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vitamin c

Small moleculeapproved

Approved

Jul 28, 1947

Magnesium ascorbate is a non-acidic buffered form of Vitamin C and a source of the essential mineral Magnesium. The in vitro model system consisted of the isolated section of rat small intestine. The sources of magnesium ion (Mg2+) were magnesium chloride, magnesium sulphate, magnesium acetate, magnesium lactate, magnesium hydrocitrate and magnesium ascorbate. Magnesium ions from magnesium ascorbate were absorbed after the first 15 minutes to the highest extent of all salts, but after 120 minutes their absorption was the smallest of all. The use of magnesium ascorbate in food supplements may lead to an additional exposure to vitamin C and Magnesium. — NCATS

Clinical trial activity

635 trials · 651 clinical orgs · 14 marketing orgs

Phase 1
106
Phase 2
218
Phase 3
103
Phase 4
73

Earliest trial started Sep 1, 1992 (NCT00000539)

Timeline

1940s

  1. Jul 28, 1947

    Roche — Earliest FDA Approval

  2. Jul 28, 1947

    Roche — Marketing Organization

  3. Jul 28, 1947

    Roche — NDA Secondary Org

  4. Jul 28, 1947

    Roche — NDA Organization

1950s

  1. Feb 20, 1953

    Hospira — Marketing Organization

  2. Feb 20, 1953

    Hospira — NDA Secondary Org

1980s

  1. Nov 6, 1981

    Abraxis — Marketing Organization

  2. Nov 6, 1981

    Abraxis — NDA Secondary Org

  3. Jul 13, 1982

    Watson Pharmaceuticals — Marketing Organization

  4. Jul 13, 1982

    Watson Pharmaceuticals — NDA Secondary Org

1990s

  1. Jan 1, 1992

    Earliest Phase 3 Sponsor(trial)

  2. Jan 1, 1993

    Earliest Phase 2 Sponsor(trial)

  3. Jan 1, 1997

    Earliest Phase 1 Sponsor(trial)

2000s

  1. May 18, 2000

    Sandoz — Marketing Organization

  2. May 18, 2000

    Sandoz — NDA Secondary Org

  3. May 18, 2000

    Novartis — NDA Secondary Org

  4. Aug 2, 2006

    Salix — Marketing Organization

  5. Aug 2, 2006

    Salix — NDA Secondary Org

2010s

  1. Jan 25, 2012

    Novel Anti-Infective Technologies, LLC — Marketing Organization

  2. Oct 2, 2017

    McGuff Pharmaceuticals — NDA Secondary Org

  3. May 4, 2018

    Bausch Health Companies — NDA Secondary Org

2020s

  1. Jun 28, 2024

    Taro Pharmaceuticals — Marketing Organization

  2. Aug 7, 2025

    Fresenius — Marketing Organization

  3. Apr 9, 2026

    Apotex — Marketing Organization

Indications

Approved for

Studied for

Mechanism of action

  • Unspecified targetOTHER

    Supplement

    Provides a source of ascorbic acid and restores depleted ascorbic acid resources.

Combination products

Approval history

  • approvedJul 28, 1947

Chemistry & pharmacology

Loading structure…

SMILES

[Mg++].OC[C@H](O)[C@H]1OC(=O)C(O)=C1[O-].OC[C@H](O)[C@H]2OC(=O)C(O)=C2[O-]
Mol. weight
374.5374 g/mol
Lipinski Ro5
Pass
Rule of 3
No
Chirality
Single Stereoisomer
Inorganic
No
Polymer
No
Delivery
Oral, Parenteral
Availability
Prescription Only

Oral

Yes

Parenteral

Yes

Topical

No

Sources

Also known as

  • acide ascorbique
  • acide ascorbique
  • ácido ascórbico
  • ácido ascórbico
  • acidum ascorbicum
  • acidum ascorbicum
  • acidum ascorbinicum
  • acidum ascorbinicum
  • apetiviton
  • ascorbate
  • ascorbate
  • ascorbate
  • ascorbate
  • ascorbic acid
  • ascorbic acid
  • ascorbic acid
  • ascorbic acid
  • ascorbic acid
  • ascorbic acid
  • ascorbic acid
  • ascorbic acid
  • ascorbic acid, monosodium salt
  • ascorbic acid (vit c)
  • ascorbic acid (vit c)
  • ascorbic acid (vit c)
  • ascorbicap
  • ascorbicap
  • ascorbicap
  • ascorbin
  • ascorbin
  • ascorbinsäure
  • ascorbinsäure
  • ascur
  • bassett's
  • calcium ascorbate
  • cebione
  • cebione
  • cecon
  • cecon
  • cenolate
  • cenolate
  • cetane
  • cetane
  • cetane-caps tc
  • cetane-caps tc
  • cevalin
  • cevalin
  • cevex
  • cevex
  • cevitamic acid
  • cevitamic acid
  • chick pea extractvitamin c, l-leucine, vegetable capsule (hypromellose)
  • e300
  • e300
  • e301
  • e301
  • enantic acid
  • enantic acid
  • haliborange
  • kaprylsaeure
  • kaprylsaeure
  • l-ascorbate
  • l-ascorbate
  • l-ascorbate
  • l-(+)-ascorbic acid
  • l-(+)-ascorbic acid
  • l-ascorbic acid
  • l-ascorbic acid
  • l-ascorbic acid
  • l-ascorbic acid
  • lithium octanoate
  • n-capric acid
  • n-capric acid
  • n-caprylic acid
  • n-caprylic acid
  • n-decanoic acid
  • n-decanoic acid
  • neo-fat 8
  • neo-fat 8
  • peg-ascorbate
  • redoxon
  • redoxon
  • redoxon c
  • redoxon chew-c
  • redoxon slow release
  • sodium ascorbate
  • sodium ascorbate
  • sodium ascorbate
  • sodium ascorbate
  • sodium octanoate
  • top c
  • vital life
  • vitamin c
  • vitamin c
  • vitamin c
  • vitamin c
  • vitamin c
  • vitamin c
  • vitamin c
  • vitamin c
  • vitamins c

Clinical trials

NCT IDPhaseStart dateSponsor(s)
NCT07283900Phase 2May 1, 2026University of Iowa
NCT07197749Early Phase 1 (Phase 1)Jan 31, 2026Baylor University, The University of Texas, Dallas
NCT07177079Phase 1Dec 31, 2025University of Iowa
NCT07285109N/ADec 22, 2025Qualia Life Sciences
NCT07302828N/ADec 15, 2025TCI Co., Ltd.
NCT07184866N/AOct 31, 2025Institute of Liver and Biliary Sciences, India
NCT07151105N/AOct 1, 2025Ohio State University
NCT06995586N/ASep 1, 2025Cyprus University of Technology, Government of Russia, University of Cyprus
NCT07109115N/ASep 1, 2025University of Virginia
NCT06823999Phase 4Aug 1, 2025Chiayi Christian Hospital
NCT07070024Phase 1/Phase 2 (Phase 2)Jul 31, 2025Fayoum University
NCT06971315Early Phase 1 (Phase 1)Jun 2, 2025Centre Integre Universitaire de Sante et Services Sociaux du Nord de l'ile de Montreal
NCT06989320N/AMay 27, 2025National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), The University of Texas, Dallas, University of Alabama, Birmingham
NCT06968936N/AMay 15, 2025Chongqing Medical University, Nanjing Medical University, Wenzhou Medical University, Zhejiang University
NCT06985394N/AMay 14, 2025University of Delaware
NCT06936592N/AApr 17, 2025Minia University
NCT07121036Phase 1Mar 30, 2025Xiamen University
NCT06857734N/AMar 1, 2025Benha University
NCT06897384N/AMar 1, 2025Jiao Tong University, Shanghai Municipal Science and Technology Commission
NCT06847880Phase 1Feb 23, 2025University of Baghdad
Showing 20 of 635 trials
Page 1 / 32

Organizations

Research & Development (651)

OrganizationOrg typeTrialsAs lead sponsorPhasesEarliest year
National Cancer Institute (NCI)Government19041997
University of IowaAcademic/Hospital191822009
Cairo UniversityAcademic/Hospital141452013
University of KansasAcademic/Hospital141332002
National Institutes of Health (NIH)Government11142003
Thomas Jefferson UniversityAcademic/Hospital111032008
National Heart, Lung, and Blood Institute (NHLBI)Government10331992
University of TorontoAcademic/Hospital10742002
Seoul National UniversityAcademic/Hospital9932005
Virginia Commonwealth UniversityAcademic/Hospital9932010
Ain Shams UniversityAcademic/Hospital8842013
Department of Veteran AffairsGovernment8552005
Augusta UniversityAcademic/Hospital7632005
Swiss Federal Institute of TechnologyAcademic/Hospital7712011
Harvard UniversityAcademic/Hospital6631993
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)Government6531997
National Taiwan UniversityAcademic/Hospital6522005
University of CopenhagenAcademic/Hospital6522010
American University of BeirutAcademic/Hospital5532010
Duke UniversityAcademic/Hospital5322007
651 organizations
Page 1 / 33

Marketing (23)

OrganizationOrg typeRelationshipDate
AbraxisFor profitMKTGNov 6, 1981
AbraxisFor profitNDA2Nov 6, 1981
ApotexFor profitMKTGApr 9, 2026
Bausch Health CompaniesFor profitNDA2May 4, 2018
FreseniusFor profitMKTGAug 7, 2025
HospiraFor profitMKTGFeb 20, 1953
HospiraFor profitNDA2Feb 20, 1953
McGuff PharmaceuticalsFor profitNDA2Oct 2, 2017
NovartisFor profitNDA2May 18, 2000
Novel Anti-Infective Technologies, LLCFor profitMKTGJan 25, 2012
RocheFor profitMKTGJul 28, 1947
RocheFor profitNDA2Jul 28, 1947
RocheFor profitNDAJul 28, 1947
SalixFor profitMKTGAug 2, 2006
SalixFor profitSYNMay 4, 2018
SalixFor profitSYNMay 4, 2018
SalixFor profitNDA2Aug 2, 2006
SandozFor profitMKTGMay 18, 2000
SandozFor profitNDA2May 18, 2000
Taro PharmaceuticalsFor profitMKTGJun 28, 2024
Teligent PharmaceuticalsFor profitNDA2—
Watson PharmaceuticalsFor profitMKTGJul 13, 1982
Watson PharmaceuticalsFor profitNDA2Jul 13, 1982