lactobacillus plantarum
Lactiplantibacillus plantarum is a widespread member of the genus Lactiplantibacillus and commonly found in many fermented food products as well as anaerobic plant matter. L. plantarum was first isolated from saliva. Based on its ability to temporarily persist in plants, the insect intestine and in the intestinal tract of vertebrate animals, it was designated as a nomadic organism. L. plantarum is Gram positive, bacilli shaped bacterium. L. plantarum cells are rods with rounded ends, straight, generally 0.9–1.2 μm wide and 3–8 μm long, occurring singly, in pairs or in short chains. L. plantarum has one of the largest genomes known among the lactic acid bacteria and is a very flexible and versatile species. It is estimated to grow between pH 3.4 and 8.8. Lactiplantibacillus plantarum can grow in the temperature range 12 °C to 40 °C. The viable counts of the "L. plantarum" stored at refrigerated condition (4 °C) remained high, while a considerable reduction in the counts was observed stored at room temperature. — Wikipedia
Clinical trial activity
178 trials · 207 clinical orgs · 0 marketing orgs
Earliest trial started Jan 1, 2001 (NCT00695461)
Timeline
Indications
Approved for
Studied for
- Acute-On-Chronic Liver Failure · Phase 2/Phase 3
- Adenomatous Polyposis Coli · Phase 2
- Aged · Early Phase 1
- Anxiety Disorders · Phase 2
- Appendectomy · Early Phase 1
- Ascites · Phase 2
- Asthma · Phase 1/Phase 2
- Bacterial Infections · Phase 1
- Celiac Disease · Phase 4
- Cognitive Dysfunction · Phase 4
- Colic · Phase 4
- Colonic Diseases · Phase 4
- Colonic Diseases, Functional · Phase 4
- Colonoscopy · Phase 2
- Constipation · Phase 2/Phase 3
- Coronary Artery Disease · Phase 4
- Coronavirus Infections · Phase 2
- COVID-19 · Phase 2
- Crohn Disease · Phase 4
- Deglutition Disorders · Early Phase 1
- Depression · Phase 4
- Diabetes Mellitus · Phase 2
- Diabetes Mellitus, Type 1 · Phase 2
- Diarrhea · Phase 4
- Digestive System Diseases · Phase 4
- Disease · Phase 4
- Drug Resistance, Bacterial · Phase 2
- Esophageal and Gastric Varices · Phase 3
- Fatigue Syndrome, Chronic · Phase 2
- Fatty Liver · Phase 1
- Fibrosis · Phase 4
- Gastroenteritis · Phase 4
- Gastrointestinal Diseases · Phase 4
- Gastrointestinal Microbiome · Phase 2
- General Surgery · Phase 3
- Graft vs Host Disease · Phase 3
- Healthy Volunteers · Phase 1
- Helicobacter pylori · Phase 2
- Hematopoiesis · Phase 1
- Hepatic Encephalopathy · Phase 4
- Hirschsprung Disease · Phase 2
- Hypersensitivity · Phase 4
- Hypertriglyceridemia · Phase 3
- Inflammation · Phase 2
- Inflammatory Bowel Diseases · Phase 3
- Interleukin-17 · Phase 1/Phase 2
- Intestinal Diseases · Phase 4
- Intestinal Neoplasms · Early Phase 1
- Irritable Bowel Syndrome · Phase 4
- Kidney Failure, Chronic · Phase 2
- Klebsiella pneumoniae · Phase 1/Phase 2
- Lactiplantibacillus plantarum · Phase 2
- Leukemia · Phase 3
- Liver Cirrhosis · Phase 2/Phase 3
- Lymphoma · Phase 3
- Metabolic Syndrome · Phase 2
- Multiple Myeloma · Phase 3
- Neoplasms · Phase 3
- Non-alcoholic Fatty Liver Disease · Phase 1/Phase 2
- Osteoporosis · Phase 2
- Overweight · Phase 3
- Pathologic Processes · Phase 4
- Peritonitis · Phase 2/Phase 3
- Pneumonia, Viral · Phase 2
- Polycystic Ovary Syndrome · Phase 3
- Pregnancy · Phase 2
- Probiotics · Phase 4
- Psoriasis · Phase 2
- Renal Insufficiency, Chronic · Phase 1/Phase 2
- Scleroderma, Systemic · Phase 2
- Sepsis · Phase 2
- Uremic Toxins · Phase 1/Phase 2
- Vaginal Diseases · Phase 1
- Vaginitis · Phase 1
- Vaginosis, Bacterial · Phase 1
- Volunteers · Phase 4
- Weight Loss · Phase 4
Mechanism of action
- microbiotaTissue restoration
microbiota tissue restoration
Chemistry & pharmacology
Oral
No
Parenteral
No
Topical
No
Sources
- WikipediaLactiplantibacillus plantarum ↗
- WikipediaL. plantarum ↗
- WikipediaLactobacillus plantarum ↗
Also known as
- lactobacillus plantarum
- lactobacillus plantarum
- lactobacillus plantarum 299v
- lactobacillus plantarum 3547
- lactobacillus plantarum ky1032
- lactobacillus plantarum mf1298
- lactobacillus plantarum mf 1298
- lactobacillus plantarum pcs 26
- lactobacillus plantarum strain 299
- lactobacillus plantarum strain 299v
- lactobacillus plantarum strains 299
- lactobacillus plantarum strains 299v
- lactobacillus plantarum w1
- lactobacillus plantarum w62
- l. planetarium a7
- l. plantarum
- l. plantarum 299
- l. plantarum 299v
- l plantarum dsm 9843
- probiotic
- vsl #3
- vsl#3
Clinical trials
| NCT ID | Phase | Start date | Sponsor(s) |
|---|---|---|---|
| NCT07076849 | Phase 2 | Oct 30, 2025 | University of Illinois at Chicago |
| NCT07193927 | N/A | Oct 13, 2025 | AB Biotics, SA |
| NCT07194200 | Phase 2 | Oct 1, 2025 | Shenzhen University |
| NCT07118267 | N/A | Sep 1, 2025 | Mackay Medical College |
| NCT06856434 | Early Phase 1 (Phase 1) | Jun 1, 2025 | Padjadjaran University |
| NCT06863194 | Phase 1/Phase 2 (Phase 2) | Apr 3, 2025 | Mansoura University |
| NCT06643299 | Phase 2 | Dec 31, 2024 | Rush University |
| NCT06720805 | N/A | Dec 1, 2024 | University of Roma La Sapienza |
| NCT06754228 | N/A | Nov 13, 2024 | Natural Immune Systems Inc |
| NCT06271538 | Phase 4 | Oct 17, 2024 | EP Plus Group Sdn Bhd, Univerisiti Sains Malaysia |
| NCT06859437 | N/A | Oct 1, 2024 | Silesian University of Medicine |
| NCT06893549 | N/A | Sep 24, 2024 | GRAPE KING, National Taiwan Sport University |
| NCT06141083 | N/A | Nov 1, 2023 | Taipei Medical University, TCI Co., Ltd. |
| NCT06871540 | N/A | Oct 1, 2023 | Inonu University |
| NCT07100743 | N/A | Apr 3, 2023 | B-Crobes Marketing (M) Sdn Bhd, National University of Malaysia |
| NCT05752760 | N/A | Feb 20, 2023 | Medical College of Wisconsin |
| NCT06808061 | N/A | Feb 14, 2023 | 3 Waves Wellness, Kaneka Corporation |
| NCT05296395 | N/A | Dec 22, 2022 | Medical College of Wisconsin |
| NCT06211062 | Phase 2 | Dec 20, 2022 | Nova Southeastern University |
| NCT05767450 | N/A | Dec 16, 2022 | Vita-Salute University of Milano. Italy |
Organizations
Research & Development (207)
| Organization | Org type | Trials | As lead sponsor | Phases | Earliest year |
|---|---|---|---|---|---|
| VSL Pharmaceuticals | For profit | 8 | 3 | 4 | 2004 |
| AB Biotics, SA | For profit | 7 | 6 | 1 | 2016 |
| Medical College of Wisconsin | Academic/Hospital | 6 | 6 | 3 | 2013 |
| Bened Biomedical Co., Ltd. | For profit | 4 | 0 | 1 | 2018 |
| Lund University | Academic/Hospital | 4 | 2 | 1 | 2001 |
| Professor Lu Neurological Clinic | Academic/Hospital | 4 | 4 | 1 | 2018 |
| University of Barcelona | Academic/Hospital | 4 | 2 | 2 | 2013 |
| University of Milan | Academic/Hospital | 4 | 3 | 2 | 2010 |
| University of Roma La Sapienza | Academic/Hospital | 4 | 3 | 2 | 2014 |
| All India Institute of Medical Sciences | Academic/Hospital | 3 | 1 | 2 | 2005 |
| Hebrew University | Academic/Hospital | 3 | 3 | 3 | 2004 |
| Mackay Medical College | Academic/Hospital | 3 | 3 | 1 | 2018 |
| Medical University of Graz | Academic/Hospital | 3 | 3 | 1 | 2012 |
| National Cancer Institute (NCI) | Government | 3 | 1 | 2 | 2005 |
| National Taiwan Sport University | Academic/Hospital | 3 | 3 | 1 | 2020 |
| National Taiwan University | Academic/Hospital | 3 | 2 | 2 | 2017 |
| Synbio Tech | For profit | 3 | 0 | 1 | 2019 |
| Taipei Medical University | Academic/Hospital | 3 | 2 | 1 | 2017 |
| TCI Co., Ltd. | For profit | 3 | 3 | 1 | 2021 |
| University of Science Malaysia | Academic/Hospital | 3 | 3 | 1 | 2017 |