clostridium butyricum
Clostridium butyricum is a strictly anaerobic endospore-forming Gram-positive butyric acid–producing bacillus subsisting by means of fermentation using an intracellularly accumulated amylopectin-like α-polyglucan (granulose) as a substrate. It is uncommonly reported as a human pathogen and is widely used as a probiotic in Japan, Korea, and China. C. butyricum is a soil inhabitant in various parts of the world, has been cultured from the stool of healthy children and adults, and is common in soured milk and cheeses. The connection with dairy products is shown by the name, the butyr- in butyricum reflects the relevance of butyric acid in the bacteria's metabolism and the connection with Latin butyrum and Greek βούτυρον, with word roots pertaining to butter and cheese. — Wikipedia
Clinical trial activity
28 trials · 33 clinical orgs · 0 marketing orgs
Earliest trial started Apr 1, 2005 (NCT00947336)
Timeline
Indications
Approved for
Studied for
- Anxiety · Phase 4
- Carcinoma, Renal Cell · Phase 2
- Carcinoma, Transitional Cell · Phase 2
- Cardiovascular Diseases · Phase 4
- Clostridium Infections · Phase 2
- Colonic Neoplasms · Phase 2
- Colorectal Neoplasms · Phase 4
- Colostomy · Phase 2
- Constipation · Phase 4
- Depression · Phase 4
- Drug-Related Side Effects and Adverse Reactions · Phase 4
- Dyspepsia · Phase 4
- Gastritis · Phase 4
- Gastrointestinal Diseases · Early Phase 1
- Helicobacter pylori · Phase 4
- Ileostomy · Early Phase 1
- Infections · Early Phase 1
- Irritable Bowel Syndrome · Phase 4
- Liver Cirrhosis · Phase 3
- Lymphoma · Phase 1
- Peptic Ulcer · Phase 4
- Probiotics · Phase 4
- Rectal Neoplasms · Early Phase 1
Mechanism of action
- microbiotaTissue restoration
microbiota tissue restoration
Chemistry & pharmacology
Oral
No
Parenteral
No
Topical
No
Sources
- WikipediaClostridium butyricum ↗
Also known as
- clostridium butyricum
- miya-bm
Clinical trials
| NCT ID | Phase | Start date | Sponsor(s) |
|---|---|---|---|
| NCT07037004 | Phase 2 | May 4, 2026 | City of Hope National Medical Center, National Cancer Institute (NCI) |
| NCT07263880 | Phase 1/Phase 2 (Phase 2) | Dec 1, 2025 | Azienda Ospedaliera San Giovanni Addolorata, University of Roma La Sapienza |
| NCT07167342 | Phase 4 | Oct 31, 2025 | Dongying People's Hospital, Shandong, Jining NO.1 People 's Hospital, Linyi People's Hospital, People's Hospital of Rizhao, Qingdao University, Shandong first medical University, Shandong Province Qianfoshan Hospital, Shandong Provincial Hospital, Shandong University, Tai'an Central Hospital, Weifang People's Hospital |
| NCT07152886 | Phase 4 | Oct 31, 2025 | Dongying People's Hospital, Shandong, Jining NO.1 People 's Hospital, Linyi People's Hospital, People's Hospital of Rizhao, Qingdao University, Shandong first medical University, Shandong Province Qianfoshan Hospital, Shandong Provincial Hospital, Shandong University, Tai'an Central Hospital, Weifang People's Hospital |
| NCT07182890 | Phase 4 | Sep 20, 2025 | People's Liberation Army of China |
| NCT06676514 | N/A | Nov 10, 2024 | Liaquat University of Medical & Health Sciences, University of Urbino "Carlo Bo" |
| NCT06399419 | Phase 1 | Jun 19, 2024 | City of Hope National Medical Center, National Cancer Institute (NCI), Osel, Inc. |
| NCT06677840 | N/A | May 1, 2024 | National Taiwan University |
| NCT06696742 | Phase 2 | Feb 1, 2024 | Nanjing Medical University |
| NCT06548256 | N/A | Oct 31, 2023 | Kaohsiung Medical University |
| NCT05914389 | Phase 2 | Aug 31, 2023 | Zhejiang University |
| NCT06852274 | N/A | Mar 1, 2023 | Azienda Ospedaliera San Giovanni Addolorata, Liaquat University of Medical & Health Sciences |
| NCT05724511 | Phase 4 | Feb 27, 2023 | China Medical University |
| NCT05759741 | Early Phase 1 (Phase 1) | Jan 17, 2023 | Fudan University |
| NCT05122546 | Phase 1 | Nov 1, 2021 | City of Hope National Medical Center, National Cancer Institute (NCI) |
| NCT04688242 | Phase 2 | Jan 1, 2021 | Sun Yat-Sen University |
| NCT05237115 | Phase 4 | May 5, 2020 | People's Liberation Army of China, Xijing Hospital |
| NCT03829111 | Phase 1 | May 14, 2019 | City of Hope National Medical Center, National Cancer Institute (NCI) |
| NCT03922035 | Phase 1 | Apr 18, 2019 | City of Hope National Medical Center, National Cancer Institute (NCI) |
| NCT03857425 | Phase 4 | Mar 1, 2019 | People's Liberation Army of China |