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meperidine

Trade name: demerol

Small moleculeapproved

Approved

Nov 10, 1942

Pethidine, also known as meperidine and Demerol, a narcotic analgesic that can be used for the relief of most types of moderate to severe pain, including postoperative pain and the pain of labor. Meperidine is an opioid agonist with multiple actions qualitatively similar to those of morphine. Most common adverse reactions were lightheadedness, dizziness, sedation, nausea, vomiting, and sweating. Pethidine has serious interactions that can be dangerous with monoamine oxidase inhibitors (e.g., furazolidone, isocarboxazid, moclobemide, phenelzine, procarbazine, selegiline, tranylcypromine). Pethidine can interact with muscle relaxants, some antidepressants, benzodiazepines, and ethanol. — NCATS

Clinical trial activity

76 trials · 71 clinical orgs · 27 marketing orgs

Phase 1
2
Phase 2
19
Phase 3
12
Phase 4
25

Earliest trial started May 1, 2003 (NCT00596414)

Timeline

1940s

  1. Nov 10, 1942

    Earliest FDA Approval

  2. Nov 10, 1942

    Hospira — NDA Secondary Org

  3. Nov 10, 1942

    Validus Pharmaceuticals — NDA Secondary Org

  4. Nov 10, 1942

    Validus Pharmaceuticals — Marketing Organization

  5. Nov 10, 1942

    Quagen Pharma — Marketing Organization

1960s

  1. Nov 13, 1961

    West-Ward Pharmaceutical — Marketing Organization

  2. Nov 13, 1961

    Hikma — Marketing Organization

  3. Nov 13, 1961

    Hikma — NDA Secondary Org

1970s

  1. Jul 31, 1973

    American Home Products — Marketing Organization

  2. May 19, 1976

    Parke-Davis — Marketing Organization

  3. May 19, 1976

    Warner Lambert — Marketing Organization

1980s

  1. Jun 15, 1984

    Baxalta — Marketing Organization

  2. Jun 15, 1984

    Baxter — Marketing Organization

  3. Jul 2, 1984

    Barr Laboratories — Marketing Organization

  4. Aug 16, 1984

    ICU Medical Inc — Marketing Organization

1990s

  1. Mar 17, 1992

    Watson Pharmaceuticals — Marketing Organization

  2. Aug 30, 1993

    International Medication — Marketing Organization

  3. May 12, 1997

    Specgx Llc — Marketing Organization

  4. Dec 17, 1998

    Vintage — Marketing Organization

  5. Dec 17, 1998

    Strides Pharma Science — Marketing Organization

  6. Mar 10, 1999

    Hospira — Marketing Organization

  7. May 28, 1999

    Epic Pharma Llc — Marketing Organization

  8. Oct 5, 1999

    Duramed Research — Marketing Organization

2000s

  1. Aug 8, 2002

    Sun Pharmaceuticals — Marketing Organization

  2. Jan 1, 2004

    Earliest Phase 3 Sponsor(trial)

  3. Jun 24, 2009

    Genus Oncology, LLC — Marketing Organization

  4. Jun 24, 2009

    Mikart — Marketing Organization

  5. Jun 24, 2009

    ANDA Repository — Marketing Organization

2010s

  1. Jan 1, 2010

    Earliest Phase 2 Sponsor(trial)

  2. Jan 1, 2016

    Earliest Phase 1 Sponsor(trial)

Indications

Approved for

Studied for

Mechanism of action

Combination products

Approval history

  • approvedNov 10, 1942

Chemistry & pharmacology

Loading structure…

SMILES

CCOC(=O)C1(c2ccccc2)CCN(C)CC1
Mol. weight
247.34 g/mol
Lipinski Ro5
Pass
Rule of 3
Yes
Chirality
Achiral Molecule
Inorganic
No
Polymer
No
Delivery
Oral, Parenteral
Availability
Prescription Only

Oral

Yes

Parenteral

Yes

Topical

No

Black box warning

Sources

Also known as

  • demerol
  • demerol
  • demerol
  • demerol
  • isonipecaine
  • isonipecaïne
  • isonipecaïne
  • meperdine
  • meperidine
  • meperidine
  • meperidine
  • meperidine
  • meperidine
  • meperidine
  • meperidine
  • meperidine
  • meperidine hcl
  • meperidine hcl
  • meperidine hcl
  • meperidine hydrochloride
  • meperidine hydrochloride
  • meperidine hydrochloride
  • meperidine hydrochloride
  • meperidine hydrochloride preservative free
  • meperidine hydrochloride preservative free
  • meperidol
  • pamergan
  • pethanol
  • pethidin
  • pethidin
  • pethidin
  • pethidine
  • pethidine
  • pethidine
  • pethidine
  • pethidine
  • pethidine
  • pethidine
  • péthidine
  • péthidine
  • pethidine dbl
  • pethidine dbl
  • pethidine hcl
  • pethidine hcl
  • pethidine hcl
  • pethidine hydrochloride
  • pethidine hydrochloride
  • pethidine hydrochloride
  • pethidinum
  • pethidinum
  • pethilorfan
  • petidina
  • petidina
  • petydyna
  • petydyna
  • sauteralgyl
  • sauteralgyl
  • spasmedal
  • spasmedal
  • spasmodlin
  • spasmodolin
  • spasmodolin

Clinical trials

NCT IDPhaseStart dateSponsor(s)
NCT07264309N/ANov 1, 2025Emek Medical Center
NCT06736938Phase 4Apr 1, 2025Fondazione Andrea Cesalpino Arezzo ONLUS
NCT06775431Phase 3Dec 10, 2024Alexandria University
NCT06513806Phase 4Aug 31, 2024Ain Shams University
NCT06326944Phase 2Jan 18, 2024Cairo University
NCT06172920Phase 4Dec 31, 2023Baskent University
NCT06082076Phase 2/Phase 3 (Phase 3)Nov 30, 2023Assiut University
NCT06111872Phase 2Jul 18, 2023National University of Malaysia
NCT05499234Phase 1Aug 1, 2022Istanbul Medipol University
NCT05284409Phase 4Jul 1, 2022Ain Shams University
NCT05386121Phase 4May 20, 2022Cairo University
NCT05270434N/AMar 1, 2022Changhai Hospital
NCT04735965Phase 4Jul 15, 2021Shandong Province Qianfoshan Hospital
NCT05110469Phase 4Feb 1, 2021AnestesiaR
NCT04719507N/AJan 31, 2021Cairo University
NCT05303311Phase 2/Phase 3 (Phase 3)Jan 15, 2021Zagazig University
NCT05696886N/AJan 1, 2021Mansoura University
NCT04446715N/AJun 30, 2020Makassed General Hospital
NCT04081948N/AOct 1, 2019Istanbul Medipol University
NCT04073095N/ASep 1, 2019Istanbul Medipol University
Showing 20 of 76 trials
Page 1 / 4

Organizations

Research & Development (71)

OrganizationOrg typeTrialsAs lead sponsorPhasesEarliest year
Ain Shams UniversityAcademic/Hospital7732010
Cairo UniversityAcademic/Hospital6632014
Assiut UniversityAcademic/Hospital5522013
Istanbul Medipol UniversityAcademic/Hospital3322019
Baskent UniversityAcademic/Hospital2222009
Dalin Tzu Chi General HospitalAcademic/Hospital2212011
Emek Medical CenterAcademic/Hospital2212016
Erciyes UniversityAcademic/Hospital2122012
Mansoura UniversityAcademic/Hospital2222017
National University of MalaysiaAcademic/Hospital2222014
Technion UniversityAcademic/Hospital2112006
University of WashingtonAcademic/Hospital2122016
Yonsei UniversityAcademic/Hospital2212013
Alexandria UniversityAcademic/Hospital1112024
AnestesiaRAcademic/Hospital1112021
Austin HealthAcademic/Hospital1112004
Barts & The London NHS TrustAcademic/Hospital1012014
Changhai HospitalAcademic/Hospital1112022
Cheju Halla General HospitalAcademic/Hospital1112013
Chulabhorn Cancer CenterAcademic/Hospital1112012
71 organizations
Page 1 / 4

Marketing (33)

OrganizationOrg typeRelationshipDate
ANDA RepositoryFor profitMKTGJun 24, 2009
AbbVieFor profitMKTG—
AbbottFor profitMKTG—
American Home ProductsFor profitMKTGJul 31, 1973
Barr LaboratoriesFor profitMKTGJul 2, 1984
BaxaltaFor profitMKTGJun 15, 1984
BaxterFor profitMKTGJun 15, 1984
Duramed ResearchFor profitMKTGOct 5, 1999
Epic Pharma LlcFor profitSYNMay 28, 1999
Epic Pharma LlcFor profitMKTGMay 28, 1999
Genus Oncology, LLCFor profitMKTGJun 24, 2009
HikmaFor profitMKTGNov 13, 1961
HikmaFor profitSYNJan 30, 1985
HikmaFor profitNDA2Nov 13, 1961
HospiraFor profitNDA2Nov 10, 1942
HospiraFor profitMKTGMar 10, 1999
ICU Medical IncFor profitMKTGAug 16, 1984
International MedicationFor profitMKTGAug 30, 1993
MikartFor profitMKTGJun 24, 2009
Parke-DavisFor profitMKTGMay 19, 1976
Quagen PharmaFor profitMKTGNov 10, 1942
Specgx LlcFor profitMKTGMay 12, 1997
Strides Pharma ScienceFor profitMKTGDec 17, 1998
Sun PharmaceuticalsFor profitMKTGAug 8, 2002
Sun PharmaceuticalsFor profitSYNOct 15, 1976
SynthelaboFor profitNDA—
Teligent PharmaceuticalsFor profitMKTG—
Validus PharmaceuticalsFor profitNDA2Nov 10, 1942
Validus PharmaceuticalsFor profitMKTGNov 10, 1942
VintageFor profitMKTGDec 17, 1998
Warner LambertFor profitMKTGMay 19, 1976
Watson PharmaceuticalsFor profitMKTGMar 17, 1992
West-Ward PharmaceuticalFor profitMKTGNov 13, 1961