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Anemia, Sickle Cell
A disease characterized by chronic hemolytic anemia, episodic painful crises, and pathologic involvement of many organs. It is the clinical expression of homozygosity for hemoglobin S.
Subtype terms (4)
More specific conditions that are subtypes of Anemia, Sickle Cell in the MeSH hierarchy.
- Acute Chest Syndrome
12 drugs (11 approved, 1 experimental)
- Hemoglobin SC Disease
16 drugs (11 approved, 5 experimental)
- Sickle Cell Trait
1 drug approved
- Vaso-Occlusive Crises
1 drug approved
Drugs by status
Approved for this indication (8)
Phase 4 trials (21)
Phase 3 trials (59)
- simvastatin
- montelukast
- maltodextrin
- methylprednisolone
- Poloxalene
- acetylcysteine
- urea
- procaine benzylpenicillin
- bosentan
- busulfan
- prednisone
- methylphenidate
- folic acid
- rivipansel
- famotidine
- parecoxib
- citrulline
- lentiglobin bb305
- nalbuphine
- nitric oxide
- succinylcholine
- pectin
- ticagrelor
- magnesium sulfate
- prasugrel
- Rilzabrutinib
- red blood cells
- senicapoc
- acetylsalicylic acid
- cyclophosphamide
- +29 more
Phase 2 trials (127)
- nitrous oxide
- 23-valent pneumococcal polysaccharide vaccine
- sodium nitrite
- decitabine
- nitroglycerin
- heparin
- acetylcarnitine
- riociguat
- Hydroxymethylfurfural
- plerixafor
- beetroot juice
- epoetin
- bpx-501
- canakinumab
- cd3,cd19 depleted hematopoietic stem cells
- tadalafil
- mometasone
- alpha-lipoic acid
- defibrotide
- Epeleuton
- empagliflozin
- cannabidiol
- gabapentin
- tacrolimus
- abciximab
- naltrexone
- lymphocyte immune globulin, anti-thymocyte globulin (equine)
- hemopoietic stem cell
- bone marrow derived mesenchymal stem cells
- haploidentical mononuclear cells
- +97 more
Phase 1 trials (54)
- metformin
- biotinylated red blood cells
- ambrisentan
- capsaicin
- diphenhydramine
- imatinib
- rosuvastatin
- incb059872
- meperidine
- pitavastatin
- macitentan
- nktt120
- nvx-508
- oxypurinol
- panobinostat
- pf-04447943
- repaglinide
- fostamatinib
- sitagliptin
- scd-101
- testosterone
- digoxin
- natalizumab
- furosemide
- zileuton
- autologous umbilical cord blood
- biotin
- autologous bone marrow derived mesenchymal cells
- bupropion
- autologous mononuclear stem cell
- +24 more
Other trials (24)
- ranibizumab
- ringer's lactate
- acetazolamide
- beta-hydroxyisovaleric acid
- brussel sprouts
- carbon dioxide
- enalapril
- nevulose
- alefacept
- iohexol
- lymphocytes
- hepatitis b vaccine (recombinant)
- whole blood
- inactivated influenza vaccine
- methadone
- cytarabine
- vitamin a
- broccoli
- ubiquinone
- ketone monoester
- axa4010
- allogeneic cd34+ cells
- brl-101
- nuv001
Organizations
Organization Involved with Phase 4 Indications (37)
- Emmaus Medical
- Addmedica
- Pfizer
- Apotex
- Wyeth
- Novartis
- National Institutes of Health (NIH)
- Medical Research Council
- National Heart, Lung, and Blood Institute (NHLBI)
- University of Pennsylvania
- University of Arizona
- University of Pittsburgh
- Ain Shams University
- University of London
- Harvard University
- Duke University
- Federal University of Bahia
- Loyola University
- Newark Beth Israel Medical Center
- The Baruch Padeh Medical Center, Poriya
- University of Ibadan
- Mednax Center for Research, Education and Quality
- University of California, San Francisco
- University of Cincinnati
- Icahn School of Medicine at Mount Sinai
- Global Blood Therapeutics, Inc.
- University of Sao Paulo
- University of North Carolina at Chapel Hill
- Muhimbili University
- University of Paris
- +7 more
Organization Involved with Phase 3 Indications (92)
- Actelion
- Daiichi Sankyo
- McNeil
- Bristol-Myers Squibb
- United Therapeutics
- AstraZeneca
- Merck
- Eli Lilly
- EuroPharma, Inc.
- ICAgen
- Mallinckrodt
- Micelle BioPharma
- bluebird bio
- CytRx
- Forma Therapeutics, Inc.
- ZonMw: The Netherlands Organisation for Health Research and Development
- National Institute of Neurological Disorders and Stroke (NINDS)
- National Marrow Donor Program
- Al-Neelain University
- Aminu Kano Teaching Hospital
- Augusta University
- Baylor University
- Case Western Reserve University
- Drexel University
- Emory University
- Federal University of Rio Grande do Sul
- Temple University
- Hoosier Cancer Research Network
- Howard University
- Indiana University
- +62 more
Organization Involved with Phase 2 Indications (105)
- Biomarin
- Imara, Inc.
- Eisai
- Cephalon
- Shire
- Ironwood Pharmaceuticals
- Vertex
- Gilead Sciences
- Sanofi-Aventis
- Anthera Pharmaceuticals
- Baxalta
- Bayer
- Bellicum Pharmaceuticals
- GlaxoSmithKline
- Hope Pharmaceuticals
- Modus Therapeutics AB
- Nova Laboratories Limited
- Prolong Pharmaceuticals
- Sangart
- Sponsor GmbH
- Gamida Cell
- TRF Pharma, Inc
- Center for International Blood and Marrow Transplant Research
- National Cancer Institute (NCI)
- National Center for Complementary and Integrative Health (NCCIH)
- National Center for Research Resources (NCRR)
- National Institute of Allergy and Infectious Diseases (NIAID)
- National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
- National Institute of General Medical Sciences (NIGMS)
- University of Roma La Sapienza
- +75 more
Organization Involved with Phase 1 Indications (34)
- CSL Behring
- Incyte
- Celgene
- Astellas
- Cato Research
- Sanofi
- Angiogenix
- Invenux, LLC
- NKT Therapeutics
- NuvOx Pharma Pty Ltd
- Parexel
- Agios Pharmaceuticals, Inc.
- Cornell University
- Hospital Pablo Tobón Uribe
- National Cheng Kung University
- New York Blood Center
- University of Michigan
- Noguchi Memorial Institute for Medical Research
- Purdue University
- Medpace, Inc.
- Quotient
- Fundacion Reina Isabel
- Hospital Punta Pacifica
- Fundacion BIOS
- City of Hope National Medical Center
- Kings County Medical Center
- California Institute for Regenerative Medicine
- SAIC-Frederick, Inc.
- Ricerca Biosciences LLC
- Nuventra Pharma Sciences, Inc.
- +4 more
Organization Involved with Other Experimental Indications (17)
- Genentech
- Brugmann University Hospital
- Cameroon Baptist Convention Health
- Kenya Medical Research Institute
- Kresge Eye Institute
- New England Research Institutes
- Newcastle University
- Oregon Health and Science University
- The Brooklyn Hospital Center
- University of British Columbia
- Mihumbili National Hospital
- Advanced Pharma CR, LLC
- Pennsylvania State University
- Hospital Infantil Dr. Robert Reid Cabral
- Strathmore University
- Imam Abdulrahman Bin Faisal University
- Axcella Health Inc.