propylene glycol
Small moleculeexperimental
PROPYLENE GLYCOL is a component of SYSTANE® Lubricant. It is used for the temporary relief of burning and irritation due to dryness of the eye. — NCATS
Clinical trial activity
51 trials · 41 clinical orgs · 0 marketing orgs
Phase 1
4
Phase 2
11
Phase 3
4
Phase 4
20
Earliest trial started Nov 1, 2006 (NCT00806221)
Timeline
Indications
Approved for
Studied for
- Acne Vulgaris · Phase 4
- Allergy and Immunology · Phase 1
- Blood Loss, Surgical · Phase 3
- Cataract · Phase 4
- Constipation · Phase 2
- Contact Lenses · Phase 4
- Corneal Diseases · Phase 4
- Dermatitis, Atopic · Phase 2
- Diabetes Mellitus · Phase 4
- Diabetic Neuropathies · Phase 2
- Drug-Related Side Effects and Adverse Reactions · Phase 4
- Dry Eye Syndromes · Phase 4
- Hair · Phase 4
- Healthy Volunteers · Phase 4
- Ichthyosis Vulgaris · Phase 2
- Keratosis, Actinic · Phase 3
- Melanosis · Phase 4
- Neuralgia · Phase 2
- Ophthalmology · Phase 4
- Poisoning · Phase 2
- Pruritus · Phase 4
- Skin and Connective Tissue Diseases · Phase 4
- Tears · Phase 1
- Tooth Abnormalities · Phase 3
Mechanism of action
- Unspecified targetUnclear
unclear
Chemistry & pharmacology
Loading structure…
SMILES
CC(O)CO- Mol. weight
- 76.0944 g/mol
- Lipinski Ro5
- Pass
- Rule of 3
- Yes
- Chirality
- Racemic Mixture
- Inorganic
- No
- Polymer
- No
Oral
No
Parenteral
No
Topical
No
Sources
- WikipediaPropylene glycol ↗
- NCATS6DC9Q167V3 ↗
- ChEMBLCHEMBL286398 ↗
Also known as
- 1,2-dihydroxypropane
- 1,2-dihydroxypropane
- 1,2-propanediol
- 1,2-propanediol
- 1,2-propanediol
- 1,2-propylene glycol
- 1,2-propylenglykol
- 1,2-propylenglykol
- 146-9251 cream
- 2-hydroxypropanol
- 2-hydroxypropanol
- centella asiatica
- centella asiatica
- cetaphil
- cetaphil
- e1520
- e1520
- e490
- e490
- isopropylene glycol
- isopropylene glycol
- methylethylene glycol
- methylethylene glycol
- methylethyl glycol
- methylethyl glycol
- methyl glycol
- monopropylene glycol
- monopropylene glycol
- ppd
- ppd
- propane-1,2-diol
- propane-1,2-diol
- propane-1,2-diol
- propane-1,2-diol
- propane-1,2-diol
- propane-1,2-diol
- propylene glycol
- propylene glycol
- propylene glycol
- propylene glycol
- propylene glycol
- propylene glycol
- propylene glycol
- propylene glycol cefatrizine
- propylene glycol cefatrizine
- sentry propylene glycol
- sentry propylene glycol
- sirlene
- sirlene
- α-propyleneglycol
- α-propyleneglycol
Clinical trials
| NCT ID | Phase | Start date | Sponsor(s) |
|---|---|---|---|
| NCT06926322 | N/A | Oct 31, 2025 | Ain Shams University |
| NCT06886373 | Phase 4 | Mar 25, 2025 | National Taiwan University |
| NCT06633471 | Early Phase 1 (Phase 1) | Nov 4, 2024 | PS Therapy Inc. |
| NCT06375343 | Phase 1 | Oct 30, 2024 | Laboratorios Sophia S.A de C.V. |
| NCT06427889 | Phase 4 | Aug 7, 2024 | Malmö University |
| NCT06763731 | Phase 4 | May 2, 2024 | Alcon, National Taiwan University |
| NCT05902364 | N/A | Oct 28, 2023 | Alcon |
| NCT05705518 | Phase 4 | Jan 30, 2023 | Alcon, University of California, Berkeley |
| NCT05660681 | N/A | Dec 12, 2022 | Andover Research Eye Institute, Calm Water Therapeutics LLC |
| NCT05116306 | Phase 3 | Nov 30, 2021 | Ain Shams University |
| NCT05056155 | N/A | Nov 9, 2021 | Alcon |
| NCT04837807 | N/A | Aug 18, 2021 | Alcon, University of Alabama, Birmingham |
| NCT05152186 | Phase 3 | Jun 1, 2021 | Minia University |
| NCT05028907 | Phase 4 | Nov 15, 2020 | Sohag University |
| NCT04393441 | Phase 3 | Jun 30, 2020 | Allergan |
| NCT04380090 | Phase 2 | Feb 20, 2020 | The Cleveland Clinic |
| NCT04230720 | Phase 4 | Jan 31, 2020 | Cornell University |
| NCT04111965 | Phase 1/Phase 2 (Phase 2) | Nov 1, 2019 | Laboratorios Sophia S.A de C.V. |
| NCT04091581 | Phase 4 | Oct 1, 2019 | University of Waterloo |
| NCT03848221 | Phase 4 | May 28, 2019 | Alcon, University of Alabama, Birmingham |
Showing 20 of 51 trials
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Organizations
Research & Development (41)
| Organization | Org type | Trials | As lead sponsor | Phases | Earliest year |
|---|---|---|---|---|---|
| Alcon | For profit | 14 | 8 | 2 | 2012 |
| Galderma | For profit | 5 | 4 | 2 | 2006 |
| Laboratorios Sophia S.A de C.V. | For profit | 4 | 4 | 3 | 2016 |
| Oregon Health and Science University | Academic/Hospital | 3 | 3 | 2 | 2006 |
| University of Alabama, Birmingham | Academic/Hospital | 3 | 3 | 2 | 2018 |
| Ain Shams University | Academic/Hospital | 2 | 2 | 2 | 2021 |
| Hazleton Eye Specialists | Academic/Hospital | 2 | 0 | 1 | 2007 |
| Innovative Medical Research of South Florida, Inc | For profit | 2 | 2 | 1 | 2007 |
| National Taiwan University | Academic/Hospital | 2 | 2 | 1 | 2024 |
| Sohag University | Academic/Hospital | 2 | 2 | 1 | 2015 |
| Wake Forest University | Academic/Hospital | 2 | 2 | 2 | 2006 |
| Allergan | For profit | 1 | 1 | 1 | 2020 |
| Andover Research Eye Institute | Academic/Hospital | 1 | 0 | 1 | 2022 |
| Bangladesh Medical University | Academic/Hospital | 1 | 1 | 1 | 2015 |
| Calm Water Therapeutics LLC | For profit | 1 | 1 | 1 | 2022 |
| Cornell University | Academic/Hospital | 1 | 1 | 1 | 2020 |
| Crown Laboratories, Inc. | For profit | 1 | 1 | 1 | 2017 |
| Free University of Brussels | Academic/Hospital | 1 | 1 | 1 | 2018 |
| GlaxoSmithKline | For profit | 1 | 0 | 1 | 2006 |
| Government College of Dentistry, Indore | Academic/Hospital | 1 | 1 | 1 | 2017 |
41 organizations
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