Brain Diseases
Pathologic conditions affecting the BRAIN, which is composed of the intracranial components of the CENTRAL NERVOUS SYSTEM. This includes (but is not limited to) the CEREBRAL CORTEX; intracranial white matter; BASAL GANGLIA; THALAMUS; HYPOTHALAMUS; BRAIN STEM; and CEREBELLUM.
Subtype terms (33)
More specific conditions that are subtypes of Brain Diseases in the MeSH hierarchy.
- Acute Febrile Encephalopathy
37 drugs (23 approved, 14 experimental)
- Akinetic Mutism
- Amblyopia
9 drugs (8 approved, 1 experimental)
- Amnesia, Transient Global
- Auditory Diseases, Central
5 drugs approved
- Basal Ganglia Diseases
7 drugs (1 approved, 6 experimental)
- Brain Abscess
- Brain Damage, Chronic
- Brain Death
19 drugs (16 approved, 3 experimental)
- Brain Diseases, Metabolic
1 drug experimental
- Brain Edema
32 drugs (24 approved, 8 experimental)
- Brain Injuries
117 drugs (92 approved, 25 experimental)
- Brain Neoplasms
591 drugs (291 approved, 300 experimental)
- Cavernous Sinus Syndromes
- Cerebellar Diseases
15 drugs (8 approved, 7 experimental)
- Cerebrovascular Disorders
83 drugs (58 approved, 25 experimental)
- Dementia
252 drugs (145 approved, 107 experimental)
- Diaschisis
- Diffuse Cerebral Sclerosis of Schilder
1 drug experimental
- Encephalitis
35 drugs (25 approved, 10 experimental)
- Encephalomalacia
1 drug approved
- Epilepsy
202 drugs (133 approved, 69 experimental)
- Headache Disorders
21 drugs (16 approved, 5 experimental)
- Hydrocephalus
18 drugs (16 approved, 2 experimental)
- Hypothalamic Diseases
5 drugs (3 approved, 2 experimental)
- Hypoxia, Brain
15 drugs (14 approved, 1 experimental)
- Intracranial Hypertension
11 drugs (9 approved, 2 experimental)
- Intracranial Hypotension
3 drugs (2 approved, 1 experimental)
- Leukoencephalopathies
1 drug experimental
- Neuroaxonal Dystrophies
2 drugs (1 approved, 1 experimental)
- Sepsis-Associated Encephalopathy
3 drugs approved
- Subdural Effusion
- Thalamic Diseases
Drugs by status
Approved for this indication (4)
Phase 4 trials (20)
Phase 3 trials (18)
Phase 2 trials (39)
- metformin
- didanosine
- methylprednisolone
- abemaciclib
- theophylline
- canrenone
- edaravone
- gadoversetamide
- eptifibatide
- levodopa
- fluoxetine
- memantine
- p03277
- magnesium sulfate
- nicotine
- preladenant
- caffeine
- propranolol
- elacestrant
- ceftriaxone
- semaglutide
- sgm-101
- rotigotine
- bevacizumab
- imilecleucel-t
- zidovudine
- minocycline
- dexamethasone
- erenumab
- Cerebral Dopamine Neurotrophic Factor
- +9 more
Phase 1 trials (28)
- roflumilast
- thalidomide
- 4-demethyl-4-cholesteryloxycarbonylpenclomedine
- az12807110
- bpn14770
- irinotecan
- ketamine
- foscarnet
- g207
- nivolumab
- ganciclovir
- vincristine
- azd5213
- celecoxib
- temozolomide
- tak-063
- dasatinib
- abeotaxane
- veliparib
- ondansetron
- methotrexate
- vy-aadc01
- regadenoson
- rituximab
- procarbazine
- b7-h3 car-t
- vee vlp
- fluoroethylnormemantine
Other trials (36)
- maltodextrin
- florbetaben F-18
- nitroglycerin
- olbetam
- carbon dioxide
- porcine brain-derived peptide preparation
- egg
- ethanol
- sevoflurane
- somatropin
- peanut
- ticagrelor
- lidocaine
- safflower oil
- siwu tang
- cyclophosphamide
- glucose
- vasoactive intestinal peptide
- acetic acid
- aronia extract
- bifidobacterium infantis
- bifidobacterium breve
- bifidobacterium longum
- umbilical cord mesenchymal stem cells
- coffee
- glucagon-like peptide-1
- lactobacillus plantarum
- walnut
- wild blueberry extract
- oxygen
- +6 more
Organizations
Organization Involved with Phase 4 Indications (38)
- Bausch Health Companies
- Bracco
- Norgine
- Fundación Pública Andaluza
- University of Roma La Sapienza
- Maastricht University
- Centro Regional para el Estudio de las Enfermedades Digestivas
- Chulalongkorn University
- University of London
- Federal University of Rio Grande do Sul
- Govind Ballabh Pant Institute of Postgraduate Medical Education and Research
- Hospital Juarez de Mexico
- Katholieke Universiteit Leuven
- Maharashtra University of Health Sciences
- Mahidol University
- McGill University
- Postgraduate Institute of Medical Education and Research
- Radboud University
- Tanta University
- University of Groningen
- University of Seville
- University of South Florida
- University of Bern
- Aga Khan University
- University of Basel
- Leiden University
- University of Amsterdam
- Badalona Hospital Germans Trias i Pujol
- Lokmanya Tilak Municipal Medical College
- Tampa General Medical Group
- +8 more
Organization Involved with Phase 3 Indications (70)
- CD Pharma India Pvt. Ltd.
- Hamad Medical Corporation
- Mallinckrodt
- Xenon Pharmaceuticals Inc.
- Otsuka
- Zogenix, Inc.
- National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
- Aarhus University
- University of Pennsylvania
- University of Pittsburgh
- Pakistan Army
- Boston University
- Case Western Reserve University
- Federal University of Minas Gerais
- University of Washington
- Hoosier Cancer Research Network
- Indian Council of Medical Research
- Indiana University
- New York University
- Norwegian University of Science and Technology
- Ohio State University
- Osaka University
- Semmelweis University
- Stanford University
- University Hospital of North Norway
- University of Glasgow
- University of Miami
- University of Milan
- University of New Mexico
- University of Padua
- +40 more
Organization Involved with Phase 2 Indications (75)
- AC Immune SA
- Avid Radiopharmaceuticals
- Horizon Pharma
- Arbor Pharmaceuticals
- Takeda
- Santhera
- Celgene
- Merck
- Eli Lilly
- Grifols
- Bayer
- Herantis Pharma Plc.
- Neurocrine Biosciences
- Ocera Therapeutics
- Ovid Therapeutics Inc.
- Rebiotix Inc.
- National Cancer Institute (NCI)
- National Center for Research Resources (NCRR)
- National Institute of Allergy and Infectious Diseases (NIAID)
- United States Army
- Ain Shams University
- Cornell University
- Harvard University
- Duke University
- Guangxi Medical University
- Guangzhou Medical University
- Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran
- Johns Hopkins University
- Kaiser Permanente
- Liaocheng People's Hospital
- +45 more
Organization Involved with Phase 1 Indications (32)
- AbbVie
- Ucyclyd
- Bristol-Myers Squibb
- Schering-Plough
- GlaxoSmithKline
- Molecular NeuroImaging
- SRI International
- Voyager Therapeutics
- National Center for Complementary and Integrative Health (NCCIH)
- National Institute of Neurological Disorders and Stroke (NINDS)
- Hebei University
- China Spinal Cord Injury Network
- Institute for Neurodegenerative Disorders
- KK Women's and Children's Hospital
- Medical College of Wisconsin
- Nagoya University
- Singapore General Hospital
- University of Florida
- University of Saskatchewan
- Virginia Commonwealth University
- Chinese University of Hong Kong
- St. Louis University
- Medical University of South Carolina
- National University of Singapore
- OpenBiome
- Free University of Brussels
- University of Alabama, Birmingham
- National Institute for Health Research, United Kingdom
- The Marcus Foundation
- Government of Singapore
- +2 more
Organization Involved with Other Experimental Indications (40)
- Fundació Sant Joan de Déu
- National Institutes of Health (NIH)
- National Institute of Mental Health (NIMH)
- United States Navy
- Cook Children's Health Care System
- Centre Hospitalier le Mans
- Conselho Nacional de Desenvolvimento Científico e Tecnológico
- Instituto Mexicano del Seguro Social
- Rijnstate Hospital
- Seoul National University
- University of Southern Denmark
- VieCuri Medical Centre
- Zagazig University
- Institute of Liver and Biliary Sciences, India
- Netherlands Organisation for Scientific Research
- University of Cambridge
- University of Catania
- University of Copenhagen
- University of Twente
- Hospital of South West Jutland
- Cook Children's Medical Center
- AUSL della Romagna-RAVENNA
- University of Ferrara
- Government of Mexico
- St. Antonius Hospital, Nieuwegein
- Pomeranian Medical University
- Government of China
- Medisch Spectrum Twente
- Instituto Nacional de Ciencias Medicas de Nutricion
- University of Mississippi
- +10 more