sennosides a&b
Botanicalexperimental
Sennosides are hydroxyanthracene glycosides derived from Senna leaves. They have been used as natural, safe time-tested laxatives in traditional as well as modern systems of medicine. Sennosides (Senna) is a medication used to treat constipation and empty the large intestine before surgery. The medication is taken by mouth or via the rectum. It typically begins working in minutes when given by rectum and within twelve hours when given by mouth. It is a weaker laxative than bisacodyl or castor oil. Senna is an FDA-approved nonprescription drug for adults and children ages 2 years and older. It is also used for bowel preparation before colonoscopy and diagnostic imaging. — NCATS
Clinical trial activity
24 trials · 29 clinical orgs · 0 marketing orgs
Phase 1
0
Phase 2
6
Phase 3
7
Phase 4
9
Earliest trial started Sep 1, 2005 (NCT00390598)
Timeline
Indications
Approved for
Mechanism of action
- Unspecified targetUnclear
unclear
Chemistry & pharmacology
- Chirality
- Single Stereoisomer
- Inorganic
- No
- Polymer
- No
Oral
No
Parenteral
No
Topical
No
Sources
- NCATSL0FN9W79U2 ↗
- ChEMBLCHEMBL2108559 ↗
- ChEMBLCHEMBL2108558 ↗
- NCATSAK7JF626KX ↗
- NCATS9VK7V8762D ↗
Also known as
- (9,9'-bianthracene)-2,2'-dicarboxylic acid, 5,5'-bis(beta-d-glucopyranosyloxy)-9,9',10,10'-tetrahydro-4,4'-dihydroxy-10,10'-dioxo-, (9r,9'r)-
- (9,9'-bianthracene)-2,2'-dicarboxylic acid, 5,5'-bis(beta-d-glucopyranosyloxy)-9,9',10,10'-tetrahydro-4,4'-dihydroxy-10,10'-dioxo-, (9r,9's)-, calcium salt
- (9,9'-bianthracene)-2,2'-dicarboxylic acid, 5,5'-bis(beta-d-glucopyranosyloxy)-9,9',10,10'-tetrahydro-4,4'-dihydroxy-10,10'-dioxo-, calcium salt (1:1)
- (9r,9r)-5,5-bis(beta-d-glucopyranosyloxy)-9,9,10,10-tetrahydro-4,4-dihydroxy-10,10-dioxo(9,9-bianthracene)-2,2-dicarboxylic acid
- (9r,9's)-5,5'-bis(beta-d-glucopyranosyloxy)-9,9',10,10'-tetrahydro-4,4'-dihydroxy-10,10'-dioxo(9,9'-bianthracene)-2,2'-dicarboxylic acid
- califig
- gentle nature
- glysennid
- manevac
- nd 10
- nd-10
- pursennid
- (r*,r*)-5,5'-bis(beta-d-glucopyranosyloxy)-9,9',10,10'-tetrahydro-4,4'-dihydroxy-10,10'-dioxo(9,9'-bianthracene)-2,2'-dicarboxylic acid
- senna
- senna
- senna
- senna
- senna
- senna extract
- senna extract
- senna glycosides
- senna glycosides
- sennoside
- sennoside
- sennoside
- sennoside
- sennoside
- sennoside a
- sennoside a&b
- sennoside a+b calcium
- sennoside a&b, calcium salt
- sennoside a calcium
- sennoside a calcium and sennoside b calcium
- sennoside a, calcium salt
- sennoside a, calcium salt (1:1)
- sennoside b
- sennoside b
- sennoside b
- sennoside b calcium
- sennoside b, calcium salt
- sennosides
- sennosides
- sennosides
- sennosides
- sennosides a and b
- sennosides a and b
- sennosides a&b
- sennosides a&b
- sennosides a&b
- sennosides a&b
- sennosides a&b
- sennosides sennoside a
- sennosides sennoside b
- senokot
- senokot
- senokot
- senokot max strgh
- sure-lax
- x-prep
Clinical trials
| NCT ID | Phase | Start date | Sponsor(s) |
|---|---|---|---|
| NCT06580366 | Phase 4 | Aug 22, 2024 | Hitit University |
| NCT03475680 | Phase 3 | Jun 1, 2018 | Assistance Publique - Hôpitaux de Paris |
| NCT03491540 | Phase 3 | May 1, 2018 | Assistance Publique - Hôpitaux de Paris |
| NCT03148002 | Phase 4 | Jun 1, 2017 | Government of Canada, Government of Nova Scotia |
| NCT02977286 | Phase 4 | Nov 1, 2016 | Tufts University |
| NCT02618564 | N/A | Dec 1, 2015 | Queen's University, Belfast |
| NCT02481219 | N/A | May 1, 2015 | Medtronic |
| NCT02665624 | Phase 4 | Apr 1, 2015 | Camlıca Erdem Hospital |
| NCT02383758 | N/A | Feb 1, 2015 | Emory University, Organization for Autism Research |
| NCT02239510 | N/A | Sep 1, 2014 | TriHealth |
| NCT01695850 | Phase 2 | Jun 1, 2013 | City University of Hong Kong, Hong Kong Baptist University, The University of Hong Kong |
| NCT01773096 | Phase 4 | May 1, 2013 | Shriners Hospitals for Children |
| NCT02008864 | N/A | Aug 1, 2011 | University of Tehran |
| NCT01531140 | Phase 4 | Nov 1, 2010 | Medical University of Warsaw, National Institutes of Health (NIH) |
| NCT01140295 | Phase 4 | Sep 1, 2010 | University of Pennsylvania |
| NCT00931853 | Phase 3 | Sep 1, 2010 | Sanofi |
| NCT01189409 | Phase 4 | Jun 1, 2010 | British Columbia Cancer Agency |
| NCT00994851 | Phase 3 | Sep 1, 2009 | Sanofi |
| NCT00662363 | N/A | Apr 1, 2008 | Northwestern University, Takeda |
| NCT00571896 | Phase 2/Phase 3 (Phase 3) | Jan 1, 2008 | University of Connecticut |
Showing 20 of 24 trials
Page 1 / 2
Organizations
Research & Development (29)
| Organization | Org type | Trials | As lead sponsor | Phases | Earliest year |
|---|---|---|---|---|---|
| Assistance Publique - Hôpitaux de Paris | Academic/Hospital | 2 | 2 | 1 | 2018 |
| Sanofi | For profit | 2 | 2 | 1 | 2009 |
| University of London | Academic/Hospital | 2 | 2 | 2 | 2006 |
| British Columbia Cancer Agency | Academic/Hospital | 1 | 1 | 1 | 2010 |
| Camlıca Erdem Hospital | Academic/Hospital | 1 | 1 | 1 | 2015 |
| City University of Hong Kong | Academic/Hospital | 1 | 0 | 1 | 2013 |
| College of Family Physicians of Canada | Academic/Hospital | 1 | 0 | 1 | 2006 |
| Covenant Health | Academic/Hospital | 1 | 0 | 1 | 2006 |
| Emory University | Academic/Hospital | 1 | 1 | 1 | 2015 |
| Government of Canada | Government | 1 | 0 | 1 | 2017 |
| Government of Nova Scotia | Government | 1 | 1 | 1 | 2017 |
| Hitit University | Academic/Hospital | 1 | 1 | 1 | 2024 |
| Hong Kong Baptist University | Academic/Hospital | 1 | 1 | 1 | 2013 |
| Medical University of Warsaw | Academic/Hospital | 1 | 1 | 1 | 2010 |
| Medtronic | For profit | 1 | 1 | 1 | 2015 |
| National Institutes of Health (NIH) | Government | 1 | 0 | 1 | 2010 |
| Northwestern University | Academic/Hospital | 1 | 1 | 1 | 2008 |
| Organization for Autism Research | Academic/Hospital | 1 | 0 | 1 | 2015 |
| Queen's University, Belfast | Academic/Hospital | 1 | 1 | 1 | 2015 |
| Shriners Hospitals for Children | Academic/Hospital | 1 | 1 | 1 | 2013 |
29 organizations
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