procaine benzylpenicillin
Trade name: novocaine
Small moleculeapproved
Approved
Feb 6, 1947
Procaine benzylpenicillin also known as penicillin G procaine, is an antibiotic useful for the treatment of a number of bacterial infections. Specifically it is used for syphilis, anthrax, mouth infections, pneumonia, diphtheria, cellulitis, and animal bites. It is given by injection into a muscle. — Wikipedia
Clinical trial activity
448 trials · 465 clinical orgs · 68 marketing orgs
Phase 1
49
Phase 2
133
Phase 3
103
Phase 4
163
Earliest trial started Aug 1, 1983 (NCT00000585)
Timeline
1940s
- Feb 6, 1947
Earliest FDA Approval
- Feb 6, 1947
Pfizer — Marketing Organization
- Apr 26, 1948
King Pharmaceuticals — NDA Secondary Org
- Apr 26, 1948
King Pharmaceuticals — Marketing Organization
1950s
- Apr 26, 1951
Merck — First NDA Organization
- Apr 26, 1951
Merck — NDA Organization
- Nov 22, 1951
American Home Products — NDA Secondary Org
- Dec 16, 1952
Casper Pharma LLC — NDA Secondary Org
1960s
- May 27, 1964
Teva — Marketing Organization
- Dec 17, 1965
American Home Products — Marketing Organization
1970s
- May 7, 1970
GlaxoSmithKline — Marketing Organization
- Mar 3, 1971
Apothecon — Marketing Organization
- Mar 3, 1971
Bristol-Myers Squibb — Marketing Organization
- Mar 3, 1971
Sandoz — Marketing Organization
- Nov 9, 1971
Heritage Pharma — Marketing Organization
- Nov 9, 1971
Chartwell Pharmaceuticals — Marketing Organization
- Oct 10, 1973
G & W Laboratories Inc. — Marketing Organization
- Oct 10, 1973
Cosette — Marketing Organization
- Oct 10, 1973
ACP Nimble — Marketing Organization
- Jan 21, 1974
Belcher Pharmaceuticals — Marketing Organization
- Jan 21, 1974
American Antibiotics — Marketing Organization
- Apr 7, 1975
Watson Pharmaceuticals — Marketing Organization
- Jan 13, 1976
Mylan — Marketing Organization
- Mar 11, 1976
Beecham — Marketing Organization
- May 4, 1976
Puracap Pharmaceutical — Marketing Organization
- Jul 29, 1976
Lannett Company, Inc. — Marketing Organization
- Jun 12, 1978
Ani Pharmaceuticals — Marketing Organization
- Aug 2, 1979
Neopharma — NDA Secondary Org
- Sep 6, 1979
Lederle — Marketing Organization
- Sep 6, 1979
American Cyanamid — Marketing Organization
1980s
- Jan 1, 1983
Earliest Phase 3 Sponsor(trial)
- Aug 7, 1985
Atral — Marketing Organization
- Jun 24, 1986
West-Ward Pharmaceutical — Marketing Organization
- Dec 31, 1986
Pfizer — NDA Secondary Org
- May 12, 1987
Istituto Bio Ita Spa — Marketing Organization
- Feb 25, 1988
DAVA Pharmaceuticals — Marketing Organization
- Feb 25, 1988
Strides Pharma Science — Marketing Organization
- Feb 10, 1989
Endo Pharmaceuticals — Marketing Organization
1990s
- Jun 25, 1990
Baxalta — NDA Secondary Org
- Jun 25, 1990
Baxter — NDA Secondary Org
- Jan 1, 1993
Earliest Phase 2 Sponsor(trial)
- Apr 15, 1993
Hanford Pharmaceuticals — Marketing Organization
- Apr 15, 1993
Hq Speciality Pharma — Marketing Organization
- Dec 2, 1997
Takeda — Marketing Organization
- Jan 1, 1999
Earliest Phase 1 Sponsor(trial)
- Apr 8, 1999
Sun Pharmaceuticals — Marketing Organization
2000s
- Aug 30, 2002
Novartis — Marketing Organization
- Aug 11, 2003
Ranbaxy — Marketing Organization
- Nov 9, 2005
Aurobindo Pharma — Marketing Organization
- Mar 29, 2006
Hikma — Marketing Organization
- Jun 18, 2007
Wockhardt — Marketing Organization
- Jun 29, 2007
Pharmaceutical Associates — Marketing Organization
- Jun 29, 2007
Mustafa Nevzat Pharmaceuticals — Marketing Organization
- Jun 29, 2007
Medimetriks — Marketing Organization
- Jan 23, 2008
Pragma Therapeutics — NDA Secondary Org
- May 13, 2008
Novast Labs — Marketing Organization
- Oct 20, 2008
Apotex — Marketing Organization
- Dec 22, 2009
ACS Dobfar — Marketing Organization
- Dec 28, 2009
Antibiotice — Marketing Organization
2010s
- Aug 17, 2010
Eugia Pharma — Marketing Organization
- Feb 8, 2011
Cumberland Pharmaceuticals — Marketing Organization
- Dec 21, 2011
Hospira — Marketing Organization
- Apr 7, 2014
STERISCIENCE — Marketing Organization
- Oct 20, 2015
Sagent Pharmaceuticals, Inc. — Marketing Organization
- Jan 8, 2016
Astral — Marketing Organization
- Oct 7, 2016
Rising Pharmaceuticals — Marketing Organization
- Dec 30, 2016
Micro Labs Ltd India — Marketing Organization
- Nov 1, 2019
RedHill Biopharma — NDA Secondary Org
2020s
- Oct 25, 2024
Iterum Therapeutics — NDA Secondary Org
Indications
Approved for
Studied for
- Abdomen, Acute · Phase 3
- Abdominal Abscess · Phase 3
- Abdominal Pain · Phase 4
- Abscess · Phase 3
- Acne Vulgaris · Phase 3
- Aggressive Periodontitis · Phase 4
- Amputation, Surgical · Phase 4
- Anemia, Iron-Deficiency · Phase 4
- Anemia, Sickle Cell · Phase 3
- Antibiotic Prophylaxis · Phase 3
- Anticoagulants · Phase 4
- Appendiceal Neoplasms · Phase 2
- Appendicitis · Phase 4
- Arrhythmias, Cardiac · Phase 3
- Asthma · Phase 2
- Astrocytoma · Phase 1
- Atrial Fibrillation · Phase 4
- Atrial Flutter · Phase 4
- Autoimmune Diseases · Phase 4
- Back Pain · Phase 4
- Bacteremia · Phase 4
- Bacterial Infections · Phase 4
- Biomarkers · Early Phase 1
- Bone Marrow Cells · Phase 1
- Borrelia Infections · Phase 4
- Brain Injuries, Traumatic · Phase 1/Phase 2
- Brain Neoplasms · Phase 3
- Breast Neoplasms · Phase 4
- Bronchitis · Phase 3
- Bronchitis, Chronic · Phase 4
- Bronchopulmonary Dysplasia · Phase 2
- Burns · Phase 2
- Cellulitis · Phase 4
- Central Serous Chorioretinopathy · Phase 1/Phase 2
- Cerebral Intraventricular Hemorrhage · Phase 2
- Child · Phase 3
- Chlamydia · Phase 2
- Cholecystitis, Acute · Phase 4
- Cholelithiasis · Phase 4
- Chondrocalcinosis · Early Phase 1
- Chorioamnionitis · Phase 2/Phase 3
- Chronic Periodontitis · Phase 4
- Cleft Palate · Phase 2
- Colitis, Ulcerative · Phase 4
- Communicable Diseases · Phase 3
- Community-Acquired Infections · Phase 4
- Congenital Hyperinsulinism · Phase 2
- Crohn Disease · Phase 4
- Cross Infection · Phase 3
- Cystectomy · Phase 3
- Cytomegalovirus Infections · Phase 1
- Cytomegalovirus Retinitis · Phase 4
- Dental Implants · Phase 4
- Dental Pulp Exposure · Phase 1/Phase 2
- Diabetes Mellitus · Phase 3
- Diabetic Foot · Phase 4
- Diarrhea · Phase 4
- Disease Eradication · Phase 4
- Diverticulitis · Phase 4
- Drug Interactions · Phase 1
- Drug-Related Side Effects and Adverse Reactions · Phase 3
- Drug Resistance, Bacterial · Phase 4
- Drug Resistance, Microbial · Phase 3
- Drugs, Generic · Phase 4
- Duodenal Ulcer · Phase 4
- Dyspepsia · Phase 4
- Dystonia · Phase 1
- Embolism · Phase 4
- Endocarditis · Phase 4
- Endometrium · Phase 2/Phase 3
- Endoscopy · Phase 3
- Enterobacteriaceae Infections · Phase 3
- Enterocolitis, Necrotizing · Phase 2
- Epilepsy · Phase 4
- Erysipelas · Phase 4
- Erythema · Phase 4
- Erythema Chronicum Migrans · Phase 4
- Family · Phase 3
- Fasting · Phase 1
- Fatty Liver · Phase 2
- Fever · Phase 4
- Fibrosis · Phase 4
- Focal Infection, Dental · Phase 4
- Gastritis · Phase 4
- Gastritis, Atrophic · Phase 4
- Gastroesophageal Reflux · Phase 4
- General Surgery · Phase 3
- Glioblastoma · Phase 1
- Gram-Negative Bacterial Infections · Phase 2
- Gram-Positive Bacterial Infections · Phase 2
- Head and Neck Neoplasms · Phase 2/Phase 3
- Healthy Volunteers · Phase 4
- Heart Failure, Systolic · Phase 2
- Helicobacter · Phase 4
- Helicobacter Infections · Phase 4
- Helicobacter pylori · Phase 4
- Hematologic Diseases · Phase 3
- Hemodialysis, Home · Phase 3
- Hemoglobinopathies · Phase 3
- Hemorrhage · Phase 4
- Hepatitis, Alcoholic · Phase 3
- HIV · Phase 3
- HIV Infections · Phase 4
- Hyperuricemia · Phase 2
- Hypothermia · Phase 3
- Ileum · Phase 2
- Ileus · Phase 3
- Infant · Phase 4
- Infant, Newborn · Phase 3
- Infant, Premature · Phase 4
- Infections · Phase 4
- Influenza A virus · Phase 1
- Influenza, Human · Phase 4
- Insulin Resistance · Phase 2
- Intestinal Diseases · Phase 3
- Intestinal Neoplasms · Phase 4
- Intestinal Perforation · Phase 3
- Intestinal Polyps · Phase 4
- Intraabdominal Infections · Phase 4
- Kidney Diseases · Phase 3
- Leukomalacia, Periventricular · Phase 2
- Liver Diseases · Phase 2
- Liver Diseases, Alcoholic · Phase 3
- Low Back Pain · Phase 3
- Lung Abscess · Phase 3
- Lung Diseases · Phase 2
- Lyme Disease · Phase 4
- Lymphoma · Phase 3
- Lymphoma, Large B-Cell, Diffuse · Phase 2
- Lymphoma, Non-Hodgkin · Phase 3
- Magnetic Resonance Imaging · Phase 3
- Malaria, Falciparum · Phase 3
- Malnutrition · Phase 3
- Meningitis · Phase 4
- Mental Disorders · Phase 4
- Motor Activity · Phase 3
- Neonatal Sepsis · Phase 3
- Neoplasms · Phase 3
- Neoplasms, Second Primary · Phase 3
- Nephrolithiasis · Phase 4
- Neurodevelopmental Disorders · Phase 2
- Neutropenia · Phase 3
- Non-alcoholic Fatty Liver Disease · Phase 2
- Obesity · Phase 2
- Obesity, Morbid · Phase 1
- Obsessive-Compulsive Disorder · Phase 4
- Osteomyelitis · Early Phase 1
- Otitis Media · Phase 4
- Otitis Media, Suppurative · Phase 3
- Out-of-Hospital Cardiac Arrest · Phase 4
- Oxidative Stress · Phase 1
- Pain · Phase 4
- Pancreatic Neoplasms · Phase 1
- Parkinson Disease · Phase 3
- Penicillins · Phase 3
- Peptic Ulcer · Phase 4
- Peri-Implantitis · Phase 4
- Periodontal Diseases · Phase 4
- Periodontitis · Phase 4
- Peritonitis · Phase 3
- Pharmacokinetics · Phase 1
- Pharyngitis · Phase 3
- Physiology · Phase 1
- Pneumonia · Phase 4
- Pneumonia, Aspiration · Phase 3
- Pneumonia, Bacterial · Phase 3
- Pneumonia, Staphylococcal · Phase 3
- Pneumonia, Ventilator-Associated · Phase 4
- Postoperative Complications · Phase 4
- Pre-Exposure Prophylaxis · Early Phase 1
- Prehypertension · Phase 2
- Prostatic Neoplasms · Phase 1
- Pseudomyxoma Peritonei · Phase 2
- Psoriasis · Phase 2
- Pulmonary Disease, Chronic Obstructive · Phase 4
- Pulmonary Embolism · Phase 4
- Purpura · Phase 4
- Purpura, Thrombocytopenic, Idiopathic · Phase 4
- Pyelonephritis · Phase 3
- Renal Insufficiency, Chronic · Phase 3
- Respiratory Tract Infections · Phase 4
- Rupture · Phase 3
- Sepsis · Phase 3
- Sinusitis · Phase 4
- Skin Diseases, Bacterial · Phase 4
- Skin Diseases, Infectious · Phase 4
- Sleep Apnea, Obstructive · Phase 4
- Smoking · Phase 4
- Snake Bites · Phase 4
- Soft Tissue Infections · Phase 4
- Squamous Cell Carcinoma of Head and Neck · Phase 3
- Stomach Diseases · Phase 4
- Stomach Neoplasms · Phase 4
- Stomach Ulcer · Phase 3
- Streptococcal Infections · Phase 4
- Streptococcus · Phase 2
- Stroke · Phase 4
- Surgery, Oral · Phase 3
- Surgical Wound Infection · Phase 4
- Syphilis · Phase 4
- Tic Disorders · Phase 4
- Tonsillitis · Phase 4
- Tooth Abnormalities · Early Phase 1
- Tooth Socket · Phase 4
- Treponema · Phase 3
- Tropical Medicine · Phase 3
- Tuberculosis · Phase 1
- Tuberculosis, Pulmonary · Phase 2
- Ulcer · Phase 4
- Urinary Bladder, Neurogenic · Phase 4
- Urinary Tract Infections · Phase 4
- Venous Thrombosis · Phase 4
- Vesico-Ureteral Reflux · Phase 3
- Wound Infection · Phase 4
- Yaws · Phase 4
Mechanism of action
- Bacterial penicillin-binding proteinINHIBITOR
Bacterial penicillin-binding protein inhibitor
- D-alanyl-D-alanine carboxypeptidase DacB (dacB) ↗
- Peptidoglycan D,D-transpeptidase FtsI (ftsI) ↗
- Penicillin-binding protein 1A (mrcA) ↗
- Penicillin-binding protein 1B (mrcB) ↗
- D-alanyl-D-alanine carboxypeptidase DacA (dacA) ↗
- Peptidoglycan D,D-transpeptidase MrdA (mrdA) ↗
- D-alanyl-D-alanine carboxypeptidase DacC (dacC) ↗
- Unspecified targetOTHER
Unknown
- Solute carrier family 22 member 6INHIBITOR
SLC22A6 inhibitor
- Solute carrier family 22 member 11INHIBITOR
SLC22A11 inhibitor
- Solute carrier family 22 member 8INHIBITOR
SLC22A8 inhibitor
Combination products
probampacin
with probenecid
Also known as polycillin-prb, principen w/ probeneci
unasyn
with sulbactam
Also known as ampicillin and sulbactam
Approval history
- approvedFeb 6, 1947
Chemistry & pharmacology
Loading structure…
SMILES
CC1(C)S[C@@H]2[C@H](NC(=O)Cc3ccccc3)C(=O)N2[C@H]1C(=O)[O-].[Na+]- Mol. weight
- 356.38 g/mol
- Lipinski Ro5
- Pass
- Rule of 3
- No
- Chirality
- Single Stereoisomer
- Inorganic
- No
- Polymer
- No
- Delivery
- Parenteral
- Availability
- Prescription Only
Oral
No
Parenteral
Yes
Topical
No
Sources
- WikipediaProcaine benzylpenicillin ↗
- ChEMBLCHEMBL453388 ↗
- ChEMBLCHEMBL29 ↗
- ChEMBLCHEMBL174 ↗
- ChEMBLCHEMBL1628385 ↗
- ChEMBLCHEMBL1396177 ↗
- ChEMBLCHEMBL1223 ↗
- ChEMBLCHEMBL1200936 ↗
- ChEMBLCHEMBL1200758 ↗
- ChEMBLCHEMBL1200651 ↗
- ChEMBLCHEMBL1126 ↗
- NCATSQ42T66VG0C ↗
- NCATSPO572Z7917 ↗
- ChEMBLCHEMBL897 ↗
- NCATS7C782967RD ↗
Also known as
- (2s,5r,6r)-3,3-dimethyl-7-oxo-6-(phenylacetamido)-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid
- (2s,5r,6r)-3,3-dimethyl-7-oxo-6-(phenylacetamido)-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid
- (2s,5r,6r)-6-{[(2r)-2-amino-2-(4-hydroxyphenyl)acetyl]amino}-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid
- (2s,5r,6r)-6-{[(2r)-2-amino-2-(4-hydroxyphenyl)acetyl]amino}-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid
- (2s,6r)-6-{[(2r)-2-amino-2-phenylethanoyl]amino}-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid
- (2s,6r)-6-{[(2r)-2-amino-2-phenylethanoyl]amino}-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid
- 4-(di-n-propylsulfamoyl)benzoesaeure
- 4-(di-n-propylsulfamoyl)benzoesaeure
- 4-((dipropylamino)sulfonyl)benzoic acid
- 4-((dipropylamino)sulfonyl)benzoic acid
- 4-(n,n-dipropylsulfamoyl)benzoesaeure
- 4-(n,n-dipropylsulfamoyl)benzoesaeure
- 6-(2-phenylacetamido)penicillanic acid
- 6-(2-phenylacetamido)penicillanic acid
- 6-(d-(2-amino-2-phenylacetamido))-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo(3.2.0)heptane-2-carboxylic acid
- 6-(d-(2-amino-2-phenylacetamido))-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo(3.2.0)heptane-2-carboxylic acid
- 6-(p-hydroxy-α-aminophenylacetamido)penicillanic acid
- 6-(p-hydroxy-α-aminophenylacetamido)penicillanic acid
- abpc
- abpc
- alpha-aminobenzylpenicillin
- alpha-aminobenzylpenicillin
- amcill
- amcill
- amfipen
- amfipen
- aminobenzylpenicillin
- aminobenzylpenicillin
- aminobenzylpenicillin
- amp equine
- ampicilina
- ampicilina
- ampicillin
- ampicillin
- ampicillin
- ampicillin
- ampicillin
- ampicillin
- ampicillin
- ampicillin
- ampicillin acid
- ampicillin acid
- ampicillin/ampicillin trihydrate
- ampicillin/ampicillin trihydrate
- ampicillin/ampicillin trihydrate
- ampicillin anhydrous
- ampicillin anhydrous
- ampicillin (anhydrous)
- ampicillin (anhydrous)
- ampicillin, anhydrous
- ampicillin, anhydrous
- ampicilline
- ampicilline
- ampicillin hydrate
- ampicillin hydrate
- ampicillin hydrate
- ampicillin hydrate
- ampicillin hydrate
- ampicillin sodium
- ampicillin sodium
- ampicillin sodium
- ampicillin sodium
- ampicillin trihydrate
- ampicillinum
- ampicillinum
- ampilar
- anhydrous ampicillin
- anhydrous ampicillin
- ap
- ap
- ax
- ax
- ay-6108
- ay-6108
- bencilpenicilina
- bencilpenicilina
- benecid
- benemid
- benemid
- benemid
- bensylpenicillin
- bensylpenicillin
- benuryl
- benuryl
- benzathine benzylpenicillin
- benzathine benzylpenicillin
- benzathine benzylpenicillin
- benzathine benzylpenicillin
- benzathine benzylpenicillin
- benzathine benzylpenicillin
- benzathine penicillin
- benzathine penicillin
- benzathine penicillin
- benzathine penicillin
- benzathine penicillin g
- benzathine penicillin g
- benzathine phenoxymethylpenicillin
- benzathine phenoxymethylpenicillin
- benzathine phenoxymethylpenicillin
- benzethacil
- benzyl benicillin
- benzyl benicillin
- benzylpenicillin
- benzylpenicillin
- benzylpenicillin
- benzylpenicillin
- benzylpenicillin
- benzylpenicillin
- benzylpenicillin
- benzyl penicillin
- benzyl penicillin
- benzylpenicillin benzathine
- benzylpenicillin benzathine
- benzylpénicilline
- benzylpénicilline
- benzylpenicillin g
- benzylpenicillinic acid
- benzylpenicillinic acid
- benzylpenicillinic acid
- benzylpenicillin potassium
- benzylpenicillin potassium
- benzylpenicillin potassium
- benzylpenicillin procaine
- benzylpenicillin procaine
- benzylpenicillinum
- benzylpenicillinum
- bicilin
- bicillin
- bicillin
- bicillin
- bicillin l-a
- bicillin l-a
- bicillin l-a tubex
- britcin
- brl-1341
- brl-1341
- cilicaine syringe
- cilloral
- cilloral
- crystapen g
- crysticillin
- crysticillin
- d-(−)-6-(α-aminophenylacetamido)penicillanic acid
- d-(−)-6-(α-aminophenylacetamido)penicillanic acid
- d-(−)-ampicillin
- d-(−)-ampicillin
- depocillin
- depocillin
- duracillin
- duracillin
- duracillin a.s.
- duracillin a.s.
- e705
- e705
- e707
- e707
- e708
- e708
- extencilline
- extencilline
- free penicillin g
- free penicillin ii
- free penicillin ii
- liquapen
- liquapen
- omnipen
- omnipen
- omnipen-n
- omnipen-n
- p-50
- p-50
- pcg
- pcg
- p-(dipropylsulfamoyl)benzoic acid
- p-(dipropylsulfamoyl)benzoic acid
- penadur 6-3-3
- penbritin
- penbritin
- penbritin
- penbritin-s
- penbritin-s
- penicillin
- penicillin
- penicillin
- penicillin
- penicillin-2
- penicillin-2
- penicillin g
- penicillin g
- penicillin g
- penicillin g
- penicillin g
- penicillin g
- penicillin g
- penicillin g benzathine
- penicillin g benzathine
- penicillin g benzathine
- penicillin g benzathine
- penicillin g benzathine
- penicillin-g-benzathine
- penicillin-g-benzathine
- penicillin g potassium
- penicillin g potassium
- penicillin g potassium
- penicillin g potassium
- penicillin g procaine
- penicillin g procaine
- penicillin g procaine
- penicillin g procaine
- penicillin g procaine
- penicillin g procaine
- penicillin g procaine
- penicillin potassium g, crystalline
- penicillin potassium g, crystalline
- penicillin v benzathine
- penicillin v benzathine
- penicllin
- penidural
- penidural
- penidural la
- pentids
- pentids
- pentids '200'
- pentids '200'
- pentids '250'
- pentids '250'
- pentids '400'
- pentids '400'
- pentids '800'
- pentids '800'
- permapen
- permapen
- pfizerpen
- pfizerpen
- pfizerpen-a
- pfizerpen-a
- pfizerpen-as
- pfizerpen g
- pfizerpen g
- pg
- pg
- p-hydroxyampicillin
- p-hydroxyampicillin
- polycillin
- polycillin
- polycillin-n
- polycillin-n
- polycillin-prb
- polycillin-prb
- principen
- principen
- principen-n
- probalan
- probalan
- probampacin
- probampacin
- probampicin
- probecid
- probecid
- probecid
- probenacid
- probenacid
- probenecid
- probenecid
- probenecid
- probenecid
- probenecid
- probenecid
- probenecid
- probenecid
- probenecid
- probenecid
- probenecid
- probenecida
- probenecida
- probenecid acid
- probenecid acid
- probenecid acid
- probenecide
- probenecide
- probenecidum
- probenecidum
- probenicid
- probenicid
- procaine benzylpenicillin
- procaine benzylpenicillin
- procaine benzylpenicillin
- procaine benzylpenicillin
- procaine benzylpenicillin
- procaine benzylpenicillin
- procaine penicillin
- procaine penicillin
- procaine penicillin
- procaine penicillin g
- procaine penicillin g
- retarpen
- scotcil
- scotcil
- sultamicillin
- sultamicillin
- totacillin
- totacillin
- totacillin-n
- totacillin-n
- vidopen
- vidopen
- wycillin
- wycillin
- α-amino-p-hydroxybenzylpenicillin
- α-amino-p-hydroxybenzylpenicillin
Clinical trials
| NCT ID | Phase | Start date | Sponsor(s) |
|---|---|---|---|
| NCT06025344 | Phase 1 | Dec 31, 2023 | TrippBio, Inc. |
| NCT05365451 | Early Phase 1 (Phase 1) | Apr 11, 2022 | National Institutes of Health (NIH), Washington State University |
| NCT04506801 | N/A | Sep 25, 2018 | University of Zagreb |
| NCT03692819 | N/A | May 2, 2018 | Sao Paulo State University |
| NCT03572777 | N/A | Apr 15, 2018 | University of Split |
| NCT03490123 | Phase 4 | Apr 1, 2018 | Government of Papua New Guinea, Harvard University, Lihir Medical Centre, University of Barcelona, University of Masarykova, World Health Organization |
| NCT03431337 | Phase 4 | Feb 26, 2018 | Albany Medical College |
| NCT03174184 | Phase 2 | Sep 1, 2017 | Johns Hopkins University |
| NCT03172676 | Phase 4 | Jul 1, 2017 | Assiut University |
| NCT02381470 | Phase 2 | Jul 1, 2017 | National University of Singapore |
| NCT03202511 | Early Phase 1 (Phase 1) | Jun 23, 2017 | Indiana University |
| NCT03031210 | Phase 2/Phase 3 (Phase 3) | Jun 11, 2017 | Sainte-Justine Hospital, University of Montreal |
| NCT03174236 | Phase 3 | Jun 5, 2017 | Coast General Hospital, Mombasa, Kenya, Kenya Medical Research Institute, Mbale Regional Referral Hospital, Swansea University, University of London, University of Nairobi, University of Oxford |
| NCT03177629 | Phase 3 | May 23, 2017 | Hallym University, Seoul National University |
| NCT03108690 | Phase 4 | May 1, 2017 | University of Copenhagen |
| NCT02988089 | Phase 4 | Apr 20, 2017 | Binzhou Medical University, Liaocheng People's Hospital, People's Liberation Army of China, Shandong Provincial Hospital, Shandong University |
| NCT03050307 | Phase 3 | Apr 17, 2017 | Takeda |
| NCT03105986 | Phase 1 | Apr 10, 2017 | Johnson and Johnson |
| NCT03050359 | Phase 3 | Apr 4, 2017 | Takeda |
| NCT02783404 | Phase 4 | Feb 27, 2017 | Santiago de Compostela University, University of Santiago, University of Santiago de Compostela |
Showing 20 of 448 trials
Page 1 / 23
Organizations
Research & Development (465)
| Organization | Org type | Trials | As lead sponsor | Phases | Earliest year |
|---|---|---|---|---|---|
| National Institute of Allergy and Infectious Diseases (NIAID) | Government | 16 | 11 | 5 | 1999 |
| National Taiwan University | Academic/Hospital | 13 | 11 | 3 | 1996 |
| GlaxoSmithKline | For profit | 12 | 6 | 4 | 1998 |
| Kaohsiung Medical University | Academic/Hospital | 11 | 2 | 3 | 2007 |
| Pfizer | For profit | 10 | 10 | 3 | 2002 |
| Taichung Veterans General Hospital | Academic/Hospital | 10 | 9 | 3 | 2007 |
| World Health Organization | Government | 10 | 0 | 5 | 1998 |
| Jiao Tong University | Academic/Hospital | 9 | 9 | 2 | 2011 |
| Bayer | For profit | 8 | 7 | 2 | 2001 |
| Johnson and Johnson | For profit | 8 | 7 | 2 | 2001 |
| Seoul National University | Academic/Hospital | 8 | 8 | 3 | 2003 |
| University of Paris | Academic/Hospital | 8 | 6 | 3 | 2003 |
| People's Liberation Army of China | Government | 7 | 4 | 2 | 2010 |
| Aga Khan University | Academic/Hospital | 6 | 6 | 3 | 2003 |
| Government of Taiwan | Government | 6 | 2 | 3 | 1996 |
| Harvard University | Academic/Hospital | 6 | 4 | 2 | 2011 |
| University of Pittsburgh | Academic/Hospital | 6 | 6 | 3 | 2006 |
| Baylor University | Academic/Hospital | 5 | 1 | 3 | 2006 |
| Duke University | Academic/Hospital | 5 | 1 | 3 | 1983 |
| Ranbaxy | For profit | 5 | 5 | 1 | 2002 |
465 organizations
Page 1 / 24
Marketing (89)
| Organization | Org type | Relationship | Date |
|---|---|---|---|
| ACP Nimble | For profit | MKTG | Oct 10, 1973 |
| ACS Dobfar | For profit | MKTG | Dec 22, 2009 |
| ACS Dobfar | For profit | SYN | Apr 3, 2013 |
| American Antibiotics | For profit | MKTG | Jan 21, 1974 |
| American Cyanamid | For profit | MKTG | Sep 6, 1979 |
| American Home Products | For profit | NDA2 | Nov 22, 1951 |
| American Home Products | For profit | MKTG | Dec 17, 1965 |
| Ani Pharmaceuticals | For profit | MKTG | Jun 12, 1978 |
| Ani Pharmaceuticals | For profit | SYN | Jun 12, 1978 |
| Antibiotice | For profit | MKTG | Dec 28, 2009 |
| Apotex | For profit | MKTG | Oct 20, 2008 |
| Apothecon | For profit | MKTG | Mar 3, 1971 |
| Apothecon | For profit | NDA2 | — |
| Astral | For profit | MKTG | Jan 8, 2016 |
| Atral | For profit | MKTG | Aug 7, 1985 |
| Aurobindo Pharma | For profit | MKTG | Nov 9, 2005 |
| Aurobindo Pharma | For profit | SYN | Aug 17, 2010 |
| Aurobindo Pharma | For profit | SYN | Jan 17, 2007 |
| Aurobindo Pharma | For profit | SYN | Jan 13, 1976 |
| Baxalta | For profit | NDA2 | Jun 25, 1990 |
| Baxter | For profit | NDA2 | Jun 25, 1990 |
| Beecham | For profit | MKTG | Mar 11, 1976 |
| Belcher Pharmaceuticals | For profit | MKTG | Jan 21, 1974 |
| Bristol-Myers | For profit | NDA2 | — |
| Bristol-Myers Squibb | For profit | MKTG | Mar 3, 1971 |
| Casper Pharma LLC | For profit | NDA2 | Dec 16, 1952 |
| Chartwell Pharmaceuticals | For profit | MKTG | Nov 9, 1971 |
| Consolidated Midland | For profit | MKTG | — |
| Cosette | For profit | MKTG | Oct 10, 1973 |
| Cumberland Pharmaceuticals | For profit | MKTG | Feb 8, 2011 |
| DAVA Pharmaceuticals | For profit | MKTG | Feb 25, 1988 |
| Eli Lilly | For profit | MKTG | — |
| Endo Pharmaceuticals | For profit | MKTG | Feb 10, 1989 |
| Eugia Pharma | For profit | MKTG | Aug 17, 2010 |
| G & W Laboratories Inc. | For profit | MKTG | Oct 10, 1973 |
| GlaxoSmithKline | For profit | MKTG | May 7, 1970 |
| Hanford Pharmaceuticals | For profit | MKTG | Apr 15, 1993 |
| Heritage Pharma | For profit | MKTG | Nov 9, 1971 |
| Hikma | For profit | MKTG | Mar 29, 2006 |
| Hikma | For profit | SYN | Jan 25, 2005 |
| Hospira | For profit | MKTG | Dec 21, 2011 |
| Hospira | For profit | SYN | Sep 4, 2015 |
| Hq Speciality Pharma | For profit | MKTG | Apr 15, 1993 |
| Impax Laboratories | For profit | MKTG | — |
| International Medication | For profit | MKTG | — |
| Istituto Bio Ita Spa | For profit | MKTG | May 12, 1987 |
| Iterum Therapeutics | For profit | NDA2 | Oct 25, 2024 |
| King Pharmaceuticals | For profit | NDA2 | Apr 26, 1948 |
| King Pharmaceuticals | For profit | MKTG | Apr 26, 1948 |
| Lannett Company, Inc. | For profit | MKTG | Jul 29, 1976 |
| Lederle | For profit | MKTG | Sep 6, 1979 |
| Medimetriks | For profit | MKTG | Jun 29, 2007 |
| Merck | For profit | NDA | Apr 26, 1951 |
| Micro Labs Ltd India | For profit | MKTG | Dec 30, 2016 |
| Mustafa Nevzat Pharmaceuticals | For profit | MKTG | Jun 29, 2007 |
| Mylan | For profit | MKTG | Jan 13, 1976 |
| Mylan | For profit | SYN | Apr 7, 2014 |
| Neopharma | For profit | NDA2 | Aug 2, 1979 |
| Novartis | For profit | MKTG | Aug 30, 2002 |
| Novast Labs | For profit | MKTG | May 13, 2008 |
| Parke-Davis | For profit | MKTG | — |
| Pfizer | For profit | MKTG | Feb 6, 1947 |
| Pfizer | For profit | NDA2 | Dec 31, 1986 |
| Pharmaceutical Associates | For profit | MKTG | Jun 29, 2007 |
| Pragma Therapeutics | For profit | NDA2 | Jan 23, 2008 |
| Puracap Pharmaceutical | For profit | MKTG | May 4, 1976 |
| Ranbaxy | For profit | MKTG | Aug 11, 2003 |
| RedHill Biopharma | For profit | SYN | Nov 1, 2019 |
| RedHill Biopharma | For profit | NDA2 | Nov 1, 2019 |
| Rising Pharmaceuticals | For profit | MKTG | Oct 7, 2016 |
| Rising Pharmaceuticals | For profit | SYN | Oct 7, 2016 |
| STERISCIENCE | For profit | MKTG | Apr 7, 2014 |
| STERISCIENCE | For profit | SYN | Apr 7, 2014 |
| Sagent Pharmaceuticals, Inc. | For profit | SYN | Oct 20, 2015 |
| Sagent Pharmaceuticals, Inc. | For profit | MKTG | Oct 20, 2015 |
| Sandoz | For profit | MKTG | Mar 3, 1971 |
| Sandoz | For profit | SYN | Nov 21, 2002 |
| Strides Pharma Science | For profit | MKTG | Feb 25, 1988 |
| Sun Pharmaceuticals | For profit | MKTG | Apr 8, 1999 |
| Takeda | For profit | MKTG | Dec 2, 1997 |
| Teva | For profit | SYN | May 9, 1984 |
| Teva | For profit | MKTG | May 27, 1964 |
| Teva | For profit | SYN | Oct 29, 2002 |
| Teva | For profit | SYN | Mar 2, 1977 |
| Vitarine | For profit | MKTG | — |
| Watson Pharmaceuticals | For profit | MKTG | Apr 7, 1975 |
| Watson Pharmaceuticals | For profit | SYN | Sep 13, 1988 |
| West-Ward Pharmaceutical | For profit | MKTG | Jun 24, 1986 |
| Wockhardt | For profit | MKTG | Jun 18, 2007 |