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saccharomyces boulardii

Cell therapyexperimental

Saccharomyces boulardii is a tropical yeast first isolated from lychee and mangosteen peels in 1923 by French scientist Henri Boulard. Although early reports claimed distinct taxonomic, metabolic, and genetic properties, S. boulardii is a grouping of S. cerevisiae strains, all sharing a >99% genomic relatedness. This has given rise to the synonym S. cerevisiae var. boulardii. — Wikipedia

Clinical trial activity

51 trials · 56 clinical orgs · 0 marketing orgs

Phase 1
3
Phase 2
13
Phase 3
6
Phase 4
14

Earliest trial started Nov 2, 1999 (NCT00002088)

Timeline

1990s

  1. Jan 1, 1999

    Earliest Phase 2 Sponsor(trial)

2000s

  1. Jan 1, 2006

    Earliest Phase 1 Sponsor(trial)

2010s

  1. Jan 1, 2010

    Earliest Phase 3 Sponsor(trial)

Indications

Approved for

Studied for

Mechanism of action

  • microbiotaTissue restoration

    microbiota tissue restoration

Chemistry & pharmacology

Oral

No

Parenteral

No

Topical

No

Sources

Also known as

  • saccaromyces boulardii
  • saccharomyces boulardii
  • saccharomyces cerevisiae subspecies boulardi
  • s. boulardii

Clinical trials

NCT IDPhaseStart dateSponsor(s)
NCT07168434Phase 3Oct 22, 2025Biocodex
NCT07139366Phase 4Sep 30, 2025People's Liberation Army of China
NCT07012785N/AJun 30, 2025Southeast University
NCT07015736Phase 4Jun 10, 2025Eskisehir Osmangazi University
NCT07168304N/AFeb 1, 2025ICH Multan, Pakistan, RESnTEC, Institute of Research
NCT06451913Phase 4Jun 30, 2024Biocodex, Monopar Therapeutics
NCT06568588Phase 2Jan 6, 2024Biocodex, Universidad San Francisco de Quito, University of Illinois
NCT06540209N/AApr 1, 2023RESnTEC, Institute of Research
NCT05538247Early Phase 1 (Phase 1)Dec 15, 2022Mayo Clinic
NCT05451433N/AAug 1, 2022University of Indonesia
NCT05355571N/AMay 31, 2022Comac Medical, Cultech Ltd,
NCT06657066Phase 2/Phase 3 (Phase 3)Dec 6, 2021King Edward Medical University
NCT05191875N/ADec 1, 2021Central South University
NCT05614726N/AJun 18, 2021Biohm Health, LLC, The Center for Applied Health Sciences, LLC
NCT04605783N/AApr 30, 2021Department of Defense, Uniformed Services University of the Health Sciences
NCT05231772N/AMar 1, 2021I.M. Sechenov First Moscow State Medical University
NCT04706559N/AJan 3, 2021B.P. Koirala Institute of Health Sciences, Government of Nepal
NCT05226052N/ADec 21, 2020Instituto Mexicano del Seguro Social
NCT03997279Phase 4Jun 30, 2019Clinical Centre of Serbia
NCT03941418N/AJun 1, 2019University Clinic Dr Dragisa Misovic-Dedinje, University Clinic Zvezdara
Showing 20 of 51 trials
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Organizations

Research & Development (56)

OrganizationOrg typeTrialsAs lead sponsorPhasesEarliest year
BiocodexFor profit8441999
Federal University of Minas GeraisAcademic/Hospital3232010
Zekai Tahir Burak HospitalAcademic/Hospital3322011
Aga Khan UniversityAcademic/Hospital2222007
Clinical Centre of SerbiaAcademic/Hospital2212017
Harvard UniversityAcademic/Hospital2212011
Instituto Mexicano del Seguro SocialGovernment2122015
Mayo ClinicAcademic/Hospital2222006
RESnTEC, Institute of ResearchAcademic/Hospital2212023
Universidad San Francisco de QuitoAcademic/Hospital2222016
Aswan UniversityAcademic/Hospital1112018
Bernhard Nocht Institute for Tropical MedicineAcademic/Hospital1112010
Biohm Health, LLCFor profit1012021
B.P. Koirala Institute of Health SciencesAcademic/Hospital1112021
Central South UniversityAcademic/Hospital1112021
Centro de Educación Medica e Investigaciones Clínicas Norberto QuirnoAcademic/Hospital1112017
China Medical UniversityAcademic/Hospital1112013
Comac MedicalFor profit1012022
Cultech Ltd,For profit1112022
Department of DefenseGovernment1012021
56 organizations
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