CDEK
← All drugs Report issue

ergoloid mesylate

Small moleculeapproved

Approved

Apr 12, 1946

Ergoloid mesylates (USAN), co-dergocrine mesilate (BAN) or dihydroergotoxine mesylate, trade name Hydergine, is a mixture of the methanesulfonate salts of three dihydrogenated ergot alkaloids. — Wikipedia

Clinical trial activity

2 trials · 3 clinical orgs · 20 marketing orgs

Phase 1
0
Phase 2
2
Phase 3
0
Phase 4
0

Earliest trial started Mar 1, 2002 (NCT01475578)

Timeline

1940s

  1. Apr 12, 1946

    Earliest FDA Approval

  2. Apr 12, 1946

    Bausch Health Companies — NDA Secondary Org

1950s

  1. Nov 5, 1953

    Novartis — NDA Secondary Org

1970s

  1. Dec 28, 1976

    3M — Marketing Organization

1980s

  1. Jul 7, 1980

    Watson Pharmaceuticals — Marketing Organization

  2. Nov 20, 1980

    Ivax — Marketing Organization

  3. Jan 8, 1981

    Lumara Health — Marketing Organization

  4. Mar 9, 1981

    Sandoz — Marketing Organization

  5. Aug 11, 1981

    Sun Pharmaceuticals — Marketing Organization

  6. Aug 4, 1982

    Lederle — Marketing Organization

  7. Aug 4, 1982

    American Cyanamid — Marketing Organization

  8. Sep 20, 1982

    Vanguard — Marketing Organization

  9. Nov 1, 1985

    Mutual Pharmaceutical — Marketing Organization

2000s

  1. Jan 1, 2002

    Earliest Phase 2 Sponsor(trial)

  2. Apr 28, 2003

    Paddock Laboratories — Marketing Organization

  3. Jun 9, 2003

    West-Ward Pharmaceutical — Marketing Organization

2010s

  1. Sep 15, 2017

    Hikma — Marketing Organization

  2. Jul 11, 2018

    Sagent Pharmaceuticals, Inc. — Marketing Organization

2020s

  1. Jan 7, 2020

    Apollo Hospitals, Chennai, India — Marketing Organization

  2. Feb 28, 2020

    Custopharm Inc — Marketing Organization

Indications

Approved for

Studied for

Mechanism of action

Approval history

  • approvedApr 12, 1946

Chemistry & pharmacology

Loading structure…

SMILES

CC(C)C[C@H]1C(=O)N2CCC[C@H]2[C@]2(O)O[C@](NC(=O)[C@@H]3C[C@@H]4c5cccc6[nH]cc(c56)C[C@H]4N(C)C3)(C(C)C)C(=O)N12.CC(C)[C@@]1(NC(=O)[C@@H]2C[C@@H]3c4cccc5[nH]cc(c45)C[C@H]3N(C)C2)O[C@@]2(O)[C@@H]3CCCN3C(=O)[C@H](Cc3ccccc3)N2C1=O.CC(C)[C@H]1C(=O)N2CCC[C@H]2[C@]2(O)O[C@](NC(=O)[C@@H]3C[C@@H]4c5cccc6[nH]cc(c56)C[C@H]4N(C)C3)(C(C)C)C(=O)N12.CCC(C)[C@H]1C(=O)N2CCC[C@H]2[C@]2(O)O[C@](NC(=O)[C@@H]3C[C@@H]4c5cccc6[nH]cc(c56)C[C@H]4N(C)C3)(C(C)C)C(=O)N12
Mol. weight
2330.89 g/mol
Chirality
Single Stereoisomer
Inorganic
No
Polymer
No
Delivery
Oral, Topical
Availability
Discontinued

Oral

Yes

Parenteral

No

Topical

Yes

Sources

Also known as

  • alkergot
  • alkergot
  • circanol
  • circanol
  • codergine mesylate
  • codergocrine
  • co-dergocrine mesilate
  • co-dergocrine mesilate
  • co-dergocrine mesilate
  • codergocrine mesilate
  • codergocrine mesilate
  • codergocrine mesilate
  • co-dergocrine mesylate
  • co-dergocrine mesylate
  • co-dergocrine mesylate
  • codergocrine mesylate
  • co-dergocrine methanesulfonate
  • codergocrine methanesulfonate
  • codergocrine methanesulfonate
  • deapril
  • deapril
  • deapril-st
  • deapril-st
  • dihydroergotoxine mesilate
  • dihydroergotoxine mesilate
  • dihydroergotoxine mesilate
  • dihydroergotoxine mesylate
  • dihydroergotoxine mesylate
  • dihydroergotoxine mesylate
  • dihydroergotoxine mesylate
  • dihydroergotoxine methanesulfonate
  • dihydroergotoxine methanesulfonate
  • dihydroergotoxine methanesulfonate
  • dihydroergotoxine methanesulfonates
  • dihydroergotoxine monomethanesulfonate
  • dihydroergotoxine monomethanesulfonate
  • dihydrogenated ergot alkaloids
  • dihydrogenated ergot alkaloids
  • dihydrogenated ergot alkaloids
  • ergoloid mesilates
  • ergoloid mesylate
  • ergoloid mesylate
  • ergoloid mesylate
  • ergoloid mesylate
  • ergoloid mesylate
  • ergoloid mesylate
  • ergoloid mesylate
  • ergoloid mesylates
  • ergoloid mesylates
  • ergoloid mesylates
  • ergoloid mesylates
  • ergoloid mesylates
  • ergoloid mesylates
  • ergoloid mesylates
  • ergoloid methanesulfonate
  • ergoloid methanesulfonate
  • ergoloid methanesulfonates
  • gerimal
  • gerimal
  • hydergine
  • hydergine
  • hydergine
  • hydergine
  • hydergine lc
  • hydergine lc
  • hydrogenated ergot alkaloids
  • hydrogenated ergot alkaloids
  • hydrogenated ergot alkaloids
  • hydrogenated ergot alkaloids

Clinical trials

NCT IDPhaseStart dateSponsor(s)
NCT05030129Phase 2Sep 15, 2021Rush University
NCT01475578Phase 2Mar 1, 2002Chengdu University of Traditional Chinese Medicines, Sinphar Pharmaceutical Co., Ltd
Showing 2 of 2 trials
Page 1 / 1

Organizations

Research & Development (3)

OrganizationOrg typeTrialsAs lead sponsorPhasesEarliest year
Chengdu University of Traditional Chinese MedicinesAcademic/Hospital1012002
Rush UniversityAcademic/Hospital1112021
Sinphar Pharmaceutical Co., LtdFor profit1112002
3 organizations
Page 1 / 1

Marketing (23)

OrganizationOrg typeRelationshipDate
3MFor profitMKTGDec 28, 1976
American CyanamidFor profitMKTGAug 4, 1982
Apollo Hospitals, Chennai, IndiaAcademic/HospitalMKTGJan 7, 2020
Bausch Health CompaniesFor profitNDA2Apr 12, 1946
Bausch Health CompaniesFor profitSYNApr 12, 1946
Bristol-Myers SquibbFor profitMKTG—
Custopharm IncFor profitMKTGFeb 28, 2020
HikmaFor profitMKTGSep 15, 2017
IvaxFor profitMKTGNov 20, 1980
LederleFor profitMKTGAug 4, 1982
Lumara HealthFor profitMKTGJan 8, 1981
Mutual PharmaceuticalFor profitMKTGNov 1, 1985
NovartisFor profitNDA2Nov 5, 1953
Paddock LaboratoriesFor profitMKTGApr 28, 2003
Sagent Pharmaceuticals, Inc.For profitMKTGJul 11, 2018
Sagent Pharmaceuticals, Inc.For profitSYNJul 11, 2018
SandozFor profitNDA—
SandozFor profitMKTGMar 9, 1981
Sun PharmaceuticalsFor profitMKTGAug 11, 1981
SuperpharmFor profitMKTG—
VanguardFor profitMKTGSep 20, 1982
Watson PharmaceuticalsFor profitMKTGJul 7, 1980
West-Ward PharmaceuticalFor profitMKTGJun 9, 2003