abeotaxane
Small moleculeexperimental
Clinical trial activity
17 trials · 23 clinical orgs · 0 marketing orgs
Phase 1
12
Phase 2
11
Phase 3
0
Phase 4
0
Earliest trial started May 1, 2005 (NCT00113724)
Timeline
Indications
Studied for
- Alzheimer Disease · Phase 1
- Brain Diseases · Phase 1
- Brain Neoplasms · Phase 2
- Breast Neoplasms · Phase 2
- Central Nervous System Neoplasms · Phase 1/Phase 2
- Corticobasal Degeneration · Phase 1
- Glioblastoma · Phase 2
- Hodgkin Disease · Phase 1
- Lymphoma, Non-Hodgkin · Phase 1
- Medulloblastoma · Phase 1/Phase 2
- Melanoma · Phase 1/Phase 2
- Movement Disorders · Phase 1
- Neoplasms · Phase 1
- Neuroblastoma · Phase 1/Phase 2
- Pancreatic Neoplasms · Phase 2
- Prostatic Neoplasms · Phase 2
- Recurrence · Phase 1
- Supranuclear Palsy, Progressive · Phase 1
- Tauopathies · Phase 1
Mechanism of action
- TubulinINHIBITOR
Tubulin inhibitor
- Tubulin beta-4B chain (TUBB4B) ↗
- Tubulin beta-1 chain (TUBB1) ↗
- Tubulin alpha-3C chain (TUBA3C) ↗
- Tubulin alpha-4A chain (TUBA4A) ↗
- Tubulin beta-3 chain (TUBB3) ↗
- Tubulin alpha-1A chain (TUBA1A) ↗
- Tubulin beta-4A chain (TUBB4A) ↗
- Tubulin beta-8 chain (TUBB8) ↗
- Tubulin beta chain (TUBB) ↗
- Tubulin alpha-1B chain (TUBA1B) ↗
- Tubulin alpha-1C chain (TUBA1C) ↗
- Tubulin alpha-3E chain (TUBA3E) ↗
- Tubulin beta-2A chain (TUBB2A) ↗
- Tubulin beta-2B chain (TUBB2B) ↗
- Tubulin beta-6 chain (TUBB6) ↗
Chemistry & pharmacology
Oral
No
Parenteral
No
Topical
No
Also known as
- tpi 287
- tpi 287
- tpi-287
- tpi-287
Clinical trials
| NCT ID | Phase | Start date | Sponsor(s) |
|---|---|---|---|
| NCT02187822 | Phase 1 | Oct 9, 2014 | University of South Florida |
| NCT02133846 | Phase 1 | May 1, 2014 | CBD Solutions, Tau Consortium, University of California, San Francisco |
| NCT02047214 | Phase 2 | Jan 1, 2014 | Cortice Biosciences, Inc., Dartmouth University, Memorial Hermann Health System, Northwestern University, Ohio State University, Rutgers University, University of Alabama, Birmingham, University of Rochester, University of South Florida, University of Virginia, University of Washington, Washington University in St. Louis |
| NCT01966666 | Phase 1 | Nov 1, 2013 | University of California, San Francisco |
| NCT01340729 | Phase 1/Phase 2 (Phase 2) | Sep 1, 2013 | Cortice Biosciences, Inc., University of Texas at Houston |
| NCT01933815 | Phase 1/Phase 2 (Phase 2) | Aug 1, 2013 | Cortice Biosciences, Inc., Memorial Hermann Health System, Neurological Surgery, P.C., Ohio State University, Rutgers University, University of Alabama, Birmingham, University of Rochester, University of Washington, Washington University in St. Louis |
| NCT01582152 | Phase 1/Phase 2 (Phase 2) | Jul 1, 2012 | Cortice Biosciences, Inc., University of Texas at Houston |
| NCT01483820 | Phase 1/Phase 2 (Phase 2) | Dec 1, 2011 | Cortice Biosciences, Inc., The Spectrum Health Group, University of Connecticut, Van Andel Research Institute |
| NCT01505608 | Phase 1/Phase 2 (Phase 2) | Dec 1, 2011 | Arnold Palmer Hospital for Children, Cortice Biosciences, Inc., The Spectrum Health Group |
| NCT01332630 | Phase 2 | Aug 16, 2011 | Cortice Biosciences, Inc., University of Texas at Houston |
| NCT01113463 | Phase 2 | Apr 1, 2010 | Cortice Biosciences, Inc., University of Texas at Houston |
| NCT01067066 | Phase 1/Phase 2 (Phase 2) | Feb 1, 2010 | Cortice Biosciences, Inc., University of Texas at Houston |
| NCT00867568 | Phase 1 | Mar 1, 2009 | Cortice Biosciences, Inc., The Spectrum Health Group |
| NCT00553813 | Phase 2 | Oct 1, 2007 | Cortice Biosciences, Inc., SLS Oncology, LLC |
| NCT00479635 | Phase 2 | Jan 1, 2007 | Cortice Biosciences, Inc., SLS Oncology, LLC |
| NCT00256191 | Phase 1 | Nov 1, 2005 | Cortice Biosciences, Inc., Tapestry Pharmaceuticals, Inc. |
| NCT00113724 | Phase 1 | May 1, 2005 | Cortice Biosciences, Inc., Tapestry Pharmaceuticals, Inc. |
Showing 17 of 17 trials
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Organizations
Research & Development (23)
| Organization | Org type | Trials | As lead sponsor | Phases | Earliest year |
|---|---|---|---|---|---|
| Cortice Biosciences, Inc. | For profit | 14 | 6 | 2 | 2005 |
| University of Texas at Houston | Academic/Hospital | 5 | 5 | 1 | 2010 |
| The Spectrum Health Group | Academic/Hospital | 3 | 3 | 2 | 2009 |
| Memorial Hermann Health System | Academic/Hospital | 2 | 0 | 1 | 2013 |
| Ohio State University | Academic/Hospital | 2 | 0 | 1 | 2013 |
| Rutgers University | Academic/Hospital | 2 | 0 | 1 | 2013 |
| SLS Oncology, LLC | Academic/Hospital | 2 | 0 | 1 | 2007 |
| Tapestry Pharmaceuticals, Inc. | For profit | 2 | 0 | 1 | 2005 |
| University of Alabama, Birmingham | Academic/Hospital | 2 | 0 | 1 | 2013 |
| University of California, San Francisco | Academic/Hospital | 2 | 2 | 1 | 2013 |
| University of Rochester | Academic/Hospital | 2 | 0 | 1 | 2013 |
| University of South Florida | Academic/Hospital | 2 | 1 | 2 | 2014 |
| University of Washington | Academic/Hospital | 2 | 0 | 1 | 2013 |
| Washington University in St. Louis | Academic/Hospital | 2 | 0 | 1 | 2013 |
| Arnold Palmer Hospital for Children | Academic/Hospital | 1 | 0 | 1 | 2011 |
| CBD Solutions | For profit | 1 | 0 | 1 | 2014 |
| Dartmouth University | Academic/Hospital | 1 | 0 | 1 | 2014 |
| Neurological Surgery, P.C. | Academic/Hospital | 1 | 0 | 1 | 2013 |
| Northwestern University | Academic/Hospital | 1 | 0 | 1 | 2014 |
| Tau Consortium | Academic/Hospital | 1 | 0 | 1 | 2014 |
23 organizations
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