Brain Neoplasms
Neoplasms of the intracranial components of the central nervous system, including the cerebral hemispheres, basal ganglia, hypothalamus, thalamus, brain stem, and cerebellum. Brain neoplasms are subdivided into primary (originating from brain tissue) and secondary (i.e., metastatic) forms. Primary neoplasms are subdivided into benign and malignant forms. In general, brain tumors may also be classified by age of onset, histologic type, or presenting location in the brain.
Subtype terms (5)
More specific conditions that are subtypes of Brain Neoplasms in the MeSH hierarchy.
- Cerebral Ventricle Neoplasms
- Infratentorial Neoplasms
6 drugs (5 approved, 1 experimental)
- Neurocytoma
2 drugs approved
- Pinealoma
38 drugs (27 approved, 11 experimental)
- Supratentorial Neoplasms
11 drugs (7 approved, 4 experimental)
Drugs by status
Approved for this indication (3)
Phase 4 trials (30)
- fam-trastuzumab deruxtecan-nxki
- ephedrine
- sugammadex
- lorlatinib
- phenylephrine
- ropivacaine
- gadopenteate dimeglumine
- magnesium sulfate
- perampanel
- bupivacaine
- ibuprofen
- levobupivacaine
- itraconazole
- gadoteric acid
- clevidipine
- propofol
- sodium chloride
- tramadol
- morphine
- methylphenidate
- ketorolac
- gadobenate
- temozolomide
- sevoflurane
- epinephrine
- fluorescein
- dexmedetomidine
- levetiracetam
- trastuzumab
- gadobutrol
Phase 3 trials (74)
- aminolevulinic acid
- autologous mononuclear stem cell
- ketamine
- fotemustine
- sargramostim
- ifosfamide
- vincristine
- isotretinoin
- sodium thiosulfate
- vitamin d3
- carboplatin
- carvedilol
- leflunomide
- clavulanate
- procaine benzylpenicillin
- dactinomycin
- doxorubicin
- motexafin gadolinium
- prednisolone
- modafinil
- naltrexone
- furosemide
- azd3759
- levofloxacin
- paclitaxel
- esmolol
- niraparib
- entrectinib
- osimertinib
- pembrolizumab
- +44 more
Phase 2 trials (241)
- t lymphocytes
- nimotuzumab
- 18f dpa-714
- delta-24-rgd adenovirus
- st101
- dendritic cell vaccine with mrna from tumor stem cells
- sagopilone
- dexamethasone
- sodium phenylbutyrate
- bortezomib
- dabrafenib
- alectinib
- ritonavir
- veliparib
- pbi-200
- interferon alpha-2b
- indoximod
- boswellia serrata
- rta 744
- Ferumoxtran
- vemurafenib
- gc1008
- penicillamine
- etirinotecan pegol
- furmonertinib
- mechlorethamine
- vismodegib
- perifosine
- streptozotocin
- tng456
- +211 more
Phase 1 trials (214)
- abiraterone
- atrasentan hydrochloride
- magrolimab
- boronophenylalanine
- valaciclovir
- xoma 358
- ganciclovir
- genetically-modified neural stem cells expressing e.coli cytosine deaminase
- 68ga-nodaga-rgd
- ketoconazole
- sapanisertib
- sch-58500
- entinostat
- cd133 car-t cells
- brodalumab
- cudc-907
- acetylcysteine
- cyclosporine
- asciminib
- almond
- Iopofosine
- Trotabresib
- dc/aat-flu
- satraplatin
- Laromustine
- dec-205/ny-eso-1 fusion protein cdx-1401
- neural stem cells loaded with an oncolytic adenovirus
- olaparib
- il13ralpha2-specific hinge-optimized 41bb-co-stimulatory car truncated cd19-expressing autologous t-lymphocytes
- talotrexin
- +184 more
Other trials (29)
- Bismuth Subcitrate Potassium
- anti-thyroglobulin mtcr-transduced autologous peripheral blood lymphocytes
- bafetinib
- hydrocortisone
- fluorocholine
- beractant
- liothyronine
- levothyroxine
- 11c-ace
- isoflurane
- s-methionine
- heparin
- norepinephrine
- neostigmine
- glycine
- hydroxyethyl starch
- sulfasalazine
- avm0703
- 18f-fluoro-dihydroxyphenylalanine
- iodine
- oxycodone
- vecuronium
- nm404
- ga 68-edotreotide
- 124i-crgdy-peg-dots
- tinzaparin
- nitroglycerin
- cisatracurium
- testosterone
Organizations
Organization Involved with Phase 4 Indications (26)
- The Medicines Company
- Bracco
- Guerbet
- Monte Verde SA
- National Cancer Institute (NCI)
- Aarhus University
- Baskent University
- Duke University
- Advent Health
- University of Washington
- Indiana University
- Mahidol University
- New York University
- Aga Khan University
- Capital Medical University
- Istanbul University
- Peking University
- University of Buenos Aires
- Chiangmai University
- Aristotle University of Thessaloniki
- University of Tuebingen
- Sentara
- Laboratorio Raffo
- Sungkyunkwan University
- El-Sahel Teaching Hospital
- St. Jude Children's Hospital
Organization Involved with Phase 3 Indications (45)
- Bristol-Myers Squibb
- Pharmacyclics
- Pfizer
- Allergan
- Angiochem Inc
- Bayer
- Betta Pharmaceuticals Co.,Ltd.
- Blue Earth Diagnostics
- Celtic Pharma Development Services
- Kintara Therapeutics, Inc.
- Neurobiological Technologies
- Northwest Biotherapeutics
- Colombian Foundation for Epilepsy and Neurological Disease
- Barrow Neurological Institute
- Canadian Cancer Trials Group
- George Papanicolaou Hospital
- Italian Network for Tumor Biotherapy
- McMaster University
- NRG Oncology
- Tufts University
- University of Hamburg
- University of Siena
- University of Southern California
- University of Toronto
- University of Bonn
- Wake Forest University
- University of California, Los Angeles
- University of California, San Francisco
- University of Utah
- University of Amsterdam
- +15 more
Organization Involved with Phase 2 Indications (182)
- AbbVie
- DUSA Pharmaceuticals
- Pinnacle Biologics
- Spectrum Pharmaceuticals
- Kadmon
- Daiichi Sankyo
- Seattle Genetics
- Eisai
- Celgene
- OSI Pharmaceuticals
- Roche
- Schering-Plough
- AstraZeneca
- Merck
- Eli Lilly
- Genentech
- BTG
- Genzyme
- Sanofi
- AEterna Zentaris
- AIO-Studien-gGmbH
- Novartis
- Aposense Ltd.
- Array BioPharma
- Bradmer Pharmaceuticals Inc.
- Cortice Biosciences, Inc.
- DEKK-TEC, Inc.
- Direct Therapeutics
- DNAtrix, Inc.
- Hengrui Therapeutics, Inc.
- +152 more
Organization Involved with Phase 1 Indications (61)
- Cephalon
- Millennium Pharmaceuticals
- Curis
- Siemens
- Wyeth
- Copharos
- CTI BioPharma
- GlaxoSmithKline
- IGF Oncology, LLC
- Monteris Medical
- Myrexis Inc.
- Piramal
- Solvay
- e-Therapeutics PLC
- EpicentRx, Inc.
- Ziopharm
- Rockefeller University
- Children's Cancer and Leukaemia Group
- Hoag Memorial Hospital Presbyterian
- John Wayne Cancer Institute
- Johns Hopkins University
- Minia University
- Pediatric Brain Tumor Consortium
- Providence Health & Services
- Southwest Oncology Group
- Thomas Jefferson University
- University of Miami
- University of South Carolina
- Tel Aviv University
- University of Cincinnati
- +31 more
Organization Involved with Other Experimental Indications (13)
- Shahid Beheshti University of Medical Sciences
- University Hospital, Basel, Switzerland
- Main Line Health
- Mansoura University
- Yonsei University
- All India Institute of Medical Sciences
- University of Western Ontario
- Cures Within Reach
- General Electric
- Ride for Kids
- Children's Cancer Research Fund United States
- China Medical University
- Government of France