lactobacillus plantarum

Cell therapyexperimental

Lactiplantibacillus plantarum is a widespread member of the genus Lactiplantibacillus and commonly found in many fermented food products as well as anaerobic plant matter. L. plantarum was first isolated from saliva. Based on its ability to temporarily persist in plants, the insect intestine and in the intestinal tract of vertebrate animals, it was designated as a nomadic organism. L. plantarum is Gram positive, bacilli shaped bacterium. L. plantarum cells are rods with rounded ends, straight, generally 0.9–1.2 μm wide and 3–8 μm long, occurring singly, in pairs or in short chains. L. plantarum has one of the largest genomes known among the lactic acid bacteria and is a very flexible and versatile species. It is estimated to grow between pH 3.4 and 8.8. Lactiplantibacillus plantarum can grow in the temperature range 12 °C to 40 °C. The viable counts of the "L. plantarum" stored at refrigerated condition (4 °C) remained high, while a considerable reduction in the counts was observed stored at room temperature. — Wikipedia

Clinical trial activity

178 trials · 207 clinical orgs · 0 marketing orgs

Phase 1
14
Phase 2
36
Phase 3
18
Phase 4
20

Earliest trial started Jan 1, 2001 (NCT00695461)

Timeline

2000s

  1. Jan 1, 2003

    Earliest Phase 3 Sponsor(trial)

  2. Jan 1, 2004

    Earliest Phase 1 Sponsor(trial)

  3. Jan 1, 2005

    Earliest Phase 2 Sponsor(trial)

Indications

Approved for

Studied for

Mechanism of action

  • microbiotaTissue restoration

    microbiota tissue restoration

Chemistry & pharmacology

Oral

No

Parenteral

No

Topical

No

Sources

Also known as

  • lactobacillus plantarum
  • lactobacillus plantarum
  • lactobacillus plantarum 299v
  • lactobacillus plantarum 3547
  • lactobacillus plantarum ky1032
  • lactobacillus plantarum mf1298
  • lactobacillus plantarum mf 1298
  • lactobacillus plantarum pcs 26
  • lactobacillus plantarum strain 299
  • lactobacillus plantarum strain 299v
  • lactobacillus plantarum strains 299
  • lactobacillus plantarum strains 299v
  • lactobacillus plantarum w1
  • lactobacillus plantarum w62
  • l. planetarium a7
  • l. plantarum
  • l. plantarum 299
  • l. plantarum 299v
  • l plantarum dsm 9843
  • probiotic
  • vsl #3
  • vsl#3

Clinical trials

NCT IDPhaseStart dateSponsor(s)
NCT07076849Phase 2Oct 30, 2025University of Illinois at Chicago
NCT07193927N/AOct 13, 2025AB Biotics, SA
NCT07194200Phase 2Oct 1, 2025Shenzhen University
NCT07118267N/ASep 1, 2025Mackay Medical College
NCT06856434Early Phase 1 (Phase 1)Jun 1, 2025Padjadjaran University
NCT06863194Phase 1/Phase 2 (Phase 2)Apr 3, 2025Mansoura University
NCT06643299Phase 2Dec 31, 2024Rush University
NCT06720805N/ADec 1, 2024University of Roma La Sapienza
NCT06754228N/ANov 13, 2024Natural Immune Systems Inc
NCT06271538Phase 4Oct 17, 2024EP Plus Group Sdn Bhd, Univerisiti Sains Malaysia
NCT06859437N/AOct 1, 2024Silesian University of Medicine
NCT06893549N/ASep 24, 2024GRAPE KING, National Taiwan Sport University
NCT06141083N/ANov 1, 2023Taipei Medical University, TCI Co., Ltd.
NCT06871540N/AOct 1, 2023Inonu University
NCT07100743N/AApr 3, 2023B-Crobes Marketing (M) Sdn Bhd, National University of Malaysia
NCT05752760N/AFeb 20, 2023Medical College of Wisconsin
NCT06808061N/AFeb 14, 20233 Waves Wellness, Kaneka Corporation
NCT05296395N/ADec 22, 2022Medical College of Wisconsin
NCT06211062Phase 2Dec 20, 2022Nova Southeastern University
NCT05767450N/ADec 16, 2022Vita-Salute University of Milano. Italy
Showing 20 of 178 trials
Page 1 / 9

Organizations

Research & Development (207)

OrganizationOrg typeTrialsAs lead sponsorPhasesEarliest year
VSL PharmaceuticalsFor profit8342004
AB Biotics, SAFor profit7612016
Medical College of WisconsinAcademic/Hospital6632013
Bened Biomedical Co., Ltd.For profit4012018
Lund UniversityAcademic/Hospital4212001
Professor Lu Neurological ClinicAcademic/Hospital4412018
University of BarcelonaAcademic/Hospital4222013
University of MilanAcademic/Hospital4322010
University of Roma La SapienzaAcademic/Hospital4322014
All India Institute of Medical SciencesAcademic/Hospital3122005
Hebrew UniversityAcademic/Hospital3332004
Mackay Medical CollegeAcademic/Hospital3312018
Medical University of GrazAcademic/Hospital3312012
National Cancer Institute (NCI)Government3122005
National Taiwan Sport UniversityAcademic/Hospital3312020
National Taiwan UniversityAcademic/Hospital3222017
Synbio TechFor profit3012019
Taipei Medical UniversityAcademic/Hospital3212017
TCI Co., Ltd.For profit3312021
University of Science MalaysiaAcademic/Hospital3312017
207 organizations
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