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desogestrel

Trade name: Mercilon

Small moleculeapproved

Approved

Dec 10, 1992

Desogestrel is a progestin medication which is used in birth control pills. It is also used in the treatment of menopausal symptoms in women. The medication is available and used alone or in combination with an estrogen. It is taken by mouth. — Wikipedia

Clinical trial activity

99 trials · 82 clinical orgs · 21 marketing orgs

Phase 1
6
Phase 2
34
Phase 3
24
Phase 4
37

Earliest trial started Nov 1, 2001 (NCT00725413)

Timeline

1990s

  1. Dec 10, 1992

    Earliest FDA Approval

  2. Dec 14, 1992

    Johnson and Johnson — NDA Secondary Org

  3. Apr 22, 1998

    Teva — NDA Secondary Org

  4. Aug 12, 1999

    Duramed Research — Marketing Organization

2000s

  1. Dec 20, 2000

    Aspen Pharmaceuticals — NDA Secondary Org

  2. Oct 3, 2001

    Organon — Marketing Organization

  3. Oct 3, 2001

    Organon — NDA Secondary Org

  4. Apr 5, 2002

    Barr Laboratories — Marketing Organization

  5. Jan 1, 2003

    Earliest Phase 2 Sponsor(trial)

  6. Jan 1, 2003

    Earliest Phase 3 Sponsor(trial)

  7. Jul 29, 2005

    Watson Pharmaceuticals — Marketing Organization

  8. Jan 24, 2006

    Mayne Pharma — Marketing Organization

  9. Jul 17, 2006

    Organon — First NDA Organization

  10. Jul 17, 2006

    Organon — NDA Organization

  11. Jan 1, 2008

    Earliest Phase 1 Sponsor(trial)

2010s

  1. Feb 25, 2011

    Endo Pharmaceuticals — Marketing Organization

  2. Feb 25, 2011

    Apax Partners — Marketing Organization

  3. Apr 2, 2012

    Glenmark Pharmaceuticals — Marketing Organization

  4. Mar 7, 2013

    Lupin — Marketing Organization

  5. Jul 12, 2013

    Novast Labs — Marketing Organization

  6. Aug 30, 2013

    Mylan — Marketing Organization

  7. Apr 30, 2015

    Vintage — Marketing Organization

  8. Aug 12, 2015

    Exeltis — Marketing Organization

  9. Mar 22, 2017

    Aurobindo Pharma — Marketing Organization

  10. Jun 5, 2017

    Accord Research — Marketing Organization

  11. Jun 5, 2017

    Naari Pte Ltd — Marketing Organization

  12. Dec 11, 2019

    Amneal Pharmaceuticals — Marketing Organization

2020s

  1. Jan 13, 2021

    Teva — Marketing Organization

  2. Dec 9, 2021

    Dr. Reddy's Laboratories — Marketing Organization

Indications

Approved for

Studied for

Mechanism of action

Combination products

  • desogen

    with ethinyl estradiol

    Also known as bekyree, cyclessa, desogestrel; ethinyl, emoquette, enskyce, isibloom, kalliga, kariva, kimidess, mircette, nuvaring, ortho-cept, pimtrea, velivet, viorele, volnea

Approval history

  • approvedDec 10, 1992

Chemistry & pharmacology

Loading structure…

SMILES

C#C[C@]1(O)CC[C@H]2[C@@H]3CCC4=CC(=O)CC[C@@H]4[C@H]3C(=C)C[C@@]21CC
Mol. weight
324.46 g/mol
Lipinski Ro5
Pass
Rule of 3
No
Chirality
Single Stereoisomer
Inorganic
No
Polymer
No
Delivery
Parenteral, Topical
Availability
Prescription Only

Oral

No

Parenteral

Yes

Topical

Yes

Sources

Also known as

  • 13-ethyl-11-methylene-18,19-dinor-17alpha-pregn-4-en-20-yn-17-ol
  • 13-ethyl-11-methylene-18,19-dinor-17alpha-pregn-4-en-20-yn-17-ol
  • 13-ethyl-17-hydroxy-11-methylene-18,19-dinor-17alpha-pregn-4-en-20-yn-3-one
  • 18,19-dinorpregn-4-en-20-yn-3-one, 13-ethyl-17-hydroxy-11-methylene-, (17-alpha)-
  • 3-ketodesogestrel
  • 3-ketodesogestrel
  • 3-ketodesogestrel
  • 3-keto-desogestrel
  • 3-oxodesogestrel
  • 3-oxodesogestrel
  • 3-oxodesogestrel
  • 3-oxodesogestrel
  • 3-oxo desogestrel
  • aizea
  • cerazette
  • cerazette
  • cerazette
  • cerazette
  • cerelle
  • combeq
  • combiphasic ee-dsg contraceptive
  • desogestrel
  • desogestrel
  • desogestrel
  • desogestrel
  • desogestrel
  • desogestrel
  • desogestrelum
  • desogestrelum
  • desomono
  • ethinyl estradiol-desogestrel combination
  • ethonogestrel
  • etonogestrel
  • etonogestrel
  • etonogestrel
  • etonogestrel
  • etonogestrel
  • etonogestrel
  • etonogestrel
  • etonogestrel
  • etonogestrel
  • etonogestrel
  • étonogestrel
  • étonogestrel
  • etonogestrelum
  • etonogestrelum
  • etonorgestrel
  • feanolla
  • implanon
  • implanon
  • implanon
  • implanon
  • implanon
  • mercilon
  • mercilon
  • nacrez
  • nexplanon
  • nexplanon
  • nexplanon
  • nexplanon
  • nourypharma brand of 3-keto-desogestrel
  • nuvaring
  • nuvaring
  • org 2969
  • org 2969
  • org 2969
  • org 2969
  • org 2969
  • org 2969
  • org-2969
  • org-2969
  • org-3236
  • org-3236
  • organon brand of 3-keto-desogestrel
  • zelleta

Clinical trials

NCT IDPhaseStart dateSponsor(s)
NCT07269327Phase 1Nov 24, 2025Merck KGaA
NCT06304220N/AJul 31, 2024NextFertility Valencia
NCT05730205Phase 4Jun 8, 2023University of Pennsylvania
NCT05002738Phase 4Sep 10, 2021University of Colorado, Denver
NCT04941833Phase 2/Phase 3 (Phase 3)Jun 1, 2021Rajavithi Hospital, Bangkok
NCT04728659Phase 4Oct 1, 2020Casa di Cura Privata del Policlinico SpA
NCT04422028Phase 1Jan 11, 2020Grunenthal, Laboratorios Andromaco
NCT03953716Phase 4Jun 22, 2019Chinese Academy of Medical Sciences
NCT03895099Phase 3Apr 30, 2019Centre Hospitalier Intercommunal Creteil, Merck
NCT03656289Phase 1Oct 1, 2018University of Colorado, Denver
NCT03282799Phase 2Sep 30, 2018Infectious Disease Institute, Kampala, Uganda, University of Nebraska, University of Pittsburgh
NCT03353857Phase 1Nov 29, 2017Bayer
NCT03197077Phase 3Jul 1, 2017Free University of Brussels, Merck
NCT02669238Phase 2/Phase 3 (Phase 3)Jun 1, 2017Centre Hospitalier Universitaire de la Réunion
NCT03120728Phase 4May 16, 2017University of Southern California
NCT02866643Phase 3Oct 1, 2016Stanford University
NCT05174195N/AAug 15, 2016University of Geneva
NCT02852265Phase 4Aug 1, 2016Merck, University of California, Davis
NCT02757287Phase 4May 1, 2016Universidad Autonoma de Barcelona, University Hospital Quirón Dexeus, Barcelona
NCT02445989Phase 4May 1, 2016National Institutes of Health (NIH), University of Washington
Showing 20 of 99 trials
Page 1 / 5

Organizations

Research & Development (82)

OrganizationOrg typeTrialsAs lead sponsorPhasesEarliest year
MerckFor profit231632001
BayerFor profit7542003
TevaFor profit4432007
National Institute of Allergy and Infectious Diseases (NIAID)Government3122003
National Institutes of Health (NIH)Government3022003
OrganonFor profit3022005
University of PennsylvaniaAcademic/Hospital3332011
University of PittsburghAcademic/Hospital3322005
University of Sao PauloAcademic/Hospital3322007
Cairo UniversityAcademic/Hospital2212015
Canadian Institutes of Health Research (CIHR)Academic/Hospital2012002
Harvard UniversityAcademic/Hospital2122009
Mahidol UniversityAcademic/Hospital2222012
Oregon Health and Science UniversityAcademic/Hospital2212007
Pennsylvania State UniversityAcademic/Hospital2212015
Purdue UniversityAcademic/Hospital2012015
University of California, DavisAcademic/Hospital2122008
University of CampinasAcademic/Hospital2212011
University of Colorado, DenverAcademic/Hospital2222018
University of OuluAcademic/Hospital2222007
82 organizations
Page 1 / 5

Marketing (29)

OrganizationOrg typeRelationshipDate
Accord ResearchFor profitMKTGJun 5, 2017
Amneal PharmaceuticalsFor profitMKTGDec 11, 2019
Amneal PharmaceuticalsFor profitSYNDec 11, 2019
Apax PartnersFor profitMKTGFeb 25, 2011
Aspen PharmaceuticalsFor profitNDA2Dec 20, 2000
Aurobindo PharmaFor profitMKTGMar 22, 2017
Aurobindo PharmaFor profitSYNMar 22, 2017
Barr LaboratoriesFor profitMKTGApr 5, 2002
Dr. Reddy's LaboratoriesFor profitMKTGDec 9, 2021
Duramed ResearchFor profitMKTGAug 12, 1999
Endo PharmaceuticalsFor profitMKTGFeb 25, 2011
ExeltisFor profitMKTGAug 12, 2015
Glenmark PharmaceuticalsFor profitMKTGApr 2, 2012
Glenmark PharmaceuticalsFor profitSYNApr 2, 2012
Johnson and JohnsonFor profitNDA2Dec 14, 1992
LupinFor profitMKTGMar 7, 2013
Mayne PharmaFor profitMKTGJan 24, 2006
MylanFor profitMKTGAug 30, 2013
Naari Pte LtdFor profitMKTGJun 5, 2017
Novast LabsFor profitMKTGJul 12, 2013
OrganonFor profitMKTGOct 3, 2001
OrganonFor profitNDAJul 17, 2006
OrganonFor profitSYNJul 17, 2006
OrganonFor profitNDA2Oct 3, 2001
TevaFor profitMKTGJan 13, 2021
TevaFor profitNDA2Apr 22, 1998
VintageFor profitMKTGApr 30, 2015
VintageFor profitSYNFeb 25, 2011
Watson PharmaceuticalsFor profitMKTGJul 29, 2005