The Clinical Drug Experience Knowledgebase (CDEK) is a platform intended to explore every active pharmaceutical ingredient (API) with evidence of clinical testing. CDEK aggregates metadata surrounding APIs such as clinical trial information, clinical indications, organizations responsible for development, mechanism of action, etc. The intended use of the CDEK platform reaches far across the biopharmaceutical enterprise. CDEK supports research fields such as drug discovery, chemo and bioinformatics, clinical and translational research, regulatory science, etc. Industry applications aided by CDEK include competitive intelligence, business development, identifying trends within the drug development industry, prioritizing drug development pipelines, etc. The platform is intended to serve a wide audience with a focus on drugs that have progressed to clinical investigation.
About CDEK
About CRIB
The Center for Research Innovation in Biotechnology (CRIB) is dedicated to providing transparent information and analyses of drug discovery and development. Founded in 2014 at Washington University in St Louis, CRIB first analyzed FDA-approved medicines and later expanded to include other FDA-approved biomedical products, including vaccines and biologicals. CRIB investigators are also deepening our knowledge of the scientific, medical and commercial evolution of FDA-approved products. The Center is now a joint effort between the College of Pharmacy at Purdue University and Stony Brook University.
Team
Dr. Michael Kinch in
Dr. Kinch is the inaugural Chief Innovation Officer (CINO) at Stony Brook University. In the course of his career, he has founded and led drug discovery enterprises in both industry and academia, including founding oncology at MedImmune, Inc. and founding the Center for Molecular Discovery at Yale University and the Center for Drug Discovery at Washington University in St Louis.
Tyler Schwartz in
Tyler is a software developer with a background in web and database development. He is a Computer Science graduate of Michigan Technological University (Houghton, Mich.). His interests include the gathering and presentation of large datasets and GIS.
He is the lead database & application developer for the Center for Research Innovation and Biotechnology at the Purdue University College of Pharmacy, and current architect of the CDEK platform. Outside work, Tyler enjoys gardening, hiking, and community service.
Zachary Kraft in
Zachary is a web application developer with a background in full-stack web applications and experimental web architectures. He has years of experience working on cutting-edge web platforms and solving complex programming demands. His main interests are working with open-source web technologies.
He is the frontend developer for the Center for Research Innovation and Biotechnology at the Purdue University College of Pharmacy, on the CDEK platform. In his free time he tinkers with research papers, 3D printing, and archery.
Data provenance
CDEK is primarily comprised of trial data from the AACT database, along with data sourced from various other databases including DrugBank, ChEMBL, PubChem, Drugs@FDA, EMA.
Inclusion criteria from each data source are as follows:
- AACT: all interventions associated with any trial of type Biological, Combination Product, Dietary Supplement, Drug, or Genetic.
- DrugBank: any compound that isn't labeled as experimental from the “All” drug-group release v5.0.7.
- ChEMBL: any compound with a max_phase greater than 0 from ChEMBLdb release v23.
- PubChem: any compound annotated as having ClinicalTrials.gov as a source as of 2018-05-15.
- Drugs@FDA: any approved compound listed in the database as of 2020-01-01.
- EMA: any compound listed in the European public assessment reports as of 2018-04-24.
Download database export
Portions of the CDEK database have been exported for public consumption, and are available through a PostgreSQL data dump file.
This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.
Contact or report an issue
To contact us, please email crib.cdek@gmail.com, or if you would like to report an error in the data please use this form.
This rebuild is maintained by Data4ThePeople.