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vasopressin

Trade name: vasostrict

Animal productapproved

Approved

Jul 30, 1970

Mammalian vasopressin, also called antidiuretic hormone (ADH), arginine vasopressin (AVP) or argipressin, is a hormone synthesized from the AVP gene as a peptide prohormone in neurons in the hypothalamus, and is converted to AVP. It then travels down the axon terminating in the posterior pituitary, and is released from vesicles into the circulation in response to extracellular fluid hypertonicity (hyperosmolality). AVP has two primary functions. First, it increases the amount of solute-free water reabsorbed back into the circulation from the filtrate in the kidney tubules of the nephrons. Second, AVP constricts arterioles, which increases peripheral vascular resistance and raises arterial blood pressure. — Wikipedia

Clinical trial activity

137 trials · 125 clinical orgs · 18 marketing orgs

Phase 1
20
Phase 2
45
Phase 3
30
Phase 4
26

Earliest trial started Apr 1, 1998 (NCT00599560)

Timeline

1920s

  1. Jan 1, 1927

    Parke-Davis — Marketing Organization

1930s

  1. Jul 1, 1930

    Evidence of US Marketing

1970s

  1. Jul 30, 1970

    Parke-Davis — Earliest FDA Approval

  2. Jul 30, 1970

    Parke-Davis — NDA Organization

2000s

  1. Jan 1, 2000

    Earliest Phase 2 Sponsor(trial)

  2. Jan 1, 2006

    Earliest Phase 3 Sponsor(trial)

  3. Jan 1, 2008

    Earliest Phase 1 Sponsor(trial)

2010s

  1. Apr 17, 2014

    Par Pharmaceuticals — NDA Secondary Org

  2. Apr 17, 2014

    Endo Pharmaceuticals — Marketing Organization

  3. Apr 17, 2014

    PH HEALTH — Marketing Organization

2020s

  1. Jan 28, 2020

    American Regent, Inc. — Marketing Organization

  2. Aug 3, 2020

    Sankyo — Marketing Organization

  3. Aug 3, 2020

    Daiichi Sankyo — NDA Secondary Org

  4. Dec 15, 2021

    Eagle Pharmaceuticals, Inc. — Marketing Organization

  5. Jul 18, 2022

    Amphastar Pharmaceuticals — Marketing Organization

  6. Aug 5, 2022

    Amneal Pharmaceuticals — Marketing Organization

  7. Aug 15, 2022

    Eugia Pharma — Marketing Organization

  8. May 26, 2023

    Fresenius — Marketing Organization

  9. Sep 29, 2023

    Baxalta — Marketing Organization

  10. Dec 6, 2023

    Cipla — Marketing Organization

  11. Feb 9, 2024

    Gland Pharma Ltd — Marketing Organization

  12. May 8, 2024

    Dr. Reddy's Laboratories — Marketing Organization

  13. Jul 11, 2024

    LONG GROVE PHARMS — Marketing Organization

  14. May 6, 2026

    Sandoz — Marketing Organization

Indications

Approved for

Studied for

Mechanism of action

Approval history

  • approvedJul 30, 1970
  • approvedJul 1, 1930

Chemistry & pharmacology

Loading structure…

SMILES

N=C(N)NCCC[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CSSC[C@H](N)C(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N1)C(=O)NCC(N)=O
Mol. weight
1084.25 g/mol
Chirality
Single Stereoisomer
Inorganic
No
Polymer
No
Delivery
Parenteral
Availability
Discontinued

Oral

No

Parenteral

Yes

Topical

No

Sources

Also known as

  • 8-l-arginine vasopressin
  • 8-l-arginine-vasopressin
  • antidiuretic hormone
  • arginine vasopressin
  • arginine vasopressin
  • argipressin
  • argipressin
  • argipressin
  • argipressin tannate
  • argipressin tannate
  • beta-hypophamine
  • beta-hypophamine
  • cardiopressin
  • ci-107
  • ci-107
  • leiormone
  • leiormone
  • pitressin
  • pitressin
  • pitressin tannate
  • pitressin tannate
  • pitressin tannate
  • pitressin tannate
  • pitressin tannate in oil
  • pitressin tannate (synthetic)
  • synthetic vasopressin
  • vasophysin
  • vasophysin
  • vasopressin
  • vasopressin
  • vasopressin
  • vasopressin
  • vasopressin
  • vasopressin
  • vasopressin
  • vasopressin
  • vasopressin
  • vasopressin
  • vasopressin
  • vasopressin injection
  • vasopressin injection
  • vasopressin tannate
  • vasopressin tannate
  • vasopressin tannate
  • vasopressin tannate
  • vasopressin tannate
  • vasopressin, unspecified
  • vasopressin, unspecified
  • vaspressin

Clinical trials

NCT IDPhaseStart dateSponsor(s)
NCT07245355N/AFeb 1, 2026Suleyman Demirel University
NCT07052084Phase 3Jan 31, 2026Aix-University of Marseille
NCT07222917Phase 2Dec 5, 2025AstraZeneca
NCT07102615Phase 4Oct 30, 2025Prisma Health
NCT07067866Phase 3Oct 1, 2025Hospital Nossa Senhora da Conceicao
NCT07063680Phase 3Sep 30, 2025University of Burgundy
NCT07007793Phase 3Aug 7, 2025AstraZeneca
NCT06677060Phase 3Mar 28, 2025AstraZeneca
NCT06742723Phase 3Mar 3, 2025AstraZeneca
NCT06709573Phase 4Jan 1, 2025The Cleveland Clinic
NCT06657105Phase 1Nov 1, 2024AstraZeneca
NCT06464510Phase 3Oct 31, 2024Brazilian Research In Intensive Care Network, Federal University of Sao Paulo, Hcor Research Institute, Hospital do Coracao
NCT06547892Phase 2Sep 30, 2024Hospital do Coracao
NCT06605300N/AJul 1, 2024University of Electronic Science and Technology of China
NCT06419075Phase 4Jul 1, 2024Mount Sinai Hospital, Canada, University of Texas at Houston, University of Texas, Galveston
NCT06302998Phase 2Jun 30, 2024Mansoura University
NCT06344442Phase 3Jun 20, 2024Assistance Publique - Hôpitaux de Paris
NCT06336356Phase 2Jun 10, 2024AstraZeneca
NCT06471231Phase 4May 15, 2024University of Bologna
NCT06357520Phase 1Apr 16, 2024AstraZeneca
Showing 20 of 137 trials
Page 1 / 7

Organizations

Research & Development (125)

OrganizationOrg typeTrialsAs lead sponsorPhasesEarliest year
AstraZenecaFor profit181832019
University of Electronic Science and Technology of ChinaAcademic/Hospital7712017
CinCor Pharma, Inc.For profit6622020
Stanford UniversityAcademic/Hospital4432012
University of Sao PauloAcademic/Hospital4432008
Emory UniversityAcademic/Hospital3212007
Medpace, Inc.For profit3012019
National Institute of Mental Health (NIMH)Government3132008
The Cleveland ClinicAcademic/Hospital3332020
University of GothenburgAcademic/Hospital3232016
Assistance Publique - Hôpitaux de ParisAcademic/Hospital2212020
Aswan UniversityAcademic/Hospital2212018
Cha Medical UniversityAcademic/Hospital2122013
Chulalongkorn UniversityAcademic/Hospital2212016
Department of DefenseGovernment2012013
Hebrew UniversityAcademic/Hospital2212011
Hospital do CoracaoAcademic/Hospital2222024
Hospital Nossa Senhora da ConceicaoAcademic/Hospital2222022
National Institutes of Health (NIH)Government2022014
Seoul National UniversityAcademic/Hospital2212019
125 organizations
Page 1 / 7

Marketing (21)

OrganizationOrg typeRelationshipDate
American Regent, Inc.For profitMKTGJan 28, 2020
Amneal PharmaceuticalsFor profitMKTGAug 5, 2022
Amneal PharmaceuticalsFor profitSYNAug 10, 2022
Amphastar PharmaceuticalsFor profitMKTGJul 18, 2022
BaxaltaFor profitMKTGSep 29, 2023
CiplaFor profitMKTGDec 6, 2023
Daiichi SankyoFor profitNDA2Aug 3, 2020
Dr. Reddy's LaboratoriesFor profitMKTGMay 8, 2024
Eagle Pharmaceuticals, Inc.For profitMKTGDec 15, 2021
Endo PharmaceuticalsFor profitMKTGApr 17, 2014
Eugia PharmaFor profitMKTGAug 15, 2022
FreseniusFor profitMKTGMay 26, 2023
Gland Pharma LtdFor profitMKTGFeb 9, 2024
Gland Pharma LtdFor profitSYNFeb 9, 2024
LONG GROVE PHARMSFor profitMKTGJul 11, 2024
PH HEALTHFor profitMKTGApr 17, 2014
Par PharmaceuticalsFor profitNDA2Apr 17, 2014
Parke-DavisFor profitNDAJul 30, 1970
Parke-DavisFor profitMKTGJan 1, 1927
SandozFor profitMKTGMay 6, 2026
SankyoFor profitMKTGAug 3, 2020