dexibuprofen
Small moleculeexperimental
Dexibuprofen is a nonsteroidal anti-inflammatory drug (NSAID). It is the active dextrorotatory enantiomer of ibuprofen. Most ibuprofen formulations, as well as other drugs of the profen drug class, contain a racemic mixture of both isomers. — Wikipedia
Clinical trial activity
17 trials · 17 clinical orgs · 0 marketing orgs
Phase 1
2
Phase 2
6
Phase 3
2
Phase 4
9
Earliest trial started Feb 1, 2008 (NCT00812422)
Timeline
Indications
Approved for
Studied for
- Acute Pain · Phase 2
- Dysmenorrhea · Phase 4
- Fever · Phase 3
- General Surgery · Phase 4
- Healthy Volunteers · Phase 1
- Low Back Pain · Phase 4
- Migraine Disorders · Phase 4
- Osteoarthritis · Phase 4
- Pain · Phase 4
- Postoperative Pain · Phase 4
- Respiratory Tract Infections · Phase 3
- Sprains and Strains · Phase 2
- Supratentorial Neoplasms · Phase 4
Mechanism of action
- Cyclooxygenase-2INHIBITOR
PTGS2 inhibitor
Chemistry & pharmacology
Loading structure…
SMILES
CC(C)Cc1ccc(C(C)C(=O)O)cc1.NCCCC[C@H](N)C(=O)O- Mol. weight
- 352.48 g/mol
- Lipinski Ro5
- Pass
- Rule of 3
- No
- Chirality
- Racemic Mixture
- Inorganic
- No
- Polymer
- No
- Delivery
- Parenteral
- Availability
- Prescription Only
Oral
No
Parenteral
Yes
Topical
No
Sources
- WikipediaDexibuprofen ↗
- ChEMBLCHEMBL521 ↗
- ChEMBLCHEMBL175 ↗
- ChEMBLCHEMBL1201141 ↗
Also known as
- dexibuprofen
- dexibuprofen
- dexibuprofen
- dexibuprofen
- dexibuprofen
- dexibuprofen
- dexibuprofen
- dexibuprofen
- d-ibuproten
- d-ibuproten
- neoprofen
- neoprofen
- neoprofen
- rufen
- rufen
- seractil
- seractil
- s-ibuprofen
- s-ibuprofen
- (+)-(s)-p-isobutylhydratropic acid
- (+)-(s)-p-isobutylhydratropic acid
- (s)-α-methyl-4-(2-methylpropyl)benzeneacetic acid
- (s)-α-methyl-4-(2-methylpropyl)benzeneacetic acid
Clinical trials
| NCT ID | Phase | Start date | Sponsor(s) |
|---|---|---|---|
| NCT04772781 | Phase 2 | Dec 31, 2021 | Apsen Farmaceutica S.A. |
| NCT04637529 | Phase 2 | Jul 31, 2021 | Apsen Farmaceutica S.A. |
| NCT03852459 | Phase 2 | Jan 12, 2018 | Aponia Laboratories, Inc., JBR Clinical Research |
| NCT02956525 | Phase 1 | Jun 1, 2017 | Apsen Farmaceutica S.A., Azidus |
| NCT02956512 | Phase 1 | Jun 1, 2017 | Apsen Farmaceutica S.A., Azidus |
| NCT02929147 | Phase 4 | Nov 1, 2016 | Istanbul University |
| NCT02373514 | Phase 4 | Jan 1, 2015 | Akdeniz University, Pamukkale University |
| NCT02324985 | Phase 2 | Jan 1, 2015 | Aponia Laboratories, Inc., Lotus Clinical Research |
| NCT02285972 | Phase 4 | Nov 1, 2014 | T.C. Ordu Universitesi |
| NCT02159547 | Phase 4 | May 1, 2014 | Akdeniz University, Antalya Training and Govermental Hospital |
| NCT02018601 | Phase 4 | Sep 1, 2013 | Complexo Hospitalario Universitario de A Coruña |
| NCT02602197 | Phase 3 | Aug 1, 2013 | Baskent University |
| NCT02568735 | Phase 4 | Jan 1, 2013 | Kuopio University Hospital |
| NCT01730326 | Phase 4 | Mar 1, 2012 | Pamukkale University |
| NCT01422291 | Phase 4 | Jan 1, 2011 | Pamukkale University |
| NCT01066676 | Phase 4 | Oct 1, 2009 | Gebro Pharma GmbH, Rehabilitationszentrum, Bad Hofgastein |
| NCT00812422 | Phase 3 | Feb 1, 2008 | Inje University, Seoul National University |
Showing 17 of 17 trials
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Organizations
Research & Development (17)
| Organization | Org type | Trials | As lead sponsor | Phases | Earliest year |
|---|---|---|---|---|---|
| Apsen Farmaceutica S.A. | For profit | 4 | 4 | 2 | 2017 |
| Pamukkale University | Academic/Hospital | 3 | 2 | 1 | 2011 |
| Akdeniz University | Academic/Hospital | 2 | 2 | 1 | 2014 |
| Aponia Laboratories, Inc. | For profit | 2 | 2 | 1 | 2015 |
| Azidus | For profit | 2 | 0 | 1 | 2017 |
| Antalya Training and Govermental Hospital | Academic/Hospital | 1 | 0 | 1 | 2014 |
| Baskent University | Academic/Hospital | 1 | 1 | 1 | 2013 |
| Complexo Hospitalario Universitario de A Coruña | Academic/Hospital | 1 | 1 | 1 | 2013 |
| Gebro Pharma GmbH | For profit | 1 | 1 | 1 | 2009 |
| Inje University | Academic/Hospital | 1 | 1 | 1 | 2008 |
| Istanbul University | Academic/Hospital | 1 | 1 | 1 | 2016 |
| JBR Clinical Research | For profit | 1 | 0 | 1 | 2018 |
| Kuopio University Hospital | Academic/Hospital | 1 | 1 | 1 | 2013 |
| Lotus Clinical Research | For profit | 1 | 0 | 1 | 2015 |
| Rehabilitationszentrum, Bad Hofgastein | Academic/Hospital | 1 | 0 | 1 | 2009 |
| Seoul National University | Academic/Hospital | 1 | 0 | 1 | 2008 |
| T.C. Ordu Universitesi | Academic/Hospital | 1 | 1 | 1 | 2014 |
17 organizations
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