ketone monoester
Small moleculeexperimental
Clinical trial activity
80 trials · 61 clinical orgs · 0 marketing orgs
Phase 1
4
Phase 2
15
Phase 3
3
Phase 4
2
Earliest trial started May 31, 2011 (NCT01364545)
Timeline
Indications
Approved for
Studied for
- Cardiac Output, Low · Phase 3
- Cardiomyopathies · Phase 4
- Cognition · Phase 2
- Critical Illness · Phase 2
- Dementia · Phase 4
- Diabetes Mellitus, Type 2 · Phase 2
- Diet · Phase 1
- Dietary Supplements · Phase 1
- Drug Resistant Epilepsy · Phase 2/Phase 3
- Exercise · Phase 2
- Healthy Volunteers · Phase 2
- Heart Failure · Phase 3
- Heart Failure, Diastolic · Phase 2
- Heart Failure, Systolic · Phase 2
- Hemodynamics · Phase 3
- Intensive Care Units · Phase 2
- Ketones · Phase 1
- Ketosis · Phase 3
- Muscle, Skeletal · Phase 2
- Placebos · Phase 1
- Polycystic Kidney, Autosomal Dominant · Phase 2
- Running · Phase 2
- Sleep · Phase 2
- Status Epilepticus · Phase 2/Phase 3
- Ventricular Dysfunction, Right · Phase 4
Mechanism of action
- Unspecified targetUnclear
unclear
Chemistry & pharmacology
Oral
No
Parenteral
No
Topical
No
Clinical trials
| NCT ID | Phase | Start date | Sponsor(s) |
|---|---|---|---|
| NCT06954675 | N/A | Oct 10, 2025 | University of California, San Francisco |
| NCT07051655 | N/A | Oct 8, 2025 | University of Alabama, Birmingham |
| NCT07289165 | N/A | Jul 15, 2025 | NeuroEnergy Ventures, Inc. |
| NCT07048860 | N/A | Jul 9, 2025 | University of Toulouse |
| NCT06952140 | N/A | Jun 10, 2025 | University of Copenhagen |
| NCT07082309 | N/A | Jun 4, 2025 | University of Exeter |
| NCT07063732 | N/A | May 28, 2025 | McMaster University |
| NCT06962501 | N/A | Apr 12, 2025 | Felix Platter Hospital, McMaster University |
| NCT06769100 | N/A | Jan 10, 2025 | McGill University |
| NCT07087093 | N/A | Jan 7, 2025 | Harbin Medical University |
| NCT06668168 | N/A | Jan 6, 2025 | University of Bath |
| NCT06799260 | N/A | Dec 18, 2024 | University of Oxford, University Putra Malaysia |
| NCT06683547 | N/A | Nov 30, 2024 | McGill University |
| NCT06846840 | N/A | Nov 1, 2024 | University of Bath |
| NCT06645847 | N/A | Nov 1, 2024 | Buck Institute for Research on Aging, Ohio State University, University of Connecticut |
| NCT06715748 | Phase 4 | Oct 17, 2024 | Hasselt University |
| NCT06590623 | N/A | Oct 1, 2024 | University of British Columbia |
| NCT06596083 | N/A | Sep 10, 2024 | Katholieke Universiteit Leuven |
| NCT06515717 | N/A | Jul 18, 2024 | German Institute of Human Nutrition |
| NCT06395051 | N/A | Jul 1, 2024 | Maastricht University |
Showing 20 of 80 trials
Page 1 / 4
Organizations
Research & Development (61)
| Organization | Org type | Trials | As lead sponsor | Phases | Earliest year |
|---|---|---|---|---|---|
| Aarhus University | Academic/Hospital | 10 | 10 | 3 | 2019 |
| Katholieke Universiteit Leuven | Academic/Hospital | 10 | 8 | 2 | 2020 |
| University of British Columbia | Academic/Hospital | 6 | 6 | 2 | 2018 |
| McMaster University | Academic/Hospital | 4 | 3 | 1 | 2022 |
| University of Oxford | Academic/Hospital | 4 | 2 | 1 | 2011 |
| Ohio State University | Academic/Hospital | 3 | 2 | 1 | 2023 |
| University of Alabama, Birmingham | Academic/Hospital | 3 | 3 | 1 | 2019 |
| Buck Institute for Research on Aging | Academic/Hospital | 2 | 2 | 1 | 2022 |
| Central Jutland Regional Hospital | Academic/Hospital | 2 | 2 | 1 | 2019 |
| Jozef Stefan Institute | Academic/Hospital | 2 | 2 | 1 | 2020 |
| McGill University | Academic/Hospital | 2 | 2 | 1 | 2024 |
| Sohag University | Academic/Hospital | 2 | 2 | 1 | 2023 |
| University of Bath | Academic/Hospital | 2 | 2 | 1 | 2024 |
| University of Copenhagen | Academic/Hospital | 2 | 2 | 1 | 2019 |
| University of Groningen | Academic/Hospital | 2 | 2 | 1 | 2016 |
| University of Michigan | Academic/Hospital | 2 | 2 | 1 | 2023 |
| American Heart Association | Academic/Hospital | 1 | 0 | 1 | 2024 |
| Auburn University | Academic/Hospital | 1 | 0 | 1 | 2023 |
| Barts & The London NHS Trust | Academic/Hospital | 1 | 1 | 1 | 2018 |
| Charles University | Academic/Hospital | 1 | 1 | 1 | 2020 |
61 organizations
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