022 | Ghent University |
| NCT05330793 | N/A | Oct 26, 2021 | USANA Health Sciences |
| NCT04655326 | Early Phase 1 (Phase 1) | Oct 15, 2020 | Arizona State University, Sun Genomics |
| NCT03150927 | N/A | Sep 1, 2017 | Biowish Technologies, Inc., City University of Hong Kong, Mysore Medical College and Research Institute, University of Wollongong |
| NCT03201068 | N/A | Aug 1, 2017 | Stanford University, The Clorox Company |
| NCT03134469 | N/A | Apr 18, 2017 | Probi AB |
| NCT03116789 | N/A | Apr 11, 2017 | GenMont Biotech Incorporation, Kuo General Hospital |
| NCT02949882 | Phase 4 | Apr 1, 2017 | Athena Institute, Netherlands, Free University of Amsterdam, Yakult Honsha Co., LTD |
| NCT03037918 | N/A | Feb 3, 2017 | Loughborough University, Yakult Honsha Co., LTD |
| NCT02962583 | Phase 2 | Jan 1, 2017 | Lallemand SAS, Laval University |
| NCT02893943 | N/A | Jan 1, 2017 | Lallemand SAS, University of Manitoba |
| NCT03021161 | Phase 4 | Jan 1, 2017 | University of Sao Paulo |
| NCT02957591 | N/A | Jan 1, 2017 | University of Basel |
| NCT02912416 | N/A | Sep 1, 2016 | Probi AB |
| NCT02552862 | Phase 3 | Sep 1, 2016 | University of Barcelona |
| NCT02920294 | N/A | Sep 1, 2016 | Maastricht University |
| NCT02860845 | Phase 4 | Jul 1, 2016 | Clever Instruments S.L., Ginemed Sevilla, Laboratorios Ordesa |
Showing 20 of 151 trials
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Organizations
Research & Development (204)
| Organization | Org type | Trials | As lead sponsor | Phases | Earliest year |
|---|---|---|---|---|---|
| Probi AB | For profit | 9 | 8 | 3 | 2013 |
| Huazhong University of Science and Technology | Academic/Hospital | 6 | 6 | 2 | 2008 |
| Lallemand SAS | For profit | 5 | 2 | 3 | 2009 |
| Lund University | Academic/Hospital | 4 | 1 | 2 | 2012 |
| Bar Ilan University | Academic/Hospital | 3 | 1 | 2 | 2012 |
| Danisco | For profit | 3 | 1 | 2 | 2009 |
| Maastricht University | Academic/Hospital | 3 | 3 | 1 | 2008 |
| National Cheng Kung University | Academic/Hospital | 3 | 3 | 2 | 2010 |
| Nestle | For profit | 3 | 2 | 1 | 2009 |
| Region Skane | Government | 3 | 3 | 1 | 2011 |
| Sprim Consulting | For profit | 3 | 0 | 3 | 2009 |
| Tel Aviv University | Academic/Hospital | 3 | 3 | 2 | 2005 |
| University of Chile | Academic/Hospital | 3 | 3 | 2 | 2012 |
| University of Copenhagen | Academic/Hospital | 3 | 3 | 3 | 2009 |
| University of Milan | Academic/Hospital | 3 | 1 | 3 | 2006 |
| University of Turku | Academic/Hospital | 3 | 2 | 2 | 1997 |
| Biofortis | For profit | 2 | 0 | 1 | 2011 |
| Bio-K Plus International Inc. | For profit | 2 | 2 | 2 | 2010 |
| China Medical University | Academic/Hospital | 2 | 1 | 2 | 2011 |
| Chr Hansen | For profit | 2 | 0 | 2 | 2009 |
204 organizations
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