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cefazolin

Trade name: ancef

Small moleculeapproved

Approved

Oct 4, 1973

Cefazolin is a semisynthetic cephalosporin analog with broad-spectrum antibiotic action due to inhibition of bacterial cell wall synthesis. By binding to specific penicillin-binding proteins (PBPs) located inside the bacterial cell wall, cefazolin inhibits the third and last stage of bacterial cell wall synthesis. Cell lysis is then mediated by bacterial cell wall autolytic enzymes such as autolysins. Cefazolin is used to treat bacterial infections of the skin, moderately severe bacterial infections involving the lung, bone, joint, stomach, blood, and urinary tract. It is clinically effective against infections caused by staphylococci and streptococci species of Gram positive bacteria. This drug also can be used for perioperative prophylaxis. — NCATS

Clinical trial activity

159 trials · 172 clinical orgs · 26 marketing orgs

Phase 1
16
Phase 2
35
Phase 3
27
Phase 4
55

Earliest trial started Dec 1, 2001 (NCT00035269)

Timeline

1970s

  1. Jun 1, 1971

    Smith, Kline & French — First NDA Organization

  2. Jun 1, 1971

    Smith, Kline & French — NDA Organization

  3. Oct 4, 1971

    GlaxoSmithKline — NDA Secondary Org

  4. Oct 4, 1973

    Earliest FDA Approval

  5. Nov 2, 1973

    ACS Dobfar — Marketing Organization

1980s

  1. Sep 10, 1985

    Eli Lilly — Marketing Organization

  2. Jan 12, 1988

    West-Ward Pharmaceutical — Marketing Organization

  3. Dec 9, 1988

    Sandoz — Marketing Organization

  4. Mar 14, 1989

    Teva — Marketing Organization

  5. Dec 29, 1989

    Watson Pharmaceuticals — Marketing Organization

  6. Dec 29, 1989

    Dr. Reddy's Laboratories — Marketing Organization

1990s

  1. Mar 28, 1991

    Baxalta — Marketing Organization

  2. Mar 28, 1991

    Baxter — Marketing Organization

  3. Dec 27, 1991

    Steri Pharma — Marketing Organization

  4. Dec 27, 1991

    facta — Marketing Organization

  5. Oct 31, 1993

    GlaxoSmithKline — Marketing Organization

  6. Mar 18, 1998

    Fresenius — Marketing Organization

2000s

  1. Jul 27, 2000

    B. Braun — NDA Secondary Org

  2. Jan 1, 2001

    Pfizer — Earliest Phase 3 Sponsor(trial)

  3. Sep 18, 2001

    Hikma — Marketing Organization

  4. Jan 1, 2003

    Earliest Phase 2 Sponsor(trial)

  5. Apr 21, 2005

    Hospira — Marketing Organization

  6. Nov 29, 2006

    Samson Medical — Marketing Organization

  7. May 9, 2007

    Novartis — Marketing Organization

  8. Jan 1, 2008

    Earliest Phase 1 Sponsor(trial)

  9. Aug 8, 2008

    Aurobindo Pharma — Marketing Organization

  10. Mar 18, 2009

    Cephazone Pharma — Marketing Organization

2010s

  1. Aug 7, 2015

    Baxalta — NDA Secondary Org

  2. Dec 28, 2015

    Qilu Pharmaceutical Co., Ltd. — Marketing Organization

  3. Feb 3, 2016

    Pfizer — Marketing Organization

2020s

  1. Oct 7, 2022

    Hikma — NDA Secondary Org

  2. May 8, 2023

    Hq Speciality Pharma — Marketing Organization

  3. May 8, 2023

    Hq Speciality Pharma — NDA Secondary Org

Indications

Approved for

Studied for

Mechanism of action

Approval history

  • approvedOct 4, 1973

Chemistry & pharmacology

Loading structure…

SMILES

Cc1nnc(SCC2=C(C(=O)O)N3C(=O)[C@@H](NC(=O)Cn4cnnn4)[C@H]3SC2)s1
Mol. weight
454.52 g/mol
Lipinski Ro5
1 violation(s)
Rule of 3
No
Chirality
Single Stereoisomer
Inorganic
No
Polymer
No
Delivery
Parenteral
Availability
Prescription Only

Oral

No

Parenteral

Yes

Topical

No

Sources

Also known as

  • 46083
  • (6r,7r)-3-{[(5-methyl-1,3,4-thiadiazol-2-yl)sulfanyl]methyl}-8-oxo-7-[(1h-tetrazol-1-ylacetyl)amino]-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid
  • (6r,7r)-3-{[(5-methyl-1,3,4-thiadiazol-2-yl)sulfanyl]methyl}-8-oxo-7-[(1h-tetrazol-1-ylacetyl)amino]-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid
  • ancef
  • ancef
  • ancef
  • ancef
  • cecefazolin
  • cefamezin
  • cefamezin
  • cefamezin
  • cefamezin
  • cefaprim
  • cefazil
  • cefazil
  • cefazolin
  • cefazolin
  • cefazolin
  • cefazolin
  • cefazolin
  • cefazolin
  • cefazolin
  • cefazolin
  • cefazolin
  • cefazolin
  • cefazolina
  • cefazolina
  • cefazoline
  • cefazoline
  • cefazoline
  • cefazoline
  • cefazolin sodium
  • cefazolin sodium
  • cefazolin sodium
  • cefazolin sodium
  • cefazolin sodium
  • cefazolin sodium salt
  • cefazolinum
  • cefazolinum
  • cephalozin
  • cephamezine
  • cephamezine
  • cephamezine
  • cephazolidin
  • cephazolidin
  • cephazolin
  • cephazolin
  • cephazolin
  • cephazolin
  • cephazolin
  • cephazoline
  • cephazoline
  • cephazoline
  • cez
  • cez
  • kefzol
  • kefzol
  • sk&f-41558
  • sk&f-41558
  • zolicef
  • zolicef

Clinical trials

NCT IDPhaseStart dateSponsor(s)
NCT07267650N/AJan 1, 2026Turgutlu State Hospital
NCT07043855N/AAug 31, 2025University of Ulsan
NCT07067736N/AAug 1, 2025University of Strasbourg
NCT06920147Phase 4May 1, 2025University of Texas at Houston
NCT06567808Phase 4Dec 31, 2024Canadian Institutes of Health Research (CIHR), Hamilton Health Sciences Corporation
NCT06640491Phase 1/Phase 2 (Phase 2)Dec 1, 2024The University of Texas, Dallas
NCT06814223Phase 4Oct 28, 2024Western Galilee Hospital
NCT06510452N/AOct 1, 2024General Committee of Teaching Hospitals and Institutes, Egypt
NCT06189885N/AAug 1, 2024Chang Gung University
NCT06576154Phase 3Aug 1, 2024University of Aleppo
NCT06327113Phase 2May 17, 2024University of California, Los Angeles
NCT05852158Phase 4Jan 31, 2024Government of Canada
NCT07111702N/AOct 1, 2023Sana'a University
NCT06055712Phase 4Sep 11, 2023St. Louis University
NCT06355115Phase 2Sep 1, 2023Saiful Anwar Hospital, University of Brawijaya
NCT06005168Phase 4Mar 8, 2023Department of Health and Human Services, University of Michigan
NCT05655091Phase 2Feb 28, 2023University of Basel
NCT05304871N/AJan 31, 2023Dartmouth University
NCT05647993N/ADec 14, 2022Rajavithi Hospital, Bangkok
NCT05447559Phase 4Sep 1, 2022Monash University
Showing 20 of 159 trials
Page 1 / 8

Organizations

Research & Development (172)

OrganizationOrg typeTrialsAs lead sponsorPhasesEarliest year
McMaster UniversityAcademic/Hospital5532009
University of British ColumbiaAcademic/Hospital5342004
B. BraunFor profit4432009
Duke UniversityAcademic/Hospital4422013
Tel Aviv UniversityAcademic/Hospital4332014
Emek Medical CenterAcademic/Hospital3322006
Isfahan UniversityAcademic/Hospital3322004
The Physicians' Services Incorporated FoundationAcademic/Hospital3032003
University of California, IrvineAcademic/Hospital3122008
University of MissouriAcademic/Hospital3322008
University of TorontoAcademic/Hospital3122003
West Virginia UniversityAcademic/Hospital3212007
Ankara Yildirim Beyazıt UniversityAcademic/Hospital2212008
Assistance Publique - Hôpitaux de ParisAcademic/Hospital2122005
Canadian Institutes of Health Research (CIHR)Academic/Hospital2022013
Chinese University of Hong KongAcademic/Hospital2212016
Chulalongkorn UniversityAcademic/Hospital2222012
Emory UniversityAcademic/Hospital2212016
Forest LaboratoriesFor profit2122011
Government of CanadaGovernment2122010
172 organizations
Page 1 / 9

Marketing (34)

OrganizationOrg typeRelationshipDate
ACS DobfarFor profitMKTGNov 2, 1973
AbraxisFor profitMKTG—
Aurobindo PharmaFor profitMKTGAug 8, 2008
B. BraunFor profitNDA2Jul 27, 2000
BaxaltaFor profitNDA2Aug 7, 2015
BaxaltaFor profitMKTGMar 28, 1991
BaxterFor profitNDA2—
BaxterFor profitMKTGMar 28, 1991
Bedford PharmaceuticalsFor profitMKTG—
Cephazone PharmaFor profitMKTGMar 18, 2009
Dr. Reddy's LaboratoriesFor profitMKTGDec 29, 1989
Eli LillyFor profitMKTGSep 10, 1985
FreseniusFor profitMKTGMar 18, 1998
GlaxoSmithKlineFor profitNDA2Oct 4, 1971
GlaxoSmithKlineFor profitMKTGOct 31, 1993
HikmaFor profitSYNJan 12, 1988
HikmaFor profitMKTGSep 18, 2001
HikmaFor profitNDA2Oct 7, 2022
HospiraFor profitSYNFeb 3, 2016
HospiraFor profitMKTGApr 21, 2005
Hq Speciality PharmaFor profitMKTGMay 8, 2023
Hq Speciality PharmaFor profitNDA2May 8, 2023
NovartisFor profitMKTGMay 9, 2007
PfizerFor profitMKTGFeb 3, 2016
Qilu Pharmaceutical Co., Ltd.For profitMKTGDec 28, 2015
Qilu Pharmaceutical Co., Ltd.For profitSYNDec 28, 2015
Samson MedicalFor profitMKTGNov 29, 2006
SandozFor profitMKTGDec 9, 1988
Smith, Kline & FrenchFor profitNDAJun 1, 1971
Steri PharmaFor profitMKTGDec 27, 1991
TevaFor profitMKTGMar 14, 1989
Watson PharmaceuticalsFor profitMKTGDec 29, 1989
West-Ward PharmaceuticalFor profitMKTGJan 12, 1988
factaFor profitMKTGDec 27, 1991