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estrogen

Animal productexperimental

Estrogen is a category of sex hormone responsible for the development and regulation of the female reproductive system and secondary sex characteristics. There are three major endogenous estrogens that have estrogenic hormonal activity: estrone (E1), estradiol (E2), and estriol (E3). Estradiol, an estrane, is the most potent and prevalent. Another estrogen called estetrol (E4) is produced only during pregnancy. — Wikipedia

Clinical trial activity

103 trials · 121 clinical orgs · 0 marketing orgs

Phase 1
7
Phase 2
37
Phase 3
27
Phase 4
25

Earliest trial started Apr 1, 1965 (NCT00000482)

Timeline

1960s

  1. Jan 1, 1965

    Earliest Phase 3 Sponsor(trial)

1990s

  1. Jan 1, 1998

    Earliest Phase 2 Sponsor(trial)

2000s

  1. Jan 1, 2008

    Earliest Phase 1 Sponsor(trial)

Indications

Approved for

Studied for

Mechanism of action

Chemistry & pharmacology

Loading structure…

SMILES

CC#C[C@]1(O)CC[C@H]2[C@@H]3CCc4cc(O)ccc4[C@H]3CC[C@@]21C
Mol. weight
310.44 g/mol
Lipinski Ro5
Pass
Rule of 3
No
Chirality
Single Stereoisomer
Inorganic
No
Polymer
No
Delivery
Oral, Parenteral, Topical
Availability
Prescription Only

Oral

Yes

Parenteral

Yes

Topical

Yes

Black box warning

Sources

Also known as

  • estrogen
  • estrogen
  • oestrogen
  • oestrogen

Clinical trials

NCT IDPhaseStart dateSponsor(s)
NCT07186985N/ANov 1, 2025Hanoi Medical University
NCT07030426Phase 3Oct 1, 2025Queen's University, Belfast
NCT06851754Early Phase 1 (Phase 1)Jul 17, 2025National Institutes of Health (NIH)
NCT07038070N/AJul 1, 2025New York University
NCT06808347Phase 4Feb 1, 2025United States Army
NCT06159608Early Phase 1 (Phase 1)Nov 30, 2024University of Iowa
NCT06351501Phase 3Jun 6, 2024Assistance Publique - Hôpitaux de Paris
NCT06306404Phase 4Jun 1, 2024Netherlands Brain Foundation, ZonMw: The Netherlands Organisation for Health Research and Development
NCT06425978Phase 4May 30, 2024Fundación Santiago Dexeus Font, Regen Lab SA
NCT06067217N/ASep 30, 2023Rajavithi Hospital, Bangkok
NCT06144814N/AApr 5, 2023Koru Health Groups
NCT05545592N/AOct 1, 2022Nanjing University
NCT05221021Phase 4Oct 1, 2022United States Army
NCT06479720Phase 4Jun 16, 2022Mackay Medical College
NCT05562518Phase 4Mar 21, 2022Ghent University
NCT05586724Phase 3Feb 25, 2022Karolinska Institute
NCT05059626Phase 4Jan 31, 2022Pennsylvania State University, Yale University
NCT05302726N/AJan 1, 2022University of Copenhagen
NCT05212389N/ADec 22, 2021University of Copenhagen
NCT05569577N/AJan 1, 2021Fudan University, Sun Yat-Sen University
Showing 20 of 103 trials
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Organizations

Research & Development (121)

OrganizationOrg typeTrialsAs lead sponsorPhasesEarliest year
National Heart, Lung, and Blood Institute (NHLBI)Government141241965
National Institutes of Health (NIH)Government11241987
National Institute on Aging (NIA)Government6321987
Harvard UniversityAcademic/Hospital4422002
Mayo ClinicAcademic/Hospital4421985
University of VirginiaAcademic/Hospital4412000
National Center for Research Resources (NCRR)Government3321999
National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)Government3111987
National Institute of Neurological Disorders and Stroke (NINDS)Government3221990
PfizerFor profit3021999
Washington University in St. LouisAcademic/Hospital3322004
Department of Veteran AffairsGovernment2221998
Johns Hopkins UniversityAcademic/Hospital2021996
Nanjing UniversityAcademic/Hospital2222020
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)Government2021987
National Institute of Mental Health (NIMH)Government2022003
Oregon Health and Science UniversityAcademic/Hospital2222005
Sun Yat-Sen UniversityAcademic/Hospital2112017
Thomas Jefferson UniversityAcademic/Hospital2121990
United States ArmyGovernment2212022
121 organizations
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