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bifidobacterium breve

Cell therapyexperimental

Bifidobacterium breve is a bacterial species of the genus Bifidobacterium which has probiotic properties. Bifidobacteria are a type of bacteria that live symbiotically in the intestines of humans. They have been used to treat a number of conditions including constipation, diarrhea, irritable bowel syndrome and even the cold and flu. Some of these uses have been backed up by scientific research, but others have not. B.breve also shows a stronger affinity for immature bowels than other species evidencing in its strong capabilities as a probiotic. — Wikipedia

Clinical trial activity

90 trials · 122 clinical orgs · 0 marketing orgs

Phase 1
10
Phase 2
20
Phase 3
12
Phase 4
15

Earliest trial started Dec 1, 2003 (NCT00175292)

Timeline

2000s

  1. Jan 1, 2003

    Earliest Phase 3 Sponsor(trial)

  2. Jan 1, 2004

    Earliest Phase 1 Sponsor(trial)

  3. Jan 1, 2006

    Earliest Phase 2 Sponsor(trial)

Indications

Approved for

Studied for

Mechanism of action

  • microbiotaTissue restoration

    microbiota tissue restoration

Chemistry & pharmacology

Oral

No

Parenteral

No

Topical

No

Sources

Also known as

  • bif195
  • bifidobacterium breve
  • vsl #3
  • vsl#3

Clinical trials

NCT IDPhaseStart dateSponsor(s)
NCT07234448N/ADec 1, 2025Liaquat University of Medical & Health Sciences, University of Urbino "Carlo Bo"
NCT07082062N/AJun 2, 2025Chung Shan Medical University, TCI Co., Ltd.
NCT06850714N/AFeb 23, 2025Liaquat University of Medical & Health Sciences, University of Insubria
NCT06720805N/ADec 1, 2024University of Roma La Sapienza
NCT06148714N/ADec 1, 2023Citruslabs, Maneuver Marketing
NCT05767450N/ADec 16, 2022Vita-Salute University of Milano. Italy
NCT05614726N/AJun 18, 2021Biohm Health, LLC, The Center for Applied Health Sciences, LLC
NCT04842149N/AMay 21, 2021Chr Hansen, University of Copenhagen
NCT04808271N/AApr 16, 2021Chr Hansen, University of Copenhagen
NCT04769687Phase 2Nov 21, 2020University of Franche-Comté
NCT05461833N/ASep 1, 2020Bogomolets National Medical University, Government of Ukraine
NCT04677738N/AAug 30, 2020KGK Science Inc., Morinaga Milk Industry Co. Ltd., Japan
NCT04374955N/AJul 31, 2020Halic University, Nobel Pharmaceuticals
NCT04447924N/AJun 22, 2020Chr Hansen, Methodist Cancer Center, Houston, Texas
NCT04448847N/AJun 8, 2020Chr Hansen, University of Copenhagen
NCT04172012Phase 3Mar 1, 2020Arctic University of Norway, Haydom Lutheran Hospital, Muhimbili University, University of Bergen, University of Stavanger
NCT04065503Early Phase 1 (Phase 1)Sep 30, 2019Lallemand SAS, University of Florida
NCT03910322N/AAug 1, 2019Atlantia Food Clinical Trials, Chr Hansen, Methodist Cancer Center, Houston, Texas
NCT05146921N/AJul 4, 2019University of London
NCT03893162N/AMay 31, 2019University of London
Showing 20 of 90 trials
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Organizations

Research & Development (122)

OrganizationOrg typeTrialsAs lead sponsorPhasesEarliest year
VSL PharmaceuticalsFor profit8342004
Chr HansenFor profit6412017
University of CopenhagenAcademic/Hospital4312018
University of LondonAcademic/Hospital4422007
University of MilanAcademic/Hospital4322010
Hebrew UniversityAcademic/Hospital3332004
University of Roma La SapienzaAcademic/Hospital3212014
All India Institute of Medical SciencesAcademic/Hospital2112007
Atlantia Food Clinical TrialsFor profit2012017
Bambino Gesù Hospital and Research InstituteAcademic/Hospital2212012
Biosearch S.A.For profit2222011
CD Pharma India Pvt. Ltd.For profit2212009
FerringFor profit2022010
Lallemand SASFor profit2022015
Liaquat University of Medical & Health SciencesAcademic/Hospital2212025
Methodist Cancer Center, Houston, TexasAcademic/Hospital2012019
University of AlbertaAcademic/Hospital2122003
University of CalgaryAcademic/Hospital2222017
University of Eastern PiedmontAcademic/Hospital2212013
University of FloridaAcademic/Hospital2222015
122 organizations
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