cetearyl alcohol
Small moleculeexperimental
Polyethylene glycol cetyl ether (polyethylene glycol hexadecyl ether) is a nonionic surfactant produced by the ethoxylation of cetyl alcohol to give a material with the general formula HO(C2H4O)nC16H33. Several grades of this material are available depending on the level of ethoxylation performed, with repeat units (n) of polyethylene glycol varying between 2 and 20. Commercially it can be known as Cetomacrogol 1000, Brij 58 (when n=20), Brij 56 (when n=10), and other trade names. — Wikipedia
Clinical trial activity
30 trials · 42 clinical orgs · 0 marketing orgs
Phase 1
0
Phase 2
14
Phase 3
10
Phase 4
12
Earliest trial started Jan 1, 2001 (NCT00321230)
Timeline
Indications
Approved for
Studied for
- Adenomatous Polyps · Phase 2
- Cathartics · Phase 4
- Cicatrix, Hypertrophic · Phase 4
- Colonic Diseases · Phase 4
- Colonic Polyps · Phase 4
- Colonoscopy · Phase 4
- Colorectal Neoplasms · Phase 4
- Constipation · Phase 4
- Diagnosis · Phase 3
- Exanthema · Phase 3
- Hip Fractures · Phase 4
- Intestine, Large · Phase 3
- Keloid · Phase 4
- Liver Diseases · Phase 4
- Neoplasms · Phase 3
- Physical Examination · Phase 2
- Tinnitus · Phase 4
Mechanism of action
- Unspecified targetOTHER
Osmotic laxative
- Unspecified targetOTHER
Laxative
- UnclearUnclear
Unclear unclear
Chemistry & pharmacology
Loading structure…
SMILES
OCCO- Mol. weight
- 62.07 g/mol
- Lipinski Ro5
- Pass
- Rule of 3
- Yes
- Chirality
- Single Stereoisomer
- Inorganic
- No
- Polymer
- Yes
Oral
No
Parenteral
No
Topical
No
Sources
- WikipediaPolyethylene glycol cetyl ether ↗
- ChEMBLCHEMBL2108780 ↗
- ChEMBLCHEMBL1201478 ↗
- ChEMBLCHEMBL457299 ↗
- WikipediaMacrogol ↗
- WikipediaCetostearyl alcohol ↗
- WikipediaCetomacrogol 1000 ↗
Also known as
- 1,2-ethanediol
- 1,2-ethanediol
- 1-octadecanol, mixed with 1-hexadecanol
- atpeg 300
- atpeg 300
- atpeg 4000
- carbowax sentry
- carbowax sentry
- cetearyl alcohol
- cetearyl alcohol
- cetearyl alcohol
- cetomacrogol
- cetomacrogol
- cetyl-stearyl alcohol
- dulcobalance
- ethylene glycol
- ethylene glycol
- idrolax
- macrogol
- macrogol
- macrogol
- macrogol
- macrogol
- macrogol 4000
- macrogol 4000
- macrogol 4000
- macrogol cetostearyl ethers
- polyethylene glycol 4000
- polyethylene glycol 4000
Clinical trials
| NCT ID | Phase | Start date | Sponsor(s) |
|---|---|---|---|
| NCT06455813 | Phase 4 | Sep 2, 2024 | Government of Denmark, University of Southern Denmark |
| NCT06652906 | Phase 2 | Jun 11, 2024 | Jiao Tong University |
| NCT05570669 | Phase 4 | May 25, 2021 | Azienda Ospedaliera Specializzata in Gastroenterologia IRCCS Saverio de Bellis, Societa Italiana di Endoscopia Digestiva, University of Bologna, University of Naples Frederico II, University of Roma La Sapienza |
| NCT04708366 | Phase 4 | Feb 1, 2021 | University of Bologna |
| NCT04474002 | Phase 4 | Aug 31, 2020 | The University of Hong Kong |
| NCT05362227 | N/A | Nov 1, 2019 | Hospital Agostino Gemelli, Universita' Cattolica del Sacro Cuore |
| NCT03857893 | N/A | Mar 1, 2019 | Erasmus University Rotterdam, Free University of Brussels, Hôpitaux IRIS Sud, Novavision Group SpA |
| NCT03742232 | Phase 4 | Oct 31, 2018 | Istituto Clinico Humanitas - Rozzano (MI), Italy |
| NCT03639142 | Phase 3 | Sep 1, 2018 | Medical University of Warsaw |
| NCT03562884 | Phase 3 | Jul 2, 2018 | Ipsen |
| NCT03395548 | N/A | Aug 25, 2017 | Medical University of Graz |
| NCT03106922 | Phase 3 | Apr 1, 2016 | Alfa Wassermann, University of Roma La Sapienza |
| NCT02751411 | Phase 4 | Apr 1, 2016 | Aboca, University of Naples Frederico II |
| NCT02321462 | Phase 3 | Mar 1, 2015 | Ipsen |
| NCT02266160 | Phase 4 | Nov 1, 2014 | Emek Medical Center, Technion University |
| NCT02215954 | Phase 3 | Sep 1, 2014 | Ferring |
| NCT02073552 | Phase 4 | May 1, 2014 | Fundación Canaria Rafael Clavijo para la Investigación Biomédica, University of Las Palmas de Gran Canaria |
| NCT01429779 | Phase 4 | Jul 1, 2012 | Maastricht University, Norgine |
| NCT01695863 | Phase 4 | Feb 1, 2012 | RUMC, Rush University |
| NCT01425619 | N/A | Oct 1, 2011 | Tel Aviv University |
Showing 20 of 30 trials
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Organizations
Research & Development (42)
| Organization | Org type | Trials | As lead sponsor | Phases | Earliest year |
|---|---|---|---|---|---|
| Norgine | For profit | 7 | 6 | 3 | 2001 |
| Bayer | For profit | 2 | 1 | 2 | 2006 |
| Ipsen | For profit | 2 | 2 | 1 | 2015 |
| Johannes Gutenburg University | Academic/Hospital | 2 | 0 | 1 | 2002 |
| University of Bologna | Academic/Hospital | 2 | 1 | 1 | 2021 |
| University of Naples Frederico II | Academic/Hospital | 2 | 0 | 1 | 2016 |
| University of Roma La Sapienza | Academic/Hospital | 2 | 0 | 2 | 2016 |
| Aboca | For profit | 1 | 1 | 1 | 2016 |
| Alfa Wassermann | For profit | 1 | 1 | 1 | 2016 |
| Azienda Ospedaliera Specializzata in Gastroenterologia IRCCS Saverio de Bellis | Academic/Hospital | 1 | 0 | 1 | 2021 |
| CB Boers ORG | For profit | 1 | 0 | 1 | 2010 |
| Emek Medical Center | Academic/Hospital | 1 | 1 | 1 | 2014 |
| Erasmus University Rotterdam | Academic/Hospital | 1 | 0 | 1 | 2019 |
| Ferring | For profit | 1 | 1 | 1 | 2014 |
| Free University of Brussels | Academic/Hospital | 1 | 1 | 1 | 2019 |
| Fundación Canaria Rafael Clavijo para la Investigación Biomédica | Academic/Hospital | 1 | 1 | 1 | 2014 |
| Government of Denmark | Government | 1 | 0 | 1 | 2024 |
| Hôpitaux IRIS Sud | Academic/Hospital | 1 | 0 | 1 | 2019 |
| Hospital Agostino Gemelli | Academic/Hospital | 1 | 0 | 1 | 2019 |
| Impaqtt Foundation | Academic/Hospital | 1 | 1 | 1 | 2010 |
42 organizations
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