bifidobacterium longum
Cell therapyexperimental
Bifidobacterium longum is a Gram-positive, catalase-negative, rod-shaped bacterium present in the human gastrointestinal tract and one of the 32 species that belong to the genus Bifidobacterium. It is a microaerotolerant anaerobe and considered to be one of the earliest colonizers of the gastrointestinal tract of infants. When grown on general anaerobic medium, B. longum forms white, glossy colonies with a convex shape. B. longum is one of the most common bifidobacteria present in the gastrointestinal tracts of both children and adults. B. longum is non-pathogenic, is often added to food products, and its production of lactic acid is believed to prevent growth of pathogenic organisms. — Wikipedia
Clinical trial activity
140 trials · 163 clinical orgs · 0 marketing orgs
Phase 1
11
Phase 2
33
Phase 3
26
Phase 4
18
Earliest trial started Apr 1, 2002 (NCT00255385)
Timeline
Indications
Approved for
Studied for
- Abdominal Pain · Phase 3
- Acute-On-Chronic Liver Failure · Phase 2/Phase 3
- Adenomatous Polyposis Coli · Phase 2
- Aged · Early Phase 1
- Amoxicillin · Phase 4
- Anxiety · Phase 4
- Ascites · Phase 2
- Asthma · Phase 1/Phase 2
- Attention Deficit Disorder with Hyperactivity · Phase 4
- Breast Neoplasms · Phase 2/Phase 3
- Carcinoma, Non-Small-Cell Lung · Phase 2
- Celiac Disease · Phase 4
- Child Development · Phase 3
- Clostridioides difficile · Phase 3
- Cognitive Dysfunction · Phase 4
- Colic · Phase 4
- Colonoscopy · Phase 4
- Constipation · Phase 4
- Crohn Disease · Phase 4
- Deglutition Disorders · Early Phase 1
- Depression · Phase 3
- Depressive Disorder · Phase 3
- Dermatology · Phase 3
- Diabetes Mellitus, Type 2 · Phase 2/Phase 3
- Diarrhea · Phase 3
- Diverticulitis · Phase 2
- Drug Resistance, Bacterial · Phase 2
- Dysbiosis · Phase 4
- Dyspepsia · Phase 1/Phase 2
- Esophageal and Gastric Varices · Phase 3
- Fatty Liver · Phase 1
- Fever · Phase 3
- Fibrosis · Phase 4
- Gastrointestinal Diseases · Phase 4
- Gastrointestinal Microbiome · Phase 3
- General Surgery · Phase 3
- Glutens · Phase 2
- Growth · Phase 3
- Healthy Volunteers · Phase 2/Phase 3
- Hepatic Encephalopathy · Phase 4
- Hirschsprung Disease · Phase 2
- Hypersensitivity · Phase 4
- Immune System Diseases · Phase 3
- Inflammatory Bowel Diseases · Phase 3
- Intestinal Neoplasms · Phase 3
- Irritable Bowel Syndrome · Phase 4
- Klebsiella pneumoniae · Phase 1/Phase 2
- Live Birth · Phase 2
- Liver Cirrhosis · Phase 2/Phase 3
- Major Depressive Disorder · Phase 3
- Metabolic Syndrome · Phase 3
- Neoplasms · Phase 3
- Non-alcoholic Fatty Liver Disease · Phase 3
- Obsessive-Compulsive Disorder · Phase 4
- Osteoporosis · Phase 2
- Peritonitis · Phase 2/Phase 3
- Pneumonia · Phase 3
- Postoperative Complications · Phase 4
- Prebiotics · Phase 1
- Prediabetic State · Phase 2/Phase 3
- Probiotics · Phase 4
- Psychological Distress · Phase 3
- Quality of Life · Phase 3
- Quorum Sensing · Phase 1
- Scleroderma, Systemic · Phase 2
- Sepsis · Phase 1
- Signs and Symptoms, Digestive · Phase 1/Phase 2
- Sleep Disorders, Intrinsic · Phase 2
- Stress, Psychological · Phase 3
- Tooth Extraction · Phase 4
- Water Loss, Insensible · Phase 3
Mechanism of action
- microbiotaTissue restoration
microbiota tissue restoration
Chemistry & pharmacology
Loading structure…
SMILES
COc1nccnc1NS(=O)(=O)c1ccc(N)cc1- Mol. weight
- 280.31 g/mol
- Lipinski Ro5
- Pass
- Rule of 3
- No
- Chirality
- Achiral Molecule
- Inorganic
- No
- Polymer
- No
Oral
No
Parenteral
No
Topical
No
Sources
- WikipediaBifidobacterium longum ↗
- NCATS0Z1FKO93PO ↗
- ChEMBLCHEMBL1525826 ↗
Also known as
- bifidobacterium longum
- bifidobacterium longum
- bifidobacterium longum bb536
- bifidobacterium longum bb-536
- bifidobacterium longum mm-2
- bifidobacterium longum ncc3001
- bifidobacterium longum r0175
- bifidobacterium longum spp. longum strain ah1206
- bifidobacterium longum subsp. longum r0175
- b. longum
- b.longum 1714
- b. longum r0175
- cect7210
- longum
- longum
- vsl #3
- vsl#3
Clinical trials
| NCT ID | Phase | Start date | Sponsor(s) |
|---|---|---|---|
| NCT07184905 | N/A | Sep 9, 2025 | Shenzhen University |
| NCT06639516 | N/A | Oct 14, 2024 | Nanchang University |
| NCT06729671 | N/A | May 16, 2024 | National University of Ireland |
| NCT06686420 | N/A | May 1, 2024 | Morinaga Milk Industry Co. Ltd., Japan |
| NCT07165977 | N/A | Jan 25, 2024 | National Science Centre, Poland, SWPS University |
| NCT05286047 | N/A | Sep 23, 2022 | glac Biotech Co., Ltd. |
| NCT05567653 | N/A | Sep 21, 2022 | Poznan University |
| NCT05366335 | Phase 4 | Jul 4, 2022 | Jiao Tong University |
| NCT05339243 | N/A | Apr 21, 2022 | Vedic Lifesciences Pvt. Ltd. |
| NCT05367427 | N/A | Feb 1, 2022 | Biopolis S.L., Universidad Autonoma de Madrid |
| NCT05208528 | N/A | Jan 23, 2022 | ADM Biopolis, Eurecat |
| NCT05054309 | N/A | Nov 15, 2021 | McMaster University, Nestle |
| NCT04997057 | N/A | Sep 15, 2021 | CEN Biotech, Hopital Antoine Beclere, Pileje |
| NCT04925440 | N/A | Sep 13, 2021 | Atlantia Food Clinical Trials, PrecisionBiotics Ltd. |
| NCT05086458 | N/A | Aug 17, 2021 | Huazhong University of Science and Technology |
| NCT04784182 | N/A | Jul 20, 2021 | Auburn University, University of Alabama, Birmingham |
| NCT04911556 | N/A | Jun 1, 2021 | Jiangnan University, Wuxi People's Hospital |
| NCT05477732 | N/A | Feb 12, 2021 | Taipei Medical University |
| NCT04706559 | N/A | Jan 3, 2021 | B.P. Koirala Institute of Health Sciences, Government of Nepal |
| NCT06867900 | N/A | Jan 1, 2021 | Universita' Cattolica del Sacro Cuore |
Showing 20 of 140 trials
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Organizations
Research & Development (163)
| Organization | Org type | Trials | As lead sponsor | Phases | Earliest year |
|---|---|---|---|---|---|
| Lallemand SAS | For profit | 8 | 1 | 5 | 2008 |
| VSL Pharmaceuticals | For profit | 8 | 3 | 4 | 2004 |
| Nestle | For profit | 7 | 6 | 3 | 2004 |
| McMaster University | Academic/Hospital | 5 | 2 | 4 | 2011 |
| Hebrew University | Academic/Hospital | 4 | 4 | 4 | 2004 |
| University of Florida | Academic/Hospital | 4 | 4 | 2 | 2015 |
| University of London | Academic/Hospital | 4 | 4 | 2 | 2007 |
| University of Milan | Academic/Hospital | 4 | 3 | 2 | 2010 |
| Atlantia Food Clinical Trials | For profit | 3 | 0 | 2 | 2018 |
| University of Wisconsin | Academic/Hospital | 3 | 2 | 2 | 2008 |
| All India Institute of Medical Sciences | Academic/Hospital | 2 | 1 | 1 | 2007 |
| Bambino Gesù Hospital and Research Institute | Academic/Hospital | 2 | 2 | 1 | 2012 |
| Biopolis S.L. | For profit | 2 | 1 | 2 | 2016 |
| CD Pharma India Pvt. Ltd. | For profit | 2 | 2 | 1 | 2009 |
| China Medical University | Academic/Hospital | 2 | 2 | 1 | 2017 |
| Ferring | For profit | 2 | 0 | 2 | 2010 |
| Government of Spain | Government | 2 | 1 | 2 | 2016 |
| Govind Ballabh Pant Institute of Postgraduate Medical Education and Research | Academic/Hospital | 2 | 2 | 2 | 2008 |
| Johns Hopkins University | Academic/Hospital | 2 | 1 | 2 | 2002 |
| Morinaga Milk Industry Co. Ltd., Japan | For profit | 2 | 1 | 2 | 2015 |
163 organizations
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