← All indications
Constipation
Infrequent or difficult evacuation of FECES. These symptoms are associated with a variety of causes, including low DIETARY FIBER intake, emotional or nervous disturbances, systemic and structural disorders, drug-induced aggravation, and infections.
Subtype terms (1)
More specific conditions that are subtypes of Constipation in the MeSH hierarchy.
- Opioid-Induced Constipation
17 drugs (13 approved, 4 experimental)
Drugs by status
Approved for this indication (50)
- elobixibat
- lubiprostone
- urea
- bisacodyl
- tricaprylyl glycerol
- castor oil
- docusate
- vitis vinifera
- fiber
- glucomannan
- glycerin
- lactulose
- lactositol
- linaclotide
- naldemedine
- naloxegol
- paraffin oil
- pectin
- plantago ovata
- plecanatide
- prucalopride succinate
- polycarbophil
- sennosides a&b
- sunflower oil
- tenapanor
- flax
- hemp
- oligofructose
- prunus domestica
- magnesium hydroxide
- +20 more
Phase 4 trials (44)
- mannitol
- hydrocodone
- maltodextrin
- propofol
- alvimopan
- cetearyl alcohol
- ketamine
- esmolol
- oxycodone
- ibuprofen
- gabapentin
- ketorolac
- magnesium oxide
- itropride
- rimabotulinumtoxinB
- octreotide
- acetaminophen
- lidocaine
- remimazolam
- levobupivacaine
- celecoxib
- senna alexandrina
- sorbitol
- tramadol
- hydromorphone
- ondansetron
- autologous microbiome
- bifidobacterium longum
- clostridium butyricum
- lingonberry nectar
- +14 more
Phase 3 trials (26)
- bifidobacterium animalis
- bli400
- bli-801
- cch1
- escitalopram
- glycopyrronium
- simethicone
- sodium picosulfate
- aluminum hydroxide
- renzapride
- rifaximin
- apple
- human fecal microbiota
- ficus carica
- lactobacillus plantarum
- lepicol
- prunus mume extract
- neostigmine
- cassia
- galactooligosaccharide
- desipramine
- Lactobacillus acidophilus
- kiwi fruit
- bifidobacterium lactis
- maralixibat
- runtong
Phase 2 trials (39)
- naronapride
- alfuzosin
- bevenopran
- chenodeoxycholic acid
- da jian zhong tang
- ent-01
- ethanol
- huangkui
- leucine
- fluoxetine
- mazirenwan
- ntx-1
- vitamin c
- ropivacaine
- propylene glycol
- pumosetrag
- relamorelin
- Isatuximab
- ski3246
- sp-333
- syn-010
- vancomycin
- cellulose
- velusetrag
- yh12852
- dexmedetomidine
- pradigastat
- xylooligosaccharide
- bificopec
- pyridostigmine bromide
- +9 more
Phase 1 trials (17)
Other trials (77)
- levofloxacin
- vitamin d3
- abelmoschus manihot
- agave
- atezolizumab
- aloe vera
- artichoke
- bacillus clausii
- procaine benzylpenicillin
- cinitapride
- cisapride
- ginger
- inulin
- lactobacillus gasseri
- motilitone
- niacin
- tj-100
- cow milk
- pemetrexed
- nicotine
- saccharomyces boulardii
- carboplatin
- scopolamine
- rhubarb
- bevacizumab
- diazepam
- ziyinxiehuo
- agar
- atropine
- bifidobacterium infantis
- +47 more
Organizations
Organization Involved with Phase 4 Indications (88)
- Aboca
- Takeda
- Shire
- Ironwood Pharmaceuticals
- Bausch Health Companies
- Merck
- Sanofi
- Ipsen
- Wyeth
- Allergan
- Bayer
- Braintree Laboratories
- Cumberland Pharmaceuticals
- Hospice of Henderson County, Inc.
- Laboratoires Techni Pharma
- Mundipharma
- Norgine
- Yakult Honsha Co., LTD
- British Columbia Cancer Agency
- National Center for Research Resources (NCRR)
- University of Roma La Sapienza
- University of Illinois
- Athena Institute, Netherlands
- Azienda Ospedaliera Ospedale Infantile Regina Margherita Sant'Anna
- Baylor University
- Cairo University
- CAMC Health System
- Cedars-Sinai Medical Center
- Chang Gung University
- Children's Memorial Health Institute, Poland
- +58 more
Organization Involved with Phase 3 Indications (82)
- Alizyme
- Grunenthal
- Astellas
- Pfizer
- Purdue Pharmaceuticals
- Anchen Pharmaceuticals, Inc
- Ardelyx
- Atlantia Food Clinical Trials
- BioGaia AB
- Cubist
- GlaxoSmithKline
- INC Research
- Jiangsu Chia-tai Tianqing Pharmaceutical Co.,Ltd
- Marjan Industria e Comercio ltda
- Movetis
- Parexel
- Boehringer Ingelheim
- Dynogen Pharmaceuticals
- EA Pharma Co., Ltd.
- Fonterra Research Centre
- Renew Life Formulas Inc
- Rottapharm
- National Cancer Institute (NCI)
- National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
- Huazhong University of Science and Technology
- University of London
- China Academy of Chinese Medical Sciences
- China Agricultural University
- Federal University of Rio Grande do Sul
- Harbin Medical University
- +52 more
Organization Involved with Phase 2 Indications (63)
- Abbott
- Targacept
- Theravance
- Cato Research
- Albireo
- Alkermes
- Danisco
- Kissei Pharmaceuticals
- Motus Therapeutics, Inc.
- NGM Biopharmaceuticals, Inc
- Nektar Therapeutics
- Nutrabiotix, LLC
- Rhythm Pharmaceuticals, Inc.
- Arvelle
- Enterin Inc.
- Michael J. Fox Foundation for Parkinson's Research
- University of Pittsburgh
- Arizona State University
- Augusta University
- Georgetown University
- Hong Kong Baptist University
- Nanjing University
- Northwestern University
- Onze Lieve Vrouw Hospital
- Southwest Oncology Group
- Sheffield Hallam University
- University of Johannesburg
- University of Leeds
- University of Vermont
- Yonsei University
- +33 more
Organization Involved with Phase 1 Indications (11)
Organization Involved with Other Experimental Indications (62)
- Amino Up Chemicals Co., Ltd.
- Beneo GmbH
- Bright Dairy & Food Co., Ltd
- Farmoquimica S.A.
- Harrison Clinical Research
- Inner Mongolia Yili Industrial Group Co., Ltd
- Laboratorios Ordesa
- Lesaffre International
- Montefarmaco OTC SpA
- NIZO Food Research
- Teva
- Tereos
- Fondazione Toscana Gabriele Monasterio
- Fundação de Amparo à Pesquisa do Estado de São Paulo
- Pasteur Merieux
- Vejle Hospital
- Region Syddanmark
- Children's Hospital of Philadelphia
- University of Pennsylvania
- Hebei University
- Carle Foundation Hospital
- Carle Physician Group
- Centre Hospitalier Intercommunal Creteil
- Centro Universitário Univates
- Duke University
- Hoosier Cancer Research Network
- Hospital Avicenne
- Iuppa Industriale Srl
- Nanjing Medical University
- NHS Fife
- +32 more