progestin

Small moleculeexperimental

A progestogen, also referred to as a progestagen, gestagen, or gestogen, is a type of medication which produces effects similar to those of the natural female sex hormone progesterone in the body. A progestin is a synthetic progestogen. Progestogens are used most commonly in hormonal birth control and menopausal hormone therapy. They can also be used in the treatment of gynecological conditions, to support fertility and pregnancy, to lower sex hormone levels for various purposes, and for other indications. Progestogens are used alone or in combination with estrogens. They are available in a wide variety of formulations and for use by many different routes of administration. Examples of progestogens include natural or bioidentical progesterone as well as progestins such as medroxyprogesterone acetate and norethisterone. — Wikipedia

Clinical trial activity

39 trials · 50 clinical orgs · 0 marketing orgs

Phase 1
2
Phase 2
19
Phase 3
9
Phase 4
12

Earliest trial started Aug 1, 1994 (NCT00000549)

Timeline

1990s

  1. Jan 1, 1994

    Earliest Phase 3 Sponsor(trial)

2000s

  1. Jan 1, 2002

    Earliest Phase 2 Sponsor(trial)

  2. Jan 1, 2006

    Earliest Phase 1 Sponsor(trial)

Indications

Approved for

Mechanism of action

Chemistry & pharmacology

Oral

No

Parenteral

No

Topical

No

Sources

Also known as

  • combined oral contraceptive pill
  • estroprogestins
  • progestin
  • progestin

Clinical trials

NCT IDPhaseStart dateSponsor(s)
NCT06904274Phase 3Dec 1, 2025Bayer
NCT07010146Phase 2Jul 1, 2025National Institutes of Health (NIH), University of Virginia
NCT06914297Phase 2Apr 21, 2025Fudan University
NCT06672016Phase 3Dec 31, 2024Mylan
NCT06396390Phase 4Aug 1, 2024Nesta Clinic
NCT06306404Phase 4Jun 1, 2024Netherlands Brain Foundation, ZonMw: The Netherlands Organisation for Health Research and Development
NCT06212102Phase 2Feb 29, 2024Bedaya Hospital, Cairo University
NCT05903131Phase 2Jan 31, 2024National Cancer Institute (NCI), Washington University in St. Louis
NCT05829460Phase 2Oct 31, 2023Novo Nordisk, Washington University in St. Louis
NCT06048536Phase 2Mar 7, 2023Mylan
NCT05244811Phase 3Feb 20, 2022Sohag University
NCT05050357N/AOct 1, 2021Assiut University
NCT04965116Phase 4Sep 28, 2021University of California, San Diego
NCT04396730Phase 4Apr 8, 2020Oregon Health and Science University, Society of Family Planning
NCT06560944N/AJan 17, 2020University of Lincoln
NCT03297216Phase 3Feb 7, 2018AMAG Pharmaceuticals, Inc., Bill and Melinda Gates Foundation, National Institutes of Health (NIH), University of North Carolina at Chapel Hill
NCT03077698Phase 2Jun 14, 2017Xenetic Biosciences, Inc.
NCT04008966Phase 4Jul 20, 2016Cairo University
NCT02735551Phase 4Apr 1, 2016Bayer, Merck, Oregon Health and Science University, Society of Family Planning
NCT02792517Phase 1Feb 12, 2016Amgen
Showing 20 of 39 trials
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Organizations

Research & Development (50)

OrganizationOrg typeTrialsAs lead sponsorPhasesEarliest year
National Institutes of Health (NIH)Government4032003
BayerFor profit3232015
Bill and Melinda Gates FoundationAcademic/Hospital3032011
National Heart, Lung, and Blood Institute (NHLBI)Government3221994
Oregon Health and Science UniversityAcademic/Hospital3312015
Society of Family PlanningAcademic/Hospital3012015
Cairo UniversityAcademic/Hospital2122016
Gedeon Richter Ltd.For profit2212010
MylanFor profit2222023
National Cancer Institute (NCI)Government2021999
National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)Government2111999
University of North Carolina at Chapel HillAcademic/Hospital2122014
Washington University in St. LouisAcademic/Hospital2212023
AMAG Pharmaceuticals, Inc.For profit1012018
American College of Obstetricians and GynecologistsAcademic/Hospital1012005
AmgenFor profit1112016
Assiut UniversityAcademic/Hospital1112021
Bedaya HospitalAcademic/Hospital1112024
Centers for Disease Control and Prevention (CDC)Government1112014
Creighton UniversityAcademic/Hospital1011999
50 organizations
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