l-alanine
Small moleculeexperimental
Alanine is a non-essential aminoacid encoded by GCU, GCC, GCA, and GCG codons. Besides being a building block of proteins, alanine plays a key role in glucose-alanine cycle. Alanine is medically used as a dietary supplement for conditions such as fructose intolerance, muscle atrophy, low birth weight. — NCATS
Clinical trial activity
14 trials · 22 clinical orgs · 0 marketing orgs
Phase 1
1
Phase 2
3
Phase 3
0
Phase 4
0
Earliest trial started Oct 1, 1999 (NCT00005889)
Timeline
Indications
Approved for
Mechanism of action
- alanineSupplementation
alanine supplementation
Chemistry & pharmacology
Loading structure…
SMILES
C[C@H](N)C(O)=O- Mol. weight
- 89.0932 g/mol
- Lipinski Ro5
- Pass
- Rule of 3
- No
- Chirality
- Racemic Mixture
- Inorganic
- No
- Polymer
- No
Oral
No
Parenteral
No
Topical
No
Sources
- WikipediaAlanine ↗
- NCATSOF5P57N2ZX ↗
- ChEMBLCHEMBL279597 ↗
- ChEMBLCHEMBL12198 ↗
Also known as
- (2s)-2-aminopropanoic acid
- (2s)-2-aminopropanoic acid
- alanine
- alanine
- alanine
- alanine
- alanine
- alanine
- alanine
- alanine
- e639
- e639
- l-2-aminopropionic acid
- l-2-aminopropionic acid
- l-alanin
- l-alanin
- l-alanine
- l-alanine
- l-alanine
- l-alanine
- l-alanine
- l-alpha-alanine
- l-alpha-alanine
- l-α-alanine
- l-α-alanine
- (s)-2-aminopropanoic acid
- (s)-2-aminopropanoic acid
- (s)-alanine
- (s)-alanine
- (s)-alanine
Clinical trials
| NCT ID | Phase | Start date | Sponsor(s) |
|---|---|---|---|
| NCT01922167 | N/A | Nov 1, 2013 | McGill University |
| NCT01576003 | N/A | Apr 1, 2012 | Emmaus Medical, Emory University, National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), University of Cincinnati, University of Colorado, Denver, University of Michigan |
| NCT01496768 | N/A | Jan 1, 2012 | University of Sao Paulo |
| NCT01350427 | N/A | Aug 1, 2011 | University of Sao Paulo |
| NCT01239303 | N/A | Dec 1, 2010 | Maastricht University, Top Institute Food and Nutrition |
| NCT01051999 | Phase 2 | Feb 1, 2010 | Emmaus Medical, Emory University |
| NCT01288495 | N/A | Feb 1, 2009 | Augusta University |
| NCT00760383 | N/A | Jun 1, 2008 | National Institutes of Health (NIH), University of Oregon |
| NCT01185210 | Phase 2 | Sep 1, 2007 | Teikyo University, University of Iowa |
| NCT00780520 | N/A | Jun 1, 2007 | University of Copenhagen |
| NCT00075894 | Phase 1 | Mar 1, 2004 | Emory University, National Cancer Institute (NCI) |
| NCT00586885 | N/A | Feb 1, 2004 | Ajinomoto, Mayo Clinic |
| NCT00062283 | Phase 2 | Mar 1, 2003 | Cornell University, National Cancer Institute (NCI) |
| NCT00005889 | N/A | Oct 1, 1999 | Baylor University, National Center for Research Resources (NCRR) |
Showing 14 of 14 trials
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Organizations
Research & Development (22)
| Organization | Org type | Trials | As lead sponsor | Phases | Earliest year |
|---|---|---|---|---|---|
| Emory University | Academic/Hospital | 3 | 1 | 3 | 2004 |
| Emmaus Medical | For profit | 2 | 0 | 2 | 2010 |
| National Cancer Institute (NCI) | Government | 2 | 1 | 2 | 2003 |
| University of Sao Paulo | Academic/Hospital | 2 | 2 | 1 | 2011 |
| Ajinomoto | For profit | 1 | 0 | 1 | 2004 |
| Augusta University | Academic/Hospital | 1 | 1 | 1 | 2009 |
| Baylor University | Academic/Hospital | 1 | 0 | 1 | 1999 |
| Cornell University | Academic/Hospital | 1 | 1 | 1 | 2003 |
| Maastricht University | Academic/Hospital | 1 | 1 | 1 | 2010 |
| Mayo Clinic | Academic/Hospital | 1 | 1 | 1 | 2004 |
| McGill University | Academic/Hospital | 1 | 1 | 1 | 2013 |
| National Center for Research Resources (NCRR) | Government | 1 | 1 | 1 | 1999 |
| National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) | Government | 1 | 0 | 1 | 2012 |
| National Institutes of Health (NIH) | Government | 1 | 0 | 1 | 2008 |
| Teikyo University | Academic/Hospital | 1 | 0 | 1 | 2007 |
| Top Institute Food and Nutrition | Academic/Hospital | 1 | 0 | 1 | 2010 |
| University of Cincinnati | Academic/Hospital | 1 | 1 | 1 | 2012 |
| University of Colorado, Denver | Academic/Hospital | 1 | 0 | 1 | 2012 |
| University of Copenhagen | Academic/Hospital | 1 | 1 | 1 | 2007 |
| University of Iowa | Academic/Hospital | 1 | 1 | 1 | 2007 |
22 organizations
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