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Sepsis
Systemic inflammatory response syndrome with a proven or suspected infectious etiology. When sepsis is associated with organ dysfunction distant from the site of infection, it is called severe sepsis. When sepsis is accompanied by HYPOTENSION despite adequate fluid infusion, it is called SEPTIC SHOCK.
Subtype terms (6)
More specific conditions that are subtypes of Sepsis in the MeSH hierarchy.
- Bacteremia
71 drugs (56 approved, 15 experimental)
- Fungemia
12 drugs (10 approved, 2 experimental)
- Neonatal Sepsis
42 drugs (27 approved, 15 experimental)
- Parasitemia
15 drugs (10 approved, 5 experimental)
- Shock, Septic
163 drugs (112 approved, 51 experimental)
- Viremia
11 drugs (8 approved, 3 experimental)
Drugs by status
Approved for this indication (22)
Phase 4 trials (96)
- simvastatin
- ringer's lactate
- phenylephrine
- propofol
- vitamin d3
- nitroglycerin
- heparin
- iron
- methylprednisolone
- angiotensin ii
- urea
- epoetin
- cefotaxime
- lipopolysaccharide
- prednisone
- ibuprofen
- doripenem
- fenoximone
- eravacycline
- micafungin
- fosfomycin
- gelatin
- albumin (Human)
- hydrocortisone
- ivabradine
- icosapent ethyl
- ozone
- esketamine
- iohexol
- meningococcal (groups A, C, Y, W) CRM197 conjugate vaccine
- +66 more
Phase 3 trials (77)
- metformin
- melatonin
- montelukast
- thrombomodulin alfa
- asfotase alfa
- bacille calmette-guerin
- tobramycin
- C1 Esterase Inhibitor (Human)
- alpha-lipoic acid
- pancrelipase
- doxorubicin
- eritoran
- ethanol
- gemcitabine
- fluorouracil
- paclitaxel
- l-glutamine
- rosuvastatin
- fibrinogen (human)
- insulin human
- cyanocobalamin
- in111-octreoscan
- irbesartan
- whey protein
- pembrolizumab
- citrulline
- levocarnitine
- leucovorin
- metamizole
- ursodeoxycholic acid
- +47 more
Phase 2 trials (66)
- maltodextrin
- ceftaroline fosamil
- alt-836
- lorcaserin
- paroxetine
- irinotecan
- ketamine
- esmolol
- cyt107
- durvalumab
- imatinib
- granisetron
- aldesleukin
- lactulose
- bovine colostrum
- ic14
- ifx-1
- il-7
- epirubicin
- daptomycin
- inulin
- ionis-stat3rx
- kukoamine b
- metolazone
- monalizumab
- evolocumab
- atorvastatin
- pleconaril
- carboplatin
- allogeneic hematopoietic stem cells
- +36 more
Phase 1 trials (27)
- bms-986189
- srt2104
- clavulanate
- cystatin
- nivolumab
- j5-omp vaccine
- bms-936559
- relebactam
- srt2379
- tnx-832
- tremelimumab
- vasoactive intestinal peptide
- bifidobacterium longum
- creatine
- rtsst-1v
- hexose
- agatolimod
- dnase
- corn
- nelfinavir
- rezafungin
- autologous adipose-derived mesenchymal stem cells
- carbon monoxide
- opt101
- Taurodeoxycholate
- snipr001
- bay3389934
Other trials (51)
- levofloxacin
- maltose
- linezolid
- anisodamine
- oxytocin
- petrolatum, white
- bifidobacterium animalis
- bovine lactoferrin
- cefoxitin
- ceftazidime
- doxycycline
- e. coli endotoxin
- empagliflozin
- isoflurane
- sevoflurane
- gr270774
- etomidate
- amoxicillin
- l-alanine
- nesiritide
- niacin
- beta-glucans
- human milk
- physostigmine
- atazanavir
- magnesium sulfate
- lidocaine
- si-ni-tang
- paricalcitol
- autologous microbiome
- +21 more
Organizations
Organization Involved with Phase 4 Indications (74)
- Abbott
- Fresenius
- Gilead Sciences
- AstraZeneca
- Techpool Bio-Pharma Co., Ltd.
- Tianjin Chase Sun Pharmaceutical Co., LTD
- National Institutes of Health (NIH)
- National Institute of General Medical Sciences (NIGMS)
- Sunnybrook Health Sciences Centre
- Central South University
- Ain Shams University
- CAMC Health System
- Centre Hospitalier Universitaire de Nīmes
- University of London
- Emory University
- Fernandes Tavora Hospital
- I.M. Sechenov First Moscow State Medical University
- Julius-Maximilians University
- Katholieke Universiteit Leuven
- Li Shin Hospital
- Makerere University
- Mansoura University
- Los Angeles Biomedical Research Institute
- McGill University
- Moscow Regional Research and Clinical Institute Moniki n.a. M.F. Vladimirskiy
- Ohio State University
- Onze Lieve Vrouw Hospital
- Osaka City University
- Sapporo Medical University
- Sir Takhtasinhji General Hospital
- +44 more
Organization Involved with Phase 3 Indications (133)
- Symyoo
- Zhejiang Hisun Pharmaceutical Co. Ltd.
- Eisai
- Takeda
- Green Cross Corporation
- Novo Nordisk
- ICOS
- AM-Pharma
- Novartis
- Bayer
- Biosyn
- Biosynexus Incorporated
- Chiesi
- SciClone Pharmaceuticals
- Suntory Pharmaceutical
- Agennix
- PENTA Foundation
- Wu Jieping Medical Foundation
- Save the Children
- ZonMw: The Netherlands Organisation for Health Research and Development
- National Heart, Lung, and Blood Institute (NHLBI)
- National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
- United States Air Force
- World Health Organization
- Institut d'Investigació Biomèdica de Girona Dr. Josep Trueta
- University of Pennsylvania
- Maastricht University
- University of Pittsburgh
- Aragon Institute of Health Sciences
- Azad University
- +103 more
Organization Involved with Phase 2 Indications (80)
- Accentia Biopharmaceuticals
- Cato Research
- Artisan Pharma, Inc.
- Atox Bio Ltd
- Baxalta
- GWT-TUD GmbH
- Hamilton Health Sciences Corporation
- InflaRx GmbH
- Parexel
- Thrombologic ApS
- German Research Foundation
- Medical Research Council
- National Cancer Institute (NCI)
- National Center for Complementary and Integrative Health (NCCIH)
- National Institute of Allergy and Infectious Diseases (NIAID)
- National Institute of Dental and Craniofacial Research (NIDCR)
- National Institute on Alcohol Abuse and Alcoholism (NIAAA)
- University of Roma La Sapienza
- Shanghai Changzheng Hospital
- Bambino Gesù Hospital and Research Institute
- Baylor University
- Centre Hospitalier de Meaux
- Consorzio per Valutazioni Biologiche e Farmacologiche
- Federal University of Rio Grande do Sul
- Instituto Mexicano del Seguro Social
- Northern Health and Social Care Trust
- Queen's University, Belfast
- Saint Francis Hospital and Medical Center
- University of Edinburgh
- Justus Liebig University Giessen
- +50 more
Organization Involved with Phase 1 Indications (17)
- Bristol-Myers Squibb
- Forest Laboratories
- The EMMES Corporation
- Mooselmokadem
- Duke University
- University of Nottingham
- University of Vermont
- Mayo Clinic
- Stony Brook University
- State University of New York
- University of California, Davis
- University of California, San Diego
- University of Vienna
- Food and Drug Administration
- Biotest Pharmaceuticals
- National Bank of Austria
- Shaperon
Organization Involved with Other Experimental Indications (35)
- Inhibitex
- Medical University of Graz
- Albert Schweitzer Hospital
- Changi General Hospital
- Children's Cancer and Leukaemia Group
- Dartmouth University
- Guangdong Provincial Hospital of Traditional Chinese Medicine
- Nanjing University
- Siriraj Hospital
- Tunis University
- University of Heidelberg
- Fujian Medical University
- Institute of Liver and Biliary Sciences, India
- Tel Aviv University
- University of Ankara
- University of Amsterdam
- Free University of Amsterdam
- Advocate Healthcare
- Royal Liverpool & Broadgreen University Hospitals NHS Truts
- University of Ostrava
- University of Kwa-Zulu Natal
- Kowng Wah Hospital
- University of Tuebingen
- Emergency Medicine Foundation
- The Physicians' Services Incorporated Foundation
- Lady Hardinge Medical College
- Fonds NutsOhra
- Nederlandse Internisten Vereniging ( Dutch Association of Internists)
- Ningxia Medical University
- Government of Hong Kong
- +5 more