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thiamine

Small moleculeapproved

Approved

Jul 28, 1947

Thiamine, also known as vitamin B1, plays a key role in the human metabolism. It is present in many dietary sources such as meats, eggs, fish, beans and peas, nuts, and whole grains. Upon administration thiamine is converted by thiamine pyrophosphokinase-1 (TPK1) to the active form, thiamine pyrophosphate, which serves as a cofactor for enzymes involved in the TCA cycle and the non-oxidative part of the pentose phosphate pathway. The lack of thiamine may cause the thiamine deficiency. The classical syndrome caused primarily by thiamine deficiency in humans is beriberi, however, symptoms of thiamine deficiency also include congestive heart failure, metabolic acidosis, confusion, ataxia and seizures. Thiamine is a component of many vitamin complexes, which are approved for the treatmen and prevention of general vitamin deficiency, including the thiamine deficiency. — NCATS

Clinical trial activity

129 trials · 195 clinical orgs · 28 marketing orgs

Phase 1
17
Phase 2
39
Phase 3
18
Phase 4
31

Earliest trial started Aug 1, 2001 (NCT00143702)

Timeline

1940s

  1. Jul 28, 1947

    Roche — Earliest FDA Approval

  2. Jul 28, 1947

    Roche — Marketing Organization

  3. Jul 28, 1947

    Roche — NDA Secondary Org

  4. Jul 28, 1947

    Roche — NDA Organization

1950s

  1. Feb 20, 1953

    Hospira — Marketing Organization

  2. Feb 20, 1953

    Hospira — NDA Secondary Org

1970s

  1. Jun 20, 1972

    Fresenius — Marketing Organization

  2. Dec 6, 1972

    Parke-Davis — Marketing Organization

  3. Dec 6, 1972

    Warner Lambert — Marketing Organization

  4. Feb 4, 1974

    Belmar Pharmacy — Marketing Organization

  5. Feb 26, 1974

    Watson Pharmaceuticals — Marketing Organization

  6. Feb 26, 1974

    Dr. Reddy's Laboratories — Marketing Organization

  7. Mar 27, 1974

    American Home Products — Marketing Organization

  8. Aug 6, 1974

    Del Laboratories — Marketing Organization

  9. Jun 24, 1975

    West-Ward Pharmaceutical — Marketing Organization

1980s

  1. Nov 6, 1981

    Abraxis — Marketing Organization

  2. Nov 6, 1981

    Abraxis — NDA Secondary Org

  3. Jul 13, 1982

    Watson Pharmaceuticals — NDA Secondary Org

2000s

  1. May 18, 2000

    Sandoz — Marketing Organization

  2. May 18, 2000

    Sandoz — NDA Secondary Org

  3. May 18, 2000

    Novartis — NDA Secondary Org

  4. Jan 1, 2001

    Earliest Phase 2 Sponsor(trial)

  5. Jan 1, 2003

    Earliest Phase 3 Sponsor(trial)

  6. Jan 1, 2005

    Earliest Phase 1 Sponsor(trial)

2010s

  1. Jun 25, 2012

    Mylan — Marketing Organization

  2. Dec 1, 2017

    Sagent Pharmaceuticals, Inc. — Marketing Organization

  3. Dec 1, 2017

    Nichi-Iko Pharmaceutical Co., Ltd. — Marketing Organization

2020s

  1. Apr 20, 2022

    Eugia Pharma — Marketing Organization

  2. Mar 6, 2023

    Caplin Point Laboratories — Marketing Organization

  3. Oct 29, 2024

    STERISCIENCE — Marketing Organization

  4. Oct 29, 2024

    ONESOURCE SPECIALTY — Marketing Organization

  5. Nov 6, 2024

    Aspiro — Marketing Organization

  6. Feb 24, 2025

    Gland Pharma Ltd — Marketing Organization

  7. Apr 9, 2026

    Apotex — Marketing Organization

Indications

Approved for

Studied for

Mechanism of action

Combination products

Approval history

  • approvedJul 28, 1947

Chemistry & pharmacology

Loading structure…

SMILES

Cc1ncc(C[n+]2csc(CCO)c2C)c(N)n1.[Cl-]
Mol. weight
300.81 g/mol
Lipinski Ro5
Pass
Rule of 3
No
Chirality
Achiral Molecule
Inorganic
No
Polymer
No
Delivery
Parenteral
Availability
Prescription Only

Oral

No

Parenteral

Yes

Topical

No

Sources

Also known as

  • 3-(4-amino-2-methyl-pyrimidin-5-ylmethyl)-5-(2-hydroxy-ethyl)-4-methyl-thiazol-3-ium
  • 3-(4-amino-2-methyl-pyrimidin-5-ylmethyl)-5-(2-hydroxy-ethyl)-4-methyl-thiazol-3-ium
  • 8088 c.b
  • 8088 c.b
  • aneurin
  • aneurin
  • aneurine hcl
  • aneurine hcl
  • antiberiberi factor
  • antiberiberi factor
  • benerva
  • benerva
  • benfothiamine
  • benfothiamine
  • benfotiamine
  • benfotiamine
  • benfotiamine
  • benfotiamine
  • benfotiamine
  • benfotiamine
  • benfotiamine
  • benfotiamine
  • benphothiamine
  • benzoylthiamine monophosphate
  • benzoylthiaminmonophosphat
  • benzoylthiaminmonophosphat
  • betalin s
  • betalin s
  • betaxin
  • betaxin
  • betivina
  • bevitine
  • bevitine
  • bevitol
  • bietamine
  • btmp-benfo
  • diteftin
  • fursultiamin
  • fursultiamine
  • fursultiamine
  • fursultiamine
  • fursultiamine
  • fursultiamine
  • fursultiamine
  • fursultiamine
  • fursultiamine
  • fursultiamine hcl
  • fursultiamine hcl
  • fursultiamine hcl
  • fursultiamine hydrochloride
  • judolor
  • judolor
  • milgamma
  • neurostop
  • n,n'-(dithiobis(2-(2-hydroxyethyl)-1-methylvinylene))bis(n-((4-amino-2-methyl-5-pyrimidinyl)-methyl)formamide)
  • s-benzoylthiamine monophosphate
  • s-benzoylthiamine o-monophosphate
  • tetrahydrofurfuryl thiamine disulfide
  • thiamin
  • thiamin
  • thiamine
  • thiamine
  • thiamine
  • thiamine
  • thiamine
  • thiamine
  • thiamine
  • thiamine
  • thiamine
  • thiamine
  • thiamine(1+)
  • thiamine(1+)
  • thiamine(1+) ion
  • thiamine(1+) ion
  • thiamine disulfide
  • thiamine disulfide
  • thiamine disulfide
  • thiamine disulphide
  • thiamine hcl
  • thiamine hcl
  • thiamine hcl
  • thiamine hydrochloride
  • thiamine hydrochloride
  • thiamine hydrochloride
  • thiamine hydrochloride
  • thiamine hydrochloride
  • thiamine mononitrate
  • thiamine tetrahydrofurfuryl disulfide
  • thiamine (vit b1)
  • thiamine (vit b1)
  • thiamine (vit b1)
  • thiaminium
  • thiaminium
  • thiamin tetrahydrofurfuryl disulfide
  • ttfd
  • ttfd
  • tyvera
  • vitamin b1
  • vitamin b1
  • vitamin b1
  • vitamin b1
  • vitamin b1
  • vitamin b1
  • vitamin b 1
  • vitamin b 1
  • vitamins b1
  • vit b1
  • vit b1 thiamin

Clinical trials

NCT IDPhaseStart dateSponsor(s)
NCT06959251N/AOct 2, 2025Instituto Nacional de Enfermedades Respiratorias
NCT07046429N/AAug 5, 2025American Association for the Study of Liver Diseases, Cornell University
NCT06326996Early Phase 1 (Phase 1)Oct 10, 2024University of California, Los Angeles
NCT06322212N/AAug 1, 2024National Institute on Aging (NIA), University of California, Los Angeles
NCT06298344Early Phase 1 (Phase 1)May 1, 2024Universitas Sumatera Utara
NCT06649825N/AJan 8, 2024Fudan University
NCT07304453Phase 2Jan 7, 2024Karbala University, Kufa University
NCT05817851Phase 2Jan 1, 2024Centre Hospitalier de Béthune, Centre Hospitalier Intercommunal de Toulon La Seyne sur Mer, University of Lille
NCT05873881Phase 3Nov 30, 2023Canadian Institutes of Health Research (CIHR), Hamilton Health Sciences Corporation, McMaster University
NCT06122701N/ANov 20, 2023University of Greifswald
NCT05971680Phase 3Jul 30, 2023Beni Suef University
NCT06242535Early Phase 1 (Phase 1)Jul 27, 2023Buck Institute for Research on Aging, Hoskinson Health and Wellness Clinic, University of Wyoming
NCT05642923Phase 4Dec 8, 2022Cairo University, ClinAmygate
NCT05385042Phase 4Jun 18, 2022University of Oxford
NCT05083546Phase 1/Phase 2 (Phase 2)Apr 1, 2022University of California, San Francisco
NCT04478734Phase 2Jan 1, 2022Centro de Investigación Biomédica en Red (CIBER), Fundación Pública Andaluza, University of Seville, Virgen del Rocío University Hospital, Seville
NCT05221892Phase 4Nov 22, 2021Fundação Educacional Serra dos Órgãos
NCT04651205N/AOct 31, 2021University of Glasgow
NCT04999137Phase 2Sep 1, 2021Infectious Disease Institute, Kampala, Uganda, LSTM/IDI/Walimu, University of Copenhagen, University of Liverpool, Walimu
NCT04880889Phase 3Sep 1, 2021Biolab Sanus Farmaceutica, Medcin Instituto da Pele
Showing 20 of 129 trials
Page 1 / 7

Organizations

Research & Development (195)

OrganizationOrg typeTrialsAs lead sponsorPhasesEarliest year
Harvard UniversityAcademic/Hospital10932008
Aarhus UniversityAcademic/Hospital3222015
Mahidol UniversityAcademic/Hospital3332014
Ruhr University BochumAcademic/Hospital3322004
University of California, San FranciscoAcademic/Hospital3332018
University of LyonAcademic/Hospital3212011
Canadian Institutes of Health Research (CIHR)Academic/Hospital2022014
CHU Henri MondorAcademic/Hospital2012015
Daewoong Pharmaceutical Co. LTD.For profit2212014
Hamilton Health Sciences CorporationAcademic/Hospital2222018
Helen Keller InternationalAcademic/Hospital2022014
McMaster UniversityAcademic/Hospital2022018
National Center for Complementary and Integrative Health (NCCIH)Government2022010
National Heart, Lung, and Blood Institute (NHLBI)Government2012017
National Institute of Allergy and Infectious Diseases (NIAID)Government2212002
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)Government2022018
National Institute on Aging (NIA)Government2022014
National Institutes of Health (NIH)Government2022010
National University of SingaporeAcademic/Hospital2212015
NestleFor profit2212015
195 organizations
Page 1 / 10

Marketing (36)

OrganizationOrg typeRelationshipDate
AbraxisFor profitMKTGNov 6, 1981
AbraxisFor profitNDA2Nov 6, 1981
Akorn, Inc.For profitMKTG—
American Home ProductsFor profitMKTGMar 27, 1974
ApotexFor profitMKTGApr 9, 2026
AspiroFor profitMKTGNov 6, 2024
Belmar PharmacyFor profitMKTGFeb 4, 1974
Caplin Point LaboratoriesFor profitMKTGMar 6, 2023
Del LaboratoriesFor profitMKTGAug 6, 1974
Dr. Reddy's LaboratoriesFor profitMKTGFeb 26, 1974
Eli LillyFor profitMKTG—
Eugia PharmaFor profitMKTGApr 20, 2022
FreseniusFor profitMKTGJun 20, 1972
Gland Pharma LtdFor profitMKTGFeb 24, 2025
HospiraFor profitMKTGFeb 20, 1953
HospiraFor profitNDA2Feb 20, 1953
LutipoldFor profitMKTG—
MylanFor profitMKTGJun 25, 2012
Nichi-Iko Pharmaceutical Co., Ltd.For profitMKTGDec 1, 2017
NovartisFor profitNDA2May 18, 2000
ONESOURCE SPECIALTYFor profitMKTGOct 29, 2024
Parke-DavisFor profitMKTGDec 6, 1972
RocheFor profitMKTGJul 28, 1947
RocheFor profitNDA2Jul 28, 1947
RocheFor profitNDAJul 28, 1947
STERISCIENCEFor profitMKTGOct 29, 2024
STERISCIENCEFor profitSYNOct 29, 2024
Sagent Pharmaceuticals, Inc.For profitMKTGDec 1, 2017
Sagent Pharmaceuticals, Inc.For profitSYNDec 1, 2017
SandozFor profitMKTGMay 18, 2000
SandozFor profitNDA2May 18, 2000
Teligent PharmaceuticalsFor profitNDA2—
Warner LambertFor profitMKTGDec 6, 1972
Watson PharmaceuticalsFor profitMKTGFeb 26, 1974
Watson PharmaceuticalsFor profitNDA2Jul 13, 1982
West-Ward PharmaceuticalFor profitMKTGJun 24, 1975