lipopolysaccharide
Small moleculeexperimental
Lipopolysaccharide (LPS), now more commonly known as endotoxin, is a collective term for components of the outermost membrane of the cell envelope of gram-negative bacteria, such as E. coli and Salmonella with a common structural architecture. Lipopolysaccharides are large molecules consisting of three parts: an outer core polysaccharide termed the O-antigen, an inner core oligosaccharide and Lipid A, all covalently linked. In current terminology, the term endotoxin is often used synonymously with LPS, although there are a few endotoxins that are not related to LPS, such as the so-called delta endotoxin proteins produced by Bacillus thuringiensis. — Wikipedia
Clinical trial activity
54 trials · 48 clinical orgs · 0 marketing orgs
Phase 1
29
Phase 2
2
Phase 3
2
Phase 4
5
Earliest trial started Feb 1, 2000 (NCT02211170)
Timeline
Indications
Approved for
Studied for
- Abdominal Neoplasms · Phase 1
- Alzheimer Disease · Early Phase 1
- Arthritis, Rheumatoid · Phase 1
- Asthma · Phase 1
- Autoimmune Diseases · Early Phase 1
- Cannabidiol · Early Phase 1
- Cardiovascular Diseases · Phase 1
- Depression · Early Phase 1
- Dexamethasone · Phase 4
- Drugs, Investigational · Phase 4
- Endotoxemia · Phase 4
- Escherichia coli Infections · Phase 4
- Fibromyalgia · Phase 2/Phase 3
- Healthy Volunteers · Phase 4
- Hyperoxia · Phase 1/Phase 2
- Hypoxia · Phase 1/Phase 2
- Immunity, Innate · Phase 1
- Immunosuppression Therapy · Phase 4
- Infections · Early Phase 1
- Inflammation · Phase 4
- Interleukin 1 Receptor Antagonist Protein · Phase 4
- Lung Diseases · Phase 1
- Major Depressive Disorder · Phase 1/Phase 2
- Melanoma · Phase 1
- Neoplasms · Phase 1
- Oxygen Saturation · Phase 1/Phase 2
- Regional Blood Flow · Phase 4
- Retina · Phase 4
- Schizophrenia · Phase 1
- Sepsis · Phase 4
- Stress Disorders, Post-Traumatic · Phase 1
Mechanism of action
- Toll-like receptor 4ACTIVATOR
TLR4 activator
Chemistry & pharmacology
Oral
No
Parenteral
No
Topical
No
Sources
- WikipediaLipopolysaccharide ↗
Also known as
- escherichia coli endotoxin
- lipopolysaccharide
- lipopolysaccharide
Clinical trials
| NCT ID | Phase | Start date | Sponsor(s) |
|---|---|---|---|
| NCT06624436 | Phase 4 | Oct 31, 2024 | Radboud University |
| NCT06618716 | N/A | Sep 5, 2024 | Karolinska Institute, Linkoping University, Stockholm University |
| NCT06620679 | N/A | May 3, 2024 | Katholieke Universiteit Leuven |
| NCT06270576 | Phase 1 | Apr 30, 2024 | University of Colorado, Denver |
| NCT05884242 | Phase 1 | May 22, 2023 | — |
| NCT05751837 | Phase 1 | Mar 16, 2023 | Allegheny Health Network |
| NCT04751331 | Phase 1/Phase 2 (Phase 2) | May 15, 2021 | Laureate Institute for Brain Research |
| NCT04398719 | Early Phase 1 (Phase 1) | Jun 1, 2020 | National Center for Complementary and Integrative Health (NCCIH), Yale University |
| NCT04309877 | Early Phase 1 (Phase 1) | Mar 31, 2020 | University of California, Los Angeles |
| NCT04263454 | Phase 2/Phase 3 (Phase 3) | Feb 14, 2020 | American Fibromyalgia Syndrome Association, University of Alabama, Birmingham |
| NCT03953196 | Early Phase 1 (Phase 1) | Apr 8, 2019 | Johnson and Johnson |
| NCT03859050 | N/A | Mar 31, 2019 | University of Colorado, Denver |
| NCT03271814 | Phase 1 | Oct 15, 2018 | University of Maryland |
| NCT03779360 | N/A | Oct 12, 2018 | Leiden University, Maruho Co., Ltd. |
| NCT03557684 | Early Phase 1 (Phase 1) | Aug 1, 2018 | National Institute of Mental Health (NIMH), University of California, Los Angeles |
| NCT03426995 | Phase 1 | Mar 13, 2018 | GlaxoSmithKline |
| NCT05570643 | N/A | Jan 5, 2018 | Radboud University, Utrecht University |
| NCT03392701 | N/A | Dec 20, 2017 | Barmherzige Brüder Vienna |
| NCT03306589 | Phase 1 | Aug 11, 2017 | GlaxoSmithKline |
| NCT03142919 | Phase 1 | May 1, 2017 | Laureate Institute for Brain Research |
Showing 20 of 54 trials
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Organizations
Research & Development (48)
| Organization | Org type | Trials | As lead sponsor | Phases | Earliest year |
|---|---|---|---|---|---|
| Radboud University | Academic/Hospital | 8 | 8 | 5 | 2008 |
| University of Vienna | Academic/Hospital | 8 | 7 | 3 | 2005 |
| Yale University | Academic/Hospital | 4 | 4 | 1 | 2014 |
| Duke University | Academic/Hospital | 3 | 2 | 2 | 2001 |
| GlaxoSmithKline | For profit | 3 | 3 | 1 | 2012 |
| University of Copenhagen | Academic/Hospital | 3 | 3 | 1 | 2006 |
| Boehringer Ingelheim | For profit | 2 | 2 | 1 | 2000 |
| Karolinska Institute | Academic/Hospital | 2 | 1 | 1 | 2009 |
| Laureate Institute for Brain Research | Academic/Hospital | 2 | 2 | 2 | 2017 |
| Stockholm University | Academic/Hospital | 2 | 0 | 1 | 2009 |
| University of California, Los Angeles | Academic/Hospital | 2 | 2 | 1 | 2018 |
| University of Colorado, Denver | Academic/Hospital | 2 | 2 | 2 | 2019 |
| Aarhus University | Academic/Hospital | 1 | 1 | 1 | 2014 |
| Allegheny Health Network | Academic/Hospital | 1 | 1 | 1 | 2023 |
| American Fibromyalgia Syndrome Association | Academic/Hospital | 1 | 0 | 1 | 2020 |
| Barmherzige Brüder Vienna | Academic/Hospital | 1 | 1 | 1 | 2017 |
| CHU Brugmann | Academic/Hospital | 1 | 0 | 1 | 2010 |
| CoMentis | For profit | 1 | 0 | 1 | 2008 |
| Fraunhofer | For profit | 1 | 0 | 1 | 2011 |
| Free University of Brussels | Academic/Hospital | 1 | 1 | 1 | 2010 |
48 organizations
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