ringer's lactate
Small moleculeexperimental
Ringer's lactate solution (RL), also known as sodium lactate solution, Lactated Ringer's (LR), and Hartmann's solution, is a mixture of sodium chloride, sodium lactate, potassium chloride, and calcium chloride in water. It is used for replacing fluids and electrolytes in those who have low blood volume or low blood pressure. It may also be used to treat metabolic acidosis and to wash the eye following a chemical burn. It is given by intravenous infusion or applied to the affected area. — Wikipedia
Clinical trial activity
289 trials · 318 clinical orgs · 0 marketing orgs
Phase 1
26
Phase 2
70
Phase 3
44
Phase 4
65
Earliest trial started Mar 1, 2002 (NCT00529490)
Timeline
Indications
Approved for
Studied for
- Acid-Base Imbalance · Phase 4
- Acidosis · Phase 3
- Acidosis, Lactic · Phase 2
- Acute Kidney Injury · Phase 4
- Alcoholic Intoxication · Phase 4
- Analgesia · Phase 3
- Anesthesia · Phase 4
- Anesthesia, Epidural · Phase 4
- Anesthesia, Spinal · Phase 4
- Aneurysm · Early Phase 1
- Aortic Aneurysm, Thoracic · Phase 4
- Aortic Valve Disease · Phase 4
- Appendicitis · Phase 3
- Arthrocentesis · Phase 4
- Arthroplasty, Replacement, Hip · Phase 4
- Atherosclerosis · Phase 1/Phase 2
- Blood Coagulation · Phase 4
- Blood Loss, Surgical · Phase 4
- Blood Viscosity · Phase 4
- Body Fluids · Phase 4
- Brain Injuries, Traumatic · Phase 3
- Brain Neoplasms · Phase 2
- Burns · Phase 4
- Cardiac Output, Low · Phase 3
- Cardiopulmonary Bypass · Phase 3
- Cardiovascular Diseases · Phase 1
- Cataract · Phase 2
- Cesarean Section · Phase 4
- Colitis, Ulcerative · Phase 3
- Colonic Neoplasms · Phase 3
- Colonic Polyps · Phase 3
- Colonoscopy · Phase 1
- Colorectal Neoplasms · Phase 4
- Contact Lenses · Early Phase 1
- Coronary Artery Bypass · Phase 4
- Coronary Disease · Phase 2
- COVID-19 · Phase 1
- Craniocerebral Trauma · Phase 3
- Critical Illness · Phase 3
- Crohn Disease · Phase 3
- Dehydration · Phase 4
- Delivery, Obstetric · Phase 4
- Diabetic Ketoacidosis · Phase 4
- Diverticulitis · Phase 3
- Drugs, Investigational · Phase 4
- Dysmenorrhea · Phase 2
- Endometriosis · Phase 2
- Endoscopy · Phase 4
- End Stage Liver Disease · Phase 3
- Fertilization in Vitro · Phase 4
- Fluid Therapy · Phase 4
- General Surgery · Phase 4
- Genital Neoplasms, Female · Phase 4
- Glioma · Phase 2
- Glycogen Storage Disease Type II · Phase 1
- Hearing Loss · Phase 1
- Heart Disease Risk Factors · Phase 1
- Heart Valve Diseases · Phase 4
- Hemodynamics · Phase 4
- Hemorrhagic Stroke · Phase 2
- Henipavirus Infections · Phase 1
- Hernia, Inguinal · Phase 3
- Hyperemesis Gravidarum · Phase 2
- Hyperglycemia · Phase 4
- Hypertension · Phase 4
- Hypertrophy, Left Ventricular · Phase 3
- Hypotension · Phase 4
- Hypovolemia · Phase 4
- Hypoxia · Phase 1/Phase 2
- Infertility · Phase 2
- Intestinal Diseases · Phase 4
- Intestinal Polyps · Phase 3
- Intra-Abdominal Hypertension · Phase 4
- Intraabdominal Infections · Phase 4
- Intraoperative Complications · Phase 2
- Intubation · Phase 4
- Ischemic Stroke · Phase 2
- Jaundice, Obstructive · Phase 3
- Joint Instability · Phase 4
- Ketosis · Phase 4
- Kidney Diseases · Phase 4
- Kidney Failure, Chronic · Phase 3
- Kidney Transplantation · Phase 3
- Labor, Induced · Phase 4
- Leiomyoma · Phase 4
- Liver Diseases · Phase 1/Phase 2
- Lung Diseases · Phase 4
- Malnutrition · Phase 2
- Mandibular Diseases · Phase 4
- Myocardial Ischemia · Phase 4
- Myocardium · Phase 4
- Nausea · Phase 2
- Neonatology · Phase 2
- Neoplasm Metastasis · Phase 3
- Neoplasms · Phase 4
- Neuromuscular Blockade · Phase 4
- Obesity · Phase 3
- Ovarian Cysts · Phase 1/Phase 2
- Pain · Phase 4
- Pancreaticoduodenectomy · Phase 2
- Pancreatitis · Phase 4
- Parturition · Phase 4
- Placenta Accreta · Phase 1
- Post-Dural Puncture Headache · Phase 3
- Postoperative Complications · Phase 4
- Postoperative Nausea and Vomiting · Phase 2/Phase 3
- Pre-Eclampsia · Phase 4
- Pregnancy · Phase 4
- Pregnancy Complications · Phase 2
- Procedural Sedation · Phase 4
- Prolotherapy · Phase 4
- Prostatic Neoplasms · Phase 2
- Rectal Neoplasms · Phase 3
- Renal Insufficiency · Phase 3
- Reperfusion Injury · Phase 2/Phase 3
- Respiration, Artificial · Phase 2
- Respiratory Distress Syndrome · Phase 3
- Respiratory Insufficiency · Phase 3
- Rheumatic Heart Disease · Phase 2
- Ringer's Lactate · Phase 4
- Safety · Phase 4
- Scleroderma, Systemic · Phase 2
- Sepsis · Phase 4
- Severe Dengue · Phase 3
- Shock · Phase 4
- Shock, Hemorrhagic · Phase 3
- Shock, Septic · Phase 4
- Shock, Traumatic · Phase 2
- Subarachnoid Hemorrhage · Phase 4
- Sudden Infant Death · Phase 4
- Temporomandibular Joint Disorders · Phase 4
- Therapeutic Irrigation · Phase 1
- Tuberculosis · Early Phase 1
- Urinary Tract Infections · Phase 1
- Urination Disorders · Phase 1
- Urologic Neoplasms · Phase 4
- Vasoconstriction · Phase 1
- Vasodilation · Phase 1
- Water-Electrolyte Balance · Phase 3
- Water-Electrolyte Imbalance · Phase 1/Phase 2
- Wounds and Injuries · Phase 4
Mechanism of action
- ElectrolyteSupplementation
Electrolyte supplementation
Chemistry & pharmacology
Oral
No
Parenteral
No
Topical
No
Sources
- WikipediaRinger's lactate solution ↗
- WikipediaCrystalloid ↗
Also known as
- acetate ringer's solution
- cold crystalloid
- cristalloid
- crystalloid
- crystalloid
- crystalloid colloid
- crystalloid coload
- crystalloids
- crystalloid solutions
- jonosteril
- ringer's lactate
- ringer's lactate
- ringer's lactate solution
Clinical trials
| NCT ID | Phase | Start date | Sponsor(s) |
|---|---|---|---|
| NCT07202559 | N/A | Dec 1, 2025 | Baotou Medical University, Central South University, Changhai Hospital, Chinese Academy of Medical Sciences, First People's Hospital of Hangzhou, Jiao Tong University, Ningxia Medical University, Shandong University, Yunnan University of Traditional Chinese Medicine |
| NCT07240701 | Phase 4 | Nov 30, 2025 | Kutahya City Hospital |
| NCT07212595 | Phase 2 | Nov 30, 2025 | University of Cincinnati |
| NCT07239713 | N/A | Nov 15, 2025 | CMH Lahore Medical College, Pakistan Army |
| NCT07172451 | Phase 4 | Nov 1, 2025 | B. Braun, Fudan University |
| NCT07124130 | Phase 4 | Sep 30, 2025 | Eastern Virginia Medical School, University of Modena and Reggio Emilia |
| NCT07101991 | N/A | Sep 30, 2025 | Military University Hospital, Prague, University Hospital Brno |
| NCT06985654 | Phase 4 | Jul 14, 2025 | University of Missouri |
| NCT07035509 | Phase 4 | Jul 1, 2025 | Fundación Cardioinfantil Instituto de Cardiología, University of Pittsburgh |
| NCT07192523 | N/A | Jun 15, 2025 | Kocaeli University |
| NCT06953674 | Phase 3 | Jun 1, 2025 | University of Louisville |
| NCT06541535 | Phase 4 | Dec 31, 2024 | University of Nice Sophia Antipolis |
| NCT06710353 | N/A | Dec 4, 2024 | Seoul National University |
| NCT06654687 | N/A | Oct 27, 2024 | Mansoura University |
| NCT06624956 | Phase 4 | Oct 1, 2024 | University of Washington |
| NCT06370975 | Phase 1/Phase 2 (Phase 2) | Aug 1, 2024 | Assiut University |
| NCT06478797 | Phase 2 | Jul 31, 2024 | Hospital General Pediátrico Niños de Acosta Ñu, Hospital Pablo Tobón Uribe, University of Zurich |
| NCT06414330 | N/A | Jun 1, 2024 | Assiut University |
| NCT06466655 | N/A | May 30, 2024 | National Institute of General Medical Sciences (NIGMS), University of Delaware |
| NCT06461390 | Phase 2/Phase 3 (Phase 3) | Mar 25, 2024 | University of Indonesia |
Showing 20 of 289 trials
Page 1 / 15
Organizations
Research & Development (318)
| Organization | Org type | Trials | As lead sponsor | Phases | Earliest year |
|---|---|---|---|---|---|
| University of Copenhagen | Academic/Hospital | 8 | 7 | 2 | 2009 |
| Assiut University | Academic/Hospital | 7 | 7 | 3 | 2015 |
| Mahidol University | Academic/Hospital | 6 | 6 | 3 | 2010 |
| Mansoura University | Academic/Hospital | 6 | 6 | 1 | 2016 |
| Seoul National University | Academic/Hospital | 6 | 6 | 1 | 2015 |
| University of Sao Paulo | Academic/Hospital | 6 | 5 | 4 | 2006 |
| Nanjing Medical University | Academic/Hospital | 5 | 5 | 1 | 2007 |
| Ningxia Medical University | Academic/Hospital | 5 | 3 | 1 | 2020 |
| B. Braun | For profit | 4 | 1 | 2 | 2009 |
| Cairo University | Academic/Hospital | 4 | 3 | 2 | 2018 |
| Innogene Kalbiotech Pte. Ltd | For profit | 4 | 4 | 1 | 2002 |
| Jiao Tong University | Academic/Hospital | 4 | 2 | 1 | 2018 |
| Konkuk University | Academic/Hospital | 4 | 4 | 1 | 2016 |
| Postgraduate Institute of Medical Education and Research | Academic/Hospital | 4 | 3 | 2 | 2016 |
| University of Athens | Academic/Hospital | 4 | 2 | 2 | 2008 |
| Chinese Academy of Medical Sciences | Academic/Hospital | 3 | 1 | 2 | 2022 |
| Johns Hopkins University | Academic/Hospital | 3 | 1 | 2 | 2005 |
| Karolinska Institute | Academic/Hospital | 3 | 1 | 2 | 2003 |
| Mayo Clinic | Academic/Hospital | 3 | 3 | 2 | 2016 |
| Sangart | For profit | 3 | 3 | 1 | 2003 |
318 organizations
Page 1 / 16