nevulose

Small moleculeexperimental

Fructose, or fruit sugar, is a simple ketonic monosaccharide found in many plants, where it is often bonded to glucose to form the disaccharide sucrose. At a commercial scale, fructose is often derived from sugar cane, sugar beets, and maize. Fructose is one of the three dietary monosaccharides, along with glucose and galactose, that are absorbed directly into the bloodstream. A growing body of research suggests that diet high in fructose may be contributing to incidences of obesity, insulin resistance, and diabetes. — NCATS

Clinical trial activity

28 trials · 40 clinical orgs · 0 marketing orgs

Phase 1
3
Phase 2
0
Phase 3
0
Phase 4
0

Earliest trial started Aug 1, 1995 (NCT00004797)

Timeline

2000s

  1. Jan 1, 2007

    Earliest Phase 1 Sponsor(trial)

Indications

Mechanism of action

  • Unspecified targetUnclear

    unclear

Chemistry & pharmacology

Loading structure…

SMILES

OC[C@H]1O[C@](O)(CO)[C@@H](O)[C@@H]1O
Mol. weight
180.16 g/mol
Lipinski Ro5
Pass
Rule of 3
No
Chirality
Single Stereoisomer
Inorganic
No
Polymer
No

Oral

No

Parenteral

No

Topical

No

Sources

Also known as

  • d-arabino-2-hexulose
  • d-fructopyranose
  • d-fructopyranose
  • d-fructopyranose
  • d-fructopyranose
  • d-fructopyranose
  • d-fructopyranose
  • d-(-)-fructose
  • dietade dietary foods
  • d-(-)-levulose
  • fructose
  • fructose
  • fructose
  • fructose
  • fructose
  • fructose
  • fruit sugar
  • levulose
  • levulose
  • levulose
  • nevulose

Clinical trials

NCT IDPhaseStart dateSponsor(s)
NCT03076684Early Phase 1 (Phase 1)Mar 3, 2017University of Missouri
NCT03067428N/AJan 31, 2017Maastricht University
NCT02940184N/AJun 1, 2016University of Copenhagen
NCT03173495N/AJan 10, 2016Federal University of Rio Grande do Sul
NCT02455726N/ASep 1, 2015University of Brescia
NCT02876796Phase 1Aug 1, 2015Gilead Sciences, Nimbus Apollo
NCT02891525N/AMar 1, 2015Katholieke Universiteit Leuven
NCT02590913N/AMar 1, 2015Zhejiang University
NCT02902224N/AApr 1, 2014University of Basel, University of Bern
NCT02589613N/AOct 1, 2013University of Basel, University of Bern
NCT01866215N/AMay 1, 2013University of Bern, University of Lausanne
NCT02075164N/AMay 1, 2013Medical University of Vienna, University of Vienna, Wiener Wissenschafts-, Forschungs- und Technologiefonds
NCT01713023N/AMar 1, 2013Federal University of Rio de Janeiro, Rio de Janeiro State University
NCT01918566N/AMar 1, 2012University of Bern
NCT01459406N/AOct 1, 2011University of Nottingham
NCT01445730N/AAug 1, 2011Clinical Research Institute HUCH Ltd, Laval University, Lund University, University of Gothenburg, University of Helsinki, University of Naples Frederico II
NCT01407627N/AJul 1, 2011University of Calgary
NCT02217605N/AMar 1, 2011Biotechnology and Biological Sciences Research Council, Unilever, University of Nottingham
NCT01119989N/AMay 1, 2010University of Bern, University of Lausanne
NCT01188083N/AJun 1, 2009Emory University
Showing 20 of 28 trials
Page 1 / 2

Organizations

Research & Development (40)

OrganizationOrg typeTrialsAs lead sponsorPhasesEarliest year
University of BernAcademic/Hospital5312010
University of LausanneAcademic/Hospital3312008
University of BaselAcademic/Hospital2012013
University of NottinghamAcademic/Hospital2212011
Austrian Research Promotion AgencyAcademic/Hospital1012009
Biotechnology and Biological Sciences Research CouncilAcademic/Hospital1012011
Clinical Research Institute HUCH LtdAcademic/Hospital1112011
Emory UniversityAcademic/Hospital1112009
Federal University of Rio de JaneiroAcademic/Hospital1112013
Federal University of Rio Grande do SulAcademic/Hospital1112016
Gilead SciencesFor profit1112015
Instituto Nacional de Cardiologia Ignacio ChavezAcademic/Hospital1112009
Katholieke Universiteit LeuvenAcademic/Hospital1112015
Laval UniversityAcademic/Hospital1012011
Lund UniversityAcademic/Hospital1012011
Maastricht UniversityAcademic/Hospital1112017
McGill UniversityAcademic/Hospital1112008
Medical University of GrazAcademic/Hospital1012009
Medical University of ViennaAcademic/Hospital1112013
National Center for Research Resources (NCRR)Government1111995
40 organizations
Page 1 / 2