pradigastat
Small moleculeexperimental
Clinical trial activity
11 trials · 3 clinical orgs · 0 marketing orgs
Phase 1
3
Phase 2
9
Phase 3
2
Phase 4
0
Earliest trial started Apr 1, 2009 (NCT00901979)
Timeline
Indications
Studied for
- Chylomicrons · Phase 3
- Constipation · Phase 2
- Coronary Artery Disease · Phase 2
- Diabetes Mellitus, Type 2 · Phase 2
- Hepatitis C · Phase 2
- Hyperlipoproteinemias · Phase 1/Phase 2
- Hypertriglyceridemia · Phase 2
- Kidney Failure, Chronic · Phase 1
- Liver Diseases · Phase 1
- Non-alcoholic Fatty Liver Disease · Phase 2
Mechanism of action
- Diacylglycerol O-acyltransferase 1INHIBITOR
DGAT1 inhibitor
Chemistry & pharmacology
Loading structure…
SMILES
O=C(O)C[C@H]1CC[C@H](c2ccc(-c3ccc(Nc4ccc(C(F)(F)F)nc4)cn3)cc2)CC1- Mol. weight
- 455.48 g/mol
- Lipinski Ro5
- 1 violation(s)
- Rule of 3
- No
- Chirality
- Single Stereoisomer
- Inorganic
- No
- Polymer
- No
Oral
No
Parenteral
No
Topical
No
Sources
- ChEMBLCHEMBL2364624 ↗
Also known as
- lcq908
- lcq908
- lcq908
- lcq908-nxa
- lcq908-nxa
- pradigastat
- pradigastat
- pradigastat
- pradigastat
- pradigastat
Clinical trials
| NCT ID | Phase | Start date | Sponsor(s) |
|---|---|---|---|
| NCT04620161 | Phase 2 | Sep 22, 2020 | Covance, Guangzhou Anjie Biomedical Technology Co., Ltd. |
| NCT01811472 | Phase 2 | Jun 1, 2013 | Novartis |
| NCT01589237 | Phase 3 | Feb 1, 2013 | Novartis |
| NCT01514461 | Phase 3 | Jul 1, 2012 | Novartis |
| NCT01594983 | Phase 2 | Jun 1, 2012 | Novartis |
| NCT01558323 | Phase 1 | May 1, 2012 | Novartis |
| NCT01594957 | Phase 1 | Apr 1, 2012 | Novartis |
| NCT01474434 | Phase 2 | Dec 1, 2011 | Novartis |
| NCT01387958 | Phase 2 | Jul 1, 2011 | Novartis |
| NCT01146522 | Phase 1/Phase 2 (Phase 2) | May 1, 2010 | Novartis |
| NCT00901979 | Phase 2 | Apr 1, 2009 | Novartis |
Showing 11 of 11 trials
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Organizations
Research & Development (3)
| Organization | Org type | Trials | As lead sponsor | Phases | Earliest year |
|---|---|---|---|---|---|
| Novartis | For profit | 10 | 10 | 3 | 2009 |
| Covance | For profit | 1 | 0 | 1 | 2020 |
| Guangzhou Anjie Biomedical Technology Co., Ltd. | Government | 1 | 1 | 1 | 2020 |
3 organizations
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