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Gastroesophageal Reflux
Retrograde flow of gastric juice (GASTRIC ACID) and/or duodenal contents (BILE ACIDS; PANCREATIC JUICE) into the distal ESOPHAGUS, commonly due to incompetence of the LOWER ESOPHAGEAL SPHINCTER.
Subtype terms (2)
More specific conditions that are subtypes of Gastroesophageal Reflux in the MeSH hierarchy.
- Laryngopharyngeal Reflux
12 drugs (8 approved, 4 experimental)
- Non-Erosive Reflux Disease
Drugs by status
Approved for this indication (15)
Phase 4 trials (29)
- aluminum
- aloe vera
- procaine benzylpenicillin
- cisapride
- citalopram
- diosmectite
- pectin
- aluminum hydroxide
- propranolol
- prucalopride succinate
- acetylsalicylic acid
- trimebutine
- polidocanol
- vonoprazan
- calcium alginate
- magnesium alginate
- stearic acid
- clarithromycin
- domperidone
- rebamipide
- psyllium
- baclofen
- mosapride
- indobufen
- zinc-l-carnosine
- zinc
- lactobacillus rhamnosus
- wu-chu-yu tang
- sodium alginate
Phase 3 trials (22)
Phase 2 trials (24)
Phase 1 trials (32)
Other trials (30)
- ringer's lactate
- amitriptyline
- buspirone
- chlorpromazine
- sucralfate
- denatonium benzoate
- ecabet
- gabapentin
- sevoflurane
- sertraline
- famotidine
- ursodeoxycholic acid
- piperonyl ranitidine hydrochloride
- epinephrine
- roxatidine acetate
- levobupivacaine
- xylitol
- ondansetron
- aluvra
- coffee
- midazolam
- pregabalin
- monosodium glutamate
- cimetidine
- erythromycin
- omega-3 fatty acids
- dexamethasone
- bismuth aluminate
- locust bean gum
- zuojin
Organizations
Organization Involved with Phase 4 Indications (84)
- Ferrosan AS
- Eisai
- Bausch Health Companies
- TAP Pharmaceuticals
- BTG
- Pfizer
- Wyeth
- NeuTec Pharma
- Parexel
- Torax Medical Incorporated
- Altana
- Chong Kun Dang Pharmaceutical
- Otsuka
- TTY Biopharm
- Dr. Falk Pharma GmbH
- Severance Hospital
- University of Arizona
- Advanced Center for Specialty Care
- American Institute for Voice and Ear Research
- Belarusian Medical Academy of Post-Graduate Education
- Chang Gung University
- University of London
- Digestive & Liver Disease Specialists
- Eastern Virginia Medical School
- Emory University
- Hanyang University
- Kaohsiung Medical University
- Katholieke Universiteit Leuven
- Loma Linda University
- Mansoura University
- +54 more
Organization Involved with Phase 3 Indications (89)
- Ironwood Pharmaceuticals
- Astellas
- Curis
- Novartis
- BioBalance Corporation
- Braintree Laboratories
- Dong-A Pharmaceutical
- Eurofarma Laboratorios S.A.
- Il-Yang Pharm. Co., Ltd.
- Livzon Pharmaceutical Group Inc.
- Nycomed
- Norgine
- Shandong Luoxin Pharmaceutical Group Stock Co., Ltd.
- Yooyoung Pharmaceutical Co.,Ltd.
- Ahn-Gook Pharmaceuticals Co.,Ltd
- Daewoong Pharmaceutical Co. LTD.
- Dexa Medica Group
- IlDong Pharmaceutical Co Ltd
- National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
- University of Pennsylvania
- Maastricht University
- University of Pittsburgh
- Baylor University
- Changhai Hospital
- Conselho Nacional de Desenvolvimento Científico e Tecnológico
- Harvard University
- Duke University
- Gadjah Mada University
- Hoosier Cancer Research Network
- Hospital Infantil Cândido Fontoura
- +59 more
Organization Involved with Phase 2 Indications (25)
- XenoPort, Inc.
- Shire
- Edusa Pharmaceuticals, Inc.
- Effexus Pharmaceutical
- GlaxoSmithKline
- Indivior Inc.
- Jeil Pharmaceutical Co., Ltd.
- Movetis
- Ocera Therapeutics
- Vecta Ltd.
- China Academy of Chinese Medical Sciences
- Stanford University
- Peking University
- Tel Aviv University
- Xiyuan Hospital
- University of Amsterdam
- Oklahoma Foundation for Digestive Research
- Addex Pharma
- Free University of Brussels
- University of Nantes
- University of Brussels
- University of Paris
- Yuhan Pharmaceutical Company
- Government of Taiwan
- Sinorda Biomedicine
Organization Involved with Phase 1 Indications (31)
- Sanofi
- Aradigm Corporation
- CTC Bio, Inc.
- Steba Biotech S.A.
- The EMMES Corporation
- National Heart, Lung, and Blood Institute (NHLBI)
- University of Roma La Sapienza
- Huazhong University of Science and Technology
- Ajou University
- Guangdong Provincial Hospital of Traditional Chinese Medicine
- Guangxi Medical University
- New York University
- The New York Eye & Ear Infirmary
- West Side ENT
- Aalborg University
- Tianjin University of Traditional Chinese Medicine
- University of California, Davis
- University of California, San Francisco
- Hammersmith Medicines Research
- Profil GmbH
- Liaoning Hospital of Traditional Chinese Medicine
- California Clinical Trials
- Bio-Kinetic Clinical Applications
- Clinical Applications Laboratories Inc.
- Asheville Speech Associates
- Healthcare Discoveries Inc.
- Washington University in St. Louis
- Thai Rheumatism Association
- IQVIA
- Addpharma Inc.
- +1 more
Organization Involved with Other Experimental Indications (34)
- SOFAR S.p.A.
- United Pharmaceuticals
- Midwest Biomedical Research Foundation
- National Center for Complementary and Integrative Health (NCCIH)
- Hodge, Kenneth M., M.D.
- Children's Hospital of Philadelphia
- Case Western Reserve University
- Changi General Hospital
- University of Washington
- Gunma University
- Head and Neck Surgery Associates
- Indiana University
- King Fahad Medical City
- Ochsner Health System
- Ponce Gastroenterology Research
- University of Malaya
- University of Rochester
- University of Athens
- University of Bordeaux
- Virginia Commonwealth University
- University of Virginia
- Columbia University
- University of California, Irvine
- University of Naples Frederico II
- Medical University of South Carolina
- Taipei Veteran General hospital
- Istituto Clinico Humanitas - Rozzano (MI), Italy
- National University of Singapore
- The University of Hong Kong
- Commonwealth ENT, Louisville, KY
- +4 more