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Brain Injuries
Acute and chronic (see also BRAIN INJURIES, CHRONIC) injuries to the brain, including the cerebral hemispheres, CEREBELLUM, and BRAIN STEM. Clinical manifestations depend on the nature of injury. Diffuse trauma to the brain is frequently associated with DIFFUSE AXONAL INJURY or COMA, POST-TRAUMATIC. Localized injuries may be associated with NEUROBEHAVIORAL MANIFESTATIONS; HEMIPARESIS, or other focal neurologic deficits.
Subtype terms (8)
More specific conditions that are subtypes of Brain Injuries in the MeSH hierarchy.
- Brain Hemorrhage, Traumatic
- Brain Injuries, Diffuse
- Brain Injuries, Traumatic
193 drugs (133 approved, 60 experimental)
- Brain Injury, Chronic
3 drugs (2 approved, 1 experimental)
- Epilepsy, Post-Traumatic
6 drugs (5 approved, 1 experimental)
- Pneumocephalus
1 drug approved
- Post-Cardiac Arrest Syndrome
14 drugs approved
- Shaken Baby Syndrome
Drugs by status
Phase 4 trials (25)
Phase 3 trials (12)
Phase 2 trials (39)
- melatonin
- 2-Iminobiotin
- vitamin e
- amitriptyline
- acetylcysteine
- epoetin
- lamotrigine
- edaravone
- oxycodone
- prednisone
- ibuprofen
- nnz2566
- vitamin c
- bromocriptine
- flumazenil
- indomethacin
- donepezil
- bevacizumab
- tolcapone
- tramadol
- clonidine
- rasagiline
- Anti-thymocyte Globulin (Rabbit)
- thiamine
- xenon xe-133
- ciprofloxacin
- allogeneic adipose derived mesenchymal stem cell
- autologous umbilical cord blood
- modafinil
- morphine
- +9 more
Phase 1 trials (11)
Other trials (28)
- corticotropin
- angongniuhuang
- paroxetine
- ketamine
- citalopram
- diphenhydramine
- duloxetine
- fluvoxamine
- sertraline
- albumin (Human)
- amantadine
- inulin
- fluoxetine
- metyrapone
- neuroaid
- prazosin
- qizhitongluo
- allogeneic hematopoietic stem cells
- tolvaptan
- trazodone
- oxygen
- mirtazapine
- sargramostim
- venlafaxine
- isoprenaline
- blueberry
- autologous adipose-derived mesenchymal stem cells
- Sextaphag
Organizations
Organization Involved with Phase 4 Indications (79)
- Solstice Neurosciences
- Shire
- Fresenius
- Forest Laboratories
- AstraZeneca
- Aventis
- Pfizer
- Avanir
- Novartis
- Allergan
- Ever Neuro Pharma GmbH
- Hamad Medical Corporation
- Sponsor GmbH
- Kessler Foundation
- Ontario Neurotrauma Foundation
- Swiss National Science Foundation
- National Institutes of Health (NIH)
- National Center for Research Resources (NCRR)
- University of Roma La Sapienza
- Shahid Beheshti University of Medical Sciences
- University of Pittsburgh
- Central South University
- Ain Shams University
- University of London
- Chinese Medical Association
- Craig Hospital
- Damanhour University
- Harvard University
- Georgetown University
- King Fahad Medical City
- +49 more
Organization Involved with Phase 3 Indications (100)
- Pharmos
- Takeda
- Cephalon
- Ipsen
- Cristália Produtos Químicos Farmacêuticos Ltda.
- INC Research
- Materia Medica Holding
- Merz
- Vasopharm GmbH
- Canadian Department of National Defense
- Direction Centrale du Service de Santé des Armées
- National Heart, Lung, and Blood Institute (NHLBI)
- National Institute of Neurological Disorders and Stroke (NINDS)
- United States Army
- University College Dublin
- Aarhus University
- Baylor University
- Tzu Chi University
- Cairo University
- Emory University
- Temple University
- University of Washington
- Hospital Son Espases
- Hospital Universitari Son Dureta
- Indiana University
- Institut d'Anesthesiologie des Alpes Maritimes
- Institut National de la Santé Et de la Recherche Médicale, France
- JFK Medical Center
- Katholieke Universiteit Leuven
- Johns Hopkins University
- +70 more
Organization Involved with Phase 2 Indications (79)
- INTRuST
- Abbott
- Avid Radiopharmaceuticals
- Amgen
- Novo Nordisk
- Eli Lilly
- Neuren Pharmaceuticals Limited
- NeuroHealing Pharmaceuticals Inc.
- Ortho Biotech, Inc.
- Remedy Pharmaceuticals, Inc.
- SanBio, Inc.
- Tenax Therapeutics, Inc.
- International Brain Research Foundation
- Medical Research Council
- National Institute of Nursing Research (NINR)
- National Institute on Alcohol Abuse and Alcoholism (NIAAA)
- Uniformed Services University of the Health Sciences
- University of Pennsylvania
- University of Arizona
- American Heart Association
- Atlantic Health System
- Cedars-Sinai Medical Center
- Chang Gung University
- Dartmouth University
- Duke University
- HCA International Limited
- HonorHealth Research Institute
- Hoosier Cancer Research Network
- Mashhad University of Medical Sciences
- Mclean Hospital
- +49 more
Organization Involved with Phase 1 Indications (32)
- Bioquark Inc.
- Teva
- Transition Therapeutics
- Boston University
- Children's Medical Center Dallas
- Cornell University
- Guangdong Women and Children Hospital
- McGill University
- Minia University
- Neurogen Brain and Spine Institute
- Stanford University
- University of Florida
- University of New Mexico
- Yale University
- University of Virginia
- Umea University
- Revita Life Sciences
- University of Montreal
- Lakeland Regional Medical Center
- University of Texas, San Antonio
- Anupam Hospital
- Logistics University of CAPF
- Texas Scottish Rite Hospital for Children
- Harch Hyperbaric Research Foundation
- Semper Fi Fund
- United States Marine Corps
- Coalition to Support America's Heroes
- Government of Egypt
- People's Liberation Army of China
- Neuromed IRCCS
- +2 more
Organization Involved with Other Experimental Indications (31)
- Amen Clinics, Inc.
- Hamilton Health Sciences Corporation
- POM Wonderful LLC
- National Institute of Mental Health (NIMH)
- United States Air Force
- United States Navy
- Rockefeller University
- Alexandria University
- Allegiance Health
- Centre Hospitalier Universitaire de Nīmes
- Hanyang University
- Mary Free Bed Rehabilitation Hospital
- Northern State Medical University
- Ohio State University
- Sheffield Hallam University
- University of Medicine and Dentistry of New Jersey
- University of Messina
- University of California, Berkeley
- Kessler Institute for Rehabilitation
- Laureate Institute for Brain Research
- Harborview Injury Prevention and Research Center
- Tianjin Medical University
- Padjadjaran University
- Cha Medical University
- Technion University
- Grand Valley State University
- The Defense and Veterans Brain Injury Center
- Rotherham Doncaster and South Humber NHS Foundation Trust
- The Institute for Rehabilitation and Research (TIRR) Foundation
- Gaymar Industries, Inc.
- +1 more