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magnesium oxide

Small moleculeapproved

Approved

Jun 22, 1982

Magnesium oxide (MgO), or magnesia, is a white hygroscopic solid mineral that occurs naturally as periclase and is a source of magnesium (see also oxide). It has an empirical formula of MgO and consists of a lattice of Mg2+ ions and O2− ions held together by ionic bonding. Magnesium hydroxide forms in the presence of water (MgO + H2O → Mg(OH)2), but it can be reversed by heating it to remove moisture. — Wikipedia

Clinical trial activity

107 trials · 147 clinical orgs · 7 marketing orgs

Phase 1
11
Phase 2
37
Phase 3
21
Phase 4
22

Earliest trial started Jul 1, 1997 (NCT00120588)

Timeline

1980s

  1. Jun 22, 1982

    Baxter — Earliest FDA Approval

  2. Jun 22, 1982

    Baxalta — NDA Secondary Org

  3. Jun 22, 1982

    Baxter — NDA Secondary Org

  4. Jun 22, 1982

    Baxter — NDA Organization

  5. Mar 15, 1984

    Hospira — NDA Secondary Org

1990s

  1. Jan 1, 1998

    Earliest Phase 3 Sponsor(trial)

2000s

  1. Jan 1, 2001

    Earliest Phase 2 Sponsor(trial)

  2. Jan 1, 2002

    Earliest Phase 1 Sponsor(trial)

2010s

  1. Jul 16, 2012

    Ferring — NDA Secondary Org

  2. Nov 21, 2016

    Par Pharmaceuticals — Marketing Organization

  3. Nov 21, 2016

    Bristol-Myers Squibb — Marketing Organization

2020s

  1. Jul 18, 2022

    Hetero Labs Ltd — Marketing Organization

Indications

Approved for

Studied for

Mechanism of action

  • Unspecified targetBuffer

    buffer

Combination products

Approval history

  • approvedJun 22, 1982

Chemistry & pharmacology

Loading structure…

SMILES

O=[Mg]
Mol. weight
40.3 g/mol
Chirality
Achiral Molecule
Inorganic
Yes
Polymer
No
Delivery
Oral
Availability
Prescription Only

Oral

Yes

Parenteral

No

Topical

No

Sources

Also known as

  • calcined magnesia
  • calcined magnesia
  • calcium magnesia
  • e530
  • e530
  • magdose
  • magmitt
  • magmitt
  • magnesia
  • magnesia
  • magnesium
  • magnesium
  • magnesium
  • magnesium oxide
  • magnesium oxide
  • magnesium oxide
  • magnesium oxide
  • magnesium oxide
  • magnesium oxide
  • magnesium oxide
  • magnesium oxide
  • magnesium oxide
  • magnesium oxide
  • magnesium oxide monohydrate
  • mag ox
  • mag-ox 400
  • magstar
  • oromag 160
  • oximag
  • uro-mag
  • uro-mag

Clinical trials

NCT IDPhaseStart dateSponsor(s)
NCT07173855Phase 4Nov 25, 2025Scarborough General Hospital
NCT06915701Phase 2/Phase 3 (Phase 3)Apr 28, 2025University of Guadalajara
NCT06580366Phase 4Aug 22, 2024Hitit University
NCT05774015N/ASep 25, 2023Karolinska Institute, Sultan Qaboos University
NCT06950138Phase 3Jan 3, 2023Government of Mexico
NCT05148494Phase 4Feb 1, 2022Government of Canada
NCT04161599Phase 4Feb 29, 2020Universidad Autonoma de Barcelona
NCT04483037Phase 4Jan 1, 2020Changhua Christian Hospital
NCT04113382Phase 1/Phase 2 (Phase 2)Oct 31, 2019Ferring
NCT04033250N/AAug 31, 2019Technion University
NCT03898336N/AJul 1, 2019Radboud University, University of Groningen, University of Heidelberg
NCT03840226Phase 3May 1, 2019Naveh Pharma LTD, Tel Aviv University
NCT03593252N/ASep 1, 2018McMaster University
NCT04259606N/AAug 17, 2018University of Guadalajara
NCT04216836N/AJun 28, 2018Beijing Sport University, Coventry University, University of Rochester
NCT03632590N/AMar 27, 2018Nedmag, University of Groningen
NCT03449693Phase 2Oct 19, 2017Government of Mexico, National Autonomous University of Mexico, National Polytechnic Institute, Mexico
NCT03475693Early Phase 1 (Phase 1)Sep 1, 2017Lakeland Regional Medical Center, Michigan State University
NCT03132701N/AJun 7, 2017Seoul National University
NCT03190044N/AJun 6, 2017University of Roma La Sapienza
Showing 20 of 107 trials
Page 1 / 6

Organizations

Research & Development (147)

OrganizationOrg typeTrialsAs lead sponsorPhasesEarliest year
Government of MexicoGovernment6532010
University of GuadalajaraAcademic/Hospital4332003
Tel Aviv UniversityAcademic/Hospital3322010
Ain Shams UniversityAcademic/Hospital2222016
FerringFor profit2222017
Government of FranceGovernment2021997
Isfahan UniversityAcademic/Hospital2212014
Mayo ClinicAcademic/Hospital2122011
National Heart, Lung, and Blood Institute (NHLBI)Government2121998
National University of IrelandAcademic/Hospital2122011
Pennsylvania State UniversityAcademic/Hospital2222015
Radboud UniversityAcademic/Hospital2212003
Technion UniversityAcademic/Hospital2222013
The Canadian College of Naturopathic MedicineAcademic/Hospital2122008
University of CopenhagenAcademic/Hospital2222007
University of GroningenAcademic/Hospital2112018
University of TorontoAcademic/Hospital2122008
Aarhus UniversityAcademic/Hospital1112012
AGUNCO Obstetrics and Gynecology CentreAcademic/Hospital1112013
Alberta Heritage Foundation for Medical ResearchAcademic/Hospital1012011
147 organizations
Page 1 / 8

Marketing (8)

OrganizationOrg typeRelationshipDate
BaxaltaFor profitNDA2Jun 22, 1982
BaxterFor profitNDA2Jun 22, 1982
BaxterFor profitNDAJun 22, 1982
Bristol-Myers SquibbFor profitMKTGNov 21, 2016
FerringFor profitNDA2Jul 16, 2012
Hetero Labs LtdFor profitMKTGJul 18, 2022
HospiraFor profitNDA2Mar 15, 1984
Par PharmaceuticalsFor profitMKTGNov 21, 2016